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Select item 110282211.

Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities

Alexander N. R. Weber, Yamel Cardona Gloria, Özcan Çınar, H. Christian Reinhardt, Antonio Pezzutto, Olaf-Oliver Wolz

Cancer Immunol Immunother. 2018 Nov; 67(11): 1797–1807. Published online 2018 Sep 11. doi: 10.1007/s00262-018-2242-9

PMCID:: PMC11028221

Abstract Article PDF–2.2M

Select item 104355022.

The oncogenic human B-cell lymphoma MYD88 L265P mutation genocopies activation by phosphorylation at the Toll/interleukin-1 receptor (TIR) domain

Marthe Minderman, Hildo Lantermans, Carmen van der Zwaan, Arie J. Hoogendijk, Maartje van den Biggelaar, Marie José Kersten, Marcel Spaargaren, Steven T. Pals

Blood Cancer J. 2023 Dec; 13(1): 125. Published online 2023 Aug 18. doi: 10.1038/s41408-023-00896-6

PMCID:: PMC10435502

Abstract Article PDF–2.4M

Select item 99595813.

Genetic and Clinical Characteristics of Korean Chronic Lymphocytic Leukemia Patients with High Frequencies of MYD88 Mutations

Ari Ahn, Hoon Seok Kim, Tong-Yoon Kim, Jong-Mi Lee, Dain Kang, Haein Yu, Chae Yeon Lee, Yonggoo Kim, Ki-Seong Eom, Myungshin Kim

Int J Mol Sci. 2023 Feb; 24(4): 3177. Published online 2023 Feb 6. doi: 10.3390/ijms24043177

PMCID:: PMC9959581

Abstract Article PDF–2.5M

Select item 97266494.

Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals

Xia-Ping Yao, Jian Ye, Ting Feng, Feng-Chao Jiang, Ping Zhou, Fang Wang, Jian-Guo Chen, Peng-Fei Wu

Brain Behav Immun. 2023 Feb; 108: 204–220. Published online 2022 Dec 7. doi: 10.1016/j.bbi.2022.12.007

PMCID:: PMC9726649

Abstract Article PDF–12M

Select item 95325725.

Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling

Hong Fan, Zhe Chen, Hai-Bin Tang, Le-Qun Shan, Zi-Yi Chen, Shi-Chang Liu, Yong-Yuan Zhang, Xin-Yu Guo, Hao Yang, Ding-Jun Hao

Front Endocrinol (Lausanne) 2022; 13: 994307. Published online 2022 Sep 21. doi: 10.3389/fendo.2022.994307

PMCID:: PMC9532572

Abstract Article PDF–10M

Select item 92509516.

不同方法和标本检测华氏巨球蛋白血症患者MYD88突变的初步探索

陶怡, 潘增凯, 王硕, 王黎, 赵维莅

Zhonghua Xue Ye Xue Za Zhi. 2022 May; 43(5): 388–392. Chinese. doi: 10.3760/cma.j.issn.0253-2727.2022.05.007

PMCID:: PMC9250951

Abstract Article PDF–908K

Select item 87720767.

Mechanism of MyD88S mediated signal termination

Katarzyna Pustelny, Katarzyna Kuska, Andrzej Gorecki, Bogdan Musielak, Ewelina Dobosz, Benedykt Wladyka, Joanna Koziel, Anna Czarna, Tad Holak, Grzegorz Dubin

Cell Commun Signal. 2022; 20: 10. Published online 2022 Jan 20. doi: 10.1186/s12964-021-00811-1

PMCID:: PMC8772076

Abstract Article PDF–1.9M

Select item 87532038.

Determination of MYD88^L265P mutation fraction in IgM monoclonal gammopathies

Tina Bagratuni, Athina Markou, Dimitrios Patseas, Nefeli Mavrianou-Koutsoukou, Foteini Aktypi, Christine Ivy Liacos, Aimilia D. Sklirou, Foteini Theodorakakou, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Ioannis P. Trougakos, Evi Lianidou, Evangelos Terpos, Efstathios Kastritis, Meletios A. Dimopoulos

Blood Adv. 2022 Jan 11; 6(1): 189–199. Published online 2022 Jan 7. doi: 10.1182/bloodadvances.2021005354

PMCID:: PMC8753203

Abstract Article PDF–1.2M

Select item 85866909.

