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Select item 78593591.

Development and External Validation of a Novel Immune Checkpoint–Related Gene Signature for Prediction of Overall Survival in Hepatocellular Carcinoma

Enfa Zhao, Shimin Chen, Ying Dang

Front Mol Biosci. 2020; 7: 620765. Published online 2021 Jan 21. doi: 10.3389/fmolb.2020.620765

PMCID:: PMC7859359

Abstract Article PDF–4.0M

Select item 50372812.

MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment

Hua He, Maojin Yao, Wenhao Zhang, Bangbao Tao, Feili Liu, Shu Li, Yan Dong, Chenran Zhang, Yicheng Meng, Yuxin Li, Guohan Hu, Chun Luo, Hui Zong, Yicheng Lu

Cell Mol Immunol. 2016 Sep; 13(5): 658–668. Published online 2015 Jul 20. doi: 10.1038/cmi.2015.46

PMCID:: PMC5037281

Abstract Article PDF–2.7M

Select item 12183833.

Mitogen-activated protein kinase translocates to the nucleus during ischaemia and is activated during reperfusion.

Y Mizukami, K i Yoshida

Biochem J. 1997 May 1; 323(Pt 3): 785–790. doi: 10.1042/bj3230785

PMCID:: PMC1218383

Summary PDF–434K

Select item 41806664.

Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: Transmission through four generations

Katherine A. Rauen, William E. Tidyman, Anne L. Estep, Srirangan Sampath, Henry M. Peltier, Sherri J. Bale, Yves Lacassie

Am J Med Genet A. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Am J Med Genet A. 2010 Apr; 0(4): 807–814. doi: 10.1002/ajmg.a.33342

PMCID:: PMC4180666

Abstract Article PDF–633K

Select item 2307695.

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.

A D Catling, H J Schaeffer, C W Reuter, G R Reddy, M J Weber

Mol Cell Biol. 1995 Oct; 15(10): 5214–5225. doi: 10.1128/mcb.15.10.5214

PMCID:: PMC230769

Summary PDF–1.0M

Select item 456226.

Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.

J Wu, J K Harrison, L A Vincent, C Haystead, T A Haystead, H Michel, D F Hunt, K R Lynch, T W Sturgill

Proc Natl Acad Sci U S A. 1993 Jan 1; 90(1): 173–177. doi: 10.1073/pnas.90.1.173

PMCID:: PMC45622

Summary Page Browse PDF–1.1M

Select item 11328507.

Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle.

J Wu, H Michel, A Rossomando, T Haystead, J Shabanowitz, D F Hunt, T W Sturgill

Biochem J. 1992 Aug 1; 285(Pt 3): 701–705. doi: 10.1042/bj2850701

PMCID:: PMC1132850

Summary Page Browse PDF–1.1M

Select item 25961768.

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

Laure Voisin, Catherine Julien, Stéphanie Duhamel, Kailesh Gopalbhai, Isabelle Claveau, Marc K Saba-El-Leil, Ian Gaël Rodrigue-Gervais, Louis Gaboury, Daniel Lamarre, Mark Basik, Sylvain Meloche

BMC Cancer. 2008; 8: 337. Published online 2008 Nov 17. doi: 10.1186/1471-2407-8-337

PMCID:: PMC2596176

Abstract Article PDF–3.6M

Select item 3600709.

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

J Wu, J K Harrison, P Dent, K R Lynch, M J Weber, T W Sturgill

Mol Cell Biol. 1993 Aug; 13(8): 4539–4548. doi: 10.1128/mcb.13.8.4539

PMCID:: PMC360070

Summary Page Browse PDF–2.5M

Select item 255308510.

Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway

Aida Maddahi, Lars Edvinsson

BMC Neurosci. 2008; 9: 85. Published online 2008 Sep 15. doi: 10.1186/1471-2202-9-85

PMCID:: PMC2553085

Abstract Article PDF–3.9M

Select item 209399411.

Mutation Analysis of BRAF, MEK1 and MEK2 in 15 Ovarian Cancer Cell Lines: Implications for Therapy

Anne L. Estep, Chana Palmer, Frank McCormick, Katherine A. Rauen

PLoS One. 2007; 2(12): e1279. Published online 2007 Dec 5. doi: 10.1371/journal.pone.0001279

PMCID:: PMC2093994

Abstract Article PDF–184K

Select item 561792812.

