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Select item 99418281.

Genetic tuning of β-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice

Jean Moon, Srinivasagan Ramkumar, Johannes von Lintig

Hum Mol Genet. 2023 Mar 1; 32(5): 798–809. Published online 2022 Sep 23. doi: 10.1093/hmg/ddac242

PMCID:: PMC9941828

Abstract Article PDF–2.0M

Select item 97070382.

The conversion of β-carotene to vitamin A in adipocytes drives the anti-obesogenic effects of β-carotene in mice

Johana Coronel, Jianshi Yu, Nageswara Pilli, Maureen A. Kane, Jaume Amengual

Mol Metab. 2022 Dec; 66: 101640. Published online 2022 Nov 15. doi: 10.1016/j.molmet.2022.101640

PMCID:: PMC9707038

Abstract Article PDF–1.9M

Select item 54076263.

Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturase 1

Eugenia Poliakov, William Samuel, Todd Duncan, Danielle B. Gutierrez, Nathan L. Mata, T. Michael Redmond

PLoS One. 2017; 12(4): e0176487. Published online 2017 Apr 27. doi: 10.1371/journal.pone.0176487

PMCID:: PMC5407626

Abstract Article PDF–2.6M

Select item 52569714.

Mice lacking β-carotene-15,15’-dioxygenase exhibit reduced serum testosterone, prostatic androgen receptor signaling, and prostatic cellular proliferation

Joshua W. Smith, Nikki A. Ford, Jennifer M. Thomas-Ahner, Nancy E. Moran, Eric C. Bolton, Matthew A. Wallig, Steven K. Clinton, John W. Erdman, Jr.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1; 311(6): R1135–R1148. Published online 2016 Sep 14. doi: 10.1152/ajpregu.00261.2016

PMCID:: PMC5256971

Abstract Article

Select item 42550085.

Cardiac dysfunction in β-carotene-15,15′-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism

Seung-Ah Lee, Hongfeng Jiang, Chad M. Trent, Jason J. Yuen, Sureshbabu Narayanasamy, Robert W. Curley, Jr., Earl H. Harrison, Ira J. Goldberg, Mathew S. Maurer, William S. Blaner

Am J Physiol Heart Circ Physiol. 2014 Dec 1; 307(11): H1675–H1684. Published online 2014 Sep 26. doi: 10.1152/ajpheart.00548.2014

PMCID:: PMC4255008

Abstract Article

Select item 34158626.

Lycopene Biodistribution Is Altered in 15,15′-Carotenoid Monooxygenase Knockout Mice

Brian L. Lindshield, Jennifer L. King, Adrian Wyss, Regina Goralczyk, Chi-Hua Lu, Nikki A. Ford, John W. Erdman, Jr

J Nutr. 2008 Dec; 138(12): 2367–2371. doi: 10.3945/jn.108.099663

PMCID:: PMC3415862

Abstract Article PDF–500K

Select item 32583877.

An interaction between carotene-15,15’-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone

Nikki A. Ford, Nancy Engelmann Moran, Joshua W. Smith, Steven K. Clinton, John W. Erdman, Jr.

Int J Cancer. Author manuscript; available in PMC 2013 Jul 15.

Published in final edited form as: Int J Cancer. 2012 Jul 15; 131(2): E143–E148. Published online 2011 Nov 2. doi: 10.1002/ijc.26446

PMCID:: PMC3258387

Abstract Article PDF–386K

Select item 31060098.

Beta-Carotene Reduces Body Adiposity of Mice via BCMO1

Jaume Amengual, Erwan Gouranton, Yvonne G. J. van Helden, Susanne Hessel, Joan Ribot, Evelien Kramer, Beata Kiec-Wilk, Ursula Razny, Georg Lietz, Adrian Wyss, Aldona Dembinska-Kiec, Andreu Palou, Jaap Keijer, Jean François Landrier, M. Luisa Bonet, Johannes von Lintig

PLoS One. 2011; 6(6): e20644. Published online 2011 Jun 1. doi: 10.1371/journal.pone.0020644

PMCID:: PMC3106009

Abstract Article PDF–709K

Select item 30211999.

Beta-carotene affects gene expression in lungs of male and female Bcmo1^−/− mice in opposite directions

Yvonne G. J. van Helden, Roger W. L. Godschalk, Hans J. M. Swarts, Peter C. H. Hollman, Frederik J. van Schooten, Jaap Keijer

Cell Mol Life Sci. 2011 Feb; 68(3): 489–504. Published online 2010 Sep 4. doi: 10.1007/s00018-010-0461-0

PMCID:: PMC3021199

Abstract Article PDF–326K

Select item 287731510.

Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene

Yvonne G. J. van Helden, Sandra G. Heil, Frederik J. van Schooten, Evelien Kramer, Susanne Hessel, Jaume Amengual, Joan Ribot, Katja Teerds, Adrian Wyss, Georg Lietz, M. Luisa Bonet, Johannes von Lintig, Roger W. L. Godschalk, Jaap Keijer

Cell Mol Life Sci. 2010 Jun; 67(12): 2039–2056. Published online 2010 Apr 6. doi: 10.1007/s00018-010-0341-7

PMCID:: PMC2877315

Abstract Article PDF–656K

Select item 280152311.

Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse β-carotene 15, 15'-monooxygenase

Eugenia Poliakov, Susan Gentleman, Preethi Chander, Francis X Cunningham, Jr, Bella L Grigorenko, Alexander V Nemuhin, T Michael Redmond

BMC Biochem. 2009; 10: 31. Published online 2009 Dec 14. doi: 10.1186/1471-2091-10-31

PMCID:: PMC2801523

Abstract Article PDF–1.3M

Select item 1058928112.

Bioavailability and provitamin A activity of neurosporaxanthin in mice

Anthony P. Miller, Dámaso Hornero-Méndez, Sepalika Bandara, Obdulia Parra-Rivero, M. Carmen Limón, Johannes von Lintig, Javier Avalos, Jaume Amengual

Commun Biol. 2023; 6: 1068. Published online 2023 Oct 20. doi: 10.1038/s42003-023-05446-1

PMCID:: PMC10589281

Abstract Article PDF–1.8M

Select item 739878013.

β-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans

Jaume Amengual, Johana Coronel, Courtney Marques, Celia Aradillas-García, Juan Manuel Vargas Morales, Flavia C D Andrade, John W Erdman, Jr, Margarita Teran-Garcia

J Nutr. 2020 Aug; 150(8): 2023–2030. Published online 2020 May 20. doi: 10.1093/jn/nxaa143

PMCID:: PMC7398780

Abstract Article PDF–415K

Select item 636841514.

Supplementation with Macular Carotenoids Improves Visual Performance of Transgenic Mice

Binxing Li, Gregory T. Rognon, Ty Mattinson, Preejith P. Vachali, Aruna Gorusupudi, Fu-Yen Chang, Arunkumar Ranganathan, Kelly Nelson, Evan W. George, Jeanne M. Frederick, Paul S. Bernstein

Arch Biochem Biophys. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Arch Biochem Biophys. 2018 Jul 1; 649: 22–28. Published online 2018 May 6. doi: 10.1016/j.abb.2018.05.003

PMCID:: PMC6368415

Abstract Article PDF–2.1M

Select item 549425715.

Retinal Accumulation of Zeaxanthin, Lutein, and β-Carotene in Mice Deficient in Carotenoid Cleavage Enzymes

Binxing Li, Preejith P. Vachali, Zhengqing Shen, Aruna Gorusupudi, Kelly Nelson, Brian M Besch, Alexis Bartschi, Simone Longo, Ty Mattinson, Saeed Shihab, Nikolay E. Polyakov, Lyubov P. Suntsova, Alexander V. Dushkin, Paul S. Bernstein

Exp Eye Res. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Exp Eye Res. 2017 Jun; 159: 123–131. Published online 2017 Mar 9. doi: 10.1016/j.exer.2017.02.016

PMCID:: PMC5494257

Abstract Article PDF–1.2M

Select item 500315316.

Genetic dissection in a mouse model reveals interactions between carotenoids and lipid metabolism

Grzegorz Palczewski, M. Airanthi K. Widjaja-Adhi, Jaume Amengual, Marcin Golczak, Johannes von Lintig

J Lipid Res. 2016 Sep; 57(9): 1684–1695. doi: 10.1194/jlr.M069021

PMCID:: PMC5003153

Abstract Article PDF–1.3M

Select item 420209817.

Evidence for compartmentalization of mammalian carotenoid metabolism

Grzegorz Palczewski, Jaume Amengual, Charles L. Hoppel, Johannes von Lintig

FASEB J. 2014 Oct; 28(10): 4457–4469. doi: 10.1096/fj.14-252411

PMCID:: PMC4202098

Abstract Article

Select item 380489318.

Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulates carotenoid and lipid metabolism in mice

Nikki A. Ford, Amy C. Elsen, John W. Erdman, Jr.

Nutr Res. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Nutr Res. 2013 Sep; 33(9): 733–742. Published online 2013 Aug 13. doi: 10.1016/j.nutres.2013.07.007

PMCID:: PMC3804893

Abstract Article PDF–2.6M

Select item 369227419.

Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoid

Igor Shmarakov, Matthew K. Fleshman, Diana N. D’Ambrosio, Roseann Piantedosi, Ken M. Riedl, Steven J. Schwartz, Robert W. Curley, Jr., Johannes von Lintig, Lewis P. Rubin, Earl H. Harrison, William S. Blaner

Arch Biochem Biophys. Author manuscript; available in PMC 2013 Jun 25.

Published in final edited form as: Arch Biochem Biophys. 2010 Dec 1; 504(1): 3–10. Published online 2010 May 12. doi: 10.1016/j.abb.2010.05.010