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Select item 68756281.

Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis.

Xiaohan Lu, Nathan P. Rudemiller, Jiafa Ren, Yi Wen, Bo Yang, Robert Griffiths, Jamie R. Privratsky, Babita Madan, David M Virshup, Steven D Crowley

Kidney Int. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Kidney Int. 2019 Dec; 96(6): 1308–1319. Published online 2019 Jul 31. doi: 10.1016/j.kint.2019.06.020

PMCID:: PMC6875628

Abstract Article PDF–814K

Select item 38643562.

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Jun Liu, Shifeng Pan, Mindy H. Hsieh, Nicholas Ng, Fangxian Sun, Tao Wang, Shailaja Kasibhatla, Alwin G. Schuller, Allen G. Li, Dai Cheng, Jie Li, Celin Tompkins, AnneMarie Pferdekamper, Auzon Steffy, Jane Cheng, Colleen Kowal, Van Phung, Guirong Guo, Yan Wang, Martin P. Graham, Shannon Flynn, J. Chad Brenner, Chun Li, M. Cristina Villarroel, Peter G. Schultz, Xu Wu, Peter McNamara, William R. Sellers, Lilli Petruzzelli, Anthony L. Boral, H. Martin Seidel, Margaret E. McLaughlin, Jianwei Che, Thomas E. Carey, Gary Vanasse, Jennifer L. Harris

Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50): 20224–20229. Published online 2013 Nov 25. doi: 10.1073/pnas.1314239110

PMCID:: PMC3864356

Abstract Article PDF–1.0M

Select item 38151523.

Zygotic Porcn Paternal Allele Deletion in Mice to Model Human Focal Dermal Hypoplasia

Steffen Biechele, Hibret A. Adissu, Brian J. Cox, Janet Rossant

PLoS One. 2013; 8(11): e79139. Published online 2013 Nov 1. doi: 10.1371/journal.pone.0079139

PMCID:: PMC3815152

Abstract Article PDF–2.7M

Select item 81817314.

Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing

Kenon Chua, Victor K. Lee, Cheri Chan, Andy Yew, Eric Yeo, David M. Virshup

Front Endocrinol (Lausanne) 2021; 12: 667480. Published online 2021 May 24. doi: 10.3389/fendo.2021.667480

PMCID:: PMC8181731

Abstract Article PDF–3.0M

Select item 59663315.

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

Michal Shoshkes-Carmel, Yue J. Wang, Kirk J. Wangensteen, Beáta Tóth, Ayano Kondo, Efi E. Massassa, Shalev Itzkovitz, Klaus H. Kaestner

Nature. Author manuscript; available in PMC 2018 Nov 2.

Published in final edited form as: Nature. 2018 May; 557(7704): 242–246. Published online 2018 May 2. doi: 10.1038/s41586-018-0084-4

PMCID:: PMC5966331

Abstract Article PDF–2.8M

Select item 50656286.

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

Subhrajit Saha, Evelyn Aranda, Yoku Hayakawa, Payel Bhanja, Safinur Atay, N Patrik Brodin, Jiufeng Li, Samuel Asfaha, Laibin Liu, Yagnesh Tailor, Jinghang Zhang, Andrew K. Godwin, Wolfgang A. Tome, Timothy C. Wang, Chandan Guha, Jeffrey W. Pollard

Nat Commun. 2016; 7: 13096. Published online 2016 Oct 13. doi: 10.1038/ncomms13096

PMCID:: PMC5065628

Abstract Article PDF–2.3M

Select item 48341467.

Experimental inhibition of porcupine mediated Wnt O-acylation attenuates kidney fibrosis

Babita Madan, Mehul Patel, Jiandong Zhang, Ralph Bunte, Nathan P. Rudemiller, Robert Griffiths, David M Virshup, Steven D Crowley

Kidney Int. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Kidney Int. 2016 May; 89(5): 1062–1074. Published online 2016 Mar 25. doi: 10.1016/j.kint.2016.01.017

PMCID:: PMC4834146

Abstract Article PDF–3.1M

Select item 39232278.

Wnt Secretion from Epithelial Cells and Subepithelial Myofibroblasts Is Not Required in the Mouse Intestinal Stem Cell Niche In Vivo

Adrianna K. San Roman, Chenura D. Jayewickreme, L. Charles Murtaugh, Ramesh A. Shivdasani

Stem Cell Reports. 2014 Feb 11; 2(2): 127–134. Published online 2014 Jan 30. doi: 10.1016/j.stemcr.2013.12.012

PMCID:: PMC3923227

Abstract Article PDF–2.5M

Select item 58896269.

PDGFRα⁺ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

Gediminas Greicius, Zahra Kabiri, Kristmundur Sigmundsson, Chao Liang, Ralph Bunte, Manvendra K. Singh, David M. Virshup

Proc Natl Acad Sci U S A. 2018 Apr 3; 115(14): E3173–E3181. Published online 2018 Mar 20. doi: 10.1073/pnas.1713510115

PMCID:: PMC5889626

Abstract Article PDF–2.1M

Select item 556651010.

An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine

James J. Asciolla, Matthew M. Miele, Ronald C. Hendrickson, Marilyn D. Resh

J Biol Chem. 2017 Aug 18; 292(33): 13507–13513. Published online 2017 Jun 27. doi: 10.1074/jbc.C117.800136

PMCID:: PMC5566510

Abstract Article PDF–898K

Select item 503290111.

Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling

Lisa M. Galli, Navid Zebarjadi, Lydia Li, Vishwanath R. Lingappa, Laura W. Burrus

Exp Cell Res. Author manuscript; available in PMC 2017 Sep 10.

Published in final edited form as: Exp Cell Res. 2016 Sep 10; 347(1): 171–183. Published online 2016 Aug 1. doi: 10.1016/j.yexcr.2016.07.028

PMCID:: PMC5032901

Abstract Article PDF–1.7M

Select item 495562712.

Porcupine controls hippocampal AMPAR levels, composition and synaptic transmission

Nadine Erlenhardt, Hong Yu, Kavitha Abiraman, Tokiwa Yamasaki, Jacques I. Wadiche, Susumu Tomita, David S. Bredt

Cell Rep. Author manuscript; available in PMC 2016 Jul 21.

Published in final edited form as: Cell Rep. 2016 Feb 2; 14(4): 782–794. Published online 2016 Jan 14. doi: 10.1016/j.celrep.2015.12.078

PMCID:: PMC4955627

Abstract Article PDF–2.1M

Select item 459819413.

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells

Zahra Kabiri, Akihiko Numata, Akira Kawasaki, Edison, Daniel G. Tenen, David M. Virshup

Blood. 2015 Aug 27; 126(9): 1086–1094. Prepublished online 2015 Jun 18. doi: 10.1182/blood-2014-09-598540

PMCID:: PMC4598194

Abstract Article

Select item 346452514.

Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling

Kyle D. Proffitt, David M. Virshup

J Biol Chem. 2012 Oct 5; 287(41): 34167–34178. Published online 2012 Aug 10. doi: 10.1074/jbc.M112.381970

PMCID:: PMC3464525

Abstract Article PDF–2.2M

Select item 1040819015.

Regulatory changes associated with the head to trunk developmental transition

Patrícia Duarte, Rion Brattig Correia, Ana Nóvoa, Moisés Mallo

BMC Biol. 2023; 21: 170. Published online 2023 Aug 8. doi: 10.1186/s12915-023-01675-2

PMCID:: PMC10408190

Abstract Article PDF–4.2M

Select item 748405416.

Distinct spatiotemporally dynamic Wnt-secreting niches regulate proximal airway regeneration and aging

Cody J. Aros, Preethi Vijayaraj, Carla J. Pantoja, Bharti Bisht, Luisa K. Meneses, Jenna M. Sandlin, Jonathan A. Tse, Michelle W. Chen, Arunima Purkayastha, David W. Shia, Jennifer M.S. Sucre, Tammy M. Rickabaugh, Eszter K. Vladar, Manash K. Paul, Brigitte N. Gomperts

Cell Stem Cell. Author manuscript; available in PMC 2021 Sep 3.

Published in final edited form as: Cell Stem Cell. 2020 Sep 3; 27(3): 413–429.e4. Published online 2020 Jul 27. doi: 10.1016/j.stem.2020.06.019

PMCID:: PMC7484054

Abstract Article PDF–3.6M

Select item 405914317.

Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation

Jessica Rios-Esteves, Brittany Haugen, Marilyn D. Resh

J Biol Chem. 2014 Jun 13; 289(24): 17009–17019. Published online 2014 May 5. doi: 10.1074/jbc.M114.561209

PMCID:: PMC4059143

Abstract Article PDF–2.8M

Select item 329575218.

Deletion of Porcn in Mice Leads to Multiple Developmental Defects and Models Human Focal Dermal Hypoplasia (Goltz Syndrome)

Wei Liu, Timothy M. Shaver, Alfred Balasa, M. Cecilia Ljungberg, Xiaoling Wang, Shu Wen, Hoang Nguyen, Ignatia B. Van den Veyver

PLoS One. 2012; 7(3): e32331. Published online 2012 Mar 6. doi: 10.1371/journal.pone.0032331

PMCID:: PMC3295752

Abstract Article PDF–5.2M

Select item 636281719.

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

Kaitlin J. Basham, Stéphanie Rodriguez, Adina F. Turcu, Antonio M. Lerario, Catriona Y. Logan, Madeline R. Rysztak, Celso E. Gomez-Sanchez, David T. Breault, Bon-Kyoung Koo, Hans Clevers, Roeland Nusse, Pierre Val, Gary D. Hammer

Genes Dev. 2019 Feb 1; 33(3-4): 209–220. doi: 10.1101/gad.317412.118

PMCID:: PMC6362817

Abstract Article PDF–10M

Select item 1013407320.

Graded BMP Signaling Within Intestinal Crypt Architecture Directs Self-organization of the Wnt-secreting Stem Cell Niche

Judith Kraiczy, Neil McCarthy, Ermanno Malagola, Guodong Tie, Shariq Madha, Dario Boffelli, Daniel E. Wagner, Timothy C. Wang, Ramesh A. Shivdasani

Cell Stem Cell. Author manuscript; available in PMC 2024 Apr 6.

Published in final edited form as: Cell Stem Cell. 2023 Apr 6; 30(4): 433–449.e8. doi: 10.1016/j.stem.2023.03.004

PMCID:: PMC10134073

Abstract Article PDF–5.1M

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