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Select item 60882281.

The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons

Antonio Jesús Hinojosa, Rubén Deogracias, Beatriz Rico

Cell Rep. 2018 Jul 31; 24(5): 1231–1242. Published online 2018 Jul 31. doi: 10.1016/j.celrep.2018.06.115

PMCID:: PMC6088228

Abstract Article

Select item 93853592.

miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney Injury through Downregulation of NEK7

Meng Zhang, Deyuan Zhi, Jin Lin, Pei Liu, Yajun Wang, Meili Duan

J Immunol Res. 2022; 2022: 1825490. Published online 2022 Aug 10. doi: 10.1155/2022/1825490

PMCID:: PMC9385359

Abstract Article PDF–2.6M

Select item 90126963.

A single amino acid residue defines the difference in NLRP3 inflammasome activation between NEK7 and NEK6

Devon Jeltema, Jihong Wang, Juan Cai, Nathan Kelley, Zhe Yang, Yuan He

J Immunol. Author manuscript; available in PMC 2023 Apr 15.

Published in final edited form as: J Immunol. 2022 Apr 15; 208(8): 2029–2036. Published online 2022 Mar 30. doi: 10.4049/jimmunol.2101154

PMCID:: PMC9012696

Abstract Article PDF–1.4M

Select item 87627174.

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature

Li Liu, Youde Jiang, Jena J. Steinle

Invest Ophthalmol Vis Sci. 2022 Jan; 63(1): 14. Published online 2022 Jan 10. doi: 10.1167/iovs.63.1.14

PMCID:: PMC8762717

Abstract Article PDF–1.8M

Select item 59979955.

NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization

Francisco Freixo, Paula Martinez Delgado, Yasmina Manso, Carlos Sánchez-Huertas, Cristina Lacasa, Eduardo Soriano, Joan Roig, Jens Lüders

Nat Commun. 2018; 9: 2330. Published online 2018 Jun 13. doi: 10.1038/s41467-018-04706-7

PMCID:: PMC5997995

Abstract Article PDF–4.4M

Select item 46971476.

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

Jonathan L. Schmid-Burgk, Dhruv Chauhan, Tobias Schmidt, Thomas S. Ebert, Julia Reinhardt, Elmar Endl, Veit Hornung

J Biol Chem. 2016 Jan 1; 291(1): 103–109. Published online 2015 Nov 9. doi: 10.1074/jbc.C115.700492

PMCID:: PMC4697147

Abstract Article PDF–1.2M

Select item 105481707.

MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation

Yeon‐Ji Park, Niranjan Dodantenna, Yonghyeon Kim, Tae‐Hwan Kim, Ho‐Soo Lee, Young‐Suk Yoo, June Heo, Jae‐Ho Lee, Myung‐Hee Kwon, Ho Chul Kang, Jong‐Soo Lee, Hyeseong Cho

EMBO J. 2023 Oct; 42(19): e113481. Published online 2023 Aug 14. doi: 10.15252/embj.2023113481

PMCID:: PMC10548170

Abstract Article PDF–1.8M

Select item 68855178.

NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling

Xueliang Chen, Ganglei Liu, Yuanyuan Yuan, Guotao Wu, Shalong Wang, Lianwen Yuan

Cell Death Dis. 2019 Dec; 10(12): 906. Published online 2019 Dec 2. doi: 10.1038/s41419-019-2157-1

PMCID:: PMC6885517

Abstract Article PDF–2.1M

Select item 48625889.

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Hexin Shi, Ying Wang, Xiaohong Li, Xiaoming Zhan, Miao Tan, Maggy Fina, Lijing Su, David Pratt, Chun Hui Bu, Sara Hildebrand, Stephen Lyon, Lindsay Scott, Jiexia Quan, Qihua Sun, Jamie Russell, Stephanie Arnett, Peter Jurek, Ding Chen, Vladimir V. Kravchenko, John C. Mathison, Eva Marie Y. Moresco, Nancy L. Monson, Richard J. Ulevitch, Bruce Beutler

Nat Immunol. Author manuscript; available in PMC 2016 Jun 7.

