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Items: 1 to 20 of 104

1.
UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II
Juri Habicht, Ashley Mooneyham, Asumi Hoshino, Mihir Shetty, Xiaonan Zhang, Edith Emmings, Qing Yang, Courtney Coombes, Melissa K. Gardner, Martina Bazzaro
J Cell Sci. 2021 Jan 1; 134(1): jcs248815. Published online 2021 Jan 8. doi: 10.1242/jcs.248815
PMCID:
PMC7803465
AbstractArticle
2.
UNC-45A is a Novel Microtubule-associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells
Ashley Mooneyham, Yoshie Iizuka, Qing Yang, Courtney Coombes, Mark McClellan, Vijayalakshmi Shridhar, Edith Emmings, Mihir Shetty, Liqiang Chen, Teng Ai, Joyce Meints, Michael K Lee, Melissa Gardner, Martina Bazzaro
Mol Cancer Res. Author manuscript; available in PMC 2020 Feb 1.
Published in final edited form as: Mol Cancer Res. 2019 Feb; 17(2): 370–383. Published online 2018 Oct 15. doi: 10.1158/1541-7786.MCR-18-0670
PMCID:
PMC6359974
AbstractArticlePDF–1.6M
3.
UNC-45a promotes myosin folding and stress fiber assembly
Jaakko I. Lehtimäki, Aidan M. Fenix, Tommi M. Kotila, Giuseppe Balistreri, Lassi Paavolainen, Markku Varjosalo, Dylan T. Burnette, Pekka Lappalainen
J Cell Biol. 2017 Dec 4; 216(12): 4053–4072. doi: 10.1083/jcb.201703107
PMCID:
PMC5716280
AbstractArticlePDF–3.2M
4.
UNC-45A is required for neurite extension via controlling NMII activation
Yoshie Iizuka, Ashley Mooneyham, Andrew Sieben, Kevin Chen, Makayla Maile, Raffaele Hellweg, Florian Schütz, Kebebush Teckle, Timothy Starr, Venugopal Thayanithy, Rachel Isaksson Vogel, Emil Lou, Michael K. Lee, Martina Bazzaro
Mol Biol Cell. 2017 May 15; 28(10): 1337–1346. doi: 10.1091/mbc.E16-06-0381
PMCID:
PMC5426848
AbstractArticlePDF–2.0M
5.
UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion
Yoshie Iizuka, Frank Cichocki, Andrew Sieben, Fabio Sforza, Razaul Karim, Kathleen Coughlin, Rachel Isaksson Vogel, Riccardo Gavioli, Valarie McCullar, Todd Lenvik, Michael Lee, Jeffrey Miller, Martina Bazzaro
J Immunol. Author manuscript; available in PMC 2016 Dec 27.
Published in final edited form as: J Immunol. 2015 Nov 15; 195(10): 4760–4770. Published online 2015 Oct 5. doi: 10.4049/jimmunol.1500979
PMCID:
PMC5189640
AbstractArticlePDF–3.3M
6.
Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility
Martina Bazzaro, Antonio Santillan, Zhenhua Lin, Taylor Tang, Michael K. Lee, Robert E. Bristow, Ie-Ming Shih, Richard B.S. Roden
Am J Pathol. 2007 Nov; 171(5): 1640–1649. doi: 10.2353/ajpath.2007.070325
PMCID:
PMC2043524
AbstractArticlePDF–1.8M
7.
A Functional Relationship Between UNC45A and MYO5B Connects Two Rare Diseases With Shared Enteropathy
Qinghong Li, Zhe Zhou, Yue Sun, Chang Sun, Karin Klappe, Sven C.D. van IJzendoorn
Cell Mol Gastroenterol Hepatol. 2022; 14(2): 295–310. Published online 2022 Apr 11. doi: 10.1016/j.jcmgh.2022.04.006
PMCID:
PMC9218578
AbstractArticlePDF–9.2M
8.
