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Items: 1 to 20 of 30

1.
Alpha-linolenic acid pretreatment alleviates NETs-induced alveolar macrophage pyroptosis by inhibiting pyrin inflammasome activation in a mouse model of sepsis-induced ALI/ARDS
Chenchen Liu, Yu Zhou, Qing Tu, Liangfang Yao, Jinbao Li, Zhongwei Yang
Front Immunol. 2023; 14: 1146612. Published online 2023 Mar 27. doi: 10.3389/fimmu.2023.1146612
PMCID:
PMC10083395
AbstractArticlePDF–12M
2.
Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis
Deepika Sharma, Ankit Malik, Clifford S. Guy, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti
Gastroenterology. Author manuscript; available in PMC 2019 Mar 1.
Published in final edited form as: Gastroenterology. 2018 Mar; 154(4): 948–964.e8. Published online 2017 Dec 2. doi: 10.1053/j.gastro.2017.11.276
PMCID:
PMC5847456
AbstractArticlePDF–1.2M
3.
Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes
Haleema S. Malik, Flora Magnotti, Nicole A. Loeven, Jose M. Delgado, Arminja N. Kettenbach, Thomas Henry, James B. Bliska
mBio. 2023 Sep-Oct; 14(5): e02066-23. Published online 2023 Oct 3. doi: 10.1128/mbio.02066-23
PMCID:
PMC10653879
AbstractArticlePDF–1.6M
4.
Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation
Wenqing Gao, Jieling Yang, Wang Liu, Yupeng Wang, Feng Shao
Proc Natl Acad Sci U S A. 2016 Aug 16; 113(33): E4857–E4866. Published online 2016 Aug 1. doi: 10.1073/pnas.1601700113
PMCID:
PMC4995971
AbstractArticlePDF–1.5M
5.
Succination inactivates gasdermin D and blocks pyroptosis
Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V. Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin, Scott A. Shaffer, Ranjan Dutta, Carolina Ionete, Scott Pesiridis, Shuo Yang, Paul R. Thompson, Katherine A. Fitzgerald
Science. Author manuscript; available in PMC 2022 Jan 10.
Published in final edited form as: Science. 2020 Sep 25; 369(6511): 1633–1637. Published online 2020 Aug 20. doi: 10.1126/science.abb9818
PMCID:
PMC8744141
AbstractArticlePDF–1.3M
6.
The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome
Lawton K. Chung, Yong Hwan Park, Yueting Zheng, Igor E. Brodsky, Patrick Hearing, Daniel L. Kastner, Jae Jin Chae, James B. Bliska
Cell Host Microbe. Author manuscript; available in PMC 2017 Sep 14.
Published in final edited form as: Cell Host Microbe. 2016 Sep 14; 20(3): 296–306. Published online 2016 Aug 25. doi: 10.1016/j.chom.2016.07.018
PMCID:
PMC5025386
AbstractArticlePDF–1.1M
7.
TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy
Deepika Sharma, Ankit Malik, Clifford Guy, Peter Vogel, Thirumala-Devi Kanneganti
J Clin Invest. 2019 Jan 2; 129(1): 150–162. Published online 2018 Nov 19. doi: 10.1172/JCI121372
PMCID:
PMC6307946
AbstractArticlePDF–13M
8.
Genetic Loss of Murine Pyrin, the Familial Mediterranean Fever Protein, Increases Interleukin-1β Levels
Pamela R. Hesker, MyTrang Nguyen, Martina Kovarova, Jenny P.-Y. Ting, Beverly H. Koller
PLoS One. 2012; 7(11): e51105. Published online 2012 Nov 30. doi: 10.1371/journal.pone.0051105
PMCID:
PMC3511413
AbstractArticlePDF–652K
9.
Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome
Takashi Orimo, Izumi Sasaki, Hiroaki Hemmi, Toshiya Ozasa, Yuri Fukuda-Ohta, Tomokazu Ohta, Mio Morinaka, Mariko Kitauchi, Takako Yamaguchi, Yayoi Sato, Takashi Tanaka, Katsuaki Hoshino, Kei-ichi Katayama, Shinji Fukuda, Kensuke Miyake, Masahiro Yamamoto, Takashi Satoh, Koichi Furukawa, Etsushi Kuroda, Ken J Ishii, Kiyoshi Takeda, Tsuneyasu Kaisho
Int Immunol. 2019 Oct; 31(10): 657–668. Published online 2019 Jan 25. doi: 10.1093/intimm/dxz004
PMCID:
PMC6749887
AbstractArticlePDF–1.1M
10.
Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome
Eric S. Weiss, Charlotte Girard-Guyonvarc’h, Dirk Holzinger, Adriana A. de Jesus, Zeshan Tariq, Jennifer Picarsic, Eduardo J. Schiffrin, Dirk Foell, Alexei A. Grom, Sandra Ammann, Stephan Ehl, Tomoaki Hoshino, Raphaela Goldbach-Mansky, Cem Gabay, Scott W. Canna
Blood. 2018 Mar 29; 131(13): 1442–1455. Prepublished online 2018 Jan 11. doi: 10.1182/blood-2017-12-820852
PMCID:
PMC5877443
AbstractArticle
11.
