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Select item 110789781.

Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts

Keita Okamoto, Yasuto Araki, Yoshimi Aizaki, Shinya Tanaka, Yuho Kadono, Toshihide Mimura

Sci Rep. 2024; 14: 10610. Published online 2024 May 9. doi: 10.1038/s41598-024-60860-7

PMCID:: PMC11078978

Abstract Article PDF–1.1M

Select item 108457642.

Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth

Jiayi Wu, Chuanmei Qin, Fuju Tian, Xueqing Liu, Jianing Hu, Fan Wu, Cailian Chen, Yi Lin

BMC Med. 2024; 22: 57. Published online 2024 Feb 5. doi: 10.1186/s12916-024-03264-8

PMCID:: PMC10845764

Abstract Article PDF–17M

Select item 101696363.

The KMT2A recombinome of acute leukemias in 2023

C. Meyer, P. Larghero, B. Almeida Lopes, T. Burmeister, D. Gröger, R. Sutton, N. C. Venn, G. Cazzaniga, L. Corral Abascal, G. Tsaur, L. Fechina, M. Emerenciano, M. S. Pombo-de-Oliveira, T. Lund-Aho, T. Lundán, M. Montonen, V. Juvonen, J. Zuna, J. Trka, P. Ballerini, H. Lapillonne, V. H. J. Van der Velden, E. Sonneveld, E. Delabesse, R. R. C. de Matos, M. L. M. Silva, S. Bomken, K. Katsibardi, M. Keernik, N. Grardel, J. Mason, R. Price, J. Kim, C. Eckert, L. Lo Nigro, C. Bueno, P. Menendez, U. zur Stadt, P. Gameiro, L. Sedék, T. Szczepański, A. Bidet, V. Marcu, K. Shichrur, S. Izraeli, H. O. Madsen, B. W. Schäfer, S. Kubetzko, R. Kim, E. Clappier, H. Trautmann, M. Brüggemann, P. Archer, J. Hancock, J. Alten, A. Möricke, M. Stanulla, J. Lentes, A. K. Bergmann, S. Strehl, S. Köhrer, K. Nebral, M. N. Dworzak, O. A. Haas, C. Arfeuille, A. Caye-Eude, H. Cavé, R. Marschalek

Leukemia. 2023; 37(5): 988–1005. Published online 2023 Apr 5. doi: 10.1038/s41375-023-01877-1

PMCID:: PMC10169636

Abstract Article PDF–3.7M

Select item 99687194.

Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes

Pedro Casado, Ana Rio-Machin, Juho J. Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsan, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C. Taussig, Csaba Bödör, John Gribben, Caroline Heckman, Jude Fitzgibbon, Pedro R. Cutillas

Signal Transduct Target Ther. 2023; 8: 80. Published online 2023 Feb 27. doi: 10.1038/s41392-022-01288-1

PMCID:: PMC9968719

Abstract Article PDF–5.4M

Select item 98980235.

Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma

Rex K. H. Au-Yeung, Laura Arias Padilla, Martin Zimmermann, Sarah Reinke, Ilske Oschlies, Gabriele Escherich, Wilhelm Woessmann, Birgit Burkhardt, Wolfram Klapper

Leukemia. 2023; 37(2): 488–491. Published online 2022 Nov 9. doi: 10.1038/s41375-022-01757-0

PMCID:: PMC9898023

Article PDF–1.0M

Select item 98835506.

Mutational landscape and clinical outcome of pediatric acute myeloid leukemia with 11q23/KMT2A rearrangements

Ka‐Yuk Yuen, Yong Liu, Yong‐Zhuo Zhou, Yin Wang, Dun‐Hua Zhou, Jian‐Pei Fang, Lu‐Hong Xu

Cancer Med. 2023 Jan; 12(2): 1418–1430. Published online 2022 Jul 14. doi: 10.1002/cam4.5026

PMCID:: PMC9883550

Abstract Article PDF–3.2M

Select item 98325617.

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies

Ian G. Cowell, Caroline A. Austin

Open Biol. 2023 Jan; 13(1): 220232. Published online January 11, 2023. doi: 10.1098/rsob.220232

PMCID:: PMC9832561

Abstract Article PDF–1.2M

Select item 97434128.

The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation

Sriganesh B. Sharma, William J. Melvin, Christopher O. Audu, Monica Bame, Nicole Rhoads, Weisheng Wu, Yogendra Kanthi, Jason S. Knight, Reheman Adili, Michael A. Holinstat, Thomas W. Wakefield, Peter K. Henke, Bethany B. Moore, Katherine A. Gallagher, Andrea T. Obi

Blood. 2023 Feb 16; 141(7): 725–742. Published online 2022 Dec 11. doi: 10.1182/blood.2022015917

PMCID:: PMC9743412

Abstract Article

Select item 94487739.

Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury

Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuang

Cell Death Dis. 2022 Sep; 13(9): 770. Published online 2022 Sep 6. doi: 10.1038/s41419-022-05104-0

PMCID:: PMC9448773

Abstract Article PDF–5.6M

Select item 942777510.

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S. Kotecha, Mark N. Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K. Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita

Nat Commun. 2022; 13: 4501. Published online 2022 Aug 30. doi: 10.1038/s41467-022-32266-4

PMCID:: PMC9427775

Abstract Article PDF–5.3M

Select item 939430911.

Phenotypic Variation in Two Siblings Affected with Shwachman-Diamond Syndrome: The Use of Expert Variant Interpreter (eVai) Suggests Clinical Relevance of a Variant in the KMT2A Gene

Ibrahim Taha, Federica De Paoli, Selena Foroni, Susanna Zucca, Ivan Limongelli, Marco Cipolli, Cesare Danesino, Ugo Ramenghi, Antonella Minelli

Genes (Basel) 2022 Aug; 13(8): 1314. Published online 2022 Jul 23. doi: 10.3390/genes13081314

PMCID:: PMC9394309

Abstract Article PDF–671K

Select item 932755912.

Allelic complexity of KMT2A partial tandem duplications in acute myeloid leukemia and myelodysplastic syndromes

Harrison K. Tsai, Christopher J. Gibson, H. Moses Murdock, Phani Davineni, Marian H. Harris, Eunice S. Wang, Lukasz P. Gondek, Annette S. Kim, Valentina Nardi, R. Coleman Lindsley

Blood Adv. 2022 Jul 26; 6(14): 4236–4240. Published online 2022 Jul 21. doi: 10.1182/bloodadvances.2022007613

PMCID:: PMC9327559

Abstract Article PDF–1.0M

Select item 911970413.

MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State

Hui Zhang, Le Tran Phuc Khoa, Fengbiao Mao, Hanshi Xu, Bo Zhou, Yu Han, Monique O’Leary, Asma Nusrat, Li Wang, Thomas L. Saunders, Yali Dou

Cell Rep. Author manuscript; available in PMC 2022 May 19.

Published in final edited form as: Cell Rep. 2019 Nov 26; 29(9): 2659–2671.e6. doi: 10.1016/j.celrep.2019.10.074

PMCID:: PMC9119704

Abstract Article PDF–2.6M

Select item 863125014.

Expanding the genotypic and phenotypic spectrum in a diverse cohort of 104 individuals with Wiedemann-Steiner syndrome

Sarah E. Sheppard, Ian M. Campbell, Margaret H. Harr, Nina Gold, Dong Li, Hans T. Bjornsson, Julie S. Cohen, Jill A. Fahrner, Ali Fatemi, Jacqueline R. Harris, Catherine Nowak, Cathy A. Stevens, Katheryn Grand, Margaret Au, John M. Graham, Jr, Pedro A. Sanchez-Lara, Miguel Del Campo, Marilyn C. Jones, Omar Abdul-Rahman, Fowzan S. Alkuraya, Jennifer A. Bassetti, Katherine Bergstrom, Elizabeth Bhoj, Sarah Dugan, Julie D. Kaplan, Nada Derar, Karen W. Gripp, Natalie Hauser, A. Micheil Innes, Beth Keena, Neslida Kodra, Rebecca Miller, Beverly Nelson, Malgorzata J. Nowaczyk, Zuhair Rahbeeni, Shay Ben-Shachar, Joseph T. Shieh, Anne Slavotinek, Andrew K. Sobering, Mary-Alice Abbott, Dawn C. Allain, Louise Amlie-Wolf, Ping Yee Billie Au, Emma Bedoukian, Geoffrey Beek, James Barry, Janet Berg, Jonathan A. Bernstein, Cheryl Cytrynbaum, Brian Hon-Yin Chung, Sarah Donoghue, Naghmeh Dorrani, Alison Eaton, Josue A. Flores-Daboub, Holly Dubbs, Carolyn A. Felix, Chin-To Fong, Jasmine Lee Fong Fung, Balram Gangaram, Amy Goldstein, Rotem Greenberg, Thoa K. Ha, Joseph Hersh, Kosuke Izumi, Staci Kallish, Elijah Kravets, Pui-Yan Kwok, Rebekah K. Jobling, Amy E. Knight Johnson, Jessica Kushner, Bo Hoon Lee, Brooke Levin, Kristin Lindstrom, Kandamurugu Manickam, Rebecca Mardach, Elizabeth McCormick, D. Ross McLeod, Frank D. Mentch, Kelly Minks, Colleen Muraresku, Stanley F. Nelson, Patrizia Porazzi, Pavel N. Pichurin, Nina N. Powell-Hamilton, Zoe Powis, Alyssa Ritter, Caleb Rogers, Luis Rohena, Carey Ronspies, Audrey Schroeder, Zornitza Stark, Lois Starr, Joan Stoler, Pim Suwannarat, Milen Velinov, Rosanna Weksberg, Yael Wilnai, Neda Zadeh, Dina J. Zand, Marni J. Falk, Hakon Hakonarson, Elaine H. Zackai, Fabiola Quintero-Rivera

