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Select item 112511771.

The SIRT2-AMPK axis regulates autophagy induced by acute liver failure

Qingqi Zhang, Jin Guo, Chunxia Shi, Danmei Zhang, Yukun Wang, Luwen Wang, Zuojiong Gong

Sci Rep. 2024; 14: 16278. Published online 2024 Jul 15. doi: 10.1038/s41598-024-67102-w

PMCID:: PMC11251177

Abstract Article PDF–9.6M

Select item 112269672.

Sirtuin 2 regulates neutrophil functions through NAD⁺ synthesis pathway in virus infection

Zhiyuan Zhang, Qiuli Yang, Yingjie Dong, Likun Wang, Ruiying Niu, Jingxuan Xia, Yujing Bi, Guangwei Liu

iScience. 2024 Jul 19; 27(7): 110184. Published online 2024 Jun 4. doi: 10.1016/j.isci.2024.110184

PMCID:: PMC11226967

Abstract Article PDF–4.5M

Select item 110669863.

Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis

Dan Hou, Tao Yu, Xuan Lu, Jun Young Hong, Min Yang, Yanlin Zi, Thanh Tu Ho, Hening Lin

Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2319833121. Published online 2024 Apr 22. doi: 10.1073/pnas.2319833121

PMCID:: PMC11066986

Abstract Article PDF–1.1M

Select item 110281074.

Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model

Ming Chen, Min Xu, Chengliang Zhu, Hongling Wang, Qiu Zhao, Feng Zhou

Cancer Immunol Immunother. 2019 Jun; 68(6): 961–971. Published online 2019 Apr 6. doi: 10.1007/s00262-019-02337-5

PMCID:: PMC11028107

Abstract Article PDF–1.6M

Select item 109127965.

Oligodendrocyte‐derived exosomes‐containing SIRT2 ameliorates depressive‐like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK‐3β pathway in depressed mice

Honghan Zhang, Xin‐hui Xie, Shu‐xian Xu, Chao Wang, Siqi Sun, Xinhua Song, Ruiling Li, Ningyuan Li, Yuqi Feng, Hao Duan, Di Li, Zhongchun Liu

CNS Neurosci Ther. 2024 Mar; 30(3): e14661. Published online 2024 Mar 4. doi: 10.1111/cns.14661

PMCID:: PMC10912796

Abstract Article PDF–12M

Select item 107269106.

SIRT2 transgenic over‐expression does not impact lifespan in mice

Lindsay E. Wu, Corrine E. Fiveash, Nicholas L. Bentley, Myung‐Jin Kang, Hemna Govindaraju, Jayne A. Barbour, Brendan P. Wilkins, Sarah E. Hancock, Romanthi Madawala, Abhijit Das, Hassina Massudi, Catherine Li, Lynn‐Jee Kim, Ashley S. A. Wong, Maria B. Marinova, Ghazal Sultani, Abhirup Das, Neil A. Youngson, David G. Le Couteur, David A. Sinclair, Nigel Turner

Aging Cell. 2023 Dec; 22(12): e14027. Published online 2023 Nov 27. doi: 10.1111/acel.14027

PMCID:: PMC10726910

Abstract Article PDF–2.8M

Select item 105771137.

SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer’s Disease

Noemi Sola-Sevilla, Alberto Mesa-Lombardo, Mikel Aleixo, Sara Expósito, Teresa Diaz-Perdigón, Amaya Azqueta, Farzad Zamani, Takayoshi Suzuki, Silvia Maioli, Francesca Eroli, Anna Matton, Maria J. Ramírez, Maite Solas, Rosa M. Tordera, Eduardo D. Martín, Elena Puerta

J Neuroimmune Pharmacol. 2023; 18(3): 529–550. Published online 2023 Sep 12. doi: 10.1007/s11481-023-10084-9

PMCID:: PMC10577113

Abstract Article PDF–2.7M

Select item 104548648.

A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma

Alexandra V. Schmidt, Satdarshan P. Monga, Edward V. Prochownik, Eric S. Goetzman

Int J Mol Sci. 2023 Aug; 24(16): 12618. Published online 2023 Aug 9. doi: 10.3390/ijms241612618

PMCID:: PMC10454864

Abstract Article PDF–7.2M

Select item 104437969.

Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation

Jingyuan Sun, Pei Li, Honglian Gui, Laure Rittié, David B. Lombard, Katrin Rietscher, Thomas M. Magin, Qing Xie, Li Liu, M. Bishr Omary

JCI Insight. 2023 Jul 24; 8(14): e166314. Published online 2023 Jul 24. doi: 10.1172/jci.insight.166314

PMCID:: PMC10443796

Abstract Article PDF–14M

Select item 1021920710.

SIRT2 Deficiency Aggravates Diet-Induced Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites

Xingyu Li, Yimeng Du, Chunyuan Xue, Xiaofeng Kang, Chao Sun, Huanyan Peng, Liaoxin Fang, Yuchen Han, Xiaojie Xu, Caiyan Zhao

Int J Mol Sci. 2023 May; 24(10): 8970. Published online 2023 May 18. doi: 10.3390/ijms24108970

PMCID:: PMC10219207

Abstract Article PDF–9.0M

Select item 934589611.

Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation

Miao Wang, Yugang Zhang, Garrison P. Komaniecki, Xuan Lu, Ji Cao, Mingming Zhang, Tao Yu, Dan Hou, Nicole A. Spiegelman, Ming Yang, Ian R. Price, Hening Lin

Nat Commun. 2022; 13: 4494. Published online 2022 Aug 2. doi: 10.1038/s41467-022-32227-x

PMCID:: PMC9345896

Abstract Article PDF–3.3M

Select item 922377512.

SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway

Helena Leal, João Cardoso, Patrícia Valério, Marta Quatorze, Vítor Carmona, Janete Cunha-Santos, Luís Pereira de Almeida, Cláudia Pereira, Cláudia Cavadas, Pedro Gomes

Int J Mol Sci. 2022 Jun; 23(12): 6790. Published online 2022 Jun 17. doi: 10.3390/ijms23126790

PMCID:: PMC9223775

Abstract Article PDF–6.6M

Select item 905444713.

SIRT2 Affects Cell Proliferation and Apoptosis by Suppressing the Level of Autophagy in Renal Podocytes

Shuang Liu, Xiangfu Gao, Zhenliang Fan, Qiao Wang

Dis Markers. 2022; 2022: 4586198. Published online 2022 Apr 22. doi: 10.1155/2022/4586198

PMCID:: PMC9054447

Abstract Article PDF–1.4M

Select item 905217414.

SIRT2 Regulates Proliferation and Chemotherapy Response of MLL-ENL-Driven Acute Myeloid Leukemia

Caiqing Hao, Xianyu Shao, Juan Song, Mengyuan Peng, Yimin Lao, Ryan Mack, Lei Zhang, Wei Wei, Na Liu, Tian Wang, Yuanyuan Wu, Lanyao Feng, Lijun Yin, Shouxin Wang, Xiaojian Sun, Saijuan Chen, Jiwang Zhang, Bing Li

Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Jun 12.

Published in final edited form as: Biochem Biophys Res Commun. 2022 Mar 12; 596: 36–42. Published online 2022 Jan 25. doi: 10.1016/j.bbrc.2022.01.081