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Select item 106801851.

RSK3 switches cell fate: from stress-induced senescence to malignant progression

Anda Huna, Jean-Michel Flaman, Catalina Lodillinsky, Kexin Zhu, Gabriela Makulyte, Victoria Pakulska, Yohann Coute, Clémence Ruisseaux, Pierre Saintigny, Hector Hernandez-Vargas, Pierre-Antoine Defossez, Mathieu Boissan, Nadine Martin, David Bernard

J Exp Clin Cancer Res. 2023; 42: 318. Published online 2023 Nov 27. doi: 10.1186/s13046-023-02909-5

PMCID:: PMC10680185

Abstract Article PDF–5.8M

Select item 75496072.

Genome‐wide association study of café‐au‐lait macule number in neurofibromatosis type 1

Heejong Sung, Paula L. Hyland, Alexander Pemov, Jeremy A. Sabourin, Andrea M. Baldwin, Sara Bass, Kedest Teshome, Wen Luo, Frederick National Laboratory for Cancer Research, Brigitte C. Widemann, Douglas R. Stewart, Alexander F. Wilson

Mol Genet Genomic Med. 2020 Oct; 8(10): e1400. Published online 2020 Aug 31. doi: 10.1002/mgg3.1400

PMCID:: PMC7549607

Abstract Article PDF–1.2M

Select item 38845263.

Synthetic Lethality Screen Identifies RPS6KA2 as Modifier of Epidermal Growth Factor Receptor Activity in Pancreatic Cancer

Nada Milosevic, Benjamin Kühnemuth, Leonie Mühlberg, Stefanie Ripka, Heidi Griesmann, Carolin Lölkes, Malte Buchholz, Daniela Aust, Christian Pilarsky, Sebastian Krug, Thomas Gress, Patrick Michl

Neoplasia. 2013 Dec; 15(12): 1354–1362. doi: 10.1593/neo.131660

PMCID:: PMC3884526

Abstract Article PDF–1.7M

Select item 69592984.

Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance

Fang Tai, Kunxiang Gong, Kai Song, Yanling He, Jian Shi

Nat Commun. 2020; 11: 258. Published online 2020 Jan 14. doi: 10.1038/s41467-019-14083-4

PMCID:: PMC6959298

Abstract Article PDF–3.0M

Select item 36688395.

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

Violeta Serra, Pieter J.A. Eichhorn, Celina García-García, Yasir H. Ibrahim, Ludmila Prudkin, Gertrudis Sánchez, Olga Rodríguez, Pilar Antón, Josep-Lluís Parra, Sara Marlow, Maurizio Scaltriti, José Pérez-Garcia, Aleix Prat, Joaquín Arribas, William C. Hahn, So Young Kim, José Baselga

J Clin Invest. 2013 Jun 3; 123(6): 2551–2563. Published online 2013 May 1. doi: 10.1172/JCI66343

Correction in:: J Clin Invest. 2014 Mar 3; 124(3): 1418.

PMCID:: PMC3668839

Abstract Article PDF–3.9M

Select item 2306756.

RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.

Y Zhao, C Bjørbaek, S Weremowicz, C C Morton, D E Moller

Mol Cell Biol. 1995 Aug; 15(8): 4353–4363. doi: 10.1128/mcb.15.8.4353

PMCID:: PMC230675

Summary PDF–797K

Select item 228097.

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene

Dario De Cesare, Sylvie Jacquot, André Hanauer, Paolo Sassone-Corsi

Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21): 12202–12207. doi: 10.1073/pnas.95.21.12202

PMCID:: PMC22809

Abstract Article PDF–356K

Select item 100774718.

mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer

Anju Kumari, Lisa Gesumaria, Yan-Jin Liu, V. Keith Hughitt, Xiaohu Zhang, Michele Ceribelli, Kelli M. Wilson, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Craig J. Thomas, Beverly A. Mock, David S. Schrump, Haobin Chen

JCI Insight. 2023 Mar 8; 8(5): e156657. Published online 2023 Mar 8. doi: 10.1172/jci.insight.156657

PMCID:: PMC10077471

Abstract Article PDF–7.2M

Select item 67622769.

Stimulation of Endothelin B Receptors in Astrocytes Induces cAMP Response Element-Binding Protein Phosphorylation and c-fos Expression Via Multiple Mitogen-Activated Protein Kinase Signaling Pathways

Sergio Schinelli, Patrizia Zanassi, Mayra Paolillo, Hang Wang, Antonio Feliciello, Vittorio Gallo

J Neurosci. 2001 Nov 15; 21(22): 8842–8853. doi: 10.1523/JNEUROSCI.21-22-08842.2001

PMCID:: PMC6762276

Abstract Article PDF–1.3M

Select item 312848010.

