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Select item 98493371.

Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway

Ting Lan, Ying Li, Yue Wang, Zhong-Cheng Wang, Chun-Yan Mu, Ai-Bin Tao, Jian-Li Gong, Yuan Zhou, Hao Xu, Shi-Bao Li, Bing Gu, Ping Ma, Lan Luo

Cell Death Dis. 2023 Jan; 14(1): 39. Published online 2023 Jan 19. doi: 10.1038/s41419-023-05580-y

PMCID:: PMC9849337

Abstract Article PDF–4.9M

Select item 73833752.

A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP

Matthew H. Chan, Sahar Aminzai, Tingfei Hu, Amatya Taran, Sheng Li, Choel Kim, Renate B. Pilz, Darren E. Casteel

J Biol Chem. 2020 Jul 24; 295(30): 10394–10405. Published online 2020 Jun 5. doi: 10.1074/jbc.RA119.010984

PMCID:: PMC7383375

Abstract Article PDF–2.8M

Select item 69466713.

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

Hao Nie, Haixing Ju, Jiayi Fan, Xiaoliu Shi, Yaxian Cheng, Xiaohui Cang, Zhiguo Zheng, Xiaotao Duan, Wen Yi

Nat Commun. 2020; 11: 36. Published online 2020 Jan 7. doi: 10.1038/s41467-019-13601-8

PMCID:: PMC6946671

Abstract Article PDF–3.3M

Select item 64107834.

Self-regulation and the foraging gene (PRKG1) in humans

Andriy A. Struk, Jhotisha Mugon, Andrea Huston, Abigail A. Scholer, Gertraud Stadler, E. Tory Higgins, Marla B. Sokolowski, James Danckert

Proc Natl Acad Sci U S A. 2019 Mar 5; 116(10): 4434–4439. Published online 2019 Feb 19. doi: 10.1073/pnas.1809924116

PMCID:: PMC6410783

Abstract Article PDF–891K

Select item 62953545.

Replication of the Interaction of PRKG1 and Trauma Exposure on Alcohol Misuse in an Independent African American Sample

Sage E. Hawn, Christina M. Sheerin, Bradley T. Webb, Roseann E. Peterson, Elizabeth K. Do, Danielle Dick, Kenneth S. Kendler, Silviu-Alin Bacanu, Ananda B. Amstadter

J Trauma Stress. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: J Trauma Stress. 2018 Dec; 31(6): 927–932. Published online 2018 Oct 30. doi: 10.1002/jts.22339

PMCID:: PMC6295354

Abstract Article PDF–345K

Select item 55894756.

A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus

Renato Polimanti, Joan Kaufman, Hongyu Zhao, Henry R. Kranzler, Robert J. Ursano, Ronald C. Kessler, Joel Gelernter, Murray B. Stein

Mol Psychiatry. Author manuscript; available in PMC 2018 Jan 4.

Published in final edited form as: Mol Psychiatry. 2018 Jan; 23(1): 154–160. Published online 2017 Mar 7. doi: 10.1038/mp.2017.24

PMCID:: PMC5589475

Abstract Article PDF–555K

Select item 53253447.

Reversibility of glioma stem cells’ phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery tool

Thomas J. Wilson, Daniel B. Zamler, Robert Doherty, Maria G. Castro, Pedro R. Lowenstein

Oncotarget. 2016 Sep 27; 7(39): 63020–63041. Published online 2016 Aug 24. doi: 10.18632/oncotarget.11589

PMCID:: PMC5325344

Abstract Article PDF–10M

Select item 51566088.

Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain

Lucie Valek, Annett Häussler, Stefan Dröse, Philipp Eaton, Katrin Schröder, Irmgard Tegeder

Redox Biol. 2017 Apr; 11: 176–191. Published online 2016 Dec 7. doi: 10.1016/j.redox.2016.12.004

PMCID:: PMC5156608

Abstract Article PDF–2.8M

Select item 48384169.

Structures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability

Liying Qin, Albert S. Reger, Elaine Guo, Matthew P. Yang, Peter Zwart, Darren E. Casteel, Choel Kim

Biochemistry. Author manuscript; available in PMC 2016 Apr 20.

Published in final edited form as: Biochemistry. 2015 Jul 28; 54(29): 4419–4422. Published online 2015 Jul 15. doi: 10.1021/acs.biochem.5b00572

PMCID:: PMC4838416

Abstract Article PDF–709K

Select item 466137810.

Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)

Bryan VanSchouwen, Rajeevan Selvaratnam, Rajanish Giri, Robin Lorenz, Friedrich W. Herberg, Choel Kim, Giuseppe Melacini

J Biol Chem. 2015 Nov 27; 290(48): 28631–28641. Published online 2015 Sep 14. doi: 10.1074/jbc.M115.685305

PMCID:: PMC4661378

Abstract Article PDF–3.4M

Select item 422253711.

Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design

Gilbert Y. Huang, Oksana O. Gerlits, Matthew P. Blakeley, Banumathi Sankaran, Andrey Y. Kovalevsky, Choel Kim

Biochemistry. 2014 Nov 4; 53(43): 6725–6727. Published online 2014 Oct 1. doi: 10.1021/bi501012v

PMCID:: PMC4222537

Abstract Article PDF–987K

Select item 401904312.

Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I

Gilbert Y. Huang, Jeong Joo Kim, Albert S. Reger, Robin Lorenz, Eui-Whan Moon, Chi Zhao, Darren E. Casteel, Daniela Bertinetti, Bryan VanSchouwen, Rajeevan Selvaratnam, James W. Pflugrath, Banumathi Sankaran, Giuseppe Melacini, Friedrich W. Herberg, Choel Kim

Structure. Author manuscript; available in PMC 2015 Jan 7.

Published in final edited form as: Structure. 2014 Jan 7; 22(1): 116–124. Published online 2013 Nov 14. doi: 10.1016/j.str.2013.09.021

PMCID:: PMC4019043

Abstract Article PDF–1.2M

Select item 395330513.

Nitration of Tyrosine 247 Inhibits Protein Kinase G-1α Activity by Attenuating Cyclic Guanosine Monophosphate Binding

Saurabh Aggarwal, Christine M. Gross, Ruslan Rafikov, Sanjiv Kumar, Jeffrey R. Fineman, Britta Ludewig, Danny Jonigk, Stephen M. Black

J Biol Chem. 2014 Mar 14; 289(11): 7948–7961. Published online 2014 Jan 27. doi: 10.1074/jbc.M113.534313

PMCID:: PMC3953305

Abstract Article PDF–2.6M

Select item 373883714.

Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections

Dong-chuan Guo, Ellen Regalado, Darren E. Casteel, Regie L. Santos-Cortez, Limin Gong, Jeong Joo Kim, Sarah Dyack, S. Gabrielle Horne, Guijuan Chang, Guillaume Jondeau, Catherine Boileau, Joseph S. Coselli, Zhenyu Li, Suzanne M. Leal, Jay Shendure, Mark J. Rieder, Michael J. Bamshad, Deborah A. Nickerson, GenTAC Registry Consortium, National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project, Choel Kim, Dianna M. Milewicz

Am J Hum Genet. 2013 Aug 8; 93(2): 398–404. doi: 10.1016/j.ajhg.2013.06.019

PMCID:: PMC3738837

Abstract Article PDF–1.6M

Select item 368338115.

The Switch Helix: A putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase

Thomas M. Moon, Brent W. Osborne, Wolfgang R. Dostmann

Biochim Biophys Acta. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: Biochim Biophys Acta. 2013 Jul; 1834(7): 1346–1351. Published online 2013 Feb 13. doi: 10.1016/j.bbapap.2013.02.009

PMCID:: PMC3683381

Abstract Article PDF–2.7M

Select item 308041416.

Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding

Jeong Joo Kim, Darren E. Casteel, Gilbert Huang, Taek Hun Kwon, Ronnie Kuo Ren, Peter Zwart, Jeffrey J. Headd, Nicholas Gene Brown, Dar-Chone Chow, Timothy Palzkill, Choel Kim

PLoS One. 2011; 6(4): e18413. Published online 2011 Apr 19. doi: 10.1371/journal.pone.0018413

PMCID:: PMC3080414

Abstract Article PDF–1.5M

Select item 225346817.

Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: Application to cGMP-dependent protein kinase Iα

Jason R. Schnell, Guo-Ping Zhou, Markus Zweckstetter, Alan C. Rigby, James J. Chou

Protein Sci. 2005 Sep; 14(9): 2421–2428. doi: 10.1110/ps.051528905

PMCID:: PMC2253468

Abstract Article PDF–203K

Select item 982081318.

Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting the PRKG1 Gene

Lucia Micale, Carmela Fusco, Grazia Nardella, Orazio Palmieri, Tiziana Latiano, Domenica Gioffreda, Francesca Tavano, Anna Panza, Antonio Merla, Giuseppe Biscaglia, Marco Gentile, Antonello Cuttitta, Marco Castori, Francesco Perri, Anna Latiano

Int J Mol Sci. 2023 Jan; 24(1): 668. Published online 2022 Dec 30. doi: 10.3390/ijms24010668

PMCID:: PMC9820813

Abstract Article PDF–2.1M

Select item 788830519.

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes

Neda M. Bogari, Amr A. Amin, Husni H. Rayes, Ahmed Abdelmotelb, Mohiuddin M. Taher, Faisal A. Al-Allaf, Abdellatif Bouazzaoui, Luke O'Gorman, John W. Holloway

Dis Markers. 2021; 2021: 8884229. Published online 2021 Feb 8. doi: 10.1155/2021/8884229

PMCID:: PMC7888305

Abstract Article PDF–413K

Select item 660125020.

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

Olena Rudyk, Alice Rowan, Oleksandra Prysyazhna, Susanne Krasemann, Kristin Hartmann, Min Zhang, Ajay M. Shah, Clemens Ruppert, Astrid Weiss, Ralph T. Schermuly, Tomoaki Ida, Takaaki Akaike, Lan Zhao, Philip Eaton

Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26): 13016–13025. Published online 2019 Jun 11. doi: 10.1073/pnas.1904064116

PMCID:: PMC6601250

Abstract Article PDF–2.1M

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