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Select item 65869301.

Localization of RalB signaling at endomembrane compartments and its modulation by autophagy

Manish Kumar Singh, Alexandre P. J. Martin, Carine Joffre, Giulia Zago, Jacques Camonis, Mathieu Coppey, Maria Carla Parrini

Sci Rep. 2019; 9: 8910. Published online 2019 Jun 20. doi: 10.1038/s41598-019-45443-1

Correction in:: Sci Rep. 2019; 9: 11797.

PMCID:: PMC6586930

Abstract Article PDF–4.1M

Select item 62262882.

RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

Giulia Zago, Irina Veith, Manish Kumar Singh, Laetitia Fuhrmann, Simon De Beco, Amanda Remorino, Saori Takaoka, Marjorie Palmeri, Frédérique Berger, Nathalie Brandon, Ahmed El Marjou, Anne Vincent-Salomon, Jacques Camonis, Mathieu Coppey, Maria Carla Parrini

eLife. 2018; 7: e40474. Published online 2018 Oct 15. doi: 10.7554/eLife.40474

PMCID:: PMC6226288

Abstract Article PDF–6.7M

Select item 53231443.

RALB provides critical survival signals downstream of Ras in acute myeloid leukemia

Craig E. Eckfeldt, Emily J. Pomeroy, Robin D.W. Lee, Katherine S. Hazen, Lindsey A. Lee, Branden S. Moriarity, David A. Largaespada

Oncotarget. 2016 Oct 4; 7(40): 65147–65156. Published online 2016 Aug 20. doi: 10.18632/oncotarget.11431

PMCID:: PMC5323144

Abstract Article PDF–7.4M

Select item 50000794.

Inhibition of Ral GTPases Using a Stapled Peptide Approach

Jemima C. Thomas, Jonathan M. Cooper, Natasha S. Clayton, Chensu Wang, Michael A. White, Chris Abell, Darerca Owen, Helen R. Mott

J Biol Chem. 2016 Aug 26; 291(35): 18310–18325. Published online 2016 Jun 22. doi: 10.1074/jbc.M116.720243

PMCID:: PMC5000079

Abstract Article PDF–2.4M

Select item 30254905.

Phosphorylation of RalB is important for bladder cancer cell growth and metastasis

Hong Wang, Charles Owens, Nidhi Chandra, Mark R. Conaway, David L. Brautigan, Dan Theodorescu

Cancer Res. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Cancer Res. 2010 Nov 1; 70(21): 8760–8769. Published online 2010 Oct 12. doi: 10.1158/0008-5472.CAN-10-0952

PMCID:: PMC3025490

Abstract Article PDF–1.3M

Select item 75965706.

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

Hajrah Khawaja, Andrew Campbell, Jamie Z. Roberts, Arman Javadi, Paul O’Reilly, Darragh McArt, Wendy L. Allen, Joanna Majkut, Markus Rehm, Alberto Bardelli, Federica Di Nicolantonio, Christopher J. Scott, Richard Kennedy, Nicolas Vitale, Timothy Harrison, Owen J. Sansom, Daniel B. Longley, Emma Evergren, Sandra Van Schaeybroeck

Cell Death Dis. 2020 Oct; 11(10): 930. Published online 2020 Oct 29. doi: 10.1038/s41419-020-03131-3

PMCID:: PMC7596570

Abstract Article PDF–3.4M

Select item 54649757.

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

E J Pomeroy, L A Lee, R D W Lee, D K Schirm, N A Temiz, J Ma, T A Gruber, E Diaz-Flores, B S Moriarity, J R Downing, K M Shannon, D A Largaespada, C E Eckfeldt

Oncogene. 2017 Jun 8; 36(23): 3263–3273. Published online 2016 Dec 19. doi: 10.1038/onc.2016.471

PMCID:: PMC5464975

Abstract Article PDF–2.4M

Select item 42702778.

Ral GTPases in tumorigenesis: Emerging from the shadows

David F. Kashatus

Exp Cell Res. Author manuscript; available in PMC 2014 Dec 18.

Published in final edited form as: Exp Cell Res. 2013 Sep 10; 319(15): 2337–2342. Published online 2013 Jul 2. doi: 10.1016/j.yexcr.2013.06.020

PMCID:: PMC4270277

Abstract Article PDF–315K

Select item 39347929.

Contributions of KRAS and RAL in Non-Small Cell Lung Cancer growth and progression

Sunny Guin, Yuanbin Ru, Murry W. Wynes, Rangnath Mishra, Xian Lu, Charles Owens, Anna E. Barόn, Vihas T. Vasu, Fred R. Hirsch, Jeffrey A. Kern, Dan Theodorescu

J Thorac Oncol. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: J Thorac Oncol. 2013 Dec; 8(12): 1492–1501. doi: 10.1097/JTO.0000000000000007

PMCID:: PMC3934792

Abstract Article PDF–1.8M

Select item 343614210.

RalA and RalB Proteins Are Ubiquitinated GTPases, and Ubiquitinated RalA Increases Lipid Raft Exposure at the Plasma Membrane

Vincent Neyraud, Vasily N. Aushev, Anastassia Hatzoglou, Brigitte Meunier, Ilaria Cascone, Jacques Camonis

J Biol Chem. 2012 Aug 24; 287(35): 29397–29405. Published online 2012 Jun 14. doi: 10.1074/jbc.M112.357764

PMCID:: PMC3436142

Abstract Article PDF–1.7M

Select item 340897711.

Differential involvement of RalA and RalB in colorectal cancer

Timothy D. Martin, Channing J. Der

Small GTPases. 2012 Apr 1; 3(2): 126–130. doi: 10.4161/sgtp.19571

PMCID:: PMC3408977

Abstract Article PDF–1.1M

Select item 331859312.

The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector

Nicole F. Neel, Kent L. Rossman, Timothy D. Martin, Tikvah K. Hayes, Jen Jen Yeh, Channing J. Der

Mol Cell Biol. 2012 Apr; 32(8): 1374–1386. doi: 10.1128/MCB.06291-11

PMCID:: PMC3318593

Abstract Article PDF–2.7M

Select item 296608813.

Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms

Dominico Vigil, Timothy D. Martin, Falina Williams, Jen Jen Yeh, Sharon L. Campbell, Channing J. Der

J Biol Chem. 2010 Nov 5; 285(45): 34729–34740. Published online 2010 Aug 27. doi: 10.1074/jbc.M110.116756

PMCID:: PMC2966088

Abstract Article PDF–3.4M

Select item 132633914.

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

Yuchen Chien, Michael A. White

EMBO Rep. 2003 Aug; 4(8): 800–806. Published online 2003 Jul 11. doi: 10.1038/sj.embor.embor899

PMCID:: PMC1326339

Abstract Article PDF–165K

Select item 31795415.

Coding sequences of human ralA and ralB cDNAs.

P Chardin, A Tavitian

Nucleic Acids Res. 1989 Jun 12; 17(11): 4380. doi: 10.1093/nar/17.11.4380

PMCID:: PMC317954

Summary Page Browse PDF–107K

Select item 835390916.

Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma

Shingo Yoshimachi, Ryutaro Shirakawa, Mingxin Cao, Duc Anh Trinh, Pan Gao, Natsumi Sakata, Kento Miyazaki, Kota Goto, Takayuki Miura, Kyohei Ariake, Shimpei Maeda, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Hisanori Horiuchi

Cancer Sci. 2021 Aug; 112(8): 3064–3073. Published online 2021 Jun 15. doi: 10.1111/cas.14970