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Select item 59433091.

Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer

Youenn Drouet, Isabelle Treilleux, Alain Viari, Sophie Léon, Mojgan Devouassoux-Shisheboran, Nicolas Voirin, Christelle de la Fouchardière, Brigitte Manship, Alain Puisieux, Christine Lasset, Caroline Moyret-Lalle

Sci Rep. 2018; 8: 7386. Published online 2018 May 9. doi: 10.1038/s41598-018-25631-1

PMCID:: PMC5943309

Abstract Article PDF–2.6M

Select item 104232592.

The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer

Dong Yan, Qingqing He, Lu Pei, Meihua Yang, Lifang Huang, Jianqiu Kong, Wang He, Hao Liu, Shizhong Xu, Haide Qin, Tianxin Lin, Jian Huang

Cell Death Dis. 2023 Aug; 14(8): 516. Published online 2023 Aug 12. doi: 10.1038/s41419-023-06000-x

PMCID:: PMC10423259

Abstract Article PDF–9.6M

Select item 33591233.

APC/C^Cdh1 controls the proteasome-mediated degradation of E2F3 during cell cycle exit

Zhen Ping, Ratna Lim, Tarig Bashir, Michele Pagano, Daniele Guardavaccaro

Cell Cycle. 2012 May 15; 11(10): 1999–2005. doi: 10.4161/cc.20402

PMCID:: PMC3359123

Abstract Article PDF–818K

Select item 14137264.

Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

Esther Eytan, Yakir Moshe, Ilana Braunstein, Avram Hershko

Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7): 2081–2086. Published online 2006 Feb 2. doi: 10.1073/pnas.0510695103

Correction in:: Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13): 5242.

PMCID:: PMC1413726

Abstract Article PDF–389K

Select item 31026005.

The emerging role of APC/C^Cdh1 in controlling differentiation, genomic stability and tumor suppression

Ralph Wäsch, Jonathan A. Robbins, Frederick R. Cross

Oncogene. Author manuscript; available in PMC 2011 May 26.

Published in final edited form as: Oncogene. 2010 Jan 7; 29(1): 1–10. Published online 2009 Oct 12. doi: 10.1038/onc.2009.325

PMCID:: PMC3102600

Abstract Article PDF–1.1M

Select item 84196916.

CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65

Yangge Du, Min Zhang, Xuejiao Liu, Zheng Li, Menglong Hu, Yueming Tian, Longwei Lv, Xiao Zhang, Yunsong Liu, Ping Zhang, Yongsheng Zhou

EMBO Rep. 2021 Sep 6; 22(9): e52576. Published online 2021 Aug 12. doi: 10.15252/embr.202152576

PMCID:: PMC8419691

Abstract Article PDF–4.8M

Select item 72935617.

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

Raquel C. Martinez-Chacin, Tatyana Bodrug, Derek L. Bolhuis, Katarzyna M. Kedziora, Thomas Bonacci, Alban Ordureau, Morgan E. Gibbs, Florian Weissmann, Renping Qiao, Gavin D. Grant, Jeanette G. Cook, Jan-Michael Peters, J. Wade Harper, Michael J. Emanuele, Nicholas G. Brown

Nat Struct Mol Biol. Author manuscript; available in PMC 2020 Nov 11.

Published in final edited form as: Nat Struct Mol Biol. 2020 Jun; 27(6): 550–560. Published online 2020 May 11. doi: 10.1038/s41594-020-0424-6

PMCID:: PMC7293561

Abstract Article PDF–1.9M

Select item 67172568.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

Edmond R. Watson, Christy R. R. Grace, Wei Zhang, Darcie J. Miller, Iain F. Davidson, J. Rajan Prabu, Shanshan Yu, Derek L. Bolhuis, Elizaveta T. Kulko, Ronnald Vollrath, David Haselbach, Holger Stark, Jan-Michael Peters, Nicholas G. Brown, Sachdev S. Sidhu, Brenda A. Schulman

Proc Natl Acad Sci U S A. 2019 Aug 27; 116(35): 17280–17289. Published online 2019 Jul 26. doi: 10.1073/pnas.1902889116

PMCID:: PMC6717256

Abstract Article PDF–2.7M

Select item 58286249.

Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome

Danielle Sitry-Shevah, Sharon Kaisari, Adar Teichner, Shirly Miniowitz-Shemtov, Avram Hershko

Proc Natl Acad Sci U S A. 2018 Feb 20; 115(8): 1777–1782. Published online 2018 Feb 5. doi: 10.1073/pnas.1720312115

PMCID:: PMC5828624

Abstract Article PDF–1002K

Select item 511190610.

APC/C and SCF^{Cyclin F} constitute a reciprocal feedback circuit controlling S-phase entry

Rajarshi Choudhury, Thomas Bonacci, Anthony Arceci, Debojyoti Lahiri, Christine A Mills, Jennifer L Kernan, Timothy B Branigan, James A DeCaprio, Daniel J Burke, Michael J Emanuele

Cell Rep. Author manuscript; available in PMC 2016 Nov 16.

Published in final edited form as: Cell Rep. 2016 Sep 20; 16(12): 3359–3372. doi: 10.1016/j.celrep.2016.08.058

Correction in:: Cell Rep. 2024 Mar 26; 43(3): 113974.

