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Select item 70488001.

High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation

Cyril Dian, Inmaculada Pérez-Dorado, Frédéric Rivière, Thomas Asensio, Pierre Legrand, Markus Ritzefeld, Mengjie Shen, Ernesto Cota, Thierry Meinnel, Edward W. Tate, Carmela Giglione

Nat Commun. 2020; 11: 1132. Published online 2020 Feb 28. doi: 10.1038/s41467-020-14847-3

PMCID:: PMC7048800

Abstract Article PDF–3.2M

Select item 62400782.

NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway

Lu Deng, Xinlei Gao, Bingjie Liu, Xueyan He, Jiahui Xu, Jiankun Qiang, Qingfa Wu, Suling Liu

Cell Death Dis. 2018 Dec; 9(12): 1143. Published online 2018 Nov 16. doi: 10.1038/s41419-018-1201-x

PMCID:: PMC6240078

Abstract Article PDF–3.3M

Select item 12196083.

Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme.

R A McIlhinney, K Young, M Egerton, R Camble, A White, M Soloviev

Biochem J. 1998 Aug 1; 333(Pt 3): 491–495. doi: 10.1042/bj3330491

PMCID:: PMC1219608

Summary PDF–393K

Select item 5256464.

Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae.

R J Duronio, S I Reed, J I Gordon

Proc Natl Acad Sci U S A. 1992 May 1; 89(9): 4129–4133. doi: 10.1073/pnas.89.9.4129

PMCID:: PMC525646

Summary Page Browse PDF–1.3M

Select item 100387355.

SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway

Ping Qiu, Xing Li, Min Gong, Ping Wen, Jianbo Wen, Linfang Xu, Guiliang Wang

Can J Gastroenterol Hepatol. 2023; 2023: 2021515. Published online 2023 Mar 17. doi: 10.1155/2023/2021515

PMCID:: PMC10038735

Abstract Article PDF–2.8M

Select item 73716886.

N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells

Yu-Chuan Chen, Marian S. Navarrete, Ying Wang, Natalie C. McClintock, Reiko Sakurai, Feng Wang, Kathryn T. Chen, Tsui-Fen Chou, Virender K. Rehan, Delphine J. Lee, Begoña Diaz

Sci Rep. 2020; 10: 11952. Published online 2020 Jul 20. doi: 10.1038/s41598-020-68615-w

PMCID:: PMC7371688

Abstract Article PDF–6.2M

Select item 63962967.

N-myristoyltransferase deficiency impairs AMPK activation and promotes synovial tissue inflammation

Zhenke Wen, Ke Jin, Yi Shen, Zhen Yang, Yinyin Li, Bowen Wu, Lu Tian, Stanford Shoor, Niall E. Roche, Jorg J. Goronzy, Cornelia M. Weyand

Nat Immunol. Author manuscript; available in PMC 2019 Aug 4.

Published in final edited form as: Nat Immunol. 2019 Mar; 20(3): 313–325. Published online 2019 Feb 4. doi: 10.1038/s41590-018-0296-7

PMCID:: PMC6396296

Abstract Article PDF–2.0M

Select item 61132728.

Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells

Marine Jacquier, Shiby Kuriakose, Apurva Bhardwaj, Yang Zhang, Anuraag Shrivastav, Stéphanie Portet, Shailly Varma Shrivastav

Sci Rep. 2018; 8: 12969. Published online 2018 Aug 28. doi: 10.1038/s41598-018-30447-0

PMCID:: PMC6113272

Abstract Article PDF–2.5M

Select item 57328399.

Blocking myristoylation of Src inhibits its kinase activity and suppresses prostate cancer progression

Sungjin Kim, Omar Awad Alsaidan, Octavia Goodwin, Qianjin Li, Essilvo Sulejmani, Zhen Han, Aiping Bai, Thomas Albers, Zanna Beharry, Y. George Zheng, James S. Norris, Zdzislaw M. Szulc, Alicja Bielawska, Iryna Lebedyeva, Scott D. Pegan, Houjian Cai

Cancer Res. Author manuscript; available in PMC 2018 Dec 15.