Liquid biopsy of cerebrospinal fluid for MYD88 L265P mutation is useful for diagnosis of central nervous system lymphoma

Yuki Yamagishi, Nobuyoshi Sasaki, Yoshiko Nakano, Yuko Matushita, Takaki Omura, Saki Shimizu, Kuniaki Saito, Keiichi Kobayashi, Yoshitaka Narita, Akihide Kondo, Yoshiaki Shiokawa, Motoo Nagane, Koichi Ichimura

Cancer Sci. 2021 Nov; 112(11): 4702–4710. Published online 2021 Sep 27. doi: 10.1111/cas.15133

PMCID:: PMC8586690

Abstract Article PDF–488K

Select item 821570410.

Absence of Non-Canonical, Inhibitory MYD88 Splice Variants in B Cell Lymphomas Correlates With Sustained NF-κB Signaling

Yamel Cardona Gloria, Stephan H. Bernhart, Sven Fillinger, Olaf-Oliver Wolz, Sabine Dickhöfer, Jakob Admard, Stephan Ossowski, Sven Nahnsen, Reiner Siebert, Alexander N. R. Weber

Front Immunol. 2021; 12: 616451. Published online 2021 Jun 7. doi: 10.3389/fimmu.2021.616451

PMCID:: PMC8215704

Abstract Article PDF–4.1M

Select item 811052811.

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Max T. B. Clabbers, Susannah Holmes, Timothy W. Muusse, Parimala R. Vajjhala, Sara J. Thygesen, Alpeshkumar K. Malde, Dominic J. B. Hunter, Tristan I. Croll, Leonie Flueckiger, Jeffrey D. Nanson, Md. Habibur Rahaman, Andrew Aquila, Mark S. Hunter, Mengning Liang, Chun Hong Yoon, Jingjing Zhao, Nadia A. Zatsepin, Brian Abbey, Emma Sierecki, Yann Gambin, Katryn J. Stacey, Connie Darmanin, Bostjan Kobe, Hongyi Xu, Thomas Ve

Nat Commun. 2021; 12: 2578. Published online 2021 May 10. doi: 10.1038/s41467-021-22590-6

PMCID:: PMC8110528

Abstract Article PDF–3.5M

Select item 778602212.

Modeling MyD88 Deficiency In Vitro Provides New Insights in Its Function

Nils Craig-Mueller, Ruba Hammad, Roland Elling, Jamal Alzubi, Barbara Timm, Julia Kolter, Nele Knelangen, Christien Bednarski, Birgitta Gläser, Sandra Ammann, Zoltán Ivics, Judith Fischer, Carsten Speckmann, Klaus Schwarz, Nico Lachmann, Stephan Ehl, Thomas Moritz, Philipp Henneke, Toni Cathomen

Front Immunol. 2020; 11: 608802. Published online 2020 Dec 23. doi: 10.3389/fimmu.2020.608802

PMCID:: PMC7786022

Abstract Article PDF–1.2M

Select item 772801913.

MYD88 L265P mutation in intraocular lymphoma: A potential diagnostic marker

Sandhya Narasimhan, Mayur Joshi, Sowmya Parameswaran, Pukhraj Rishi, Vikas Khetan, Suganeswari Ganesan, Jyotirmay Biswas, Natarajan Sundaram, Janani Sreenivasan, Sonali Verma, Vanitha Krishnamurthy, Krishnakumar Subramanian

Indian J Ophthalmol. 2020 Oct; 68(10): 2160–2165. Published online 2020 Jul 18. doi: 10.4103/ijo.IJO_1712_19

PMCID:: PMC7728019

Abstract Article PDF–1.0M

Select item 745007614.

Clinicopathological characterization of chronic lymphocytic leukemia with MYD88 mutations: L265P and non-L265P mutations are associated with different features

Wen Shuai, Pei Lin, Paolo Strati, Keyur P. Patel, Mark J. Routbort, Shimin Hu, Peng Wei, Joseph D. Khoury, M. James You, Sanam Loghavi, Zhenya Tang, Hong Fang, Beenu Thakral, L. Jeffrey Medeiros, Wei Wang

Blood Cancer J. 2020 Aug; 10(8): 86. Published online 2020 Aug 26. doi: 10.1038/s41408-020-00351-w

PMCID:: PMC7450076

Abstract Article PDF–1.5M

Select item 733951615.

