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Select item 109681261.

Neuroprotective Effects of the Nutraceutical Dehydrozingerone and Its C₂-Symmetric Dimer in a Drosophila Model of Parkinson’s Disease

Maria Dolores Setzu, Ignazia Mocci, Davide Fabbri, Paola Carta, Patrizia Muroni, Andrea Diana, Maria Antonietta Dettori, Maria Antonietta Casu

Biomolecules. 2024 Mar; 14(3): 273. Published online 2024 Feb 24. doi: 10.3390/biom14030273

PMCID:: PMC10968126

Abstract Article PDF–5.8M

Select item 100380512.

The utility and caveat of split-GAL4s in the study of neurodegeneration

Luca Stickley, Rafael Koch, Emi Nagoshi

Fly (Austin) 2023; 17(1): 2192847. Published online 2023 Mar 23. doi: 10.1080/19336934.2023.2192847

PMCID:: PMC10038051

Abstract Article PDF–909K

Select item 93165983.

Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research

Valeria Olguín, Anyelo Durán, Macarena Las Heras, Juan Carlos Rubilar, Francisco A. Cubillos, Patricio Olguín, Andrés D. Klein

Int J Mol Sci. 2022 Jul; 23(14): 7570. Published online 2022 Jul 8. doi: 10.3390/ijms23147570

PMCID:: PMC9316598

Abstract Article PDF–1.1M

Select item 70311584.

Neuroprotection by the Immunomodulatory Drug Pomalidomide in the Drosophila LRRK2^WD40 Genetic Model of Parkinson’s Disease

Maria Antonietta Casu, Ignazia Mocci, Raffaella Isola, Augusta Pisanu, Laura Boi, Giovanna Mulas, Nigel H. Greig, Maria Dolores Setzu, Anna R. Carta

Front Aging Neurosci. 2020; 12: 31. Published online 2020 Feb 13. doi: 10.3389/fnagi.2020.00031

PMCID:: PMC7031158

Abstract Article PDF–4.1M

Select item 70170785.

Improvements of Motor Performances in the Drosophila LRRK2 Loss-of-Function Model of Parkinson’s Disease: Effects of Dialyzed Leucocyte Extracts from Human Serum

Andrea Diana, Maria Collu, Maria Antonietta Casu, Ignazia Mocci, Miguel Aguilar-Santelises, Maria Dolores Setzu

Brain Sci. 2020 Jan; 10(1): 45. Published online 2020 Jan 14. doi: 10.3390/brainsci10010045

PMCID:: PMC7017078

Abstract Article PDF–2.4M

Select item 50183376.

Drosophila Mutant Model of Parkinson's Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences

Francescaelena De Rose, Valentina Corda, Paolo Solari, Patrizia Sacchetti, Antonio Belcari, Simone Poddighe, Sanjay Kasture, Paolo Solla, Francesco Marrosu, Anna Liscia

Parkinsons Dis. 2016; 2016: 3508073. Published online 2016 Aug 28. doi: 10.1155/2016/3508073

PMCID:: PMC5018337

Abstract Article PDF–2.5M

Select item 46997647.

Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson’s Disease: Drug Effects of Withania somnifera (Dunal) Administration

Francescaelena De Rose, Roberto Marotta, Simone Poddighe, Giuseppe Talani, Tiziano Catelani, Maria Dolores Setzu, Paolo Solla, Francesco Marrosu, Enrico Sanna, Sanjay Kasture, Elio Acquas, Anna Liscia

PLoS One. 2016; 11(1): e0146140. Published online 2016 Jan 4. doi: 10.1371/journal.pone.0146140

PMCID:: PMC4699764

Abstract Article PDF–5.6M

Select item 82235048.

Dopamine Neuron-Specific LRRK2 G2019S Effects on Gene Expression Revealed by Translatome Profiling

Judit Pallos, Sophia Jeng, Shannon McWeeney, Ian Martin

Neurobiol Dis. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Neurobiol Dis. 2021 Jul; 155: 105390. Published online 2021 May 11. doi: 10.1016/j.nbd.2021.105390

PMCID:: PMC8223504

Abstract Article PDF–1.2M

Select item 77264329.

Local Secretory Trafficking Pathways in Neurons and the Role of Dendritic Golgi Outposts in Different Cell Models

Jingqi Wang, Lou Fourriere, Paul A. Gleeson

Front Mol Neurosci. 2020; 13: 597391. Published online 2020 Nov 26. doi: 10.3389/fnmol.2020.597391

PMCID:: PMC7726432

Abstract Article PDF–659K

Select item 738113010.

