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Select item 110730891.

Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade

Anuradha Kirtonia, Amit Kumar Pandey, Balaji Ramachandran, Durga Prasad Mishra, David W. Dawson, Gautam Sethi, Trivadi S. Ganesan, H. Phillip Koeffler, Manoj Garg

Cell Mol Life Sci. 2022 Jul; 79(7): 362. Published online 2022 Jun 14. doi: 10.1007/s00018-022-04392-1

PMCID:: PMC11073089

Abstract Article PDF–3.0M

Select item 110694872.

LAMC2 regulates the proliferation, invasion, and metastasis of gastric cancer via PI3K/Akt signaling pathway

Lulu Cheng, Xiaofei Li, Wenhui Dong, Jing Yang, Pengmei Li, Xihui Qiang, Jiajun Yin, Lianyi Guo

J Cancer Res Clin Oncol. 2024; 150(5): 230. Published online 2024 May 4. doi: 10.1007/s00432-024-05720-7

PMCID:: PMC11069487

Abstract Article PDF–2.9M

Select item 106455873.

LAMC2 promotes EGFR cell membrane localization and acts as a novel biomarker for tyrosine kinase inhibitors (TKIs) sensitivity in lung cancer

Dongdong Tong, Xiaofei Wang, Liying Liu, Ting Wen, QiaoYi Chen, Chen Huang

Cancer Gene Ther. 2023; 30(11): 1498–1512. Published online 2023 Aug 4. doi: 10.1038/s41417-023-00654-7

PMCID:: PMC10645587

Abstract Article PDF–7.1M

Select item 96770434.

LAMC2 as a prognostic biomarker in human cancer: a systematic review and meta-analysis

Tao Fu, Jun-Xia Liu, Juan Xie, Zhen Gao, Zhenshan Yang

BMJ Open. 2022; 12(11): e063682. Published online 2022 Nov 16. doi: 10.1136/bmjopen-2022-063682

PMCID:: PMC9677043

Abstract Article PDF–2.4M

Select item 96092885.

LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

Donatella Delle Cave, Silvia Buonaiuto, Bruno Sainz, Jr, Marco Fantuz, Maria Mangini, Alessandro Carrer, Annalisa Di Domenico, Tea Teresa Iavazzo, Gennaro Andolfi, Carme Cortina, Marta Sevillano, Christopher Heeschen, Vincenza Colonna, Marco Corona, Antonio Cucciardi, Martina Di Guida, Eduard Batlle, Annachiara De Luca, Enza Lonardo

J Exp Clin Cancer Res. 2022; 41: 315. Published online 2022 Oct 26. doi: 10.1186/s13046-022-02516-w

PMCID:: PMC9609288

Abstract Article PDF–2.9M

Select item 89615016.

Orchestrated expression of vasculogenic mimicry and laminin‐5γ2 is an independent prognostic marker in oral squamous cell carcinoma

Depanwita Saha, Debarpan Mitra, Neyaz Alam, Sagar Sen, Saunak Mitra Mustafi, Syamsundar Mandal, Biswanath Majumder, Nabendu Murmu

Int J Exp Pathol. 2022 Apr; 103(2): 54–64. Published online 2022 Feb 16. doi: 10.1111/iep.12430

PMCID:: PMC8961501

Abstract Article PDF–1.1M

Select item 80867667.

LAMC2 promotes cancer progression and gemcitabine resistance through modulation of EMT and ATP-binding cassette transporters in pancreatic ductal adenocarcinoma

Yasuyuki Okada, Naoki Takahashi, Tetsuji Takayama, Ajay Goel

Carcinogenesis. 2021 Apr; 42(4): 546–556. Published online 2021 Feb 24. doi: 10.1093/carcin/bgab011

PMCID:: PMC8086766

Abstract Article PDF–5.7M

Select item 79405978.

