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Select item 69935461.

The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis

Anne M. Scruggs, Gintautas Grabauskas, Steven K. Huang

Am J Respir Cell Mol Biol. 2020 Feb; 62(2): 191–203. doi: 10.1165/rcmb.2019-0163OC

PMCID:: PMC6993546

Abstract Article PDF–1.5M

Select item 69335322.

Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients

Tong Lu, Qiang Chai, Guoqing Jiao, Xiao-Li Wang, Xiaojing Sun, Jonathan D Furuseth, John M Stulak, Richard C Daly, Kevin L Greason, Yong-Mei Cha, Hon-Chi Lee

Cardiovasc Res. 2019 Jan 1; 115(1): 145–153. Published online 2018 May 30. doi: 10.1093/cvr/cvy137

PMCID:: PMC6933532

Abstract Article PDF–733K

Select item 65790313.

Phenotypic Alteration of a Human BK (hSlo) Channel byhSloβ Subunit Coexpression: Changes in Blocker Sensitivity, Activation/Relaxation and Inactivation Kinetics, and Protein Kinase A Modulation

Steven I. Dworetzky, Christopher G. Boissard, Janet T. Lum-Ragan, M. Craig McKay, Debra J. Post-Munson, Joanne T. Trojnacki, Chia-Ping Chang, Valentin K. Gribkoff

J Neurosci. 1996 Aug 1; 16(15): 4543–4550. doi: 10.1523/JNEUROSCI.16-15-04543.1996

PMCID:: PMC6579031

Abstract Article PDF–371K

Select item 44031534.

Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels

Karen Castillo, Gustavo F. Contreras, Amaury Pupo, Yolima P. Torres, Alan Neely, Carlos González, Ramon Latorre

Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15): 4809–4814. Published online 2015 Mar 30. doi: 10.1073/pnas.1504378112

PMCID:: PMC4403153

Abstract Article PDF–1.3M

Select item 41836565.

Both Transmembrane Domains of BK β1 Subunits Are Essential to Confer the Normal Phenotype of β1-Containing BK Channels

Guruprasad Kuntamallappanavar, Ligia Toro, Alex M. Dopico

PLoS One. 2014; 9(10): e109306. Published online 2014 Oct 2. doi: 10.1371/journal.pone.0109306

PMCID:: PMC4183656

Abstract Article PDF–1.7M

Select item 29757316.

Common Charge-Shift Mutation Glu65Lys in K⁺ Channel β₁-Subunit KCNMB1: Pleiotropic Consequences for Glomerular Filtration Rate and Progressive Renal Disease

Yuqing Chen, Rany M. Salem, Fangwen Rao, Maple M. Fung, Vibha Bhatnagar, Braj Pandey, Manjula Mahata, Jill Waalen, Caroline M. Nievergelt, Michael S. Lipkowitz, Bruce A. Hamilton, Sushil K. Mahata, Daniel T. O'Connor

Am J Nephrol. 2010 Nov; 32(5): 414–424. Published online 2010 Sep 23. doi: 10.1159/000320131

PMCID:: PMC2975731

Abstract Article PDF–215K

Select item 27338057.

An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity

Max A. Seibold, Bin Wang, Celeste Eng, Gunjan Kumar, Kenneth B. Beckman, Saunak Sen, Shweta Choudhry, Kelley Meade, Michael Lenoir, H. Geoffrey Watson, Shannon Thyne, L. Keoki Williams, Rajesh Kumar, Kevin B. Weiss, Leslie C. Grammer, Pedro C. Avila, Robert P. Schleimer, Esteban González Burchard, Robert Brenner

Hum Mol Genet. 2008 Sep 1; 17(17): 2681–2690. Published online 2008 Jun 4. doi: 10.1093/hmg/ddn168

PMCID:: PMC2733805

Abstract Article PDF–487K

Select item 27135848.

KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)

Amber L. Beitelshees, Yan Gong, Danxin Wang, Nicholas J. Schork, Rhonda M. Cooper-DeHoff, Taimour Y. Langaee, Mark D. Shriver, Wolfgang Sadee, Harm J. Knot, Carl J. Pepine, Julie A. Johnson

Pharmacogenet Genomics. Author manuscript; available in PMC 2009 Jul 21.

Published in final edited form as: Pharmacogenet Genomics. 2007 Sep; 17(9): 719–729. doi: 10.1097/FPC.0b013e32810f2e3c

PMCID:: PMC2713584

Abstract Article PDF–710K

Select item 27135759.