Prognostic value of MYD88 L265P mutation in diffuse large B cell lymphoma via droplet digital PCR

Jing Niu, Zhiping Ma, Aijiang Nuerlan, Sijing Li, Wenli Cui, Haixia Gao, Gulinaer Abulajiang, Wei Zhang, Xinxia Li

Mol Med Rep. 2020 Aug; 22(2): 1243–1256. Published online 2020 May 27. doi: 10.3892/mmr.2020.11186

PMCID:: PMC7339516

Abstract Article PDF–1.1M

Select item 701246916.

MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavorable prognosis

Joost S. Vermaat, Sebastiaan F. Somers, Liesbeth C. de Wreede, Willem Kraan, Ruben A.L. de Groen, Anne M. R. Schrader, Emile D. Kerver, Cornelis G. Scheepstra, Henriëtte Berenschot, Wendy Deenik, Jurgen Wegman, Rianne Broers, Jan-Paul D. de Boer, Marcel Nijland, Tom van Wezel, Hendrik Veelken, Marcel Spaargaren, Arjen H. Cleven, Marie José Kersten, Steven T. Pals

Haematologica. 2020 Feb; 105(2): 424–434. Prepublished online 2019 May 23. doi: 10.3324/haematol.2018.214122

PMCID:: PMC7012469

Abstract Article PDF–1.7M

Select item 688535917.

MyD88 Regulates LPS-induced NF-ĸB/MAPK Cytokines and Promotes Inflammation and Malignancy in Colorectal Cancer Cells

GUANGWEI ZHU, ZHIBIN CHENG, CHUNLIN LIN, ROBERT M HOFFMAN, YONGJIAN HUANG, SHREE RAM SINGH, WEI ZHENG, SHUGANG YANG, JIANXIN YE

Cancer Genomics Proteomics. 2019 Nov-Dec; 16(6): 409–419. Published online 2019 Nov 3. doi: 10.21873/cgp.20145

PMCID:: PMC6885359

Abstract Article PDF–871K

Select item 673673518.

A novel truncating mutation in MYD88 in a patient with BCG adenitis, neutropenia and delayed umbilical cord separation

Craig D. Platt, Fatima Zaman, Jacqueline G. Wallace, Michael Seleman, Janet Chou, Nashat Al Sukaiti, Raif S. Geha

Clin Immunol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Clin Immunol. 2019 Oct; 207: 40–42. Published online 2019 Jul 10. doi: 10.1016/j.clim.2019.07.004

PMCID:: PMC6736735

Abstract Article PDF–583K

Select item 646346919.

MyD88 signalling is critical in the development of pancreatic cancer cachexia

Xinxia Zhu, Kevin G. Burfeind, Katherine A. Michaelis, Theodore P. Braun, Brennan Olson, Katherine R. Pelz, Terry K. Morgan, Daniel L. Marks

J Cachexia Sarcopenia Muscle. 2019 Apr; 10(2): 378–390. Published online 2019 Jan 21. doi: 10.1002/jcsm.12377

PMCID:: PMC6463469

Abstract Article PDF–1.2M

Select item 623383320.

Potential Diagnosis of Vitreoretinal Lymphoma by Detection of MYD88 Mutation in Aqueous Humor With Ultrasensitive Droplet Digital Polymerase Chain Reaction

Laura S. Hiemcke-Jiwa, Ninette H. ten Dam-van Loon, Roos J. Leguit, Stefan Nierkens, Jeannette Ossewaarde-van Norel, Joke H. de Boer, Floor F. Roholl, Roel A. de Weger, Manon M. H. Huibers, Jolanda D. F. de Groot-Mijnes, Jonas J. W. Kuiper

JAMA Ophthalmol. 2018 Oct; 136(10): 1098–1104. Published online 2018 Jul 19. doi: 10.1001/jamaophthalmol.2018.2887

PMCID:: PMC6233833

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