UNC45A deficiency causes microvillus inclusion disease–like phenotype by impairing myosin VB–dependent apical trafficking
Rémi Duclaux-Loras, Corinne Lebreton, Jérémy Berthelet, Fabienne Charbit-Henrion, Ophelie Nicolle, Céline Revenu des Courtils, Stephanie Waich, Taras Valovka, Anis Khiat, Marion Rabant, Caroline Racine, Ida Chiara Guerrera, Júlia Baptista, Maxime M. Mahe, Michael W. Hess, Béatrice Durel, Nathalie Lefort, Céline Banal, Mélanie Parisot, Cecile Talbotec, Florence Lacaille, Emmanuelle Ecochard-Dugelay, Arzu Meltem Demir, Georg F. Vogel, Laurence Faivre, Astor Rodrigues, Darren Fowler, Andreas R. Janecke, Thomas Müller, Lukas A. Huber, Fernando Rodrigues-Lima, Frank M. Ruemmele, Holm H. Uhlig, Filippo Del Bene, Grégoire Michaux, Nadine Cerf-Bensussan, Marianna Parlato
J Clin Invest. 2022 May 16; 132(10): e154997. Published online 2022 May 16. doi: 10.1172/JCI154997
PMCID:
PMC9106349
AbstractArticlePDF–22M
9.
A myosin chaperone, UNC‐45A, is a novel regulator of intestinal epithelial barrier integrity and repair
Susana Lechuga, Alexander X. Cartagena‐Rivera, Afshin Khan, Bert I. Crawford, Vani Narayanan, Daniel E. Conway, Jaakko Lehtimäki, Pekka Lappalainen, Florian Rieder, Michelle S. Longworth, Andrei I. Ivanov
FASEB J. 2022 May; 36(5): e22290. Published online 2022 Mar 28. doi: 10.1096/fj.202200154R
PMCID:
PMC9044500
AbstractArticlePDF–3.1M
10.
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis
Nada H. Eisa, Yasmeen Jilani, Kashish Kainth, Priscilla Redd, Su Lu, Oulia Bougrine, Houssein Abdul Sater, Chaitanya A. Patwardhan, Austin Shull, Huidong Shi, Kebin Liu, Nehal M. Elsherbiny, Laila A. Eissa, Mamdouh M. El-Shishtawy, Anatolij Horuzsko, Roni Bollag, Nita Maihle, Joan Roig, Hasan Korkaya, John K. Cowell, Ahmed Chadli
J Biol Chem. 2019 Apr 5; 294(14): 5246–5260. Published online 2019 Feb 8. doi: 10.1074/jbc.RA118.006597
PMCID:
PMC6462532
AbstractArticlePDF–4.5M
11.
UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM
Susana Gómez Escalante, Joseph A. Brightmore, Peter W. Piper, Stefan H. Millson
Cell Stress Chaperones. 2018 Jul; 23(4): 609–615. Published online 2017 Dec 29. doi: 10.1007/s12192-017-0870-1
PMCID:
PMC6045556
AbstractArticlePDF–4.1M
12.
UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation
Yasmeen Jilani, Su Lu, Huang Lei, Larry M. Karnitz, Ahmed Chadli
Cancer Lett. Author manuscript; available in PMC 2016 Feb 1.
Published in final edited form as: Cancer Lett. 2015 Feb 1; 357(1): 114–120. Published online 2014 Nov 10. doi: 10.1016/j.canlet.2014.11.009
PMCID:
PMC4277927
AbstractArticlePDF–870K
13.