Identification of LAMC2 as a prognostic and predictive biomarker for determining response to gemcitabine-based therapy in pancreatic ductal adenocarcinoma

Yasuyuki Okada, Satoshi Nishiwada, Kensuke Yamamura, Masayuki Sho, Hideo Baba, Tetsuji Takayama, Ajay Goel

Eur J Cancer. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Eur J Cancer. 2021 Mar; 146: 125–134. Published online 2021 Feb 16. doi: 10.1016/j.ejca.2020.12.031

PMCID:: PMC7940597

Abstract Article PDF–949K

Select item 47146639.

Urinary laminin‐γ2 is a novel biomarker of non‐muscle invasive urothelial carcinoma

Masayuki Kamada, Naohiko Koshikawa, Tomoko Minegishi, Chiaki Kawada, Takashi Karashima, Taro Shuin, Motoharu Seiki

Cancer Sci. 2015 Dec; 106(12): 1730–1737. Published online 2015 Nov 6. doi: 10.1111/cas.12832

PMCID:: PMC4714663

Abstract Article PDF–1.5M

Select item 431782710.

Amino-terminal fragments of laminin γ2 chain retract vascular endothelial cells and increase vascular permeability

Hiroki Sato, Jun Oyanagi, Eriko Komiya, Takashi Ogawa, Shouichi Higashi, Kaoru Miyazaki

Cancer Sci. 2014 Feb; 105(2): 168–175. Published online 2014 Jan 7. doi: 10.1111/cas.12323

PMCID:: PMC4317827

Abstract Article PDF–1.7M

Select item 384960111.

Expression of the gamma 2 chain of laminin-332 in eutopic and ectopic endometrium of patients with endometriosis

Rosella Locci, Michelle Nisolle, Stefano Angioni, Jean-Michel Foidart, Carine Munaut

Reprod Biol Endocrinol. 2013; 11: 94. Published online 2013 Sep 26. doi: 10.1186/1477-7827-11-94

PMCID:: PMC3849601

Abstract Article PDF–3.6M

Select item 379029312.

Laminin, gamma 2 (LAMC2): A Promising New Putative Pancreatic Cancer Biomarker Identified by Proteomic Analysis of Pancreatic Adenocarcinoma Tissues

Hari Kosanam, Ioannis Prassas, Caitlin C. Chrystoja, Ireena Soleas, Alison Chan, Apostolos Dimitromanolakis, Ivan M. Blasutig, Felix Rückert, Robert Gruetzmann, Christian Pilarsky, Masato Maekawa, Randall Brand, Eleftherios P. Diamandis

Mol Cell Proteomics. 2013 Oct; 12(10): 2820–2832. Published online 2013 Jun 24. doi: 10.1074/mcp.M112.023507

PMCID:: PMC3790293

Abstract Article PDF–1.5M

Select item 263054713.

Profiling Bladder Cancer Organ Site-Specific Metastasis Identifies LAMC2 as a Novel Biomarker of Hematogenous Dissemination

Steven Christopher Smith, Brian Nicholson, Matthew Nitz, Henry F. Frierson, Jr, Mark Smolkin, Garret Hampton, Wael El-Rifai, Dan Theodorescu

Am J Pathol. 2009 Feb; 174(2): 371–379. doi: 10.2353/ajpath.2009.080538

PMCID:: PMC2630547

Abstract Article PDF–925K

Select item 228967114.

A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment

J Cell Biol. 1992 Nov 1; 119(3): 679–693. doi: 10.1083/jcb.119.3.679

PMCID:: PMC2289671

Summary PDF–4.0M

Select item 122326915.

Converging signals synergistically activate the LAMC2 promoter and lead to accumulation of the laminin gamma 2 chain in human colon carcinoma cells.

Jørgen Olsen, Lene T Kirkeby, Marianne M Brorsson, Sally Dabelsteen, Jesper T Troelsen, Randi Bordoy, Kirsten Fenger, Lars-Inge Larsson, Patricia Simon-Assmann

Biochem J. 2003 Apr 1; 371(Pt 1): 211–221. doi: 10.1042/BJ20021454