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Select item 112342681.

Lens autophagy protein ATG16L1: a potential target for cataract treatment

Yilei Cui, Xiaoning Yu, Jing Bao, Xiyuan Ping, Silu Shi, Yuxin Huang, Qichuan Yin, Hao Yang, Ruoqi Chen, Ke Yao, Xiangjun Chen, Xingchao Shentu

Theranostics. 2024; 14(10): 3984–3996. Published online 2024 Jul 1. doi: 10.7150/thno.93864

PMCID:: PMC11234268

Abstract Article PDF–7.6M

Select item 109790312.

Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection

Renée R. C. E. Schreurs, Athanasios Koulis, Thijs Booiman, Brigitte Boeser-Nunnink, Alexandra P. M. Cloherty, Anusca G. Rader, Kharishma S. Patel, Neeltje A. Kootstra, Carla M. S. Ribeiro

Nat Commun. 2024; 15: 2465. Published online 2024 Mar 28. doi: 10.1038/s41467-024-46606-z

PMCID:: PMC10979031

Abstract Article PDF–3.6M

Select item 108597133.

ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta‐analysis on inflammatory bowel disease risk and clinical outcomes

Isidora Simovic, Ida Hilmi, Ruey Terng Ng, Kee Seang Chew, Shin Yee Wong, Way Seah Lee, Stephen Riordan, Natalia Castaño‐Rodríguez

United European Gastroenterol J. 2024 Feb; 12(1): 103–121. Published online 2023 Oct 14. doi: 10.1002/ueg2.12477

PMCID:: PMC10859713

Abstract Article PDF–1.1M

Select item 95336924.

Altered splicing of ATG16‐L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non‐small cell lung cancer

Anne‐Sophie Hatat, Clara Benoit‐Pilven, Amélie Pucciarelli, Florence de Fraipont, Lucie Lamothe, Pascal Perron, Amandine Rey, Matteo Giaj Levra, Anne‐Claire Toffart, Didier Auboeuf, Beatrice Eymin, Sylvie Gazzeri

Mol Oncol. 2022 Oct; 16(19): 3490–3508. Published online 2022 Aug 30. doi: 10.1002/1878-0261.13229

PMCID:: PMC9533692

Abstract Article PDF–1.8M

Select item 94592945.

Associations between ATG16L1 gene polymorphism and antineutrophil cytoplasmic antibody‐associated vasculitis in the Chinese Guangxi population: A case–control study

Bing‐Mei Feng, Chao Xue, Hai‐Zheng Huang, Yu‐gan Lu, Tao Feng, Xue‐Yi Huang, Wei Li

J Clin Lab Anal. 2022 Sep; 36(9): e24642. Published online 2022 Aug 10. doi: 10.1002/jcla.24642

PMCID:: PMC9459294

Abstract Article PDF–365K

Select item 93315266.

Alterations of autophagic and innate immune responses by the Crohn’s disease-associated ATG16L1 mutation

Natsuki Okai, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Hajime Honjo, Masatoshi Kudo

World J Gastroenterol. 2022 Jul 14; 28(26): 3063–3070. Published online 2022 Jul 14. doi: 10.3748/wjg.v28.i26.3063

PMCID:: PMC9331526

Abstract Article PDF–563K

Select item 87613987.

Autophagy ATG16L1 rs2241880 impacts the colorectal cancer risk: A case‐control study

Leila Jamali, Hossein Sadeghi, Mohammad‐Reza Ghasemi, Roohollah Mohseni, Ehsan Nazemalhosseini‐Mojarad, Vahid Reza Yassaee, Pegah Larki, Mohammad Reza Zali, Reza Mirfakhraie

J Clin Lab Anal. 2022 Jan; 36(1): e24169. Published online 2021 Dec 11. doi: 10.1002/jcla.24169

PMCID:: PMC8761398

Abstract Article PDF–276K

Select item 82308108.

The Association of ATG16L1 Variations with Clinical Phenotypes of Adult-Onset Still’s Disease

Wei-Ting Hung, Shuen-Iu Hung, Yi-Ming Chen, Chia-Wei Hsieh, Hsin-Hua Chen, Kuo-Tung Tang, Der-Yuan Chen, Tsuo-Hung Lan

Genes (Basel) 2021 Jun; 12(6): 904. Published online 2021 Jun 11. doi: 10.3390/genes12060904

PMCID:: PMC8230810

Abstract Article PDF–1.2M

Select item 80995939.

Crohn's disease-associated ATG16L1 T300A genotype is associated with improved survival in gastric cancer

Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu

EBioMedicine. 2021 May; 67: 103347. Published online 2021 Apr 25. doi: 10.1016/j.ebiom.2021.103347

PMCID:: PMC8099593

Abstract Article PDF–2.5M

Select item 807664210.

Impaired ATG16L-Dependent Autophagy Promotes Renal Interstitial Fibrosis in Chronic Renal Graft Dysfunction Through Inducing EndMT by NF-κB Signal Pathway

Zeping Gui, Chuanjian Suo, Zijie Wang, Ming Zheng, Shuang Fei, Hao Chen, Li Sun, Zhijian Han, Jun Tao, Xiaobin Ju, Haiwei Yang, Min Gu, Ruoyun Tan

Front Immunol. 2021; 12: 650424. Published online 2021 Apr 13. doi: 10.3389/fimmu.2021.650424

PMCID:: PMC8076642

Abstract Article PDF–5.9M

Select item 725548511.

