PMC Links for Gene (Select 56246) - PMC

Select item 46460361.

Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane

Sundeep Malik, Terrance M. Dolan, Zachary J. Maben, Patricia M. Hinkle

J Biol Chem. 2015 Nov 13; 290(46): 27972–27985. Published online 2015 Sep 30. doi: 10.1074/jbc.M115.668491

PMCID:: PMC4646036

Abstract Article PDF–3.3M

Select item 32147582.

Neonatal presentation of familial glucocorticoid deficiency resulting from a novel splice mutation in the melanocortin 2 receptor accessory protein

V Jain, L A Metherell, A David, R Sharma, P K Sharma, A J L Clark, L F Chan

Eur J Endocrinol. 2011 Dec; 165(6): 987–991. doi: 10.1530/EJE-11-0581

PMCID:: PMC3214758

Abstract Article PDF–149K

Select item 66028833.

Distinct MRAP domains are required for MC2R interaction and promotion of receptor trafficking

Tom R. Webb, Li Chan, Sadani N. Cooray, Michael E. Cheetham, J. Paul Chapple, Adrian J. L. Clark

Endocrinology. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Endocrinology. 2009 Feb 1; 150(2): 720–726. Published online 2008 Sep 25. doi: 10.1210/en.2008-0941

PMCID:: PMC6602883

Abstract Article PDF–1.3M

Select item 57800644.

Regulation of Lipolytic Response and Energy Balance by Melanocortin 2 Receptor Accessory Protein (MRAP) in Adipocytes

Xiaodong Zhang, Alicia M. Saarinen, Latoya E. Campbell, Elena A. De Filippis, Jun Liu

Diabetes. 2018 Feb; 67(2): 222–234. Published online 2017 Dec 7. doi: 10.2337/db17-0862

PMCID:: PMC5780064

Abstract Article PDF–1.7M

Select item 28558305.

Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2

Teng-Teng L L Chung, Li F Chan, Louise A Metherell, Adrian J L Clark

Clin Endocrinol (Oxf) 2010 May; 72(5): 589–594. doi: 10.1111/j.1365-2265.2009.03663.x

PMCID:: PMC2855830

Abstract Article PDF–334K

Select item 27543776.

Functional consequence of a novel Y129C mutation in a patient with two contradictory melanocortin-2-receptor mutations

Li F Chan, Teng-Teng Chung, Ahmed F Massoud, Louise A Metherell, Adrian J L Clark

Eur J Endocrinol. 2009 Apr; 160(4): 705–710. doi: 10.1530/EJE-08-0636

PMCID:: PMC2754377

Abstract Article PDF–188K

Select item 26355467.

The majority of ACTH receptor (MC2R) mutations found in Familial Glucocorticoid Deficiency type 1 lead to defective trafficking of the receptor to the cell surface

Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP, Clark AJL

J Clin Endocrinol Metab. Author manuscript; available in PMC 2009 Feb 3.

Published in final edited form as: J Clin Endocrinol Metab. 2008 Dec; 93(12): 4948–4954. Published online 2008 Oct 7. doi: 10.1210/jc.2008-1744

PMCID:: PMC2635546

Abstract Article PDF–902K

Select item 46074518.

hMRAPα, but Not hMRAP2, Enhances hMC4R Constitutive Activity in HEK293 Cells and This Is Not Dependent on hMRAPα Induced Changes in hMC4R Complex N-linked Glycosylation

Emma I. Kay, Rikus Botha, Johanna M. Montgomery, Kathleen G. Mountjoy

PLoS One. 2015; 10(10): e0140320. Published online 2015 Oct 15. doi: 10.1371/journal.pone.0140320

PMCID:: PMC4607451

Abstract Article PDF–12M

Select item 28082029.

Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency

R P Dias, L F Chan, L A Metherell, S H S Pearce, A J L Clark

Eur J Endocrinol. 2010 Feb; 162(2): 357–359. doi: 10.1530/EJE-09-0720

PMCID:: PMC2808202

Abstract Article PDF–80K

Select item 215441610.

Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers

Julien A. Sebag, Patricia M. Hinkle

Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51): 20244–20249. Published online 2007 Dec 12. doi: 10.1073/pnas.0708916105

PMCID:: PMC2154416

Abstract Article PDF–640K

Select item 299281011.

Regulation of G Protein–Coupled Receptor Signaling: Specific Dominant-Negative Effects of Melanocortin 2 Receptor Accessory Protein 2

Julien A. Sebag, Patricia M. Hinkle

Sci Signal. Author manuscript; available in PMC 2010 Nov 28.

Published in final edited form as: Sci Signal. 2010 Apr 6; 3(116): ra28. Published online 2010 Apr 6. doi: 10.1126/scisignal.2000593

PMCID:: PMC2992810

Abstract Article PDF–764K

Select item 261051412.

Regions of Melanocortin 2 (MC2) Receptor Accessory Protein Necessary for Dual Topology and MC2 Receptor Trafficking and Signaling

Julien A. Sebag, Patricia M. Hinkle

J Biol Chem. 2009 Jan 2; 284(1): 610–618. doi: 10.1074/jbc.M804413200

PMCID:: PMC2610514

Abstract Article PDF–723K

Select item 266184613.

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

Li F. Chan, Tom R. Webb, Teng-Teng Chung, Eirini Meimaridou, Sadani N. Cooray, Leonardo Guasti, J. Paul Chapple, Michaela Egertová, Maurice R. Elphick, Michael E. Cheetham, Louise A. Metherell, Adrian J. L. Clark

Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15): 6146–6151. Published online 2009 Mar 27. doi: 10.1073/pnas.0809918106

PMCID:: PMC2661846

Abstract Article PDF–642K

Select item 295285714.

Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters

Hans-Jörg Warnatz, Robert Querfurth, Anna Guerasimova, Xi Cheng, Stefan A. Haas, Andrew L. Hufton, Thomas Manke, Dominique Vanhecke, Wilfried Nietfeld, Martin Vingron, Michal Janitz, Hans Lehrach, Marie-Laure Yaspo

Nucleic Acids Res. 2010 Oct; 38(18): 6112–6123. Published online 2010 May 21. doi: 10.1093/nar/gkq402

PMCID:: PMC2952857

Abstract Article PDF–4.0M

Select item 537173015.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 756688116.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z