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Select item 108701161.

TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non–Small Cell Lung Cancer

Alban Bessede, Florent Peyraud, Benjamin Besse, Sophie Cousin, Mathilde Cabart, François Chomy, Christophe Rey, Oren Lara, Ophélie Odin, Imane Nafia, Lucile Vanhersecke, Fabrice Barlesi, Jean-Philippe Guégan, Antoine Italiano

Clin Cancer Res. 2024 Feb 16; 30(4): 779–785. Published online 2023 Dec 4. doi: 10.1158/1078-0432.CCR-23-2566

PMCID:: PMC10870116

Abstract Article PDF–3.5M

Select item 108349912.

DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells

A. Gehring, K. Huebner, H. Rani, K. Erlenbach-Wuensch, S. Merkel, V. Mahadevan, R. Grutzmann, A. Hartmann, R. Schneider-Stock

Sci Rep. 2024; 14: 2683. Published online 2024 Feb 1. doi: 10.1038/s41598-024-52437-1

PMCID:: PMC10834991

Abstract Article PDF–2.3M

Select item 103748253.

TROP-2 is widely expressed in vulvar squamous cell carcinoma and represents a potential new therapeutic target

Mateja Condic, Eva K. Egger, Niklas Klümper, Glen Kristiansen, Alexander Mustea, Thore Thiesler, Damian J. Ralser

J Cancer Res Clin Oncol. 2023; 149(11): 8235–8241. Published online 2023 Apr 17. doi: 10.1007/s00432-023-04761-8

PMCID:: PMC10374825

Abstract Article PDF–1.3M

Select item 95879484.

Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance

Jing Zhu, Wenwen Wu, Yukiko Togashi, Naoe Taira Nihira, Yoshikazu Johmura, Dajiang Zhu, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta

Breast Cancer. 2022; 29(6): 1076–1087. Published online 2022 Jul 27. doi: 10.1007/s12282-022-01389-3

PMCID:: PMC9587948

Abstract Article PDF–2.2M

Select item 95096255.

Trophoblast cell-surface antigen 2 (TROP2) expression in triple-negative breast cancer

Yeonjin Jeon, Uiree Jo, Jongmoo Hong, Gyungyub Gong, Hee Jin Lee

BMC Cancer. 2022; 22: 1014. Published online 2022 Sep 24. doi: 10.1186/s12885-022-10076-7

PMCID:: PMC9509625

Abstract Article PDF–1.1M

Select item 87450086.

Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma

Ramona Erber, Steffen Spoerl, Andreas Mamilos, Rosemarie Krupar, Arndt Hartmann, Matthias Ruebner, Juergen Taxis, Mareike Wittenberg, Torsten E. Reichert, Gerrit Spanier, Silvia Spoerl

Int J Mol Sci. 2022 Jan; 23(1): 87. Published online 2021 Dec 22. doi: 10.3390/ijms23010087

PMCID:: PMC8745008

Abstract Article PDF–29M

Select item 83343867.

Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer

Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Romina Tripaldi, Giovanna Vacca, Martina Ceci, Khouloud Boujnah, Valeria Garbo, Antonino Moschella, Romina Zappacosta, Pasquale Simeone, Robert de Lange, Ulrich H. Weidle, Maria Teresa Rotelli, Arcangelo Picciariello, Raffaella Depalo, Patrizia Querzoli, Massimo Pedriali, Enzo Bianchini, Domenico Angelucci, Giuseppe Pizzicannella, Carla Di Loreto, Mauro Piantelli, Laura Antolini, Xiao-Feng Sun, Donato F. Altomare, Saverio Alberti

Neoplasia. 2021 Sep; 23(9): 898–911. Published online 2021 Jul 25. doi: 10.1016/j.neo.2021.07.002

PMCID:: PMC8334386

Abstract Article PDF–4.7M

Select item 83049088.

Trop2 Expression in Extramammary Paget’s Disease and Normal Skin

Takamichi Ito, Keiko Tanegashima, Yuka Tanaka, Hiroki Hashimoto, Maho Murata, Yoshinao Oda, Yumiko Kaku-Ito

Int J Mol Sci. 2021 Jul; 22(14): 7706. Published online 2021 Jul 19. doi: 10.3390/ijms22147706

PMCID:: PMC8304908

Abstract Article PDF–4.7M

Select item 80610659.

DNA methylation of tumor associated calcium signal transducer 2 (TACSTD2) loci shows association with clinically aggressive renal cell cancers

Olga Katzendorn, Inga Peters, Natalia Dubrowinskaja, Hossein Tezval, Pouriya Faraj Tabrizi, Christoph A. von Klot, Jörg Hennenlotter, Marcel Lafos, Markus A. Kuczyk, Jürgen Serth

BMC Cancer. 2021; 21: 444. Published online 2021 Apr 21. doi: 10.1186/s12885-021-08172-1

PMCID:: PMC8061065

Abstract Article PDF–926K

Select item 804265110.

Trop‐2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis

Marco Trerotola, Emanuela Guerra, Zeeshan Ali, Anna Laura Aloisi, Martina Ceci, Pasquale Simeone, Angela Acciarito, Paola Zanna, Giovanna Vacca, Antonella D'Amore, Khouloud Boujnah, Valeria Garbo, Antonino Moschella, Rossano Lattanzio, Saverio Alberti

Neoplasia. 2021 Apr; 23(4): 415–428. Published online 2021 Apr 8. doi: 10.1016/j.neo.2021.03.006

PMCID:: PMC8042651

Abstract Article PDF–3.1M

Select item 745092911.

Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation

Baoping Zhang, Shuting Gao, Ruiping Li, Yiting Li, Rui Cao, Jingyang Cheng, Yumeng Guo, Errui Wang, Ying Huang, Kailiang Zhang

BMC Cancer. 2020; 20: 815. Published online 2020 Aug 27. doi: 10.1186/s12885-020-07257-7

PMCID:: PMC7450929

Abstract Article PDF–4.5M

Select item 699686312.

Trop2 Promotes Multidrug Resistance by Regulating Notch1 Signaling Pathway in Gastric Cancer Cells

Xingwang Kuai, Lizhou Jia, Tingting Yang, Xiaochen Huang, Wei Zhao, Mingjiong Zhang, Yuan Chen, Jin Zhu, Zhenqing Feng, Qi Tang

Med Sci Monit. 2020; 26: e919566-1–e919566-9. Published online 2020 Jan 22. doi: 10.12659/MSM.919566

PMCID:: PMC6996863

Abstract Article PDF–1.9M

Select item 697659113.

Cervical carcinomas that overexpress human trophoblast cell-surface marker (Trop-2) are highly sensitive to the antibody-drug conjugate sacituzumab govitecan

Burak Zeybek, Aranzazu Manzano, Anna Bianchi, Elena Bonazzoli, Stefania Bellone, Natalia Buza, Pei Hui, Salvatore Lopez, Emanuele Perrone, Paola Manara, Luca Zammataro, Gary Altwerger, Chanhee Han, Joan Tymon-Rosario, Gulden Menderes, Elena Ratner, Dan-Arin Silasi, Gloria S. Huang, Masoud Azodi, Peter E. Schwartz, Alessandro Santin

Sci Rep. 2020; 10: 973. Published online 2020 Jan 22. doi: 10.1038/s41598-020-58009-3

PMCID:: PMC6976591

Abstract Article PDF–1.8M

Select item 684462114.

TROP2 increases growth and metastasis of human oral squamous cell carcinoma through activation of the PI3K/Akt signaling pathway

Genxiong Tang, Qi Tang, Lizhou Jia, Yuan Chen, Liangyuan Lin, Xingwang Kuai, Aixiu Gong, Zhengqing Feng

Int J Mol Med. 2019 Dec; 44(6): 2161–2170. Published online 2019 Oct 21. doi: 10.3892/ijmm.2019.4378

PMCID:: PMC6844621

Abstract Article PDF–1.3M

Select item 666386415.

Trophoblast cell surface antigen 2 (Trop-2) phosphorylation by protein kinase C α/δ (PKCα/δ) enhances cell motility

Yugo Mori, Kaoru Akita, Kazuki Ojima, Shungo Iwamoto, Tomoko Yamashita, Eiichi Morii, Hiroshi Nakada

J Biol Chem. 2019 Jul 26; 294(30): 11513–11524. Published online 2019 Jun 7. doi: 10.1074/jbc.RA119.008084

PMCID:: PMC6663864

Abstract Article PDF–2.5M

Select item 643449816.

The role and molecular mechanism of Trop2 induced epithelial‐mesenchymal transition through mediated β‐catenin in gastric cancer

Wei Zhao, Lizhou Jia, Xingwang kuai, Qi Tang, Xiaochen Huang, Tingting Yang, Zhenning Qiu, Jin Zhu, Jianfei Huang, Wenbin Huang, Zhenqing Feng

Cancer Med. 2019 Mar; 8(3): 1135–1147. Published online 2019 Jan 11. doi: 10.1002/cam4.1934

PMCID:: PMC6434498

Abstract Article PDF–1.4M

Select item 642138417.

Silencing of the TROP2 gene suppresses proliferation and invasion of hepatocellular carcinoma HepG2 cells

Jian Zhang, Hai Ma, Liu Yang, Hongchun Yang, Zhenxing He

J Int Med Res. 2019 Mar; 47(3): 1319–1329. Published online 2019 Jan 24. doi: 10.1177/0300060518822913

PMCID:: PMC6421384

Abstract Article PDF–1.0M

Select item 631298918.

TROP2 promotes the proliferation and metastasis of glioblastoma cells by activating the JAK2/STAT3 signaling pathway

Jianbing Hou, Ailing Lv, Qing Deng, Guanghui Zhang, Xiaosong Hu, Hongjuan Cui

Oncol Rep. 2019 Feb; 41(2): 753–764. Published online 2018 Nov 9. doi: 10.3892/or.2018.6859

PMCID:: PMC6312989

Abstract Article PDF–3.4M

Select item 588215019.

Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma

Vandana Sekhar, Teresa Pollicino, Giacomo Diaz, Ronald E. Engle, Farah Alayli, Marta Melis, Juraj Kabat, Ashley Tice, Anna Pomerenke, Nihal Altan-Bonnet, Fausto Zamboni, Paolo Lusso, Suzanne U. Emerson, Patrizia Farci

PLoS Pathog. 2018 Mar; 14(3): e1006916. Published online 2018 Mar 14. doi: 10.1371/journal.ppat.1006916

PMCID:: PMC5882150

Abstract Article PDF–9.7M

Select item 560396820.

The Potential Diagnostic Utility of TROP-2 in Thyroid Neoplasms

Haiyan Liu, Jianhui Shi, Fan Lin

Appl Immunohistochem Mol Morphol. 2017 Sep; 25(8): 525–533. Published online 2016 Feb 9. doi: 10.1097/PAI.0000000000000332

PMCID:: PMC5603968

Abstract Article PDF–999K

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