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Select item 108839331.

Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis

Ji Geng, Shuangxi Li, Yu Li, Zhihao Wu, Sunil Bhurtel, Suman Rimal, Danish Khan, Rani Ohja, Onn Brandman, Bingwei Lu

Nat Commun. 2024; 15: 1637. Published online 2024 Feb 22. doi: 10.1038/s41467-024-45525-3

PMCID:: PMC10883933

Abstract Article PDF–3.9M

Select item 65555322.

The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development

Lucas G. Dent, Samuel A. Manning, Benjamin Kroeger, Audrey M. Williams, Abdul Jabbar Saiful Hilmi, Luke Crea, Shu Kondo, Sally Horne-Badovinac, Kieran F. Harvey

PLoS Genet. 2019 May; 15(5): e1008083. Published online 2019 May 22. doi: 10.1371/journal.pgen.1008083

PMCID:: PMC6555532

Abstract Article PDF–6.3M

Select item 59895593.

Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy

Zhihao Wu, Yan Wang, Junghyun Lim, Boxiang Liu, Yanping Li, Rasika Vartak, Trisha Stankiewicz, Stephen Montgomery, Bingwei Lu

Cell Metab. Author manuscript; available in PMC 2019 Jul 3.

Published in final edited form as: Cell Metab. 2018 Jul 3; 28(1): 130–144.e7. Published online 2018 May 31. doi: 10.1016/j.cmet.2018.05.007

PMCID:: PMC5989559

Abstract Article PDF–1.6M

Select item 55828294.

The neuronal protein Neurexin directly interacts with the Scribble–Pix complex to stimulate F-actin assembly for synaptic vesicle clustering

Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie

J Biol Chem. 2017 Sep 1; 292(35): 14334–14348. Published online 2017 Jul 14. doi: 10.1074/jbc.M117.794040

PMCID:: PMC5582829

Abstract Article PDF–5.1M

Select item 85222495.

Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease

Suman Rimal, Yu Li, Rasika Vartak, Ji Geng, Ishaq Tantray, Shuangxi Li, Sungun Huh, Hannes Vogel, Charles Glabe, Lea T. Grinberg, Salvatore Spina, William W. Seeley, Su Guo, Bingwei Lu

Acta Neuropathol Commun. 2021; 9: 169. Published online 2021 Oct 18. doi: 10.1186/s40478-021-01268-6

PMCID:: PMC8522249

Abstract Article PDF–2.5M

Select item 109112796.

The Drosophila tumour suppressor Lgl and Vap33 activate the Hippo pathway through a dual mechanism

Marta Portela, Swastik Mukherjee, Sayantanee Paul, John E. La Marca, Linda M. Parsons, Alexey Veraksa, Helena E. Richardson

J Cell Sci. 2024 Feb 15; 137(4): jcs261917. Published online 2024 Feb 16. doi: 10.1242/jcs.261917

PMCID:: PMC10911279

Abstract Article

Select item 70930507.

Mechanisms Linking Mitochondria Dysfunction and Proteostasis Failure

Bingwei Lu, Su Guo

Trends Cell Biol. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: Trends Cell Biol. 2020 Apr; 30(4): 317–328. Published online 2020 Feb 12. doi: 10.1016/j.tcb.2020.01.008

PMCID:: PMC7093050

Abstract Article PDF–840K

Select item 73462848.

Specific isoforms of the guanine nucleotide exchange factor dPix couple neuromuscular synapse growth to muscle growth

Cheuk Hei Ho, Jessica E. Treisman

Dev Cell. Author manuscript; available in PMC 2021 Jul 6.

Published in final edited form as: Dev Cell. 2020 Jul 6; 54(1): 117–131.e5. Published online 2020 Jun 8. doi: 10.1016/j.devcel.2020.05.015

PMCID:: PMC7346284

Abstract Article PDF–1.4M

Select item 95863049.

Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2–encoded Nsp1

Xingjun Wang, Suman Rimal, Ishaq Tantray, Ji Geng, Sunil Bhurtel, Tejinder Pal Khaket, Wen Li, Zhe Han, Bingwei Lu

Proc Natl Acad Sci U S A. 2022 Oct 18; 119(42): e2202322119. Published online 2022 Sep 28. doi: 10.1073/pnas.2202322119

PMCID:: PMC9586304

Abstract Article PDF–2.6M

Select item 895609910.

Domesticated LTR-Retrotransposon gag-Related Gene (Gagr) as a Member of the Stress Response Network in Drosophila

Lidia Nefedova, Alexey Gigin, Alexander Kim

Life (Basel) 2022 Mar; 12(3): 364. Published online 2022 Mar 3. doi: 10.3390/life12030364

PMCID:: PMC8956099

Abstract Article PDF–1.1M

Select item 754724611.

Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD

Shuangxi Li, Zhihao Wu, Ishaq Tantray, Yu Li, Songjie Chen, Jason Dong, Steven Glynn, Hannes Vogel, Michael Snyder, Bingwei Lu

Proc Natl Acad Sci U S A. 2020 Oct 6; 117(40): 25104–25115. Published online 2020 Sep 21. doi: 10.1073/pnas.2005506117

PMCID:: PMC7547246

Abstract Article PDF–2.3M

Select item 289170312.

Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF–Dependent Transcription in Hypoxia

Andrés Dekanty, Nuria M. Romero, Agustina P. Bertolin, María G. Thomas, Claudia C. Leishman, Joel I. Perez-Perri, Graciela L. Boccaccio, Pablo Wappner

PLoS Genet. 2010 Jun; 6(6): e1000994. Published online 2010 Jun 24. doi: 10.1371/journal.pgen.1000994

PMCID:: PMC2891703

Abstract Article PDF–903K

Select item 922651913.

Tissue-specific regulation of translational readthrough tunes functions of the traffic jam transcription factor

Prajwal Karki, Travis D Carney, Cristina Maracci, Andriy S Yatsenko, Halyna R Shcherbata, Marina V Rodnina

Nucleic Acids Res. 2022 Jun 24; 50(11): 6001–6019. Published online 2021 Dec 13. doi: 10.1093/nar/gkab1189

PMCID:: PMC9226519

Abstract Article PDF–4.7M

Select item 736287914.

MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure

Zhihao Wu, Ishaq Tantray, Junghyun Lim, Songjie Chen, Yu Li, Zoe Davis, Cole Sitron, Jason Dong, Suzana Gispert, Georg Auburger, Onn Brandman, Xiaolin Bi, Michael Snyder, Bingwei Lu

Mol Cell. Author manuscript; available in PMC 2020 Jul 15.

Published in final edited form as: Mol Cell. 2019 Aug 22; 75(4): 835–848.e8. Published online 2019 Aug 1. doi: 10.1016/j.molcel.2019.06.031

PMCID:: PMC7362879

Abstract Article PDF–4.3M

Select item 145677415.

A Genetic Screen for Dominant Modifiers of a Small-Wing Phenotype in Drosophila melanogaster Identifies Proteins Involved in Splicing and Translation

Carmen M. A. Coelho, Benjamin Kolevski, Cherryl D. Walker, Irene Lavagi, Thomas Shaw, Anselm Ebert, Sally J. Leevers, Steven J. Marygold

Genetics. 2005 Oct; 171(2): 597–614. doi: 10.1534/genetics.105.045021

PMCID:: PMC1456774

Abstract Article PDF–631K

Select item 401247716.

Insight into Insulin Secretion from Transcriptome and Genetic Analysis of Insulin-Producing Cells of Drosophila

Jian Cao, Julie Ni, Wenxiu Ma, Vanessa Shiu, Luis A. Milla, Sangbin Park, Maria L. Spletter, Sheng Tang, Jun Zhang, Xing Wei, Seung K. Kim, Matthew P. Scott

Genetics. 2014 May; 197(1): 175–192. Published online 2014 Feb 20. doi: 10.1534/genetics.113.160663