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Select item 109113801.

Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma

Jie Zheng, Yingqing Liu, Jiawei Wang, Jiewu Shi, Lin Li, Xuefeng Jiang, Lingsong Tao

Aging (Albany NY) 2024 Feb 15; 16(3): 2715–2735. Published online 2024 Feb 2. doi: 10.18632/aging.205506

PMCID:: PMC10911380

Abstract Article PDF–3.2M

Select item 94871122.

Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer

Cora Palanca-Ballester, David Hervas, Maria Villalba, Teresa Valdes-Sanchez, Diana Garcia, Maria Isabel Alcoriza-Balaguer, Marta Benet, Raquel Martinez-Tomas, Andres Briones-Gomez, Jose Galbis-Caravajal, Alfonso Calvo, Oscar Juan, Agustin Lahoz, Enrique Cases, Juan Sandoval

Clin Epigenetics. 2022; 14: 116. Published online 2022 Sep 19. doi: 10.1186/s13148-022-01334-3

PMCID:: PMC9487112

Abstract Article PDF–878K

Select item 94836103.

BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation

Mengdan YU, Qianwei ZHAO, Jinxia LI, Fang XU, Zhibiao ZHANG, Yixian LIU, Liping DAI, Bingxia ZHANG, Jianying ZHANG, Jintao ZHANG

J Zhejiang Univ Sci B. 2022 Sep 15; 23(9): 760–769. doi: 10.1631/jzus.B2100985

PMCID:: PMC9483610

Article PDF–2.7M

Select item 88947184.

BCAT1: A risk factor in multiple cancers based on a pan‐cancer analysis

Guo‐Sheng Li, He‐Qing Huang, Yao Liang, Qiu‐Yu Pang, Hao‐Jia Sun, Zhi‐Guang Huang, Yi‐Wu Dang, Lin‐Jie Yang, Gang Chen

Cancer Med. 2022 Mar; 11(5): 1396–1412. Published online 2022 Jan 4. doi: 10.1002/cam4.4525

PMCID:: PMC8894718

Abstract Article PDF–4.8M

Select item 84905235.

Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis

Lin Mao, Jin Chen, Xue Lu, Canlin Yang, Yi Ding, Mingming Wang, Yunpeng Zhang, Yuying Tian, Xing Li, Yunyun Fu, Yueying Yang, Yunyun Gu, Fei Gao, Junxing Huang, Lujian Liao

Theranostics. 2021; 11(19): 9705–9720. Published online 2021 Sep 27. doi: 10.7150/thno.61731

PMCID:: PMC8490523

Abstract Article PDF–3.4M

Select item 80650126.

Differential expression of the BCAT isoforms between breast cancer subtypes

Mai Ahmed Shafei, Arwa Flemban, Carl Daly, Paul Kendrick, Paul White, Sarah Dean, David Qualtrough, Myra E. Conway

Breast Cancer. 2021; 28(3): 592–607. Published online 2020 Dec 24. doi: 10.1007/s12282-020-01197-7

PMCID:: PMC8065012

Abstract Article PDF–3.2M

Select item 79061757.

Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas

Li Yi, Xiaoguang Fan, Jiabo Li, Feng Yuan, Jian Zhao, Monica Nistér, Xuejun Yang

Aging (Albany NY) 2021 Feb 15; 13(3): 3645–3660. Published online 2021 Jan 20. doi: 10.18632/aging.202328

PMCID:: PMC7906175

Abstract Article PDF–2.3M

Select item 74382758.

Tumor-Reprogrammed Stromal BCAT1 Fuels Branched Chain Ketoacid Dependency in Stromal-Rich PDAC Tumors

Ziwen Zhu, Abhinav Achreja, Noah Meurs, Olamide Animasahun, Sarah Owen, Anjali Mittal, Pooja Parikh, Ting-Wen Lo, Janusz Franco-Barraza, Jiaqi Shi, Valerie Gunchick, Mara H. Sherman, Edna Cukierman, Andrew M. Pickering, Anirban Maitra, Vaibhav Sahai, Meredith A. Morgan, Sunitha Nagrath, Theodore S. Lawrence, Deepak Nagrath

Nat Metab. Author manuscript; available in PMC 2021 Jan 6.

Published in final edited form as: Nat Metab. 2020 Aug; 2(8): 775–792. Published online 2020 Jul 6. doi: 10.1038/s42255-020-0226-5

PMCID:: PMC7438275

Abstract Article PDF–3.0M

Select item 71164279.

BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages

Jeong-Hun Ko, Antoni Olona, Adonia E. Papathanassiu, Norzawani Buang, Kwon-Sik Park, Ana S. H. Costa, Claudio Mauro, Christian Frezza, Jacques Behmoaras

J Cell Sci. 2020 Nov 15; 133(22): jcs247957. Published online 2020 Nov 27. doi: 10.1242/jcs.247957

PMCID:: PMC7116427

Abstract Article

Select item 616188510.

Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study

Kara Wegermann, Ricardo Henao, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, Cynthia A. Moylan

PLoS One. 2018; 13(9): e0204308. Published online 2018 Sep 28. doi: 10.1371/journal.pone.0204308

Correction in:: PLoS One. 2019; 14(2): e0212144.

PMCID:: PMC6161885

Abstract Article PDF–2.4M

Select item 474162211.

BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism

Zhi-Qiang Wang, Adnen Faddaoui, Magdalena Bachvarova, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Alexandra Sebastianelli, Chantal Guillemette, Stéphane Gobeil, Elizabeth Macdonald, Barbara Vanderhyden, Dimcho Bachvarov

Oncotarget. 2015 Oct 13; 6(31): 31522–31543. Published online 2015 Sep 10. doi: 10.18632/oncotarget.5159

PMCID:: PMC4741622

Abstract Article PDF–8.6M

Select item 410067312.

ECA39 is a novel distant metastasis-related biomarker in colorectal cancer

Reigetsu Yoshikawa, Hidenori Yanagi, Chun-Shen Shen, Yoshinori Fujiwara, Masafumi Noda, Toshihiko Yagyu, Makoto Gega, Tsutomu Oshima, Takehira Yamamura, Haruki Okamura, Yoshiro Nakano, Tomonori Morinaga, Tomoko Hashimoto-Tamaoki

World J Gastroenterol. 2006 Sep 28; 12(36): 5884–5889. Published online 2006 Sep 28. doi: 10.3748/wjg.v12.i36.5884

PMCID:: PMC4100673

Abstract Article PDF–946K

Select item 369820413.

Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma

Wen Zhou, Xiangling Feng, Caiping Ren, Xingjun Jiang, Weidong Liu, Wei Huang, Zhihong Liu, Zan Li, Liang Zeng, Lei Wang, Bin Zhu, Jia Shi, Jie Liu, Chang Zhang, Yanyu Liu, Kaitai Yao

Mol Cancer. 2013; 12: 53. Published online 2013 Jun 8. doi: 10.1186/1476-4598-12-53

PMCID:: PMC3698204

Abstract Article PDF–1.7M

Select item 731004214.

Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer

Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yan Lin, Liangrui Zhou, Qiang Sun

BMC Cancer. 2020; 20: 584. Published online 2020 Jun 22. doi: 10.1186/s12885-020-07070-2

PMCID:: PMC7310042

Abstract Article PDF–2.1M

Select item 573262815.

Branched-chain amino acid metabolism in cancer

Elitsa A. Ananieva, Adam C. Wilkinson

Curr Opin Clin Nutr Metab Care. 2018 Jan; 21(1): 64–70. Published online 2017 Dec 1. doi: 10.1097/MCO.0000000000000430

PMCID:: PMC5732628

Abstract Article PDF–252K

Select item 551022916.

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

Adonia E. Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K. Srivastava, Hong A. Vu, Danilo Cucchi, Stephen P. McAdoo, Elitsa A. Ananieva, Claudio Mauro, Jacques Behmoaras

Nat Commun. 2017; 8: 16040. Published online 2017 Jul 12. doi: 10.1038/ncomms16040

PMCID:: PMC5510229

Abstract Article PDF–1.8M

Select item 491664917.

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

Martje Tönjes, Sebastian Barbus, Yoon Jung Park, Wei Wang, Magdalena Schlotter, Anders M Lindroth, Sabrina V Pleier, Alfa H C Bai, Daniela Karra, Rosario M Piro, Jörg Felsberg, Adele Addington, Dieter Lemke, Irene Weibrecht, Volker Hovestadt, Claudio G Rolli, Benito Campos, Sevin Turcan, Dominik Sturm, Hendrik Witt, Timothy A Chan, Christel Herold-Mende, Ralf Kemkemer, Rainer König, Kathrin Schmidt, William-Edmund Hull, Stefan M Pfister, Manfred Jugold, Susan M Hutson, Christoph Plass, Jürgen G Okun, Guido Reifenberger, Peter Lichter, Bernhard Radlwimmer

Nat Med. Author manuscript; available in PMC 2016 Jun 22.

Published in final edited form as: Nat Med. 2013 Jul; 19(7): 901–908. Published online 2013 Jun 23. doi: 10.1038/nm.3217

PMCID:: PMC4916649

Abstract Article PDF–1.8M

Select item 796210118.

BCAT1 overexpression regulates proliferation and c-Myc/GLUT1 signaling in head and neck squamous cell carcinoma

Hongming Wang, Fei Wang, Wenyu Ouyang, Xuejun Jiang, Yan Wang

Oncol Rep. 2021 May; 45(5): 52. Published online 2021 Mar 4. doi: 10.3892/or.2021.8003

PMCID:: PMC7962101

Abstract Article PDF–1.5M

Select item 595653319.

Circulating tumour DNA for monitoring colorectal cancer—a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection

Erin L. Symonds, Susanne K. Pedersen, David H. Murray, Maher Jedi, Susan E. Byrne, Philippa Rabbitt, Rohan T. Baker, Dawn Bastin, Graeme P. Young

Clin Epigenetics. 2018; 10: 63. Published online 2018 May 16. doi: 10.1186/s13148-018-0500-5

PMCID:: PMC5956533

Abstract Article PDF–1.4M

Select item 428131320.

Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia

Setareh Safavi, Markus Hansson, Karin Karlsson, Andrea Biloglav, Bertil Johansson, Kajsa Paulsson

Haematologica. 2015 Jan; 100(1): 55–61. doi: 10.3324/haematol.2014.112912

PMCID:: PMC4281313

Abstract Article PDF–369K

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