Published in final edited form as: Nat Immunol. 2016 Mar; 17(3): 250–258. Published online 2015 Dec 7. doi: 10.1038/ni.3333

PMCID:: PMC4862588

Abstract Article PDF–1.3M

Select item 481078810.

Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Yuan He, Melody Y. Zeng, Dahai Yang, Benny Motro, Gabriel Núñez

Nature. Author manuscript; available in PMC 2016 Jul 27.

Published in final edited form as: Nature. 2016 Feb 18; 530(7590): 354–357. Published online 2016 Jan 27. doi: 10.1038/nature16959

PMCID:: PMC4810788

Abstract Article PDF–2.8M

Select item 327912411.

The Cell-Adhesion Gene PVRL3 is Associated with Congenital Ocular Defects

Salil A. Lachke, Anne W. Higgins, Maiko Inagaki, Irfan Saadi, Qiongchao Xi, Michelle Long, Bradley J. Quade, Michael E. Talkowski, James F. Gusella, Atsuko Fujimoto, Michael L. Robinson, Ying Yang, Quynh T. Duong, Irit Shapira, Benny Motro, Jun Miyoshi, Yoshimi Takai, Cynthia C. Morton, Richard L. Maas

Hum Genet. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: Hum Genet. 2012 Feb; 131(2): 235–250. Published online 2011 Jul 17. doi: 10.1007/s00439-011-1064-z

PMCID:: PMC3279124

Abstract Article PDF–5.2M

Select item 842743012.

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi

Front Immunol. 2021; 12: 741839. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.741839

PMCID:: PMC8427430

Abstract Article PDF–2.1M

Select item 849492213.

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

Tingting Niu, Charlotte De Rosny, Séverine Chautard, Amaury Rey, Danish Patoli, Marine Groslambert, Camille Cosson, Brice Lagrange, Zhirong Zhang, Orane Visvikis, Sabine Hacot, Maggy Hologne, Olivier Walker, Jeimin Wong, Ping Wang, Roméo Ricci, Thomas Henry, Laurent Boyer, Virginie Petrilli, Bénédicte F. Py

Nat Commun. 2021; 12: 5862. Published online 2021 Oct 6. doi: 10.1038/s41467-021-26142-w

PMCID:: PMC8494922

Abstract Article PDF–3.7M

Select item 381794614.

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates

Jeremy A. Miller, Jason Nathanson, Daniel Franjic, Sungbo Shim, Rachel A. Dalley, Sheila Shapouri, Kimberly A. Smith, Susan M. Sunkin, Amy Bernard, Jeffrey L. Bennett, Chang-Kyu Lee, Michael J. Hawrylycz, Allan R. Jones, David G. Amaral, Nenad Sestan, Fred H. Gage, Ed S. Lein

Development. 2013 Nov 15; 140(22): 4633–4644. doi: 10.1242/dev.097212

PMCID:: PMC3817946

Abstract Article

Select item 534152015.

The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4^WDTC¹ E3 ligase

Beezly S Groh, Feng Yan, Matthew D Smith, Yanbao Yu, Xian Chen, Yue Xiong

EMBO Rep. 2016 May; 17(5): 638–647. Published online 2016 Apr 9. doi: 10.15252/embr.201540500

PMCID:: PMC5341520

Abstract Article PDF–1.1M

Select item 431955916.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 396495517.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 30876318.

GenePaint.org: an atlas of gene expression patterns in the mouse embryo

Axel Visel, Christina Thaller, Gregor Eichele

Nucleic Acids Res. 2004 Jan 1; 32(Database issue): D552–D556. doi: 10.1093/nar/gkh029

PMCID:: PMC308763

Abstract Article PDF–253K

Select item 16551119.

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

Doug Stryke, Michiko Kawamoto, Conrad C. Huang, Susan J. Johns, Leslie A. King, Courtney A. Harper, Elaine C. Meng, Roy E. Lee, Alice Yee, Larry L'Italien, Pao-Tien Chuang, Stephen G. Young, William C. Skarnes, Patricia C. Babbitt, Thomas E. Ferrin

Nucleic Acids Res. 2003 Jan 1; 31(1): 278–281. doi: 10.1093/nar/gkg064

PMCID:: PMC165511

Abstract Article PDF–217K

Select item 793877020.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

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