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Select item 103514361.

PIK3C3/VPS34 keeps body fats healthy

Wenqiang Song, J. Luke Postoak, Lan Wu, Luc Van Kaer

Autophagy. 2023; 19(8): 2398–2400. Published online 2023 Jan 18. doi: 10.1080/15548627.2023.2166275

PMCID:: PMC10351436

Abstract Article PDF–610K

Select item 74468952.

An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells

Marek J. Kobylarz, Jonathan M. Goodwin, Zhao B. Kang, John W. Annand, Sarah Hevi, Ellen O’Mahony, Gregory McAllister, John Reece-Hoyes, Qiong Wang, John Alford, Carsten Russ, Alicia Lindeman, Martin Beibel, Guglielmo Roma, Walter Carbone, Judith Knehr, Joseph Loureiro, Christophe Antczak, Dmitri Wiederschain, Leon O. Murphy, Suchithra Menon, Beat Nyfeler

PLoS One. 2020; 15(8): e0235551. Published online 2020 Aug 24. doi: 10.1371/journal.pone.0235551

PMCID:: PMC7446895

Abstract Article PDF–4.1M

Select item 73264973.

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

Yohei Ohashi, Shirley Tremel, Glenn Robert Masson, Lauren McGinney, Jerome Boulanger, Ksenia Rostislavleva, Christopher M Johnson, Izabella Niewczas, Jonathan Clark, Roger L Williams

eLife. 2020; 9: e58281. Published online 2020 Jun 30. doi: 10.7554/eLife.58281

PMCID:: PMC7326497

Abstract Article PDF–33M

Select item 72805104.

PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor

Fengchao Liu, Xiaoling Wu, Yanzhi Qian, Xin Jiang, Yiying Wang, Jian Gao

Cell Death Dis. 2020 Jun; 11(6): 427. Published online 2020 Jun 8. doi: 10.1038/s41419-020-2631-9

PMCID:: PMC7280510

Abstract Article PDF–3.9M

Select item 51985135.

Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling

Yasunori Uchida, Florentine U. Rutaganira, Damien Jullié, Kevan M. Shokat, Mark von Zastrow

Mol Pharmacol. 2017 Jan; 91(1): 65–73. Published online 2017 Jan. doi: 10.1124/mol.116.106252

PMCID:: PMC5198513

Abstract Article PDF–1.3M

Select item 48352116.

MTOR, PIK3C3, and autophagy: Signaling the beginning from the end

Michael J Munson, Ian G Ganley

Autophagy. 2015 Dec; 11(12): 2375–2376. Published online 2015 Nov 13. doi: 10.1080/15548627.2015.1106668

PMCID:: PMC4835211

Abstract Article PDF–123K

Select item 40283427.

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

Hai-Xin Yuan, Ryan C Russell, Kun-Liang Guan

Autophagy. 2013 Dec 1; 9(12): 1983–1995. Published online 2013 Sep 5. doi: 10.4161/auto.26058

PMCID:: PMC4028342

Abstract Article PDF–4.1M

Select item 29105088.

Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients

Silvia N. Kariuki, Beverly S. Franek, Rachel A. Mikolaitis, Tammy O. Utset, Meenakshi Jolly, Andrew D. Skol, Timothy B. Niewold

J Biomed Biotechnol. 2010; 2010: 826434. Published online 2010 Jul 4. doi: 10.1155/2010/826434

PMCID:: PMC2910508

Abstract Article PDF–829K

Select item 12423239.

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Takahiro Nobukuni, Manel Joaquin, Marta Roccio, Stephen G. Dann, So Young Kim, Pawan Gulati, Maya P. Byfield, Jonathan M. Backer, Francois Natt, Johannes L. Bos, Fried J. T. Zwartkruis, George Thomas

Proc Natl Acad Sci U S A. 2005 Oct 4; 102(40): 14238–14243. Published online 2005 Sep 21. doi: 10.1073/pnas.0506925102

PMCID:: PMC1242323

Abstract Article PDF–468K

Select item 39440110.

