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Select item 108892281.

Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2

Lucía Paniagua-Herranz, Irene Moreno, Cristina Nieto-Jiménez, Esther Garcia-Lorenzo, Cristina Díaz-Tejeiro, Adrián Sanvicente, Bernard Doger, Manuel Pedregal, Jorge Ramón, Jorge Bartolomé, Arancha Manzano, Balázs Gyorffy, Álvaro Gutierrez-Uzquiza, Pedro Pérez Segura, Emiliano Calvo, Víctor Moreno, Alberto Ocana

Int J Mol Sci. 2024 Feb; 25(4): 2222. Published online 2024 Feb 13. doi: 10.3390/ijms25042222

PMCID:: PMC10889228

Abstract Article PDF–3.4M

Select item 47053802.

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

Shihui Guo, Wolfgang Skala, Viktor Magdolen, Peter Briza, Martin L. Biniossek, Oliver Schilling, Josef Kellermann, Hans Brandstetter, Peter Goettig

J Biol Chem. 2016 Jan 8; 291(2): 593–604. Published online 2015 Nov 18. doi: 10.1074/jbc.M115.691097

PMCID:: PMC4705380

Abstract Article PDF–2.4M

Select item 42563583.

Structure-Function Analyses of Human Kallikrein-related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity

Wolfgang Skala, Daniel T. Utzschneider, Viktor Magdolen, Mekdes Debela, Shihui Guo, Charles S. Craik, Hans Brandstetter, Peter Goettig

J Biol Chem. 2014 Dec 5; 289(49): 34267–34283. Published online 2014 Oct 17. doi: 10.1074/jbc.M114.598201

PMCID:: PMC4256358

Abstract Article PDF–4.5M

Select item 39823194.

Exploratory study of a KLK2 polymorphism as a prognostic marker in prostate cancer

Manish Kohli, Paul G. Rothberg, Changyong Feng, Edward Messing, Jean Joseph, Sreevidya Sadasiva Rao, Allison Hendershot, Deepak Sahsrabudhe

Cancer Biomark. Author manuscript; available in PMC 2014 Apr 10.

Published in final edited form as: Cancer Biomark. 2010; 7(2): 101–108. doi: 10.3233/CBM-2010-0152

PMCID:: PMC3982319

Abstract Article PDF–513K

Select item 34139195.

Tissue Kallikrein Promotes Cardiac Neovascularization by Enhancing Endothelial Progenitor Cell Functional Capacity

Yuyu Yao, Zulong Sheng, Yefei Li, Fengdi Yan, Cong Fu, Yongjun Li, Genshan Ma, Naifeng Liu, Julie Chao, Lee Chao

Hum Gene Ther. 2012 Aug; 23(8): 859–870. Published online 2012 Mar 22. doi: 10.1089/hum.2011.123

PMCID:: PMC3413919

Abstract Article PDF–1.3M

Select item 68249326.

Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer

Melanie A. Krook, Hannah Barker, Hui-Zi Chen, Julie W. Reeser, Michele R. Wing, Dorrelyn Martin, Amy M. Smith, Thuy Dao, Russell Bonneville, Eric Samorodnitsky, Jharna Miya, Aharon G. Freud, J. Paul Monk, Steven K. Clinton, Sameek Roychowdhury

Prostate Cancer Prostatic Dis. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Prostate Cancer Prostatic Dis. 2019 Dec; 22(4): 624–632. Published online 2019 May 1. doi: 10.1038/s41391-019-0145-2

PMCID:: PMC6824932

Abstract Article PDF–1.3M

Select item 40767917.

Proteomic analysis of patient tissue reveals PSA protein in the stroma of benign prostatic hyperplasia

Katherine J. O’Malley, Kurtis Eisermann, Laura E. Pascal, Anil V. Parwani, Tsuyoshi Majima, Lara Graham, Katherine Hrebinko, Marie Acquafondata, Nicolas A. Stewart, Joel B. Nelson, Naoki Yoshimura, Zhou Wang

Prostate. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Prostate. 2014 Jun; 74(8): 892–900. Published online 2014 Apr 7. doi: 10.1002/pros.22807

PMCID:: PMC4076791

Abstract Article PDF–2.9M

Select item 39436148.

