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Select item 96646641.

Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan, Jiequn Li

J Transl Med. 2022; 20: 529. Published online 2022 Nov 14. doi: 10.1186/s12967-022-03734-8

PMCID:: PMC9664664

Abstract Article PDF–5.4M

Select item 70291122.

A genome-wide analysis of targets of macrolide antibiotics in mammalian cells

Amita Gupta, Aye Ökesli-Armlovich, David Morgens, Michael C. Bassik, Chaitan Khosla

J Biol Chem. 2020 Feb 14; 295(7): 2057–2067. Published online 2020 Jan 8. doi: 10.1074/jbc.RA119.010770

PMCID:: PMC7029112

Abstract Article PDF–2.0M

Select item 30853183.

Incorporating age at onset of smoking into genetic models for nicotine dependence: Evidence for interaction with multiple genes

Richard A. Grucza, Eric O. Johnson, Robert F. Krueger, Naomi Breslau, Nancy L. Saccone, Li-Shiun Chen, Jaime Derringer, Arpana Agrawal, Micheal Lynskey, Laura J. Bierut

Addict Biol. Author manuscript; available in PMC 2011 Jul 1.

Published in final edited form as: Addict Biol. 2010 Jul; 15(3): 346–357. doi: 10.1111/j.1369-1600.2010.00220.x

PMCID:: PMC3085318

Abstract Article PDF–384K

Select item 11866894.

Interferon-γ-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes

Ursula M. Halfter, Zachary E. Derbyshire, Richard R. Vaillancourt

Biochem J. 2005 May 15; 388(Pt 1): 17–28. Prepublished online 2004 Dec 16. Published online 2005 May 10. doi: 10.1042/BJ20041236

PMCID:: PMC1186689

Abstract Article PDF–785K

Select item 98512335.

CircMAP3K4 protects human lens epithelial cells from H₂O₂-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract

Yu Ma, Yi Liu, Baotong Shu, Jianguo Yang, Liang Lv, Lixiao Zhou, Lichun Wang, Zongli Shi

Cell Cycle. 2023; 22(3): 303–315. Published online 2022 Sep 7. doi: 10.1080/15384101.2022.2114587

PMCID:: PMC9851233

Abstract Article PDF–3.2M

Select item 89763366.

A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma

Jin-Ling Duan, Wei Chen, Juan-Juan Xie, Mao-Lei Zhang, Run-Cong Nie, Hu Liang, Jie Mei, Kai Han, Zhi-Cheng Xiang, Feng-Wei Wang, Kai Teng, Ri-Xin Chen, Min-Hua Deng, Yi-Xin Yin, Nu Zhang, Dan Xie, Mu-Yan Cai

Mol Cancer. 2022; 21: 93. Published online 2022 Apr 2. doi: 10.1186/s12943-022-01537-5

PMCID:: PMC8976336

Abstract Article PDF–7.6M

Select item 74557157.

Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching

Noha Ahmed Mohammed Shendy, Deepthi Raghu, Sujoy Roy, Charles Hamilton Perry, Adiba Safi, Miguel Ramos Branco, Ramin Homayouni, Amy Noel Abell

Commun Biol. 2020; 3: 475. Published online 2020 Aug 28. doi: 10.1038/s42003-020-01200-z

PMCID:: PMC7455715

Abstract Article PDF–3.3M

Select item 38697078.

HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4)

James J. Sollome, Elangovan Thavathiru, Todd D. Camenisch, Richard R. Vaillancourt

Cell Signal. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Cell Signal. 2014 Jan; 26(1): 10.1016/j.cellsig.2013.08.043. Published online 2013 Sep 12. doi: 10.1016/j.cellsig.2013.08.043

PMCID:: PMC3869707

Abstract Article PDF–2.3M

Select item 37183309.

The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1

Gopal P. Sapkota

Open Biol. 2013 Jun; 3(6): 130067. doi: 10.1098/rsob.130067

PMCID:: PMC3718330

Abstract Article PDF–769K

Select item 117013210.

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways.

M Takekawa, F Posas, H Saito

EMBO J. 1997 Aug 15; 16(16): 4973–4982. doi: 10.1093/emboj/16.16.4973

PMCID:: PMC1170132

Summary PDF–675K

Select item 13389411.

Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding

Hiroaki Mita, Junichiro Tsutsui, Mutsuhiro Takekawa, Elizabeth A. Witten, Haruo Saito

Mol Cell Biol. 2002 Jul; 22(13): 4544–4555. doi: 10.1128/MCB.22.13.4544-4555.2002

PMCID:: PMC133894

Abstract Article PDF–719K

Select item 942597112.

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR

Xiaolong Wang, Tong Chen, Chen Li, Wenhao Li, Xianyong Zhou, Yaming Li, Dan Luo, Ning Zhang, Bing Chen, Lijuan Wang, Wenjing Zhao, Shanji Fu, Qifeng Yang

J Hematol Oncol. 2022; 15: 122. Published online 2022 Aug 29. doi: 10.1186/s13045-022-01345-w

PMCID:: PMC9425971

Abstract Article PDF–19M

Select item 304159313.

MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation

Bo K Sun, Joo-Hang Kim, Hoan N. Nguyen, Seeun Oh, So Y. Kim, Hye J. Choi, Yong J. Lee, Jae J. Song

Oncol Rep. Author manuscript; available in PMC 2011 Mar 1.

Published in final edited form as: Oncol Rep. 2011 Feb; 25(2): 537–544. Published online 2010 Dec 7. doi: 10.3892/or.2010.1079

PMCID:: PMC3041593

Abstract Article PDF–1.5M

Select item 121991014.

Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades.

P Y Chan-Hui, R Weaver

Biochem J. 1998 Dec 15; 336(Pt 3): 599–609. doi: 10.1042/bj3360599

PMCID:: PMC1219910

Summary PDF–413K

Select item 117048615.

Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator.

F Posas, H Saito

EMBO J. 1998 Mar 2; 17(5): 1385–1394. doi: 10.1093/emboj/17.5.1385

PMCID:: PMC1170486

Summary PDF–395K

Select item 302349016.

A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses

Jill M. Marinis, Craig R. Homer, Christine McDonald, Derek W. Abbott

J Biol Chem. 2011 Jan 21; 286(3): 1938–1950. Published online 2010 Nov 19. doi: 10.1074/jbc.M110.189308

PMCID:: PMC3023490

Abstract Article PDF–3.0M

Select item 283320617.

Phosphorylation of Human Tristetraprolin in Response to Its Interaction with the Cbl Interacting Protein CIN85

Vishram P. Kedar, Martyn K. Darby, Jason G. Williams, Perry J. Blackshear

PLoS One. 2010; 5(3): e9588. Published online 2010 Mar 8. doi: 10.1371/journal.pone.0009588

PMCID:: PMC2833206

Abstract Article PDF–947K

Select item 343448218.

IκB Kinase α Phosphorylation of TRAF4 Downregulates Innate Immune Signaling

Jill M. Marinis, Jessica E. Hutti, Craig R. Homer, Brian A. Cobb, Lewis C. Cantley, Christine McDonald, Derek W. Abbott

Mol Cell Biol. 2012 Jul; 32(13): 2479–2489. doi: 10.1128/MCB.00106-12

PMCID:: PMC3434482

Abstract Article PDF–3.0M

Select item 267289219.

ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway

Young Joo Jeon, Joon Seok Choi, Jung Yun Lee, Kyung Ryun Yu, Sangman Michael Kim, Seung Hyeun Ka, Kyu Hee Oh, Keun Il Kim, Dong-Er Zhang, Ok Sun Bang, Chin Ha Chung

EMBO Rep. 2009 Apr; 10(4): 374–380. Published online 2009 Mar 6. doi: 10.1038/embor.2009.23

PMCID:: PMC2672892

Abstract Article PDF–1.0M

Select item 401419720.

Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice

Nick Warr, Pam Siggers, Gwenn-Aël Carré, Debora Bogani, Rachel Brixey, Mika Akiyoshi, Makoto Tachibana, Lydia Teboul, Sara Wells, Jeremy Sanderson, Andy Greenfield

Hum Mol Genet. 2014 Jun 1; 23(11): 3035–3044. Published online 2014 Jan 22. doi: 10.1093/hmg/ddu020