Progress in LRRK2-Associated Parkinson’s Disease Animal Models

Steven P. Seegobin, George R. Heaton, Dongxiao Liang, Insup Choi, Marian Blanca Ramirez, Beisha Tang, Zhenyu Yue

Front Neurosci. 2020; 14: 674. Published online 2020 Jul 15. doi: 10.3389/fnins.2020.00674

PMCID:: PMC7381130

Abstract Article PDF–469K

Select item 459451511.

Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes

Ian Martin, Leire Abalde-Atristain, Jungwoo Wren Kim, Ted M Dawson, Valina L Dawson

Fly (Austin) 2014 Jul; 8(3): 165–169. Published online 2014 Dec 7. doi: 10.4161/19336934.2014.983382

PMCID:: PMC4594515

Abstract Article PDF–370K

Select item 227650112.

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

Danling Wang, Beisha Tang, Guohua Zhao, Qian Pan, Kun Xia, Rolf Bodmer, Zhuohua Zhang

Mol Neurodegener. 2008; 3: 3. Published online 2008 Feb 8. doi: 10.1186/1750-1326-3-3

PMCID:: PMC2276501

Abstract Article PDF–891K

Select item 883592013.

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease

Mari Suzuki, Kazunori Sango, Yoshitaka Nagai

Int J Mol Sci. 2022 Feb; 23(3): 1519. Published online 2022 Jan 28. doi: 10.3390/ijms23031519

PMCID:: PMC8835920

Abstract Article PDF–354K

Select item 690050814.

A locomotor assay reveals deficits in heterozygous Parkinson’s disease model and proprioceptive mutants in adult Drosophila

Aman Aggarwal, Heinrich Reichert, K. VijayRaghavan

Proc Natl Acad Sci U S A. 2019 Dec 3; 116(49): 24830–24839. Published online 2019 Nov 20. doi: 10.1073/pnas.1807456116

PMCID:: PMC6900508

Abstract Article PDF–9.1M

Select item 646200915.

Vitamin B₁₂ modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection

Adam Schaffner, Xianting Li, Yacob Gomez-Llorente, Emmanouela Leandrou, Anna Memou, Nicolina Clemente, Chen Yao, Farinaz Afsari, Lianteng Zhi, Nina Pan, Keita Morohashi, Xiaoluan Hua, Ming-Ming Zhou, Chunyu Wang, Hui Zhang, Shu G. Chen, Christopher J. Elliott, Hardy Rideout, Iban Ubarretxena-Belandia, Zhenyu Yue

Cell Res. 2019 Apr; 29(4): 313–329. Published online 2019 Mar 11. doi: 10.1038/s41422-019-0153-8

PMCID:: PMC6462009

Abstract Article PDF–6.5M

Select item 426793316.

Fast and Efficient Drosophila melanogaster Gene Knock-Ins Using MiMIC Transposons

Sven Vilain, Roeland Vanhauwaert, Ine Maes, Nils Schoovaerts, Lujia Zhou, Sandra Soukup, Raquel da Cunha, Elsa Lauwers, Mark Fiers, Patrik Verstreken

G3 (Bethesda) 2014 Dec; 4(12): 2381–2387. Published online 2014 Oct 8. doi: 10.1534/g3.114.014803

PMCID:: PMC4267933

Abstract Article PDF–1.0M

Select item 411940317.

Abnormal visual gain control in a Parkinson's disease model

Farinaz Afsari, Kenneth V. Christensen, Garrick Paul Smith, Morten Hentzer, Olivia M. Nippe, Christopher J. H. Elliott, Alex R. Wade

Hum Mol Genet. 2014 Sep 1; 23(17): 4465–4478. Published online 2014 Apr 9. doi: 10.1093/hmg/ddu159

PMCID:: PMC4119403

Abstract Article PDF–1.6M

Select item 226819818.

A Drosophila model for LRRK2-linked parkinsonism

Zhaohui Liu, Xiaoyue Wang, Yi Yu, Xueping Li, Tao Wang, Haibing Jiang, Qiuting Ren, Yuchen Jiao, Akira Sawa, Timothy Moran, Christopher A. Ross, Craig Montell, Wanli W. Smith

Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7): 2693–2698. Published online 2008 Feb 7. doi: 10.1073/pnas.0708452105

PMCID:: PMC2268198

Abstract Article PDF–1.2M

Select item 967899719.

The role of tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis

Zhi Dong Zhou, Wuan Ting Saw, Patrick Ghim Hoe Ho, Zhi Wei Zhang, Li Zeng, Ya Yin Chang, Alfred Xu Yang Sun, Dong Rui Ma, Hong Yan Wang, Lei Zhou, Kah Leong Lim, Eng-King Tan

Cell Mol Life Sci. 2022; 79(12): 599. Published online 2022 Nov 21. doi: 10.1007/s00018-022-04574-x