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Select item 104259061.

IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4⁺T cells

Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu

iScience. 2023 Aug 18; 26(8): 107464. Published online 2023 Jul 25. doi: 10.1016/j.isci.2023.107464

PMCID:: PMC10425906

Abstract Article PDF–6.2M

Select item 90127012.

IL-27 enhances γδ T cell-mediated innate resistance to primary hookworm infection in the lungs

Arjun Sharma, Jason B. Noon, Konstantinos Kontodimas, Lucien P. Garo, Johannes Platten, Lee J. Quinton, Joseph F. Urban, Jr, Christoph Reinhardt, Markus Bosmann

J Immunol. Author manuscript; available in PMC 2023 Apr 15.

Published in final edited form as: J Immunol. 2022 Apr 15; 208(8): 2008–2018. Published online 2022 Mar 30. doi: 10.4049/jimmunol.2000945

PMCID:: PMC9012701

Abstract Article PDF–2.2M

Select item 83053133.

Deficiency of IL-27 Signaling Exacerbates Experimental Autoimmune Uveitis with Elevated Uveitogenic Th1 and Th17 Responses

Sihan Wu, Rui Ma, Yajie Zhong, Zilin Chen, Hongyan Zhou, Minyi Zhou, Waipo Chong, Jun Chen

Int J Mol Sci. 2021 Jul; 22(14): 7517. Published online 2021 Jul 14. doi: 10.3390/ijms22147517

PMCID:: PMC8305313

Abstract Article PDF–1.9M

Select item 75212684.

IL‐27 Rα⁺ cells promoted allorejection via enhancing STAT1/3/5 phosphorylation

Shanshan Zhao, Ting Liang, Chao Zhang, Dai Shi, Wen Jiang, Chen Su, Guihua Hou

J Cell Mol Med. 2020 Sep; 24(18): 10756–10767. Published online 2020 Aug 6. doi: 10.1111/jcmm.15700

PMCID:: PMC7521268

Abstract Article PDF–2.0M

Select item 70729315.

IL-27Rα: A Novel Molecular Imaging Marker for Allograft Rejection

Shanshan Zhao, Dai Shi, Chen Su, Wen Jiang, Chao Zhang, Ting Liang, Guihua Hou

Int J Mol Sci. 2020 Feb; 21(4): 1315. Published online 2020 Feb 15. doi: 10.3390/ijms21041315

PMCID:: PMC7072931

Abstract Article PDF–4.0M

Select item 48238136.

IL-Y, a Synthetic Member of the IL-12 Cytokine Family, Suppresses the Development of Type 1 Diabetes in NOD Mice

Rafael R. Flores, Eun Kim, Liqiao Zhou, Chenjie Yang, Jing Zhao, Andrea Gambotto, Paul D. Robbins

Eur J Immunol. Author manuscript; available in PMC 2016 Apr 7.

Published in final edited form as: Eur J Immunol. 2015 Nov; 45(11): 3114–3125. Published online 2015 Sep 1. doi: 10.1002/eji.201445403

PMCID:: PMC4823813

Abstract Article PDF–3.1M

Select item 40447177.

IL-27R–Mediated Regulation of IL-17 Controls the Development of Respiratory Syncytial Virus–Associated Pathogenesis

Denise E. de Almeida Nagata, Tine Demoor, Catherine Ptaschinski, Hung-An Ting, Sihyug Jang, Michelle Reed, Sumanta Mukherjee, Nicholas W. Lukacs

Am J Pathol. 2014 Jun; 184(6): 1807–1818. doi: 10.1016/j.ajpath.2014.02.004

PMCID:: PMC4044717

Abstract Article PDF–2.1M

Select item 39118758.

IL-27 Receptor Signaling Regulates Memory CD4⁺ T Cell Populations and Suppresses Rapid Inflammatory Responses during Secondary Malaria Infection

Emily Gwyer Findlay, Ana Villegas-Mendez, Noelle O'Regan, J. Brian de Souza, Lisa-Marie Grady, Christiaan J. Saris, Eleanor M. Riley, Kevin N. Couper

Infect Immun. 2014 Jan; 82(1): 10–20. doi: 10.1128/IAI.01091-13

PMCID:: PMC3911875

Abstract Article PDF–2.5M

Select item 32041919.

IL-27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice

Hirokazu Fujimoto, Tetsuaki Hirase, Yoshiyuki Miyazaki, Hiromitsu Hara, Noriko Ide-Iwata, Ai Nishimoto-Hazuku, Christiaan J.M. Saris, Hiroki Yoshida, Koichi Node

Am J Pathol. 2011 Nov; 179(5): 2327–2336. doi: 10.1016/j.ajpath.2011.08.001

PMCID:: PMC3204191

Abstract Article PDF–2.2M

Select item 306989610.

The IL-27 Receptor Has Biphasic Effects in Crescentic Glomerulonephritis Mediated Through Th1 Responses

Shaun A. Summers, Richard K.S. Phoon, Joshua D. Ooi, Stephen R. Holdsworth, A. Richard Kitching

Am J Pathol. 2011 Feb; 178(2): 580–590. doi: 10.1016/j.ajpath.2010.10.013

PMCID:: PMC3069896

Abstract Article PDF–3.6M

Select item 193285911.

