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Select item 98398071.

Heterozygous variants in the DVL2 interaction region of DACT1 cause CAKUT and features of Townes–Brocks syndrome 2

Anne Christians, Esra Kesdiren, Imke Hennies, Alejandro Hofmann, Mark-Oliver Trowe, Frank Brand, Helge Martens, Ann Christin Gjerstad, Zoran Gucev, Matthias Zirngibl, Robert Geffers, Tomáš Seeman, Heiko Billing, Anna Bjerre, Velibor Tasic, Andreas Kispert, Benno Ure, Dieter Haffner, Jens Dingemann, Ruthild G. Weber

Hum Genet. 2023; 142(1): 73–88. Published online 2022 Sep 6. doi: 10.1007/s00439-022-02481-6

PMCID:: PMC9839807

Abstract Article PDF–3.6M

Select item 92759702.

Disheveled binding antagonist of β-catenin 1 interacted with β-catenin and connexin 43 in human-induced pluripotent stem cells-derived cardiomyocytes

Jian Hou, Suiqing Huang, Yan Long, Kangni Feng, Liqun Shang, Zhuoming Zhou, Yuan Yue, Xiaolin Huang, Guangxian Chen, Zhongkai Wu

Bioengineered. 2022; 13(5): 11594–11601. Published online 2022 May 5. doi: 10.1080/21655979.2022.2070448

PMCID:: PMC9275970

Abstract Article PDF–2.5M

Select item 55709463.

DACT1 Overexpression in type I ovarian cancer inhibits malignant expansion and cis-platinum resistance by modulating canonical Wnt signalling and autophagy

Ruo-nan Li, Bin Liu, Xue-mei Li, Liang-si Hou, Xiao-ling Mu, Hui Wang, Hua Linghu

Sci Rep. 2017; 7: 9285. Published online 2017 Aug 24. doi: 10.1038/s41598-017-08249-7

PMCID:: PMC5570946

Abstract Article PDF–3.8M

Select item 53906824.

Heterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes–Brocks Syndrome

Bryn D. Webb, Sanjeeva Metikala, Patricia G. Wheeler, Mingma D. Sherpa, Sander M. Houten, Marko E. Horb, Eric E. Schadt

Hum Mutat. Author manuscript; available in PMC 2017 Apr 13.

Published in final edited form as: Hum Mutat. 2017 Apr; 38(4): 373–377. Published online 2017 Feb 2. doi: 10.1002/humu.23171

PMCID:: PMC5390682

Abstract Article PDF–546K

Select item 53484035.

Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway

Yuegeng Liu, Jingwan Zhang, Weifang Yu, Xiaoming Zhang, Guiqi Wang, Zengren Zhao

Oncotarget. 2016 Dec 6; 7(49): 81423–81434. Published online 2016 Nov 9. doi: 10.18632/oncotarget.13234

PMCID:: PMC5348403

Abstract Article PDF–9.1M

Select item 46409576.

Dact1 Regulates the Ability of 3T3-J2 Cells to Support Proliferation of Human Epidermal Keratinocytes

Daisuke Suzuki, Makoto Senoo

J Invest Dermatol. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: J Invest Dermatol. 2015 Nov; 135(11): 2894–2897. Published online 2015 Jun 22. doi: 10.1038/jid.2015.235

PMCID:: PMC4640957

Article PDF–623K

Select item 35336447.

Dapper Homolog 1 Is a Novel Tumor Suppressor in Gastric Cancer through Inhibiting the Nuclear Factor-κB Signaling Pathway

Shiyan Wang, Wei Kang, Minnie Y Y Go, Joanna H M Tong, Lili Li, Ning Zhang, Qian Tao, Xiaoxing Li, Ka Fai To, Joseph J Y Sung, Jun Yu

Mol Med. 2012; 18(1): 1402–1411. Published online 2012 Oct 10. doi: 10.2119/molmed.2012.00243

PMCID:: PMC3533644

Abstract Article PDF–5.3M

Select item 32011618.

Cytoplasmic HDPR1 Is Involved in Regional Lymph Node Metastasis and Tumor Development via Beta-Catenin Accumulation in Esophageal Squamous Cell Carcinoma

Jian Hou, En-Min Li, Jin-Hui Shen, Qing-Zhao, Zhi-Yong Wu, Xiu-E Xu, Jian-Yi Wu, Qiao-Huang, Jian Shen, Ming-Zhou Guo, Li-Yan Xu

J Histochem Cytochem. 2011 Jul; 59(7): 711–718. doi: 10.1369/0022155411409941

PMCID:: PMC3201161

Abstract Article PDF–388K

Select item 83286929.

Histone Deacetylation Regulated by KDM1A to Suppress DACT1 in Proliferation and Migration of Cervical Cancer

Lingjuan Zeng, Chunyan Chen, Chanjiao Yao

Anal Cell Pathol (Amst) 2021; 2021: 5555452. Published online 2021 Jul 24. doi: 10.1155/2021/5555452

PMCID:: PMC8328692

Abstract Article PDF–3.6M

Select item 629507610.

