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Select item 90974151.

Nanomolar EP4 receptor potency and expression of eicosanoid-related enzymes in normal appearing colonic mucosa from patients with colorectal neoplasia

Ulrike Ries Feddersen, Sebastian Kjærgaard Hendel, Mark Alexander Berner-Hansen, Thomas Andrew Jepps, Mark Berner-Hansen, Niels Bindslev

BMC Gastroenterol. 2022; 22: 234. Published online 2022 May 12. doi: 10.1186/s12876-022-02311-z

Correction in:: BMC Gastroenterol. 2022; 22: 298.

PMCID:: PMC9097415

Abstract Article PDF–1.2M

Select item 84306232.

Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage

Lin Peng, Anca Chelariu-Raicu, Yao Ye, Zhi Ma, Huixia Yang, Hellen Ishikawa-Ankerhold, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt

Int J Mol Sci. 2021 Sep; 22(17): 9134. Published online 2021 Aug 24. doi: 10.3390/ijms22179134

PMCID:: PMC8430623

Abstract Article PDF–30M

Select item 74473663.

Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis

Peng-Bo Wu, Rao Qian, Chai Hong, Yi-tian Guo, Yuan-jie Yu, Guo Zhang, Shi-Yun Tan

Medicine (Baltimore) 2020 Aug 21; 99(34): e19756. Published online 2020 Aug 21. doi: 10.1097/MD.0000000000019756

PMCID:: PMC7447366

Abstract Article PDF–199K

Select item 72531914.

Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation

Taro Hiromi, Utako Yokoyama, Daisuke Kurotaki, Al Mamun, Ryo Ishiwata, Yasuhiro Ichikawa, Hiroshi Nishihara, Masanari Umemura, Takayuki Fujita, Shota Yasuda, Tomoyuki Minami, Motohiko Goda, Keiji Uchida, Shinichi Suzuki, Ichiro Takeuchi, Munetaka Masuda, Richard M. Breyer, Tomohiko Tamura, Yoshihiro Ishikawa

Arterioscler Thromb Vasc Biol. 2020 Jun; 40(6): 1559–1573. Published online 2020 Apr 23. doi: 10.1161/ATVBAHA.120.314297

PMCID:: PMC7253191

Abstract Article PDF–4.1M

Select item 65992605.

Prostaglandin receptor EP4 expression by Th17 cells is associated with high disease activity in ankylosing spondylitis

Charlotte Klasen, Anja Meyer, Paula S. Wittekind, Iris Waqué, Schafiq Nabhani, David M. Kofler

Arthritis Res Ther. 2019; 21: 159. Published online 2019 Jun 28. doi: 10.1186/s13075-019-1948-1

PMCID:: PMC6599260

Abstract Article PDF–1.7M

Select item 53989386.

Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer

Jeffrey F. Hiken, James I. McDonald, Keith F. Decker, Cesar Sanchez, Jeremy Hoog, Nathan D. VanderKraats, Kyle L. Jung, Margaret Akinhanmi, Lisa E. Rois, Matthew J. Ellis, John R. Edwards

Oncogene. Author manuscript; available in PMC 2017 May 21.

Published in final edited form as: Oncogene. 2017 Apr 20; 36(16): 2319–2327. Published online 2016 Nov 21. doi: 10.1038/onc.2016.397

PMCID:: PMC5398938

Abstract Article PDF–1.0M

Select item 53623017.

EP4 RECEPTOR PROMOTES INVADOPODIA AND INVASION IN HUMAN BREAST CANCER

Felix Tönisen, Louisiane Perrin, Battuya Bayarmagnai, Koen van den Dries, Alessandra Cambi, Bojana Gligorijevic

Eur J Cell Biol. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Eur J Cell Biol. 2017 Mar; 96(2): 218–226. Published online 2017 Jan 10. doi: 10.1016/j.ejcb.2016.12.005

PMCID:: PMC5362301

Abstract Article PDF–2.0M

Select item 46341558.

PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

Luis Rodriguez-Rodriguez, Jose Ivorra-Cortes, F. David Carmona, Javier Martín, Alejandro Balsa, Hanna W. van Steenbergen, Annette H. M. van der Helm-van Mil, Isidoro González-Álvaro, Benjamín Fernandez-Gutiérrez

Arthritis Res Ther. 2015; 17: 306. Published online 2015 Nov 5. doi: 10.1186/s13075-015-0830-z

PMCID:: PMC4634155

Abstract Article PDF–579K

Select item 37525359.

