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Select item 110280841.

Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature

Emily Hinchcliff, Cherie Paquette, Jason Roszik, Sarah Kelting, Mark H. Stoler, Samuel C. Mok, Tsz-Lun Yeung, Qian Zhang, Melinda Yates, Weiyi Peng, Patrick Hwu, Amir Jazaeri

Cancer Immunol Immunother. 2019 Sep; 68(9): 1515–1526. Published online 2019 Sep 12. doi: 10.1007/s00262-019-02385-x

PMCID:: PMC11028084

Abstract Article PDF–1.5M

Select item 107306912.

Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK

Baerbel Keller, Shlomit Kfir-Erenfeld, Paul Matusewicz, Frederike Hartl, Atar Lev, Yu Nee Lee, Amos J. Simon, Tali Stauber, Orly Elpeleg, Raz Somech, Polina Stepensky, Susana Minguet, Burkhart Schraven, Klaus Warnatz

J Clin Immunol. 2024; 44(1): 4. Published online 2023 Dec 19. doi: 10.1007/s10875-023-01614-4

PMCID:: PMC10730691

Abstract Article PDF–7.3M

Select item 107243243.

A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature

Anna-Lisa Lanz, Serife Erdem, Alper Ozcan, Gulay Ceylaner, Murat Cansever, Serdar Ceylaner, Raffaele Conca, Thomas Magg, Oreste Acuto, Sylvain Latour, Christoph Klein, Turkan Patiroglu, Ekrem Unal, Ahmet Eken, Fabian Hauck

J Clin Immunol. 2024; 44(1): 1. Published online 2023 Dec 15. doi: 10.1007/s10875-023-01602-8

Correction in:: J Clin Immunol. 2024; 44(1): 41.

PMCID:: PMC10724324

Abstract Article PDF–1.6M

Select item 104879174.

Identification of Breast Cancer LCK Proto-Oncogene as a Master Regulator of TNBC Neutrophil Enrichment and Polarization

Fatma Al Qutami, Walaa Al Halabi, Mahmood Y. Hachim

Int J Mol Sci. 2023 Sep; 24(17): 13269. Published online 2023 Aug 26. doi: 10.3390/ijms241713269

PMCID:: PMC10487917

Abstract Article PDF–7.8M

Select item 81941795.

Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation

Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner

Mol Cancer. 2021; 20: 88. Published online 2021 Jun 11. doi: 10.1186/s12943-021-01384-w

Correction in:: Mol Cancer. 2023; 22: 50.

PMCID:: PMC8194179

Abstract Article PDF–5.0M

Select item 71931646.

LCK expression is a potential biomarker for distinguishing primary central nervous system lymphoma from glioblastoma multiforme

Le Ge, Lixia Xu, Shan Lu, Hua Yan

FEBS Open Bio. 2020 May; 10(5): 904–911. Published online 2020 Apr 13. doi: 10.1002/2211-5463.12849

PMCID:: PMC7193164

Abstract Article PDF–3.0M

Select item 64628697.

Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor

J. P. Zepecki, K. M. Snyder, M. M. Moreno, E. Fajardo, A. Fiser, J. Ness, A. Sarkar, S. A. Toms, N. Tapinos

Oncogene. 2019; 38(10): 1734–1750. Published online 2018 Oct 23. doi: 10.1038/s41388-018-0546-z

PMCID:: PMC6462869

Abstract Article PDF–6.3M

Select item 57361038.

Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells

Ardiyanto Liaunardy-Jopeace, Ben L Murton, Mohan Mahesh, Jason W Chin, John R James

Nat Struct Mol Biol. Author manuscript; available in PMC 2018 Apr 30.

Published in final edited form as: Nat Struct Mol Biol. 2017 Dec; 24(12): 1155–1163. Published online 2017 Oct 30. doi: 10.1038/nsmb.3492

PMCID:: PMC5736103

Abstract Article PDF–1.7M

Select item 57118409.

Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome

Kathleen J. Till, John C. Allen, Fatima Talab, Ke Lin, David Allsup, Lynn Cawkwell, Alison Bentley, Ingo Ringshausen, Andrew D. Duckworth, Andrew R. Pettitt, Nagesh Kalakonda, Joseph R. Slupsky

Sci Rep. 2017; 7: 16784. Published online 2017 Dec 1. doi: 10.1038/s41598-017-17021-w

PMCID:: PMC5711840

Abstract Article PDF–1.5M

Select item 501616010.

Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain

Ren Sheng, Da-Jung Jung, Antonina Silkov, Hyunjin Kim, Indira Singaram, Zhi-Gang Wang, Yao Xin, Eui Kim, Mi-Jeong Park, Pallavi Thiagarajan-Rosenkranz, Sean Smrt, Barry Honig, Kwanghee Baek, Sungho Ryu, Justin Lorieau, You-Me Kim, Wonhwa Cho

J Biol Chem. 2016 Aug 19; 291(34): 17639–17650. Published online 2016 Jun 22. doi: 10.1074/jbc.M116.720284

PMCID:: PMC5016160

Abstract Article PDF–2.0M

Select item 449300311.

A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization

Heather L. Parrish, Caleb R. Glassman, Madeline M. Keenen, Neha R. Deshpande, Matthew P. Bronnimann, Michael S. Kuhns

PLoS One. 2015; 10(7): e0132333. Published online 2015 Jul 6. doi: 10.1371/journal.pone.0132333

Correction in:: PLoS One. 2016; 11(3): e0150876.

PMCID:: PMC4493003

Abstract Article PDF–1.5M

Select item 389327212.

Lck Mediates Signal Transmission from CD59 to the TCR/CD3 Pathway in Jurkat T Cells

Anna M. Lipp, Kata Juhasz, Christian Paar, Christoph Ogris, Paul Eckerstorfer, Roland Thuenauer, Jan Hesse, Benedikt Nimmervoll, Hannes Stockinger, Gerhard J. Schütz, Ulrich Bodenhofer, Zsolt Balogi, Alois Sonnleitner

PLoS One. 2014; 9(1): e85934. Published online 2014 Jan 15. doi: 10.1371/journal.pone.0085934

PMCID:: PMC3893272

Abstract Article PDF–1.2M

Select item 339784513.

Cytoskeletal Modulation of Lipid Interactions Regulates Lck Kinase Activity

Gurunadh R. Chichili, Robert C. Cail, William Rodgers

J Biol Chem. 2012 Jul 13; 287(29): 24186–24194. Published online 2012 May 21. doi: 10.1074/jbc.M111.320747

PMCID:: PMC3397845

Abstract Article PDF–1.3M

Select item 338095814.

Stage I non-small cell lung cancer: the presence of the lymphocyte-specific protein tyrosin kinase in the tumour infiltrate is associated with a better long-term prognosis

Antonio D'Andrilli, Guido Natoli, Stefania Scarpino, Erino A. Rendina

Interact Cardiovasc Thorac Surg. 2012 Jul; 15(1): 148–151. Published online 2012 Mar 28. doi: 10.1093/icvts/ivr128

PMCID:: PMC3380958

Abstract Article PDF–97K

Select item 299660715.

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

Konstantina Nika, Cristiana Soldani, Mogjiborahman Salek, Wolfgang Paster, Adrian Gray, Ruth Etzensperger, Lars Fugger, Paolo Polzella, Vincenzo Cerundolo, Omer Dushek, Thomas Höfer, Antonella Viola, Oreste Acuto

Immunity. 2010 Jun 25; 32(6): 766–777. doi: 10.1016/j.immuni.2010.05.011