Genetic variation in KLK2 and KLK3 is associated with levels of hK2 and PSA in seminal plasma and in serum in young men

Charlotta Sävblom, Christer Halldén, Angel M. Cronin, Torbjörn Säll, Caroline Savage, Emily A. Vertosick, Robert J. Klein, Aleksander Giwercman, Hans Lilja

Clin Chem. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: Clin Chem. 2014 Mar; 60(3): 490–499. Published online 2013 Nov 22. doi: 10.1373/clinchem.2013.211219

PMCID:: PMC3943614

Abstract Article PDF–191K

Select item 37860599.

Predictive Value of Four Kallikrein Markers for Pathologically Insignificant Compared With Aggressive Prostate Cancer in Radical Prostatectomy Specimens: Results From the European Randomized Study of Screening for Prostate Cancer Section Rotterdam

Sigrid Carlsson, Alexandra Maschino, Fritz Schröder, Chris Bangma, Ewout W. Steyerberg, Theo van der Kwast, Geert van Leenders, Andrew Vickers, Hans Lilja, Monique J. Roobol

Eur Urol. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Eur Urol. 2013 Nov; 64(5): 693–699. Published online 2013 May 2. doi: 10.1016/j.eururo.2013.04.040

PMCID:: PMC3786059

Abstract Article PDF–304K

Select item 277677310.

Evaluation of molecular forms of PSA and human kallikrein 2 in predicting biochemical failure following radical prostatectomy

Sven Wenske, Ruslan Korets, Angel M. Cronin, Andrew J. Vickers, Martin Fleisher, Howard I. Scher, Kim Pettersson, Bertrand Guillonneau, Peter T. Scardino, James A. Eastham, Hans Lilja

Int J Cancer. Author manuscript; available in PMC 2009 Nov 12.

Published in final edited form as: Int J Cancer. 2009 Feb 1; 124(3): 659–663. doi: 10.1002/ijc.23983

PMCID:: PMC2776773

Abstract Article PDF–72K

Select item 195047211.

Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hk2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum

Thomas Steuber, Andrew J. Vickers, Alexander Haese, Charlotte Becker, Kim Pettersson, Felix K.-H. Chun, Michael W. Kattan, James A. Eastham, Peter T. Scardino, Hartwig Huland, Hans Lilja

Int J Cancer. Author manuscript; available in PMC 2007 Aug 21.

Published in final edited form as: Int J Cancer. 2006 Mar 1; 118(5): 1234–1240. doi: 10.1002/ijc.21474

PMCID:: PMC1950472

Abstract Article PDF–181K

Select item 355694212.

Genome-wide Association Study Identifies Loci at ATF7IP and KLK2 Associated with Percentage of Circulating Free PSA

Guangfu Jin, Siqun Lilly Zheng, Hans Lilja, Seong-Tae Kim, Sha Tao, Zhengrong Gao, Tracey Young, Fredrik Wiklund, Junjie Feng, William B Isaacs, Roger S Rittmaster, Henrik Gronberg, Lynn D Condreay, Jielin Sun, Jianfeng Xu

Neoplasia. 2013 Jan; 15(1): 95–101. doi: 10.1593/neo.121620

PMCID:: PMC3556942

Abstract Article PDF–717K

Select item 279337813.

A comprehensive resequence analysis of the KLK15–KLK3–KLK2 locus on chromosome 19q13.33

Hemang Parikh, Zuoming Deng, Meredith Yeager, Joseph Boland, Casey Matthews, Jinping Jia, Irene Collins, Ariel White, Laura Burdett, Amy Hutchinson, Liqun Qi, Jennifer A. Bacior, Victor Lonsberry, Matthew J. Rodesch, Jeffrey A. Jeddeloh, Thomas J. Albert, Heather A. Halvensleben, Timothy T. Harkins, Jiyoung Ahn, Sonja I. Berndt, Nilanjan Chatterjee, Robert Hoover, Gilles Thomas, David J. Hunter, Richard B. Hayes, Stephen J. Chanock, Laufey Amundadottir

Hum Genet. 2010; 127(1): 91–99. Published online 2009 Oct 13. doi: 10.1007/s00439-009-0751-5

PMCID:: PMC2793378

Abstract Article PDF–439K

Select item 361291614.

Genome-wide Association Study Identifies Genetic Determinants of Urine PCA3 Levels in Men

Zhuo Chen, Jielin Sun, Seong-Tae Kim, Jack Groskopf, Junjie Feng, William B Isaacs, Roger S Rittmaster, Lynn D Condreay, Siqun Lilly Zheng, Jianfeng Xu

Neoplasia. 2013 Apr; 15(4): 448–453. doi: 10.1593/neo.122144

PMCID:: PMC3612916

Abstract Article PDF–455K

Select item 291760715.

