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Select item 111580391.

Plasma membrane‐associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane‐treated transgenic mice

Kazuhiro Shiozaki, Kazunori Yamaguchi, Ikuro Sato, Taeko Miyagi

Cancer Sci. 2009 Apr; 100(4): 588–594. Published online 2009 Feb 2. doi: 10.1111/j.1349-7006.2008.01080.x

PMCID:: PMC11158039

Abstract Article PDF–1.0M

Select item 106945972.

Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis

Maria L. Allende, Y. Terry Lee, Colleen Byrnes, Cuiling Li, Galina Tuymetova, Jenna Y. Bakir, Elena-Raluca Nicoli, Virginia K. James, Jennifer S. Brodbelt, Cynthia J. Tifft, Richard L. Proia

J Lipid Res. 2023 Dec; 64(12): 100463. Published online 2023 Oct 21. doi: 10.1016/j.jlr.2023.100463

PMCID:: PMC10694597

Abstract Article PDF–3.1M

Select item 83076183.

Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

Won Ho Yang, Julia S. Westman, Douglas M. Heithoff, Markus Sperandio, Jin Won Cho, Michael J. Mahan, Jamey D. Marth

Proc Natl Acad Sci U S A. 2021 Jul 20; 118(29): e2100937118. Published online 2021 Jul 15. doi: 10.1073/pnas.2100937118

PMCID:: PMC8307618

Abstract Article PDF–1.9M

Select item 77860794.

High-Fat Diet–Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice Are Reduced by Inhibiting Sialidases

Darrell Pilling, Tejas R. Karhadkar, Richard H. Gomer

Am J Pathol. 2021 Jan; 191(1): 131–143. doi: 10.1016/j.ajpath.2020.09.011

PMCID:: PMC7786079

Abstract Article PDF–3.6M

Select item 70899485.

The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion

Akira Minami, Yuka Fujita, Sumika Shimba, Mako Shiratori, Yukiko K. Kaneko, Toshiaki Sawatani, Tadamune Otsubo, Kiyoshi Ikeda, Hiroaki Kanazawa, Yasuyo Mikami, Risa Sekita, Yuuki Kurebayashi, Tadanobu Takahashi, Taeko Miyagi, Tomohisa Ishikawa, Takashi Suzuki

Sci Rep. 2020; 10: 5198. Published online 2020 Mar 23. doi: 10.1038/s41598-020-62203-8

PMCID:: PMC7089948

Abstract Article PDF–3.2M

Select item 69858706.

Attenuated pulmonary fibrosis in sialidase-3 knockout (Neu3^−/−) mice

Tejas R. Karhadkar, Wensheng Chen, Richard H. Gomer

Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1; 318(1): L165–L179. Published online 2019 Oct 16. doi: 10.1152/ajplung.00275.2019

PMCID:: PMC6985870

Abstract Article

Select item 40556047.

Sialidase NEU3 Dynamically Associates to Different Membrane Domains Specifically Modifying Their Ganglioside Pattern and Triggering Akt Phosphorylation

Dario Bonardi, Nadia Papini, Mario Pasini, Loredana Dileo, Flavia Orizio, Eugenio Monti, Luigi Caimi, Bruno Venerando, Roberto Bresciani

PLoS One. 2014; 9(6): e99405. Published online 2014 Jun 12. doi: 10.1371/journal.pone.0099405

PMCID:: PMC4055604

Abstract Article PDF–2.8M

Select item 33989398.

Reduced Susceptibility to Colitis-Associated Colon Carcinogenesis in Mice Lacking Plasma Membrane-Associated Sialidase

Kazunori Yamaguchi, Kazuhiro Shiozaki, Setsuko Moriya, Koichi Koseki, Tadashi Wada, Hiroo Tateno, Ikuro Sato, Masahide Asano, Yoichiro Iwakura, Taeko Miyagi

PLoS One. 2012; 7(7): e41132. Published online 2012 Jul 17. doi: 10.1371/journal.pone.0041132

PMCID:: PMC3398939

Abstract Article PDF–1.2M

Select item 26622969.

