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Select item 112104481.

TXNRD1 drives innate immune response in senescent cells with implications in age-associated inflammation

Xue Hao, Bo Zhao, Martina Towers, Liping Liao, Edgar Luzete Monteiro, Xin Xu, Christina Freeman, Hongzhuang Peng, Hsin-Yao Tang, Aaron Havas, Andrew V. Kossenkov, Shelley L. Berger, Peter D. Adams, David W. Speicher, David Schultz, Ronen Marmorstein, Kenneth S. Zaret, Rugang Zhang

Nat Aging. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Nat Aging. 2024 Feb; 4(2): 185–197. Published online 2024 Jan 24. doi: 10.1038/s43587-023-00564-1

PMCID:: PMC11210448

Abstract Article PDF–4.9M

Select item 110759062.

Unraveling the genetics of arsenic toxicity with cellular morphology QTL

Callan O’Connor, Gregory R. Keele, Whitney Martin, Timothy Stodola, Daniel Gatti, Brian R. Hoffman, Ron Korstanje, Gary A. Churchill, Laura G. Reinholdt

PLoS Genet. 2024 Apr; 20(4): e1011248. Published online 2024 Apr 25. doi: 10.1371/journal.pgen.1011248

PMCID:: PMC11075906

Abstract Article PDF–3.2M

Select item 107718653.

Thioredoxin reductase 1 (TR1) modulates pigmentation and photobiology of murine melanocytes in vivo

Evan L. Carpenter, Mark B. Wyant, Aaryan Indra, Shosuke Ito, Kazumasa Wakamatsu, Gary F. Merrill, Philip J. Moos, Pamela B. Cassidy, Sancy A. Leachman, Gitali Ganguli-Indra, Arup K. Indra

J Invest Dermatol. Author manuscript; available in PMC 2024 Jan 7.

Published in final edited form as: J Invest Dermatol. 2022 Jul; 142(7): 1903–1911.e5. Published online 2022 Jan 11. doi: 10.1016/j.jid.2021.11.030

PMCID:: PMC10771865

Abstract Article PDF–1.1M

Select item 93013234.

Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function

Jennifer S Stancill, Polly A Hansen, Angela J Mathison, Edward E Schmidt, John A Corbett

Function (Oxf) 2022; 3(4): zqac034. Published online 2022 Jul 4. doi: 10.1093/function/zqac034

PMCID:: PMC9301323

Abstract Article PDF–6.3M

Select item 63605495.

Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia

Stephanie B. Wall, Rachael Wood, Katelyn Dunigan, Qian Li, Rui Li, Lynette K. Rogers, Trent E. Tipple

Oxid Med Cell Longev. 2019; 2019: 7945983. Published online 2019 Jan 21. doi: 10.1155/2019/7945983

PMCID:: PMC6360549

Abstract Article PDF–1.6M

Select item 63343006.

Disruption of Thioredoxin Reductase 1 Protects Mice from Acute Acetaminophen-Induced Hepatotoxicity through Enhanced NRF2 Activity

Andrew D. Patterson, Bradley A. Carlson, Fei Li, Jessica A. Bonzo, Min-Hyuk Yoo, Kristopher W. Krausz, Marcus Conrad, Chi Chen, Frank J. Gonzalez, Dolph L. Hatfield

Chem Res Toxicol. Author manuscript; available in PMC 2019 Jan 16.

Published in final edited form as: Chem Res Toxicol. 2013 Jul 15; 26(7): 1088–1096. Published online 2013 Jun 7. doi: 10.1021/tx4001013

PMCID:: PMC6334300

Abstract Article PDF–851K

Select item 40264037.

The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Attenuates Lung Injury and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome

Rodney D. Britt, Jr., Markus Velten, Morgan L. Locy, Lynette K. Rogers, Trent E. Tipple

Antioxid Redox Signal. 2014 Jun 10; 20(17): 2681–2691. doi: 10.1089/ars.2013.5332

PMCID:: PMC4026403

Abstract Article PDF–970K

Select item 38277838.

A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

Sonya V. Iverson, Sofi Eriksson, Jianqiang Xu, Justin R. Prigge, Emily A. Talago, Tesia A. Meade, Erin S. Meade, Mario R. Capecchi, Elias S.J. Arnér, Edward E. Schmidt

Free Radic Biol Med. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Free Radic Biol Med. 2013 Oct; 63: 10.1016/j.freeradbiomed.2013.05.028. Published online 2013 Jun 3. doi: 10.1016/j.freeradbiomed.2013.05.028

PMCID:: PMC3827783

Abstract Article PDF–6.3M

Select item 35087249.

Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism

Ryuta Tobe, Min-Hyuk Yoo, Noelia Fradejas, Bradley A. Carlson, Soledad Calvo, Vadim N. Gladyshev, Dolph L. Hatfield

Biochem J. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: Biochem J. 2012 Aug 1; 445(3): 423–430. doi: 10.1042/BJ20120618

PMCID:: PMC3508724

Abstract Article PDF–2.8M

Select item 327841610.

HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia

Salvador Naranjo-Suarez, Bradley A. Carlson, Petra A. Tsuji, Min-Hyuk Yoo, Vadim N. Gladyshev, Dolph L. Hatfield

PLoS One. 2012; 7(2): e30470. Published online 2012 Feb 13. doi: 10.1371/journal.pone.0030470

PMCID:: PMC3278416

Abstract Article PDF–732K

Select item 289465611.

Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration

MaryClare F. Rollins, Dana M. van der Heide, Carla M. Weisend, Jean A. Kundert, Kristin M. Comstock, Elena S. Suvorova, Mario R. Capecchi, Gary F. Merrill, Edward E. Schmidt

J Cell Sci. 2010 Jul 15; 123(14): 2402–2412. Published online 2010 Jun 22. doi: 10.1242/jcs.068106

PMCID:: PMC2894656

Abstract Article

Select item 204020212.

Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication

Min-Hyuk Yoo, Xue-Ming Xu, Bradley A. Carlson, Andrew D. Patterson, Vadim N. Gladyshev, Dolph L. Hatfield

PLoS One. 2007; 2(10): e1112. Published online 2007 Oct 31. doi: 10.1371/journal.pone.0001112

PMCID:: PMC2040202

Abstract Article PDF–591K

Select item 983345013.

Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury

Colin T. Shearn, Aimee L. Anderson, Colin G. Miller, Reed C. Noyd, Michael W. Devereaux, Nata Balasubramaniyan, David J. Orlicky, Edward E. Schmidt, Ronald J. Sokol

Hepatol Commun. 2023 Jan; 7(1): e0020. Published online 2023 Jan 10. doi: 10.1097/HC9.0000000000000020

PMCID:: PMC9833450

Abstract Article PDF–1.7M

Select item 554312114.

MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation

Neri Mercatelli, Simona Fittipaldi, Elisa De Paola, Ivan Dimauro, Maria Paola Paronetto, Malcolm J. Jackson, Daniela Caporossi

Sci Rep. 2017; 7: 7219. Published online 2017 Aug 3. doi: 10.1038/s41598-017-07575-0

PMCID:: PMC5543121

Abstract Article PDF–3.7M

Select item 502302415.

Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2–Related Factor 2 Activation

Qian Li, Stephanie B. Wall, Changchun Ren, Markus Velten, Cynthia L. Hill, Morgan L. Locy, Lynette K. Rogers, Trent E. Tipple

Am J Respir Cell Mol Biol. 2016 Sep; 55(3): 419–428. doi: 10.1165/rcmb.2015-0228OC

PMCID:: PMC5023024

Abstract Article PDF–1.2M

Select item 492186116.

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

Xiaoxiao Peng, Alfredo Giménez-Cassina, Paul Petrus, Marcus Conrad, Mikael Rydén, Elias S. J. Arnér

Sci Rep. 2016; 6: 28080. Published online 2016 Jun 27. doi: 10.1038/srep28080

PMCID:: PMC4921861

Abstract Article PDF–2.5M

Select item 440153917.

The 15kDa Selenoprotein and Thioredoxin Reductase 1 Promote Colon Cancer by Different Pathways

Petra A. Tsuji, Bradley A. Carlson, Min-Hyuk Yoo, Salvador Naranjo-Suarez, Xue-Ming Xu, Yiwen He, Esther Asaki, Harold E. Seifried, William C. Reinhold, Cindy D. Davis, Vadim N. Gladyshev, Dolph L. Hatfield

PLoS One. 2015; 10(4): e0124487. Published online 2015 Apr 17. doi: 10.1371/journal.pone.0124487

PMCID:: PMC4401539

Abstract Article PDF–757K

Select item 376541818.

Abrogated Thioredoxin System Causes Increased Sensitivity to TNF-α-Induced Apoptosis via Enrichment of p-ERK 1/2 in the Nucleus

Min-Hyuk Yoo, Bradley A. Carlson, Vadim N. Gladyshev, Dolph L. Hatfield

PLoS One. 2013; 8(9): e71427. Published online 2013 Sep 6. doi: 10.1371/journal.pone.0071427

PMCID:: PMC3765418

Abstract Article PDF–1.1M

Select item 376078519.

Selenocysteine Confers Resistance to Inactivation by Oxidation in Thioredoxin Reductase: Comparison of Selenium and Sulfur Enzymes

Gregg W. Snider, Erik Ruggles, Nadeem Khan, Robert J. Hondal

Biochemistry. Author manuscript; available in PMC 2014 Aug 13.

Published in final edited form as: Biochemistry. 2013 Aug 13; 52(32): 5472–5481. Published online 2013 Jul 31. doi: 10.1021/bi400462j

PMCID:: PMC3760785

Abstract Article PDF–1.5M

Select item 351490520.

Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis

Bradley A. Carlson, Min-Hyuk Yoo, Ryuta Tobe, Charles Mueller, Salvador Naranjo-Suarez, Victoria J. Hoffmann, Vadim N. Gladyshev, Dolph L. Hatfield

Carcinogenesis. 2012 Sep; 33(9): 1806–1813. Published online 2012 Jul 12. doi: 10.1093/carcin/bgs230

PMCID:: PMC3514905

Abstract Article PDF–1.8M

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