Generalizability of Associations from Prostate Cancer GWAS in Multiple Populations

Kevin M. Waters, Loic Le Marchand, Laurence N. Kolonel, Kristine R. Monroe, Daniel O. Stram, Brian E. Henderson, Christopher A. Haiman

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2010 Aug 7.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 Apr; 18(4): 1285–1289. Published online 2009 Mar 24. doi: 10.1158/1055-9965.EPI-08-1142

PMCID:: PMC2917607

Abstract Article PDF–291K

Select item 373200916.

Susceptibility Loci Associated with Prostate Cancer Progression and Mortality

David J. Gallagher, Joseph Vijai, Angel M. Cronin, Jasmine Bhatia, Andrew J. Vickers, Mia M. Gaudet, Samson Fine, Victor Reuter, Howard I. Scher, Christer Halldén, Ana Dutra-Clarke, Robert J. Klein, Peter T. Scardino, James A. Eastham, Hans Lilja, Tomas Kirchhoff, Kenneth Offit

Clin Cancer Res. Author manuscript; available in PMC 2013 Aug 2.

Published in final edited form as: Clin Cancer Res. 2010 May 15; 16(10): 2819–2832. Published online 2010 May 11. doi: 10.1158/1078-0432.CCR-10-0028

PMCID:: PMC3732009

Abstract Article PDF–683K

Select item 311061617.

Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent

Bao-Li Chang, Elaine Spangler, Stephen Gallagher, Christopher A. Haiman, Brian Henderson, William Isaacs, Marnita L. Benford, LaCreis R. Kidd, Kathleen Cooney, Sara Strom, Sue Ann Ingles, Mariana C. Stern, Roman Corral, Amit D. Joshi, Jianfeng Xu, Veda N. Giri, Benjamin Rybicki, Christine Neslund-Dudas, Adam S. Kibel, Ian M. Thompson, Robin J. Leach, Elaine A. Ostrander, Janet L. Stanford, John Witte, Graham Casey, Rosalind Eeles, Ann W. Hsing, Stephen Chanock, Jennifer J. Hu, Esther M. John, Jong Park, Klara Stefflova, Charnita Zeigler-Johnson, Timothy R. Rebbeck

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 Jul 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2011 Jan; 20(1): 23–32. Published online 2010 Nov 11. doi: 10.1158/1055-9965.EPI-10-0698

PMCID:: PMC3110616

Abstract Article PDF–592K

Select item 286557018.

Blood biomarker levels to aid discovery of cancer-related single nucleotide polymorphisms: kallikreins and prostate cancer

Robert J. Klein, Christer Halldén, Angel M Cronin, Alexander Ploner, Fredrik Wiklund, Anders S Bjartell, Pär Stattin, Jianfeng Xu, Peter T Scardino, Kenneth Offit, Andrew J Vickers, Henrik Grönberg, Hans Lilja

Cancer Prev Res (Phila) Author manuscript; available in PMC 2011 May 1.

Published in final edited form as: Cancer Prev Res (Phila). 2010 May; 3(5): 611–619. Published online 2010 Apr 27. doi: 10.1158/1940-6207.CAPR-09-0206

PMCID:: PMC2865570

Abstract Article PDF–517K

Select item 373228619.

A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease

Malin Östensson, Caroline Montén, Jonas Bacelis, Audur H. Gudjonsdottir, Svetlana Adamovic, Johan Ek, Henry Ascher, Elisabet Pollak, Henrik Arnell, Lars Browaldh, Daniel Agardh, Jan Wahlström, Staffan Nilsson, Åsa Torinsson-Naluai

PLoS One. 2013; 8(8): e70174. Published online 2013 Aug 2. doi: 10.1371/journal.pone.0070174

PMCID:: PMC3732286

Abstract Article PDF–1.7M

Select item 39575220.

An unappreciated role for RNA surveillance

R Tyler Hillman, Richard E Green, Steven E Brenner

Genome Biol. 2004; 5(2): R8. Published online 2004 Feb 2. doi: 10.1186/gb-2004-5-2-r8

PMCID:: PMC395752

Abstract Article PDF–378K

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