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Select item 98284691.

Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma: The role of Arginase 2 in sorafenib-induced ferroptosis in melanoma

Yi Yu, Yuanyuan Ren, Caihua Wang, Zhuozhuo Li, Fanglin Niu, Zi Li, Qiang Ye, Jiangxia Wang, Yuan Yan, Ping Liu, Lu Qian, Yuyan Xiong

Acta Biochim Biophys Sin (Shanghai) 2022 Nov; 54(11): 1658–1670. Published online 2022 Nov 9. doi: 10.3724/abbs.2022166

PMCID:: PMC9828469

Abstract Article PDF–2.1M

Select item 98084622.

Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression

A. Giannoudis, D. Varešlija, V. Sharma, R. Zakaria, A. Platt-Higgins, P.S. Rudland, M.D. Jenkinson, L.S. Young, C. Palmieri

ESMO Open. 2022 Dec; 7(6): 100636. Published online 2022 Nov 21. doi: 10.1016/j.esmoop.2022.100636

PMCID:: PMC9808462

Abstract Article PDF–678K

Select item 91751343.

Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase‐2 expression and proliferation

Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. Nelin

Physiol Rep. 2022 Jun; 10(11): e15342. Published online 2022 Jun 8. doi: 10.14814/phy2.15342

PMCID:: PMC9175134

Abstract Article PDF–1.2M

Select item 86259804.

Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

Lorella Marselli, Emanuele Bosi, Carmela De Luca, Silvia Del Guerra, Marta Tesi, Mara Suleiman, Piero Marchetti

Int J Mol Sci. 2021 Nov; 22(22): 12099. Published online 2021 Nov 9. doi: 10.3390/ijms222212099

PMCID:: PMC8625980

Abstract Article PDF–4.7M

Select item 75815505.

Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity

Barbara Érsek, Pálma Silló, Ugur Cakir, Viktor Molnár, András Bencsik, Balázs Mayer, Eva Mezey, Sarolta Kárpáti, Zoltán Pós, Krisztián Németh

Cell Mol Life Sci. 2021 Jan; 78(2): 661–673. Published online 2020 Apr 23. doi: 10.1007/s00018-020-03517-8

PMCID:: PMC7581550

Abstract Article PDF–3.1M

Select item 75315646.

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action

Mark Austin, Daniel Burschowsky, Denice T.Y. Chan, Lesley Jenkinson, Stuart Haynes, Agata Diamandakis, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise H. Slater, Andreas V. Hadjinicolaou, Uzi Gileadi, Ellen Gowans, Yoko Shibata, Michelle Barnard, Teresa Kaserer, Pooja Sharma, Nadia M. Luheshi, Robert W. Wilkinson, Tristan J. Vaughan, Sarah V. Holt, Vincenzo Cerundolo, Mark D. Carr, Maria A. T. Groves

MAbs. 2020 Jan-Dec; 12(1): 1801230. Published online 2020 Sep 3. doi: 10.1080/19420862.2020.1801230

PMCID:: PMC7531564

Abstract Article PDF–9.1M

Select item 68215997.

Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology

Amalie B. Nielsen, Mi Zhou, Adam J. de Smith, Rong Wang, Lucie McCoy, Helen Hansen, Libby Morimoto, Kirsten Grønbæk, Christoffer Johansen, Scott C. Kogan, Catherine Metayer, Paige M. Bracci, Xiaomei Ma, Joseph L. Wiemels

Haematologica. 2019 Nov; 104(11): e514–e516. doi: 10.3324/haematol.2019.216465

PMCID:: PMC6821599

Article PDF–2.3M

Select item 59904828.

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity

Joshua D. Ochocki, Sanika Khare, Markus Hess, Daniel Ackerman, Bo Qiu, Jennie I. Daisak, Andrew J. Worth, Nan Lin, Pearl Lee, Hong Xie, Bo Li, Bradley Wubbenhorst, Tobi G. Maguire, Katherine L. Nathanson, James C. Alwine, Ian A. Blair, Itzhak Nissim, Brian Keith, M. Celeste Simon

Cell Metab. Author manuscript; available in PMC 2019 Jun 5.

Published in final edited form as: Cell Metab. 2018 Jun 5; 27(6): 1263–1280.e6. Published online 2018 May 10. doi: 10.1016/j.cmet.2018.04.009

PMCID:: PMC5990482

Abstract Article PDF–1.4M

Select item 54070969.

Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKα₁ signaling

Jianjing Xue, Leif D. Nelin, Bernadette Chen

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312(4): L568–L578. Published online 2017 Feb 17. doi: 10.1152/ajplung.00117.2016

PMCID:: PMC5407096

Abstract Article

Select item 521693610.

Human cytomegalovirus may promote tumour progression by upregulating arginase-2

Helena Costa, Xinling Xu, Gitta Overbeek, Suhas Vasaikar, C. Pawan K. Patro, Ourania N. Kostopoulou, Masany Jung, Gowhar Shafi, Sharan Ananthaseshan, Giorgos Tsipras, Belghis Davoudi, Abdul-Aleem Mohammad, Hoyin Lam, Klas Strååt, Vanessa Wilhelmi, Mingmei Shang, Jesper Tegner, Joo Chuan Tong, Kum Thong Wong, Cecilia Söderberg-Naucler, Koon-Chu Yaiw

Oncotarget. 2016 Jul 26; 7(30): 47221–47231. Published online 2016 May 30. doi: 10.18632/oncotarget.9722

PMCID:: PMC5216936

Abstract Article PDF–5.7M

Select item 452766211.

Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity

Francis Mussai, Sharon Egan, Stuart Hunter, Hannah Webber, Jonathan Fisher, Rachel Wheat, Carmel McConville, Yordan Sbirkov, Kate Wheeler, Gavin Bendle, Kevin Petrie, John Anderson, Louis Chesler, Carmela De Santo

Cancer Res. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Cancer Res. 2015 Aug 1; 75(15): 3043–3053. Published online 2015 Jun 8. doi: 10.1158/0008-5472.CAN-14-3443

PMCID:: PMC4527662

Abstract Article PDF–2.5M

Select item 377409612.

Hypoxic upregulation of arginase II in human lung endothelial cells

Karina Krotova, Jawaharlal M. Patel, Edward R. Block, Sergey Zharikov

Am J Physiol Cell Physiol. 2010 Dec; 299(6): C1541–C1548. Published online 2010 Sep 22. doi: 10.1152/ajpcell.00068.2010

PMCID:: PMC3774096

Abstract Article

Select item 357047113.

Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer

Yoshinori Ino, Rie Yamazaki-Itoh, Seiji Oguro, Kazuaki Shimada, Tomoo Kosuge, Jan Zavada, Yae Kanai, Nobuyoshi Hiraoka

PLoS One. 2013; 8(2): e55146. Published online 2013 Feb 12. doi: 10.1371/journal.pone.0055146

PMCID:: PMC3570471

Abstract Article PDF–5.7M

Select item 342346714.

Pharmacologic Agents Elevating cAMP Prevent Arginase II Expression and Proliferation of Pulmonary Artery Smooth Muscle Cells

Bernadette Chen, Andrea E. Calvert, Xiaomei Meng, Leif D. Nelin

Am J Respir Cell Mol Biol. 2012 Aug; 47(2): 218–226. doi: 10.1165/rcmb.2011-0015OC

PMCID:: PMC3423467

Abstract Article PDF–1.3M

Select item 266478715.

Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline

Xiu-Fen Ming, Angana Gupta Rajapakse, João Miguel Carvas, Jean Ruffieux, Zhihong Yang

BMC Cardiovasc Disord. 2009; 9: 12. Published online 2009 Mar 13. doi: 10.1186/1471-2261-9-12

PMCID:: PMC2664787

Abstract Article PDF–588K

Select item 222598716.

Amplified Expression Profiling of Platelet Transcriptome Reveals Changes in Arginine Metabolic Pathways in Patients With Sickle Cell Disease

Nalini Raghavachari, Xiuli Xu, Amy Harris, Jose Villagra, Carolea Logun, Jennifer Barb, Michael A. Solomon, Anthony F. Suffredini, Robert L. Danner, Gregory Kato, Peter J. Munson, Sidney M. Morris, Jr, Mark T. Gladwin

Circulation. Author manuscript; available in PMC 2008 Feb 4.

Published in final edited form as: Circulation. 2007 Mar 27; 115(12): 1551–1562. Published online 2007 Mar 12. doi: 10.1161/CIRCULATIONAHA.106.658641