Cyclin G2 suppresses Wnt/β-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1

Jinlan Gao, Chenyang Zhao, Qi Liu, Xiaoyu Hou, Sen Li, Xuesha Xing, Chunhua Yang, Yang Luo

J Exp Clin Cancer Res. 2018; 37: 317. Published online 2018 Dec 14. doi: 10.1186/s13046-018-0973-2

PMCID:: PMC6295076

Abstract Article PDF–12M

Select item 522553411.

Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma

Yan-li Guo, Bao-En Shan, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Su-Peng Shen, Xin Guo, Jia Liang, Gang Kuang

J Biomed Sci. 2017; 24: 6. Published online 2017 Jan 11. doi: 10.1186/s12929-016-0308-6

PMCID:: PMC5225534

Abstract Article PDF–4.2M

Select item 264605912.

Dact1, a Nutritionally Regulated Preadipocyte Gene, Controls Adipogenesis by Coordinating the Wnt/β-Catenin Signaling Network

Claire Lagathu, Constantinos Christodoulides, Sam Virtue, William P. Cawthorn, Chiara Franzin, Wendy A. Kimber, Edoardo Dalla Nora, Mark Campbell, Gema Medina-Gomez, Benjamin N.R. Cheyette, Antonio J. Vidal-Puig, Jaswinder K. Sethi

Diabetes. 2009 Mar; 58(3): 609–619. doi: 10.2337/db08-1180

PMCID:: PMC2646059

Abstract Article PDF–566K

Select item 707755313.

Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy

Chenyang Zhao, Jinlan Gao, Sen Li, Qi Liu, Xiaoyu Hou, Xuesha Xing, Danning Wang, Manni Sun, Shusen Wang, Yang Luo

J Cell Mol Med. 2020 Mar; 24(5): 2749–2760. Published online 2020 Jan 24. doi: 10.1111/jcmm.14946

PMCID:: PMC7077553

Abstract Article PDF–2.0M

Select item 371127914.

SEC14 and Spectrin Domains 1 (Sestd1) and Dapper Antagonist of Catenin 1 (Dact1) Scaffold Proteins Cooperatively Regulate the Van Gogh-like 2 (Vangl2) Four-pass Transmembrane Protein and Planar Cell Polarity (PCP) Pathway during Embryonic Development in Mice

XiaoYong Yang, Benjamin N. R. Cheyette

J Biol Chem. 2013 Jul 12; 288(28): 20111–20120. Published online 2013 May 21. doi: 10.1074/jbc.M113.465427

PMCID:: PMC3711279

Abstract Article PDF–3.0M

Select item 330990115.

Oncogenic Function of DACT1 in Colon Cancer through the Regulation of β-catenin

Guohong Yuan, Chongkai Wang, Chaolai Ma, Ning Chen, Qinghe Tian, Tonglin Zhang, Wei Fu

PLoS One. 2012; 7(3): e34004. Published online 2012 Mar 21. doi: 10.1371/journal.pone.0034004

PMCID:: PMC3309901

Abstract Article PDF–4.0M

Select item 308322616.

Protein Kinase A-mediated 14-3-3 Association Impedes Human Dapper1 to Promote Dishevelled Degradation

Hua Chen, Linhua Liu, Benyu Ma, Ting Martin Ma, Jun-Jie Hou, Guo-Ming Xie, Wei Wu, Fu-Quan Yang, Ye-Guang Chen

J Biol Chem. 2011 Apr 29; 286(17): 14870–14880. Published online 2011 Jan 24. doi: 10.1074/jbc.M110.211607

PMCID:: PMC3083226

Abstract Article PDF–4.1M

Select item 412329617.

Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation

Benyu Ma, Weipeng Cao, Wenxia Li, Chan Gao, Zhen Qi, Yan Zhao, Jun Du, Hua Xue, Junya Peng, Jun Wen, Hua Chen, Yuanheng Ning, Lei Huang, Hong Zhang, Xiang Gao, Li Yu, Ye-Guang Chen

Cell Res. 2014 Aug; 24(8): 912–924. Published online 2014 Jul 1. doi: 10.1038/cr.2014.84

PMCID:: PMC4123296

Abstract Article PDF–3.7M

Select item 442436418.

The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy

Benyu Ma, Bofeng Liu, Weipeng Cao, Chan Gao, Zhen Qi, Yuanheng Ning, Ye-Guang Chen

J Biol Chem. 2015 May 8; 290(19): 12346–12354. Published online 2015 Mar 30. doi: 10.1074/jbc.M115.654590

PMCID:: PMC4424364

Abstract Article PDF–2.7M

Select item 293657719.

Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort

Ceres Fernández-Rozadilla, Luisa de Castro, Juan Clofent, Alejandro Brea-Fernández, Xavier Bessa, Anna Abulí, Montserrat Andreu, Rodrigo Jover, Rosa Xicola, Xavier Llor, Antoni Castells, Sergi Castellví-Bel, Angel Carracedo, Clara Ruiz-Ponte, for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association

PLoS One. 2010; 5(9): e12673. Published online 2010 Sep 9. doi: 10.1371/journal.pone.0012673