Disruption of Interleukin-27 Signaling Results in Impaired Gamma Interferon Production but Does Not Significantly Affect Immunopathology in Murine Schistosome Infection

Mara G. Shainheit, Rosita Saraceno, Lindsey E. Bazzone, Laura I. Rutitzky, Miguel J. Stadecker

Infect Immun. 2007 Jun; 75(6): 3169–3177. Published online 2007 Apr 2. doi: 10.1128/IAI.01053-06

PMCID:: PMC1932859

Abstract Article PDF–422K

Select item 159268312.

Interleukin-27R (WSX-1/T-Cell Cytokine Receptor) Gene-Deficient Mice Display Enhanced Resistance to Leishmania donovani Infection but Develop Severe Liver Immunopathology

Lucia E. Rosas, Anjali A. Satoskar, Kimberly M. Roth, Tracy L. Keiser, Joseph Barbi, Christopher Hunter, Frederic J. de Sauvage, Abhay R. Satoskar

Am J Pathol. 2006 Jan; 168(1): 158–169. doi: 10.2353/ajpath.2006.050013

PMCID:: PMC1592683

Abstract Article PDF–4.7M

Select item 1123351413.

IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation

Mingyue Zhang, Dehai Li, Jing Zhu, Xue Xia, Hua Zhang, Jie Wu, Shengli Wang, Anyi Deng, Qiong Wen, Jingyi Tan, Jianlei Hao, Jun Jiang, Xiucong Bao, Guodong Sun, Jiajing Lu, Quanli Yang, Hengwen Yang, Guangchao Cao, Zhinan Yin, Qian Wang

Cell Death Dis. 2024 Jul; 15(7): 491. Published online 2024 Jul 9. doi: 10.1038/s41419-024-06887-0

PMCID:: PMC11233514

Abstract Article PDF–6.6M

Select item 1098499614.

IL-27-induced PD-L1^highSca-1⁺ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner

Keun Young Min, Do-Kyun Kim, Min Geun Jo, min Yeong Choi, Dajeong Lee, Jeong Won Park, Young-Jun Park, Yeonseok Chung, Young Mi Kim, Yeong-Min Park, Hyuk Soon Kim, Wahn Soo Choi

Exp Mol Med. 2024 Mar; 56(3): 616–629. Published online 2024 Mar 1. doi: 10.1038/s12276-024-01187-1

PMCID:: PMC10984996

Abstract Article PDF–6.6M

Select item 998660615.

Interleukin-27-dependent transcriptome signatures during neonatal sepsis

Jessica M. Povroznik, Halima Akhter, Jordan K. Vance, Madhavi Annamanedi, Sebastian A. Dziadowicz, Lei Wang, Ashley M. Divens, Gangqing Hu, Cory M. Robinson

Front Immunol. 2023; 14: 1124140. Published online 2023 Feb 20. doi: 10.3389/fimmu.2023.1124140

PMCID:: PMC9986606

Abstract Article PDF–1.9M

Select item 853180816.

IL-27 Mediates Pro-Inflammatory Effects via the ERK Signaling Pathway During Preterm Labor

Dongni Huang, Yuxin Ran, Zheng Liu, Jie He, Nanlin Yin, Hongbo Qi

Front Immunol. 2021; 12: 709229. Published online 2021 Oct 8. doi: 10.3389/fimmu.2021.709229

PMCID:: PMC8531808

Abstract Article PDF–13M

Select item 736846117.

Loss of the IL-27R Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses

Gaia M Coppock, Lillian R Aronson, Jihwan Park, Chengxiang Qiu, Jeongho Park, Jonathan H. DeLong, Enrico Radaelli, Katalin Suszták, Christopher A Hunter

J Immunol. Author manuscript; available in PMC 2021 Jul 15.

Published in final edited form as: J Immunol. 2020 Jul 15; 205(2): 377–386. Published online 2020 Jun 10. doi: 10.4049/jimmunol.1901463

PMCID:: PMC7368461

Abstract Article PDF–1.8M

Select item 711891018.

Intra-Tumoral Delivery of IL-27 Using Adeno-Associated Virus Stimulates Anti-tumor Immunity and Enhances the Efficacy of Immunotherapy

Aiyan Hu, Miao Ding, Jianmin Zhu, Jin-Qing Liu, Xueliang Pan, Kalpana Ghoshal, Xue-Feng Bai

Front Cell Dev Biol. 2020; 8: 210. Published online 2020 Mar 27. doi: 10.3389/fcell.2020.00210

PMCID:: PMC7118910

Abstract Article PDF–2.1M

Select item 702869019.

Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease

Hongnga T. Le, Karen Keslar, Quang Tam Nguyen, Bruce R. Blazar, Betty K. Hamilton, Booki Min

Front Immunol. 2020; 11: 181. Published online 2020 Feb 12. doi: 10.3389/fimmu.2020.00181

PMCID:: PMC7028690

Abstract Article PDF–1.7M

Select item 683466120.

IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development

Iuliia O. Peshkova, Turan Aghayev, Aliia R. Fatkhullina, Petr Makhov, Elizaveta K. Titerina, Satoru Eguchi, Yin Fei Tan, Andrew V. Kossenkov, Marina V. Khoreva, Lyudmila V. Gankovskaya, Stephen M. Sykes, Ekaterina K. Koltsova

Nat Commun. 2019; 10: 5046. Published online 2019 Nov 6. doi: 10.1038/s41467-019-13017-4