Gain-of-function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice
Jae Jin Chae, Young-Hun Cho, Geun-Shik Lee, Jun Cheng, P. Paul Liu, Lionel Feigenbaum, Stephen I. Katz, Daniel L. Kastner
Immunity. Author manuscript; available in PMC 2012 May 27.
Published in final edited form as: Immunity. 2011 May 27; 34(5): 755–768. Published online 2011 May 19. doi: 10.1016/j.immuni.2011.02.020
PMCID:
PMC3129608
AbstractArticlePDF–3.0M
12.
AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense
SangJoon Lee, Rajendra Karki, Yaqiu Wang, Lam Nhat Nguyen, Ravi C. Kalathur, Thirumala-Devi Kanneganti
Nature. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Nature. 2021 Sep; 597(7876): 415–419. Published online 2021 Sep 1. doi: 10.1038/s41586-021-03875-8
PMCID:
PMC8603942
AbstractArticlePDF–7.4M
13.
Inflammasome activation and assembly at a glance
Ankit Malik, Thirumala-Devi Kanneganti
J Cell Sci. 2017 Dec 1; 130(23): 3955–3963. doi: 10.1242/jcs.207365
PMCID:
PMC5769591
AbstractArticle
14.
IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever
Deepika Sharma, Bhesh Raj Sharma, Peter Vogel, Thirumala-Devi Kanneganti
Am J Pathol. 2017 Feb; 187(2): 236–244. doi: 10.1016/j.ajpath.2016.10.015
PMCID:
PMC5389372
AbstractArticlePDF–1.7M
15.
Pyrin Inflammasome Activation and RhoA Signaling in the Autoinflammatory Diseases FMF and HIDS
Yong Hwan Park, Geryl Wood, Daniel L. Kastner, Jae Jin Chae
Nat Immunol. Author manuscript; available in PMC 2016 Dec 6.
Published in final edited form as: Nat Immunol. 2016 Aug; 17(8): 914–921. Published online 2016 Jun 6. doi: 10.1038/ni.3457
PMCID:
PMC4955684
AbstractArticlePDF–1.9M
16.
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
Parimal Samir, Sannula Kesavardhana, Deanna M. Patmore, Sebastien Gingras, R. K. Subbarao Malireddi, Rajendra Karki, Clifford S. Guy, Benoit Briard, David E. Place, Anannya Bhattacharya, Bhesh raj Sharma, Amanda Nourse, Sharon V. King, Aaron Pitre, Amanda R. Burton, Stephane Pelletier, Richard J. Gilbertson, Thirumala-Devi Kanneganti
Nature. Author manuscript; available in PMC 2020 Mar 11.
Published in final edited form as: Nature. 2019 Sep; 573(7775): 590–594. Published online 2019 Sep 11. doi: 10.1038/s41586-019-1551-2
PMCID:
PMC6980284
AbstractArticlePDF–5.6M
17.
Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation
Hanne Van Gorp, Pedro H. V. Saavedra, Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Lieselotte Vande Walle, Magdalena Matusiak, Giusi Prencipe, Antonella Insalaco, Filip Van Hauwermeiren, Dieter Demon, Delfien J. Bogaert, Melissa Dullaers, Elfride De Baere, Tino Hochepied, Joke Dehoorne, Karim Y. Vermaelen, Filomeen Haerynck, Fabrizio De Benedetti, Mohamed Lamkanfi
Proc Natl Acad Sci U S A. 2016 Dec 13; 113(50): 14384–14389. Published online 2016 Nov 22. doi: 10.1073/pnas.1613156113
PMCID:
PMC5167202
AbstractArticlePDF–1.3M
18.
The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis
Aline Dumas, Nathalie Amiable, Juan Pablo de Rivero Vaccari, Jae Jin Chae, Robert W. Keane, Steve Lacroix, Luc Vallières
PLoS Pathog. 2014 May; 10(5): e1004150. Published online 2014 May 29. doi: 10.1371/journal.ppat.1004150
PMCID:
PMC4038594
AbstractArticlePDF–1.4M
19.
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling
Shouya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing, Cheng Shen, Chinh Ngo, Melkamu B. Tessema, Fei-Ju Li, Daniel Fox, Anukriti Mathur, Anyang Zhao, Runli Wang, Klaus Pfeffer, Daniel Degrandi, Masahiro Yamamoto, Patrick C. Reading, Gaetan Burgio, Si Ming Man
Nat Commun. 2022; 13: 4395. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32127-0
PMCID:
PMC9338265
AbstractArticlePDF–3.0M
20.
RIPK3 promotes Mefv expression and pyrin inflammasome activation via modulation of mTOR signaling
Deepika Sharma, Ankit Malik, Arjun Balakrishnan, R.K. Subbarao Malireddi, Thirumala-Devi Kanneganti
J Immunol. Author manuscript; available in PMC 2022 Sep 6.
Published in final edited form as: J Immunol. 2020 Nov 15; 205(10): 2778–2785. Published online 2020 Sep 28. doi: 10.4049/jimmunol.2000244
PMCID:
PMC9447007
AbstractArticlePDF–1.7M

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