Published in final edited form as: Cancer Res. 2017 Dec 15; 77(24): 6950–6962. Published online 2017 Oct 16. doi: 10.1158/0008-5472.CAN-17-0981

PMCID:: PMC5732839

Abstract Article PDF–2.8M

Select item 308629910.

The effects of HIV-1 Nef on human N-myristoyl transferase 1

Christopher R. Morgan, Brian V. Miglionico, John R. Engen

Biochemistry. Author manuscript; available in PMC 2012 Apr 26.

Published in final edited form as: Biochemistry. 2011 Apr 26; 50(16): 3394–3403. Published online 2011 Mar 30. doi: 10.1021/bi200197e

PMCID:: PMC3086299

Abstract Article PDF–1.6M

Select item 228928411.

A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin

J Cell Biol. 1992 Jan 2; 116(2): 405–422. doi: 10.1083/jcb.116.2.405

PMCID:: PMC2289284

Summary PDF–2.9M

Select item 220398612.

N-myristoyltransferase: A potential novel diagnostic marker for colon cancer

Anuraag Shrivastav, Shailly Varma, Anurag Saxena, John DeCoteau, Rajendra K Sharma

J Transl Med. 2007; 5: 58. Published online 2007 Nov 16. doi: 10.1186/1479-5876-5-58

PMCID:: PMC2203986

Abstract Article PDF–3.3M

Select item 185330013.

Point mutations in the HIV-1 matrix protein turn off the myristyl switch

Jamil S. Saad, Erin Loeliger, Paz Luncsford, Mellisa Liriano, Janet Tai, Andrew Kim, Jaime Miller, Anjali Joshi, Eric O. Freed, Michael F. Summers

J Mol Biol. Author manuscript; available in PMC 2008 Feb 16.

Published in final edited form as: J Mol Biol. 2007 Feb 16; 366(2): 574–585. Published online 2006 Dec 1. doi: 10.1016/j.jmb.2006.11.068

PMCID:: PMC1853300

Abstract Article PDF–1.9M

Select item 53856414.

Human N-Myristoyltransferases Form Stable Complexes with Lentiviral Nef and Other Viral and Cellular Substrate Proteins

Brian T. Hill, Jacek Skowronski

J Virol. 2005 Jan; 79(2): 1133–1141. doi: 10.1128/JVI.79.2.1133-1141.2005

PMCID:: PMC538564

Abstract Article PDF–318K

Select item 5333915.

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

S M Mumby, R O Heukeroth, J I Gordon, A G Gilman

Proc Natl Acad Sci U S A. 1990 Jan; 87(2): 728–732. doi: 10.1073/pnas.87.2.728

PMCID:: PMC53339

Summary Page Browse PDF–1.3M

Select item 4541516.

Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids.

C T Sigal, W Zhou, C A Buser, S McLaughlin, M D Resh

Proc Natl Acad Sci U S A. 1994 Dec 6; 91(25): 12253–12257. doi: 10.1073/pnas.91.25.12253

PMCID:: PMC45415

Summary Page Browse PDF–1.5M

Select item 472742417.

Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA

Eric Soupene, Joseph Kao, Daniel H. Cheng, Derek Wang, Alexander L. Greninger, Giselle M. Knudsen, Joseph L. DeRisi, Frans A. Kuypers

J Lipid Res. 2016 Feb; 57(2): 288–298. doi: 10.1194/jlr.M065003

PMCID:: PMC4727424

Abstract Article PDF–1.2M

Select item 366078818.

Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation

Dominic Alibhai, Douglas J Kelly, Sean Warren, Sunil Kumar, Anca Margineau, Remigiusz A Serwa, Emmanuelle Thinon, Yuriy Alexandrov, Edward J Murray, Frank Stuhmeier, Edward W Tate, Mark A A Neil, Chris Dunsby, Paul M W French

J Biophotonics. 2013 May; 6(5): 398–408. Published online 2012 Nov 27. doi: 10.1002/jbio.201200185