Loss-of-Function Mutations in UNC45A Cause a Syndrome Associating Cholestasis, Diarrhea, Impaired Hearing, and Bone Fragility
Clothilde Esteve, Ludmila Francescatto, Perciliz L. Tan, Aurélie Bourchany, Cécile De Leusse, Evelyne Marinier, Arnaud Blanchard, Patrice Bourgeois, Céline Brochier-Armanet, Ange-Line Bruel, Arnauld Delarue, Yannis Duffourd, Emmanuelle Ecochard-Dugelay, Géraldine Hery, Frédéric Huet, Philippe Gauchez, Emmanuel Gonzales, Catherine Guettier-Bouttier, Mina Komuta, Caroline Lacoste, Raphaelle Maudinas, Karin Mazodier, Yves Rimet, Jean-Baptiste Rivière, Bertrand Roquelaure, Sabine Sigaudy, Xavier Stephenne, Christel Thauvin-Robinet, Julien Thevenon, Jacques Sarles, Nicolas Levy, Catherine Badens, Olivier Goulet, Jean-Pierre Hugot, Nicholas Katsanis, Laurence Faivre, Alexandre Fabre
Am J Hum Genet. 2018 Mar 1; 102(3): 364–374. Published online 2018 Feb 8. doi: 10.1016/j.ajhg.2018.01.009
PMCID:
PMC5985364
AbstractArticlePDF–2.0M
14.
GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway
Ahmed Chadli, J. Dinny Graham, M. Greg Abel, Twila A. Jackson, David F. Gordon, William M. Wood, Sara J. Felts, Kathryn B. Horwitz, David Toft
Mol Cell Biol. 2006 Mar; 26(5): 1722–1730. doi: 10.1128/MCB.26.5.1722-1730.2006
PMCID:
PMC1430258
AbstractArticlePDF–350K
15.
Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival
Susana Gomez-Escalante, Peter W. Piper, Stefan H. Millson
Cell Stress Chaperones. 2017 Jan; 22(1): 135–141. Published online 2016 Nov 25. doi: 10.1007/s12192-016-0750-0
PMCID:
PMC5225067
AbstractArticlePDF–1.2M
16.
GCUNC45 Is the First Hsp90 Co-chaperone to Show α/β Isoform Specificity
Ahmed Chadli, Sara J. Felts, David O. Toft
J Biol Chem. 2008 Apr 11; 283(15): 9509–9512. doi: 10.1074/jbc.C800017200
PMCID:
PMC2442279
AbstractArticlePDF–262K
17.
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
Judd F. Hultquist, Kathrin Schumann, Jonathan M. Woo, Lara Manganaro, Michael J. McGregor, Jennifer Doudna, Viviana Simon, Nevan J. Krogan, Alexander Marson
Cell Rep. Author manuscript; available in PMC 2016 Nov 25.
Published in final edited form as: Cell Rep. 2016 Oct 25; 17(5): 1438–1452. doi: 10.1016/j.celrep.2016.09.080
PMCID:
PMC5123761
AbstractArticlePDF–1.7M
18.
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia
Nat Commun. 2020; 11: 2948. Published online 2020 Jun 11. doi: 10.1038/s41467-020-16718-3
PMCID:
PMC7290032
AbstractArticlePDF–3.0M
19.
DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination
Syed Feroj Ahmed, Lori Buetow, Mads Gabrielsen, Sergio Lilla, Chatrin Chatrin, Gary J. Sibbet, Sara Zanivan, Danny T. Huang
Sci Adv. 2020 Aug; 6(34): eabc0629. Published online 2020 Aug 21. doi: 10.1126/sciadv.abc0629
PMCID:
PMC7442474
AbstractArticlePDF–2.4M
20.
E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs
Enguang Bi, Rong Li, Laura C. Bover, Haiyan Li, Pan Su, Xingzhe Ma, Chunjian Huang, Qiang Wang, Lintao Liu, Maojie Yang, Zhijuan Lin, Jianfei Qian, Weijun Fu, Yong-Jun Liu, Qing Yi
J Clin Invest. 2018 Nov 1; 128(11): 4821–4831. Published online 2018 Oct 2. doi: 10.1172/JCI121421
PMCID:
PMC6205396
AbstractArticlePDF–5.0M

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