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

S Volinia, R Dhand, B Vanhaesebroeck, L K MacDougall, R Stein, M J Zvelebil, J Domin, C Panaretou, M D Waterfield

EMBO J. 1995 Jul 17; 14(14): 3339–3348. doi: 10.1002/j.1460-2075.1995.tb07340.x

PMCID:: PMC394401

Summary Page Browse PDF–2.3M

Select item 1041365211.

ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation

Mengshu Jia, Xiao Yue, Weixia Sun, Qianjun Zhou, Cheng Chang, Weihua Gong, Jian Feng, Xie Li, Ruonan Zhan, Kemin Mo, Lijuan Zhang, Yajie Qian, Yuying Sun, Aoxue Wang, Yejun Zou, Weicai Chen, Yan Li, Li Huang, Yi Yang, Yuzheng Zhao, Xiawei Cheng

Sci Adv. 2023 Jun 2; 9(22): eadg4993. Published online 2023 Jun 2. doi: 10.1126/sciadv.adg4993

PMCID:: PMC10413652

Abstract Article PDF–2.8M

Select item 997328012.

Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34

Robert J. Cain, Mariela Scortti, Héctor J. Monzó, José A. Vázquez-Boland

mBio. 2023 Jan-Feb; 14(1): e03221-22. Published online 2023 Jan 19. doi: 10.1128/mbio.03221-22

PMCID:: PMC9973280

Abstract Article PDF–2.4M

Select item 912461513.

Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss

Xiaobo Wang, Min Gu, Yongjian Ju, Juying Zhou

J Radiat Res. 2022 May; 63(3): 331–341. Published online 2022 Mar 25. doi: 10.1093/jrr/rrac004

PMCID:: PMC9124615

Abstract Article PDF–2.0M

Select item 838661514.

Binding of Avibirnavirus VP3 to the PIK3C3-PDPK1 complex inhibits autophagy by activating the AKT-MTOR pathway

Yina Zhang, Boli Hu, Yahui Li, Tingjuan Deng, Yuting Xu, Jing Lei, Jiyong Zhou

Autophagy. 2020; 16(9): 1697–1710. Published online 2019 Dec 29. doi: 10.1080/15548627.2019.1704118

PMCID:: PMC8386615

Abstract Article PDF–3.6M

Select item 828969515.

Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication

Caroline G. Williams, Alexander S. Jureka, Jesus A. Silvas, Anthony M. Nicolini, Stacie A. Chvatal, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Christopher F. Basler

Cell Rep. 2021 Aug 3; 36(5): 109479. Published online 2021 Jul 20. doi: 10.1016/j.celrep.2021.109479

PMCID:: PMC8289695

Abstract Article PDF–4.1M

Select item 711114716.

PIK3C3 Acts as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and Was Regulated by MiR-340-5p

Xiaobo Wang, Min Gu, Yongjian Ju, Juying Zhou

Med Sci Monit. 2020; 26: e920642-1–e920642-11. Prepublished online 2020 Jan 31. Published online 2020 Mar 24. doi: 10.12659/MSM.920642

PMCID:: PMC7111147

Abstract Article PDF–1012K

Select item 698445317.

Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy

Hirotaka Toh, Takashi Nozawa, Atsuko Minowa-Nozawa, Miyako Hikichi, Shintaro Nakajima, Chihiro Aikawa, Ichiro Nakagawa

Autophagy. 2020; 16(2): 334–346. Published online 2019 Jun 14. doi: 10.1080/15548627.2019.1628539

PMCID:: PMC6984453

Abstract Article PDF–3.6M

Select item 655780618.

MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway

Chien-An Chu, Chung-Ta Lee, Jenq-Chang Lee, Yi-Wen Wang, Ching-Tang Huang, Sheng-Hui Lan, Peng-Chan Lin, Bo-Wen Lin, Yu-Feng Tian, Hsiao-Sheng Liu, Nan-Haw Chow

EBioMedicine. 2019 May; 43: 270–281. Published online 2019 Apr 12. doi: 10.1016/j.ebiom.2019.04.010