NEU3 Sialidase Strictly Modulates GM3 Levels in Skeletal Myoblasts C2C12 Thus Favoring Their Differentiation and Protecting Them from Apoptosis

Luigi Anastasia, Nadia Papini, Francesca Colazzo, Giacomo Palazzolo, Cristina Tringali, Loredana Dileo, Marco Piccoli, Erika Conforti, Clementina Sitzia, Eugenio Monti, Maurilio Sampaolesi, Guido Tettamanti, Bruno Venerando

J Biol Chem. 2008 Dec 26; 283(52): 36265–36271. doi: 10.1074/jbc.M805755200

PMCID:: PMC2662296

Abstract Article PDF–592K

Select item 226735210.

Sialidase NEU3 is a peripheral membrane protein localized on the cell surface and in endosomal structures

Gabriele Zanchetti, Paolo Colombi, Marta Manzoni, Luigi Anastasia, Luigi Caimi, Giuseppe Borsani, Bruno Venerando, Guido Tettamanti, Augusto Preti, Eugenio Monti, Roberto Bresciani

Biochem J. 2007 Dec 1; 408(Pt 2): 211–219. Prepublished online 2007 Aug 21. Published online 2007 Nov 14. doi: 10.1042/BJ20070503

PMCID:: PMC2267352

Abstract Article PDF–485K

Select item 122222211.

Degradation of G(M1) and G(M2) by mammalian sialidases.

S C Li, Y T Li, S Moriya, T Miyagi

Biochem J. 2001 Nov 15; 360(Pt 1): 233–237. doi: 10.1042/0264-6021:3600233

PMCID:: PMC1222222

Summary PDF–138K

Select item 1072032512.

Characterization of a phenotypically severe animal model for human AB-Variant GM2 gangliosidosis

Natalie M. Deschenes, Camilyn Cheng, Prem Khanal, Brianna M. Quinville, Alex E. Ryckman, Melissa Mitchell, Alexey V. Pshezhetsky, Jagdeep S. Walia

Front Mol Neurosci. 2023; 16: 1242814. Published online 2023 Nov 30. doi: 10.3389/fnmol.2023.1242814

PMCID:: PMC10720325

Abstract Article PDF–2.4M

Select item 1001974313.

Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse model

Tugce Sengul, Melike Can, Nurselin Ateş, Volkan Seyrantepe

PLoS One. 2023; 18(3): e0280650. Published online 2023 Mar 16. doi: 10.1371/journal.pone.0280650

PMCID:: PMC10019743

Abstract Article PDF–2.6M

Select item 620193714.

Presence of aberrant epididymal tubules revealing undifferentiated epithelial cells and absence of spermatozoa in a combined neuraminidase-3 and -4 deficient adult mouse model

Regiana Oliveira, Louis Hermo, Alexey V. Pshezhetsky, Carlos R. Morales

PLoS One. 2018; 13(10): e0206173. Published online 2018 Oct 25. doi: 10.1371/journal.pone.0206173

PMCID:: PMC6201937

Abstract Article PDF–5.4M

Select item 932347315.

The Janus‐like role of neuraminidase isoenzymes in inflammation

Md. Amran Howlader, Ekaterina P. Demina, Suzanne Samarani, Tianlin Guo, Antoine Caillon, Ali Ahmad, Alexey V. Pshezhetsky, Christopher W. Cairo

FASEB J. 2022 May; 36(5): e22285. Published online 2022 Apr 1. doi: 10.1096/fj.202101218R

PMCID:: PMC9323473

Abstract Article PDF–2.3M

Select item 356153716.

NEU3 Sialidase Is Activated under Hypoxia and Protects Skeletal Muscle Cells from Apoptosis through the Activation of the Epidermal Growth Factor Receptor Signaling Pathway and the Hypoxia-inducible Factor (HIF)-1α

Raffaella Scaringi, Marco Piccoli, Nadia Papini, Federica Cirillo, Erika Conforti, Sonia Bergante, Cristina Tringali, Andrea Garatti, Cecilia Gelfi, Bruno Venerando, Lorenzo Menicanti, Guido Tettamanti, Luigi Anastasia

J Biol Chem. 2013 Feb 1; 288(5): 3153–3162. Published online 2012 Dec 3. doi: 10.1074/jbc.M112.404327