MiR‐339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling

Jidong Chen, Xiaolei Cui, Li Li, Junle Qu, J. Usha Raj, Deming Gou

Physiol Rep. 2017 Sep; 5(18): e13441. Published online 2017 Sep 26. doi: 10.14814/phy2.13441

PMCID:: PMC5617928

Abstract Article PDF–1.6M

Select item 363385313.

Anthrax Lethal Toxin Downregulates Claudin-5 Expression in Human Endothelial Tight Junctions

Felice D’Agnillo, Matthew C. Williams, Mahtab Moayeri, Jason M. Warfel

PLoS One. 2013; 8(4): e62576. Published online 2013 Apr 23. doi: 10.1371/journal.pone.0062576

PMCID:: PMC3633853

Abstract Article PDF–7.3M

Select item 39516514.

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

M T Diaz-Meco, I Dominguez, L Sanz, P Dent, J Lozano, M M Municio, E Berra, R T Hay, T W Sturgill, J Moscat

EMBO J. 1994 Jun 15; 13(12): 2842–2848. doi: 10.1002/j.1460-2075.1994.tb06578.x

PMCID:: PMC395165

Summary Page Browse PDF–1.6M

Select item 485433015.

c-Raf, but not B-Raf, is essential for development of K-Ras oncogene driven non-small cell lung carcinoma

Rafael B. Blasco, Sarah Francoz, David Santamaría, Marta Cañamero, Pierre Dubus, Jean Charron, Manuela Baccarini, Mariano Barbacid

Cancer Cell. Author manuscript; available in PMC 2016 May 3.

Published in final edited form as: Cancer Cell. 2011 May 17; 19(5): 652–663. Published online 2011 Apr 21. doi: 10.1016/j.ccr.2011.04.002

PMCID:: PMC4854330

Abstract Article PDF–2.6M

Select item 643312016.

MEK drives BRAF activation through allosteric control of KSR proteins

Hugo Lavoie, Malha Sahmi, Pierre Maisonneuve, Sara A. Marullo, Neroshan Thevakumaran, Ting Jin, Igor Kurinov, Frank Sicheri, Marc Therrien

Nature. Author manuscript; available in PMC 2019 Mar 25.

Published in final edited form as: Nature. 2018 Feb 22; 554(7693): 549–553. Published online 2018 Feb 12. doi: 10.1038/nature25478

PMCID:: PMC6433120

Abstract Article PDF–2.4M

Select item 257938717.

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

Jason Newbern, Jian Zhong, Rasika S. Wickramasinghe, Xiaoyan Li, Yaohong Wu, Ivy Samuels, Natalie Cherosky, J. Colleen Karlo, Brianne O'Loughlin, Jamie Wikenheiser, Madhusudhana Gargesha, Yong Qiu Doughman, Jean Charron, David D. Ginty, Michiko Watanabe, Sulagna C. Saitta, William D. Snider, Gary E. Landreth

Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44): 17115–17120. Published online 2008 Oct 24. doi: 10.1073/pnas.0805239105

PMCID:: PMC2579387

Abstract Article PDF–1.8M

Select item 185278518.

Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation

Melinda D Willard, Francis S Willard, Xiaoyan Li, Steven D Cappell, William D Snider, David P Siderovski

EMBO J. 2007 Apr 18; 26(8): 2029–2040. Published online 2007 Mar 22. doi: 10.1038/sj.emboj.7601659

PMCID:: PMC1852785

Abstract Article PDF–392K

Select item 8439719.

Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization

Scott Stewart, Meera Sundaram, Yanping Zhang, Jeeyong Lee, Min Han, Kun-Liang Guan

Mol Cell Biol. 1999 Aug; 19(8): 5523–5534. doi: 10.1128/mcb.19.8.5523

PMCID:: PMC84397

Abstract Article PDF–1.0M

Select item 382580620.

Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome

Silvia Remeseiro, Ana Cuadrado, Shimako Kawauchi, Anne L. Calof, Arthur D. Lander, Ana Losada

Biochim Biophys Acta. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Biochim Biophys Acta. 2013 Dec; 1832(12): 10.1016/j.bbadis.2013.07.020. Published online 2013 Aug 3. doi: 10.1016/j.bbadis.2013.07.020