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Select item 63904101.

The contribution of mutant GBA to the development of Parkinson disease in Drosophila

Gali Maor, Or Cabasso, Olga Krivoruk, Joe Rodriguez, Hermann Steller, Daniel Segal, Mia Horowitz

Hum Mol Genet. 2016 Jul 1; 25(13): 2712–2727. Published online 2016 May 9. doi: 10.1093/hmg/ddw129

PMCID:: PMC6390410

Abstract Article PDF–1.7M

Select item 107349782.

Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease

Magda L. Atilano, Alexander Hull, Catalina-Andreea Romila, Mirjam L. Adams, Jacob Wildfire, Enric Ureña, Miranda Dyson, Jorge Ivan-Castillo-Quan, Linda Partridge, Kerri J. Kinghorn

PLoS Genet. 2023 Dec; 19(12): e1011063. Published online 2023 Dec 21. doi: 10.1371/journal.pgen.1011063

PMCID:: PMC10734978

Abstract Article PDF–4.3M

Select item 78886653.

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

Kathryn A. Jewett, Ruth E. Thomas, Chi Q. Phan, Bernice Lin, Gillian Milstein, Selina Yu, Lisa F. Bettcher, Fausto Carnevale Neto, Danijel Djukovic, Daniel Raftery, Leo J. Pallanck, Marie Y. Davis

PLoS Genet. 2021 Feb; 17(2): e1008859. Published online 2021 Feb 4. doi: 10.1371/journal.pgen.1008859

PMCID:: PMC7888665

Abstract Article PDF–4.5M

Select item 57314144.

Death by over-eating: The Gaucher disease associated gene GBA1, identified in a screen for mediators of autophagic cell death, is necessary for developmental cell death in Drosophila midgut

Santosh K. Dasari, Eyal Schejter, Shani Bialik, Aya Shkedy, Vered Levin-Salomon, Smadar Levin-Zaidman, Adi Kimchi

Cell Cycle. 2017; 16(21): 2003–2010. Published online 2017 Oct 9. doi: 10.1080/15384101.2017.1380134

PMCID:: PMC5731414

Abstract Article PDF–868K

Select item 38196555.

Unfolded protein response in Gaucher disease: from human to Drosophila

Gali Maor, Sigal Rencus-Lazar, Mirella Filocamo, Hermann Steller, Daniel Segal, Mia Horowitz

Orphanet J Rare Dis. 2013; 8: 140. Published online 2013 Sep 11. doi: 10.1186/1750-1172-8-140

PMCID:: PMC3819655

Abstract Article PDF–1.5M

Select item 51252256.

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

Kerri J. Kinghorn, Sebastian Grönke, Jorge Iván Castillo-Quan, Nathaniel S. Woodling, Li Li, Ernestas Sirka, Matthew Gegg, Kevin Mills, John Hardy, Ivana Bjedov, Linda Partridge

J Neurosci. 2016 Nov 16; 36(46): 11654–11670. doi: 10.1523/JNEUROSCI.4527-15.2016

PMCID:: PMC5125225

Abstract Article PDF–3.0M

Select item 48097187.

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration

Marie Y. Davis, Kien Trinh, Ruth E. Thomas, Selina Yu, Alexandre A. Germanos, Brittany N. Whitley, Sergio Pablo Sardi, Thomas J. Montine, Leo J. Pallanck

PLoS Genet. 2016 Mar; 12(3): e1005944. Published online 2016 Mar 28. doi: 10.1371/journal.pgen.1005944

PMCID:: PMC4809718

Abstract Article PDF–9.4M

Select item 27883278.

The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis

Michael A. Horner, Keith Pardee, Suya Liu, Kirst King-Jones, Gilles Lajoie, Aled Edwards, Henry M. Krause, Carl S. Thummel

Genes Dev. 2009 Dec 1; 23(23): 2711–2716. doi: 10.1101/gad.1833609

PMCID:: PMC2788327

Abstract Article PDF–432K

Select item 96326589.

Exploring therapeutic potential of mitophagy modulators using Drosophila models of Parkinson’s disease

Jyotsna Asthana, Bhupendra V. Shravage

Front Aging Neurosci. 2022; 14: 986849. Published online 2022 Oct 19. doi: 10.3389/fnagi.2022.986849

PMCID:: PMC9632658

Abstract Article PDF–1.2M

Select item 678079010.

Drosophila melanogaster Mutated in its GBA1b Ortholog Recapitulates Neuronopathic Gaucher Disease

Or Cabasso, Sumit Paul, Orly Dorot, Gali Maor, Olga Krivoruk, Metsada Pasmanik-Chor, Mina Mirzaian, Maria Ferraz, Johannes Aerts, Mia Horowitz

J Clin Med. 2019 Sep; 8(9): 1420. Published online 2019 Sep 9. doi: 10.3390/jcm8091420

PMCID:: PMC6780790

Abstract Article PDF–3.3M

Select item 590001511.

Modeling Parkinson’s Disease in Drosophila: What Have We Learned for Dominant Traits?

Yulan Xiong, Jianzhong Yu

Front Neurol. 2018; 9: 228. Published online 2018 Apr 9. doi: 10.3389/fneur.2018.00228

PMCID:: PMC5900015

Abstract Article PDF–347K

Select item 937836112.

‘Fly’ing from rare to common neurodegenerative disease mechanisms

Mengqi Ma, Matthew J. Moulton, Shenzhao Lu, Hugo J. Bellen

Trends Genet. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Trends Genet. 2022 Sep; 38(9): 972–984. Published online 2022 Apr 25. doi: 10.1016/j.tig.2022.03.018

PMCID:: PMC9378361

Abstract Article PDF–1.0M

Select item 800006613.

The Uncovered Function of the Drosophila GBA1a-Encoded Protein

Or Cabasso, Sumit Paul, Gali Maor, Metsada Pasmanik-Chor, Wouter Kallemeijn, Johannes Aerts, Mia Horowitz

Cells. 2021 Mar; 10(3): 630. Published online 2021 Mar 12. doi: 10.3390/cells10030630

PMCID:: PMC8000066

Abstract Article PDF–5.0M

Select item 799831614.

The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease

Melissa Vos, Christine Klein

Cells. 2021 Mar; 10(3): 579. Published online 2021 Mar 6. doi: 10.3390/cells10030579

PMCID:: PMC7998316

Abstract Article PDF–1.7M

Select item 1023179215.

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg, Timothy Wu, Tom V. Lee, Yarong Li, Duc Duong, Bridget Phillips, Carlos Cruchaga, Genevera I. Allen, Nicholas T. Seyfried, Ismael Al-Ramahi, Juan Botas, Joshua M. Shulman

PLoS Genet. 2023 May; 19(5): e1010760. Published online 2023 May 18. doi: 10.1371/journal.pgen.1010760