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

Shannon Elf, Dean Blevins, Lingtao Jin, Tae-Wook Chung, Ifor R. Williams, Benjamin H. Lee, Jian-Xin Lin, Warren J. Leonard, Jack Taunton, Hanna J. Khoury, Sumin Kang

Blood. 2011 Jun 23; 117(25): 6885–6894. Prepublished online 2011 Apr 28. doi: 10.1182/blood-2010-10-315721

PMCID:: PMC3128480

Abstract Article

Select item 122117811.

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.

J M Lizcano, N Morrice, P Cohen

Biochem J. 2000 Jul 15; 349(Pt 2): 547–557. doi: 10.1042/0264-6021:3490547

PMCID:: PMC1221178

Summary PDF–390K

Select item 16220612.

Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity

Philippe P. Roux, Stephanie A. Richards, John Blenis

Mol Cell Biol. 2003 Jul; 23(14): 4796–4804. doi: 10.1128/MCB.23.14.4796-4804.2003

PMCID:: PMC162206

Abstract Article PDF–501K

Select item 303858813.

Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer

Martha L. Slattery, Abbie Lundgreen, Jennifer S. Herrick, Roger K. Wolff

Mutat Res. Author manuscript; available in PMC 2012 Jan 10.

Published in final edited form as: Mutat Res. 2011 Jan 10; 706(1-2): 13–20. Published online 2010 Oct 28. doi: 10.1016/j.mrfmmm.2010.10.005

PMCID:: PMC3038588

Abstract Article PDF–349K

Select item 150098014.

FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCɛ, B-Raf and S6K2

Olivier E Pardo, Claudia Wellbrock, Umme K Khanzada, Muriel Aubert, Imanol Arozarena, Sally Davidson, Frances Bowen, Peter J Parker, V V Filonenko, Ivan T Gout, Neil Sebire, Richard Marais, Julian Downward, Michael J Seckl

EMBO J. 2006 Jul 12; 25(13): 3078–3088. Published online 2006 Jun 29. doi: 10.1038/sj.emboj.7601198

PMCID:: PMC1500980

Abstract Article PDF–271K

Select item 125773115.

Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission

Gareth M. Thomas, Gavin R. Rumbaugh, Dana B. Harrar, Richard L. Huganir

Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42): 15006–15011. Published online 2005 Oct 10. doi: 10.1073/pnas.0507476102

PMCID:: PMC1257731

Abstract Article PDF–420K

Select item 116979516.

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.

R Fukunaga, T Hunter

EMBO J. 1997 Apr 15; 16(8): 1921–1933. doi: 10.1093/emboj/16.8.1921

PMCID:: PMC1169795

Summary PDF–813K

Select item 117077517.

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

M Deak, A D Clifton, L M Lucocq, D R Alessi

EMBO J. 1998 Aug 3; 17(15): 4426–4441. doi: 10.1093/emboj/17.15.4426

PMCID:: PMC1170775

Summary PDF–1.5M

Select item 440234818.

Gene–Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study

Yun J. Sung, Lisa de las Fuentes, Karen L. Schwander, Jeannette Simino, Dabeeru C. Rao

Am J Hypertens. 2015 Mar; 28(3): 343–354. Published online 2014 Sep 3. doi: 10.1093/ajh/hpu149

PMCID:: PMC4402348

Abstract Article PDF–38M

Select item 357404219.

Genome-wide association Scan of dental caries in the permanent dentition

Xiaojing Wang, John R Shaffer, Zhen Zeng, Ferdouse Begum, Alexandre R Vieira, Jacqueline Noel, Ida Anjomshoaa, Karen T Cuenco, Myoung-Keun Lee, James Beck, Eric Boerwinkle, Marilyn C Cornelis, Frank B Hu, David R Crosslin, Cathy C Laurie, Sarah C Nelson, Kimberly F Doheny, Elizabeth W Pugh, Deborah E Polk, Robert J Weyant, Richard Crout, Daniel W McNeil, Daniel E Weeks, Eleanor Feingold, Mary L Marazita

BMC Oral Health. 2012; 12: 57. Published online 2012 Dec 21. doi: 10.1186/1472-6831-12-57

PMCID:: PMC3574042

Abstract Article PDF–3.4M

Select item 404386820.

Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries

Zhen Zeng, Eleanor Feingold, Xiaojing Wang, Daniel E. Weeks, Myoungkeun Lee, Karen T. Cuenco, Barbara Broffitt, Robert J. Weyant, Richard Crout, Daniel W. McNeil, Steven M. Levy, Mary L. Marazita, John. R. Shaffer

Caries Res. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Caries Res. 2014; 48(4): 330–338. doi: 10.1159/000356299

PMCID:: PMC4043868

Abstract Article PDF–225K

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