The prostaglandin E₂ receptor EP4 is integral to a positive feedback loop for prostaglandin E₂ production in human macrophages infected with Mycobacterium tuberculosis

Tomoyasu Nishimura, Xiaomin Zhao, Huixian Gan, Shigeo Koyasu, Heinz G. Remold

FASEB J. 2013 Sep; 27(9): 3827–3836. doi: 10.1096/fj.13-228858

PMCID:: PMC3752535

Abstract Article

Select item 362915610.

Lymphocytic Colitis Is Associated with Increased Pro-Inflammatory Cytokine Profile and Up Regulation of Prostaglandin Receptor EP4

Indranil Dey, Paul L. Beck, Kris Chadee

PLoS One. 2013; 8(4): e61891. Published online 2013 Apr 17. doi: 10.1371/journal.pone.0061891

PMCID:: PMC3629156

Abstract Article PDF–420K

Select item 360006211.

PGE₂ Regulates Pancreatic Stellate Cell Activity Via The EP4 Receptor

Chantale Charo, Vijaykumar Holla, Thiruvengadam Arumugam, Rosa Hwang, Peiying Yang, Raymond N. Dubois, David G. Menter, Craig D. Logsdon, Vijaya Ramachandran

Pancreas. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Pancreas. 2013 Apr; 42(3): 467–474. doi: 10.1097/MPA.0b013e318264d0f8

PMCID:: PMC3600062

Abstract Article PDF–1.9M

Select item 353133512.

PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites

Jürgen Glas, Julia Seiderer, Darina Czamara, Giulia Pasciuto, Julia Diegelmann, Martin Wetzke, Torsten Olszak, Christiane Wolf, Bertram Müller-Myhsok, Tobias Balschun, Jean-Paul Achkar, M. Ilyas Kamboh, Andre Franke, Richard H. Duerr, Stephan Brand

PLoS One. 2012; 7(12): e52873. Published online 2012 Dec 27. doi: 10.1371/journal.pone.0052873

PMCID:: PMC3531335

Abstract Article PDF–197K

Select item 334304113.

Genome-Wide Association Study of Multiple Sclerosis Confirms a Novel Locus at 5p13.1

Fuencisla Matesanz, Antonio González-Pérez, Miguel Lucas, Serena Sanna, Javier Gayán, Elena Urcelay, Ilenia Zara, Maristella Pitzalis, María L. Cavanillas, Rafael Arroyo, Magdalena Zoledziewska, Marisa Marrosu, Oscar Fernández, Laura Leyva, Antonio Alcina, Maria Fedetz, Concha Moreno-Rey, Juan Velasco, Luis M. Real, Juan Luis Ruiz-Peña, Francesco Cucca, Agustín Ruiz, Guillermo Izquierdo

PLoS One. 2012; 7(5): e36140. Published online 2012 May 3. doi: 10.1371/journal.pone.0036140

PMCID:: PMC3343041

Abstract Article PDF–510K

Select item 333607314.

MicroRNA-101 (miR-101) post-transcriptionally regulates the expression of EP4 receptor in colon cancers

Anupama Chandramouli, Benjamin Chidi Onyeagucha, Melania E Mercado-Pimentel, Lenka Stankova, Nisreen Abu Shahin, Bonnie J LaFleur, Ronald L Heimark, Achyut K Bhattacharyya, Mark A Nelson

Cancer Biol Ther. 2012 Feb 1; 13(3): 175–183. Published online 2012 Feb 1. doi: 10.4161/cbt.13.3.18874

PMCID:: PMC3336073

Abstract Article PDF–8.3M

Select item 319228515.

EP4 receptor stimulation down-regulates human eosinophil function

Petra Luschnig-Schratl, Eva M. Sturm, Viktoria Konya, Sonia Philipose, Gunther Marsche, Eleonore Fröhlich, Claudia Samberger, Doris Lang-Loidolt, Stefan Gattenlöhner, Irmgard Th. Lippe, Bernhard A. Peskar, Rufina Schuligoi, Akos Heinemann

Cell Mol Life Sci. 2011 Nov; 68(21): 3573–3587. Published online 2011 Mar 2. doi: 10.1007/s00018-011-0642-5