Am J Med Genet A. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Am J Med Genet A. 2021 Jun; 185(6): 1649–1665. Published online 2021 Mar 30. doi: 10.1002/ajmg.a.62124

Correction in:: Am J Med Genet A. 2021 Nov 11

PMCID:: PMC8631250

Abstract Article PDF–2.2M

Select item 861161715.

Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia

Wenjuan Liao, M. Eric Kohler, Terry Fry, Patricia Ernst

Exp Hematol. Author manuscript; available in PMC 2021 Nov 24.

Published in final edited form as: Exp Hematol. 2021 Aug; 100: 1–11. Published online 2021 Jul 21. doi: 10.1016/j.exphem.2021.07.002

Correction in:: Exp Hematol. 2021 Sep 20

PMCID:: PMC8611617

Abstract Article PDF–854K

Select item 858008716.

Three de novo variants in KMT2A (MLL) identified by whole exome sequencing in patients with Wiedemann–Steiner syndrome

Sukun Luo, Bo Bi, Wenqian Zhang, Rui Zhou, Wei Chen, Peiwei Zhao, Yufeng Huang, Li Yuan, Xuelian He

Mol Genet Genomic Med. 2021 Oct; 9(10): e1798. Published online 2021 Sep 1. doi: 10.1002/mgg3.1798

PMCID:: PMC8580087

Abstract Article PDF–895K

Select item 857109717.

Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia

Derek H. Janssens, Michael P. Meers, Steven J. Wu, Ekaterina Babaeva, Soheil Meshinchi, Jay F. Sarthy, Kami Ahmad, Steven Henikoff

Nat Genet. 2021; 53(11): 1586–1596. Published online 2021 Oct 18. doi: 10.1038/s41588-021-00941-9

PMCID:: PMC8571097

Abstract Article PDF–19M

Select item 848126418.

Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements

Ghayas C. Issa, Jabra Zarka, Koji Sasaki, Wei Qiao, Daewoo Pak, Jing Ning, Nicholas J. Short, Fadi Haddad, Zhenya Tang, Keyur P. Patel, Branko Cuglievan, Naval Daver, Courtney D. DiNardo, Elias Jabbour, Tapan Kadia, Gautam Borthakur, Guillermo Garcia-Manero, Marina Konopleva, Michael Andreeff, Hagop M. Kantarjian, Farhad Ravandi

Blood Cancer J. 2021 Sep; 11(9): 162. Published online 2021 Sep 29. doi: 10.1038/s41408-021-00557-6

PMCID:: PMC8481264

Abstract Article PDF–1.4M

Select item 836284619.

Epigenetic regulation of protein translation in KMT2A-rearranged AML

Alexandra Lenard, Hongbo Michael Xie, Taylor Pastuer, Tyler Shank, Clara Libbrecht, Molly Kingsley, Simone S Riedel, Zuo-Fei Yuan, Nan Zhu, Tobias Neff, Kathrin M Bernt

Exp Hematol. Author manuscript; available in PMC 2021 Aug 13.

Published in final edited form as: Exp Hematol. 2020 May; 85: 57–69. Published online 2020 May 11. doi: 10.1016/j.exphem.2020.04.007

PMCID:: PMC8362846

Abstract Article PDF–1.9M

Select item 824518420.

Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia

Juan Ramón Tejedor, Clara Bueno, Meritxell Vinyoles, Paolo Petazzi, Antonio Agraz-Doblas, Isabel Cobo, Raúl Torres-Ruiz, Gustavo F. Bayón, Raúl F. Pérez, Sara López-Tamargo, Francisco Gutierrez-Agüera, Pablo Santamarina-Ojeda, Manuel Ramírez-Orellana, Michela Bardini, Giovanni Cazzaniga, Paola Ballerini, Pauline Schneider, Ronald W. Stam, Ignacio Varela, Mario F. Fraga, Agustín F. Fernández, Pablo Menéndez

J Clin Invest. 2021 Jul 1; 131(13): e138833. Published online 2021 Jul 1. doi: 10.1172/JCI138833

PMCID:: PMC8245184

Abstract Article PDF–3.7M

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