PMCID:: PMC5111906

Abstract Article PDF–3.5M

Select item 332560011.

Regulation of APC/C^Cdc20 activity by RASSF1A–APC/C^Cdc20 circuitry

C Chow, N Wong, M Pagano, S W-M Lun, K-I Nakayama, K Nakayama, K-W Lo

Oncogene. 2012 Apr 12; 31(15): 1975–1987. Published online 2011 Aug 29. doi: 10.1038/onc.2011.372

PMCID:: PMC3325600

Abstract Article PDF–954K

Select item 131688412.

Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases

Engin Özkan, Hongtao Yu, Johann Deisenhofer

Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52): 18890–18895. Published online 2005 Dec 19. doi: 10.1073/pnas.0509418102

PMCID:: PMC1316884

Abstract Article PDF–613K

Select item 118619113.

Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability

Po-Yuan Ke, Yuan-Yeh Kuo, Chuan-Mei Hu, Zee-Fen Chang

Genes Dev. 2005 Aug 15; 19(16): 1920–1933. doi: 10.1101/gad.1322905

PMCID:: PMC1186191

Abstract Article PDF–892K

Select item 761310314.

Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S

Anna KL Liess, Alena Kucerova, Kristian Schweimer, Dörte Schlesinger, Olexandr Dybkov, Henning Urlaub, Jörg Mansfeld, Sonja Lorenz

Sci Signal. Author manuscript; available in PMC 2022 Jul 20.

Published in final edited form as: Sci Signal. 2020 Oct 20; 13(654): eaba8208. Published online 2020 Oct 20. doi: 10.1126/scisignal.aba8208

PMCID:: PMC7613103

Abstract Article PDF–2.5M

Select item 750552015.

The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance

Shizhen Zhang, Yanwen Shen, Hua Li, Chao Bi, Yilun Sun, Xiufang Xiong, Wenyi Wei, Yi Sun

Cell Rep. Author manuscript; available in PMC 2020 Sep 21.

Published in final edited form as: Cell Rep. 2020 Sep 8; 32(10): 108102. doi: 10.1016/j.celrep.2020.108102

PMCID:: PMC7505520

Abstract Article PDF–2.4M

Select item 671205616.

Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C

Suyang Zhang, Thomas Tischer, David Barford

Nat Commun. 2019; 10: 3863. Published online 2019 Aug 27. doi: 10.1038/s41467-019-11833-2

PMCID:: PMC6712056

Abstract Article PDF–5.4M

Select item 603587317.

Emi1 switches from being a substrate to an inhibitor of APC/C^Cdh1 to start the cell cycle

Steven D. Cappell, Kevin G. Mark, Damien Garbett, Lindsey R. Pack, Michael Rape, Tobias Meyer

Nature. Author manuscript; available in PMC 2018 Jul 8.

Published in final edited form as: Nature. 2018 Jun; 558(7709): 313–317. Published online 2018 Jun 6. doi: 10.1038/s41586-018-0199-7

PMCID:: PMC6035873

Abstract Article PDF–2.3M

Select item 514812818.

Cryo EM of Mitotic Checkpoint Complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation

Masaya Yamaguchi, Ryan VanderLinden, Florian Weissmann, Renping Qiao, Prakash Dube, Nicholas G. Brown, David Haselbach, Wei Zhang, Sachdev S. Sidhu, Jan-Michael Peters, Holger Stark, Brenda A. Schulman

Mol Cell. Author manuscript; available in PMC 2017 Aug 18.

Published in final edited form as: Mol Cell. 2016 Aug 18; 63(4): 593–607. Published online 2016 Aug 10. doi: 10.1016/j.molcel.2016.07.003

PMCID:: PMC5148128

Abstract Article PDF–3.1M

Select item 501934419.

Molecular basis of APC/C regulation by the spindle assembly checkpoint

Claudio Alfieri, Leifu Chang, Ziguo Zhang, Jing Yang, Sarah Maslen, Mark Skehel, David Barford

Nature. Author manuscript; available in PMC 2017 Feb 25.

Published in final edited form as: Nature. 2016 Aug 25; 536(7617): 431–436. doi: 10.1038/nature19083

PMCID:: PMC5019344

Abstract Article PDF–6.0M

Select item 499121220.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

Nicholas G. Brown, Ryan VanderLinden, Edmond R. Watson, Florian Weissmann, Alban Ordureau, Kuen-Phon Wu, Wei Zhang, Shanshan Yu, Peter Y. Mercredi, Joseph S. Harrison, Iain F. Davidson, Renping Qiao, Ying Lu, Prakash Dube, Michael R. Brunner, Christy R.R. Grace, Darcie J. Miller, David Haselbach, Marc A. Jarvis, Masaya Yamaguchi, David Yanishevski, Georg Petzold, Sachdev S. Sidhu, Brian Kuhlman, Marc W. Kirschner, J. Wade Harper, Jan-Michael Peters, Holger Stark, Brenda A. Schulman

Cell. Author manuscript; available in PMC 2016 Aug 19.

Published in final edited form as: Cell. 2016 Jun 2; 165(6): 1440–1453. doi: 10.1016/j.cell.2016.05.037

PMCID:: PMC4991212

Abstract Article PDF–2.3M

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