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Select item 102981361.

PCTAIRE Protein Kinase 1 (PCTK1) Suppresses Proliferation, Stemness, and Chemoresistance in Colorectal Cancer through the BMPR1B-Smad1/5/8 Signaling Pathway

Po-Li Wei, Chien-Yu Huang, Tung-Cheng Chang, Jang-Chun Lin, Cheng-Chin Lee, G. M. Shazzad Hossain Prince, Precious Takondwa Makondi, Angelina Wong-Ying Chui, Yu-Jia Chang

Int J Mol Sci. 2023 Jun; 24(12): 10008. Published online 2023 Jun 11. doi: 10.3390/ijms241210008

PMCID:: PMC10298136

Abstract Article PDF–8.3M

Select item 90270502.

CDK16 promotes the progression and metastasis of triple-negative breast cancer by phosphorylating PRC1

Xiao Li, Jinpeng Li, Liming Xu, Wei Wei, Anyi Cheng, Lingxian Zhang, Mengna Zhang, Gaosong Wu, Cheguo Cai

J Exp Clin Cancer Res. 2022; 41: 149. Published online 2022 Apr 21. doi: 10.1186/s13046-022-02362-w

PMCID:: PMC9027050

Abstract Article PDF–11M

Select item 69371263.

Transcriptomic Analysis in Liquid Biopsy Identifies Circulating PCTAIRE-1 mRNA as a Biomarker in NSCLC

JOHN WEN-CHENG CHANG, CHUN-LIANG SHIH, CHIH-LIANG WANG, JI-DUNG LUO, CHIH-WEI WANG, JIA-JUAN HSIEH, CHIA-JUNG YU, CHIUAN-CHIAN CHIOU

Cancer Genomics Proteomics. 2020 Jan-Feb; 17(1): 91–100. Published online 2020 Jan 3. doi: 10.21873/cgp.20170

PMCID:: PMC6937126

Abstract Article PDF–471K

Select item 57710834.

CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer

Jie Xie, Yan Li, Ke Jiang, Kaishun Hu, Sheng Zhang, Xiaorong Dong, Xiaofang Dai, Li Liu, Tao Zhang, Kunyu Yang, Kai Huang, Junjie Chen, Shaojun Shi, Yu Zhang, Gang Wu, Shuangbing Xu

Theranostics. 2018; 8(3): 650–662. Published online 2018 Jan 1. doi: 10.7150/thno.21963

PMCID:: PMC5771083

Abstract Article PDF–2.6M

Select item 46428675.

Upregulated CDK16 Expression in Serous Epithelial Ovarian Cancer Cells

Qi Zhou, Yanni Yu

Med Sci Monit. 2015; 21: 3409–3414. Published online 2015 Nov 7. doi: 10.12659/MSM.894990

PMCID:: PMC4642867

Abstract Article PDF–870K

Select item 89365276.

Lung cancer cells expressing a shortened CDK16 3′UTR escape senescence through impaired miR‐485‐5p targeting

Qi Jia, Baiyun Xie, Zhaozhao Zhao, Leihuan Huang, Gang Wei, Ting Ni

Mol Oncol. 2022 Mar; 16(6): 1347–1364. Published online 2021 Nov 9. doi: 10.1002/1878-0261.13125

PMCID:: PMC8936527

Abstract Article PDF–4.1M

Select item 77540307.

circRNA 001306 enhances hepatocellular carcinoma growth by up‐regulating CDK16 expression via sponging miR‐584‐5p

Qian Liu, Cixiao Wang, Zeyou Jiang, Shan Li, Fang Li, Hua‐Bing Tan, Su‐yang Yue

J Cell Mol Med. 2020 Dec; 24(24): 14306–14315. Published online 2020 Nov 1. doi: 10.1111/jcmm.16047

PMCID:: PMC7754030

Abstract Article PDF–2.0M

Select item 64679958.

Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex

Sara Hernández-Ortega, Abril Sánchez-Botet, Eva Quandt, Núria Masip, Laura Gasa, Gaetano Verde, Javier Jiménez, Rebecca S. Levin, Florentine U. Rutaganira, Alma L. Burlingame, Don Wolfgeher, Mariana P. C. Ribeiro, Stephen J. Kron, Kevan M. Shokat, Josep Clotet

Exp Mol Med. 2019 Apr; 51(4): 44. Published online 2019 Apr 16. doi: 10.1038/s12276-019-0242-2

PMCID:: PMC6467995

Abstract Article PDF–2.7M

Select item 43815829.

RNA interference screening identifies a novel role for PCTK1/CDK16 in medulloblastoma with c-Myc amplification

Paulina Ćwiek, Zaira Leni, Fabiana Salm, Valeriya Dimitrova, Beata Styp-Rekowska, Gianpaolo Chiriano, Michael Carroll, Katrin Höland, Valentin Djonov, Leonardo Scapozza, Patrick Guiry, Alexandre Arcaro

Oncotarget. 2015 Jan; 6(1): 116–129. Published online 2014 Nov 6. doi: 10.18632/oncotarget.2699

PMCID:: PMC4381582

Abstract Article PDF–5.5M

Select item 419989710.

PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells

Teruki Yanagi, Maryla Krajewska, Shu-ichi Matsuzawa, John C. Reed

Cancer Res. Author manuscript; available in PMC 2015 Oct 15.

Published in final edited form as: Cancer Res. 2014 Oct 15; 74(20): 5795–5807. Published online 2014 Sep 9. doi: 10.1158/0008-5472.CAN-14-0872

PMCID:: PMC4199897

Abstract Article PDF–1.7M

Select item 392954311.

Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly

EI Ramos, GA Bien-Willner, J Li, AEO Hughes, J Giacalone, S Chasnoff, S Kulkarni, M Parmacek, FS Cole, TE Druley

Clin Genet. 2014 May; 85(5): 423–432. Published online 2013 Jun 18. doi: 10.1111/cge.12197

PMCID:: PMC3929543

Abstract Article PDF–907K

Select item 359045012.

Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

Saifeldin N. Shehata, Roger W. Hunter, Eriko Ohta, Mark W. Peggie, Hua Jane Lou, Frank Sicheri, Elton Zeqiraj, Benjamin E. Turk, Kei Sakamoto

Cell Signal. 2012 Nov; 24(11): 2085–2094. doi: 10.1016/j.cellsig.2012.06.018

PMCID:: PMC3590450

Abstract Article

Select item 704232913.

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

Marc Dohmen, Sarah Krieg, Georgios Agalaridis, Xiaoqing Zhu, Saifeldin N. Shehata, Elisabeth Pfeiffenberger, Jan Amelang, Mareike Bütepage, Elena Buerova, Carolina M. Pfaff, Dipanjan Chanda, Stephan Geley, Christian Preisinger, Kei Sakamoto, Bernhard Lüscher, Dietbert Neumann, Jörg Vervoorts

Nat Commun. 2020; 11: 1032. Published online 2020 Feb 25. doi: 10.1038/s41467-020-14812-0

PMCID:: PMC7042329

Abstract Article PDF–2.9M

Select item 634917814.

Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell

Yibing Si, Junfeng Liu, Hongliang Shen, Chen Zhang, Yuanhao Wu, Yongyi Huang, Zhangbin Gong, Jun Xue, Te Liu

J Cell Mol Med. 2019 Feb; 23(2): 1095–1105. Published online 2018 Nov 8. doi: 10.1111/jcmm.14010

PMCID:: PMC6349178

Abstract Article PDF–1.4M

Select item 464421315.

Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma

Hong-Fang Duan, Xiao-Qing Li, Hong-Yi Hu, Yu-Chi Li, Zhi Cai, Xue-Shuang Mei, Peng Yu, Li-Ping Nie, Wei Zhang, Zhen-Dong Yu, Guo-Hui Nie

Tumour Biol. 2015 Sep; 36(9): 6679–6689. Published online 2015 Mar 26. doi: 10.1007/s13277-015-3356-8

PMCID:: PMC4644213

Abstract Article PDF–3.2M

Select item 461351516.

Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16

Saifeldin N. Shehata, Maria Deak, Nicholas A. Morrice, Eriko Ohta, Roger W. Hunter, Vera M. Kalscheuer, Kei Sakamoto

Biochem J. 2015 Aug 1; 469(Pt 3): 409–420. Prepublished online 2015 Jun 10. Published online 2015 Jul 23. doi: 10.1042/BJ20150486

PMCID:: PMC4613515

Abstract Article PDF–1.1M

Select item 435553917.

PCTK1 Regulates Integrin-Dependent Spindle Orientation via Protein Kinase A Regulatory Subunit KAP0 and Myosin X

Sayaka Iwano, Ayaka Satou, Shigeru Matsumura, Naoyuki Sugiyama, Yasushi Ishihama, Fumiko Toyoshima

Mol Cell Biol. 2015 Apr; 35(7): 1197–1208. Prepublished online 2015 Jan 20. Published online 2015 Mar 10. doi: 10.1128/MCB.01017-14

PMCID:: PMC4355539

Abstract Article PDF–6.7M

Select item 343628818.

Brain-selective Kinase 2 (BRSK2) Phosphorylation on PCTAIRE1 Negatively Regulates Glucose-stimulated Insulin Secretion in Pancreatic β-Cells

Xin-Ya Chen, Xiu-Ting Gu, Hexige Saiyin, Bo Wan, Yu-Jing Zhang, Jing Li, Ying-Li Wang, Rui Gao, Yu-Fan Wang, Wei-Ping Dong, Sonia M. Najjar, Chen-Yu Zhang, Han-Fei Ding, Jun O. Liu, Long Yu

J Biol Chem. 2012 Aug 31; 287(36): 30368–30375. Published online 2012 Jul 13. doi: 10.1074/jbc.M112.375618