Emerging roles of let-7d in attenuating pulmonary arterial hypertension via suppression of pulmonary artery endothelial cell autophagy and endothelin synthesis through ATG16L1 downregulation

Minghui Ou, Xia Li, Shichao Cui, Shibo Zhao, Jie Tu

Int J Mol Med. 2020 Jul; 46(1): 83–96. Published online 2020 Apr 7. doi: 10.3892/ijmm.2020.4567

PMCID:: PMC7255485

Abstract Article PDF–2.4M

Select item 672279412.

Investigation of ATG16L1 rs2241880 Polymorphism with Cancer Risk: A Meta-Analysis

Abdolkarim Moazeni-Roodi, Farhad Tabasi, Saeid Ghavami, Mohammad Hashemi

Medicina (Kaunas) 2019 Aug; 55(8): 425. Published online 2019 Jul 31. doi: 10.3390/medicina55080425

PMCID:: PMC6722794

Abstract Article PDF–5.5M

Select item 624944813.

Association of Autophagy Gene ATG16L1 Polymorphism with Human Prostate Cancer and Bladder Cancer in Turkish Population

Songül Budak Diler, Fatma Aybuğa

Asian Pac J Cancer Prev. 2018; 19(9): 2625–2630. doi: 10.22034/APJCP.2018.19.9.2625

PMCID:: PMC6249448

Abstract Article PDF–319K

Select item 580518114.

Association between ATG16L1 gene polymorphism and the risk of Crohn’s disease

Bei-Bei Zhang, Yu Liang, Bo Yang, Ying-Jun Tan

J Int Med Res. 2017 Dec; 45(6): 1636–1650. Published online 2016 Oct 2. doi: 10.1177/0300060516662404

PMCID:: PMC5805181

Abstract Article PDF–871K

Select item 571451315.

A Functional ATG16L1 (T300A) Variant is Associated with Necrotizing Enterocolitis in Premature Infants

Venkatesh Sampath, Vineet Bhandari, Jessica Berger, Daniel Merchant, Liyun Zhang, Mihoko Ladd, Heather Menden, Jeffery Garland, Namasivayam Ambalavanan, Neil Mulrooney, Michael Quasney, John Dagle, Pascal M Lavoie, Pippa Simpson, Mary Dahmer

Pediatr Res. Author manuscript; available in PMC 2017 Dec 4.

Published in final edited form as: Pediatr Res. 2017 Apr; 81(4): 582–588. Published online 2016 Nov 28. doi: 10.1038/pr.2016.260

PMCID:: PMC5714513

Abstract Article PDF–380K

Select item 556314716.

Structure of the WD40‐domain of human ATG16L1

Milica Bajagic, Archna Archna, Petra Büsing, Andrea Scrima

Protein Sci. 2017 Sep; 26(9): 1828–1837. Published online 2017 Jul 15. doi: 10.1002/pro.3222

PMCID:: PMC5563147

Abstract Article PDF–880K

Select item 548636317.

The Thr300Ala variant of ATG16L1 is associated with decreased risk of brain metastasis in patients with non-small cell lung cancer

Qian-xia Li, Xiao Zhou, Ting-ting Huang, Yang Tang, Bo Liu, Ping Peng, Li Sun, Yi-hua Wang, Xiang-lin Yuan

Autophagy. 2017; 13(6): 1053–1063. Published online 2017 Apr 25. doi: 10.1080/15548627.2017.1308997

PMCID:: PMC5486363

Abstract Article PDF–1.0M

Select item 543825818.

Association of ATG16L1 gene haplotype with inflammatory bowel disease in Indians

Srinivasan Pugazhendhi, Kirankumar Baskaran, Srikanth Santhanam, Balakrishnan S. Ramakrishna

PLoS One. 2017; 12(5): e0178291. Published online 2017 May 19. doi: 10.1371/journal.pone.0178291

PMCID:: PMC5438258

Abstract Article PDF–8.0M

Select item 495746419.

Autophagy Contributes to the Induction of Anti-TNF Induced Macrophages

Alon D. Levin, Pim J. Koelink, Felicia M. Bloemendaal, Anne Christine W. Vos, Geert R. D’Haens, Gijs R. van den Brink, Manon E. Wildenberg

J Crohns Colitis. 2016 Mar; 10(3): 323–329. Published online 2015 Sep 27. doi: 10.1093/ecco-jcc/jjv174

PMCID:: PMC4957464

Abstract Article PDF–1.0M

Select item 478982820.

The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon

Wesley A Grimm, Jeannette S Messer, Stephen F Murphy, Thomas Nero, James P Lodolce, Christopher R Weber, Mark F Logsdon, Sarah Bartulis, Brooke E Sylvester, Amanda Springer, Urszula Dougherty, Timothy B Niewold, Sonia S Kupfer, Nathan Ellis, Dezheng Huo, Marc Bissonnette, David L Boone

Gut. 2016 Mar; 65(3): 456–464. Published online 2015 Feb 2. doi: 10.1136/gutjnl-2014-308735