Single nucleotide polymorphism discovery and haplotype analysis of Ca²⁺-dependent K⁺ channel beta-1 subunit

Yan Gong, Amber L. Beitelshees, Jennifer Wessel, Taimour Y. Langaee, Nicholas J. Schork, Julie A. Johnson

Pharmacogenet Genomics. Author manuscript; available in PMC 2009 Jul 21.

Published in final edited form as: Pharmacogenet Genomics. 2007 Apr; 17(4): 267–275. doi: 10.1097/FPC.0b013e3280105235

PMCID:: PMC2713575

Abstract Article PDF–1.8M

Select item 265968910.

THE PROTECTIVE EFFECT OF KCNMB1 E65K AGAINST HYPERTENSION IS RESTRICTED TO BLOOD PRESSURE TREATMENT WITH BETA-BLOCKADE

Alyson Kelley-Hedgepeth, Inga Peter, Kevin E. Kip, Maria Claudia Montefusco, Sophia Kogan, Daniel Cox, Jose M. Ordovas, Daniel Levy, Steven E. Reis, Michael E. Mendelsohn, David Housman, Gordon S. Huggins

J Hum Hypertens. Author manuscript; available in PMC 2009 Mar 23.

Published in final edited form as: J Hum Hypertens. 2008 Jul; 22(7): 512–515. Published online 2008 Apr 17. doi: 10.1038/jhh.2008.23

PMCID:: PMC2659689

Abstract Article PDF–289K

Select item 263776311.

The KCNMB1 E65K Variant is Associated with Reduced Central Pulse Pressure in the Community-Based Framingham Offspring Cohort

Alyson Kelley-Hedgepeth, Inga Peter, M. Claudia Montefusco, Daniel Levy, Emelia J. Benjamin, Ramachandran S. Vasan, Michael E. Mendelsohn, David Housman, Gordon S. Huggins, Gary F. Mitchell

J Hypertens. Author manuscript; available in PMC 2010 Jan 1.

Published in final edited form as: J Hypertens. 2009 Jan; 27(1): 55–60. doi: 10.1097/HJH.0b013e328317c8ae

PMCID:: PMC2637763

Abstract Article PDF–324K

Select item 37932412.

Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension

José M. Fernández-Fernández, Marta Tomás, Esther Vázquez, Patricio Orio, Ramón Latorre, Mariano Sentí, Jaume Marrugat, Miguel A. Valverde

J Clin Invest. 2004 Apr 1; 113(7): 1032–1039. doi: 10.1172/JCI20347

PMCID:: PMC379324

Abstract Article PDF–1.5M

Select item 18776413.

β1 subunits facilitate gating of BK channels by acting through the Ca²⁺, but not the Mg²⁺, activating mechanisms

Xiang Qian, Karl L. Magleby

Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17): 10061–10066. Published online 2003 Jul 31. doi: 10.1073/pnas.1731650100

PMCID:: PMC187764

Abstract Article PDF–2.1M

Select item 3861914.

Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain.

J Tseng-Crank, N Godinot, T E Johansen, P K Ahring, D Strøbaek, R Mertz, C D Foster, S P Olesen, P H Reinhart

Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17): 9200–9205. doi: 10.1073/pnas.93.17.9200

PMCID:: PMC38619

Summary Page Browse PDF–1.8M

Select item 553148615.

The unique N-terminal sequence of the BK_Ca channel α-subunit determines its modulation by β-subunits

Ramón A. Lorca, Xiaofeng Ma, Sarah K. England

PLoS One. 2017; 12(7): e0182068. Published online 2017 Jul 27. doi: 10.1371/journal.pone.0182068

PMCID:: PMC5531486

Abstract Article PDF–3.2M

Select item 498858916.

β1-subunit–induced structural rearrangements of the Ca²⁺- and voltage-activated K⁺ (BK) channel

Juan P. Castillo, Jorge E. Sánchez-Rodríguez, H. Clark Hyde, Cristian A. Zaelzer, Daniel Aguayo, Romina V. Sepúlveda, Louis Y. P. Luk, Stephen B. H. Kent, Fernando D. Gonzalez-Nilo, Francisco Bezanilla, Ramón Latorre

Proc Natl Acad Sci U S A. 2016 Jun 7; 113(23): E3231–E3239. Published online 2016 May 23. doi: 10.1073/pnas.1606381113