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Select item 99584941.

Complex interaction network revealed by mutation of human telomerase ‘insertion in fingers’ and essential N-terminal domains and the telomere protein TPP1

Patrick Lambert-Lanteigne, Adrian Young, Chantal Autexier

J Biol Chem. 2023 Mar; 299(3): 102916. Published online 2023 Jan 14. doi: 10.1016/j.jbc.2023.102916

PMCID:: PMC9958494

Abstract Article PDF–2.5M

Select item 65996382.

Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells

Sherilyn Grill, Kamlesh Bisht, Valerie M. Tesmer, Adrienne Niederriter Shami, Saher S. Hammoud, Jayakrishnan Nandakumar

Cell Rep. Author manuscript; available in PMC 2019 Jun 30.

Published in final edited form as: Cell Rep. 2019 Jun 18; 27(12): 3511–3521.e7. doi: 10.1016/j.celrep.2019.05.073

PMCID:: PMC6599638

Abstract Article PDF–1.9M

Select item 62938693.

Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita–like phenotypes

Hemanth Tummala, Laura C. Collopy, Amanda J. Walne, Alicia Ellison, Shirleny Cardoso, Tekin Aksu, Nese Yarali, Deniz Aslan, Rüştü Fikret Akata, Juliana Teo, Zhou Songyang, Nikolas Pontikos, Jude Fitzgibbon, Kazunori Tomita, Tom Vulliamy, Inderjeet Dokal

Blood. 2018 Sep 20; 132(12): 1349–1353. Prepublished online 2018 Jul 31. doi: 10.1182/blood-2018-03-837799

PMCID:: PMC6293869

Article

Select item 51374434.

Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance

Malligarjunan Rajavel, Tivadar Orban, Mengyuan Xu, Wilnelly Hernandez-Sanchez, Maria de la Fuente, Krzysztof Palczewski, Derek J. Taylor

Nucleic Acids Res. 2016 Dec 1; 44(21): 10467–10479. Published online 2016 Sep 20. doi: 10.1093/nar/gkw846

PMCID:: PMC5137443

Abstract Article PDF–3.2M

Select item 51353505.

Structural and functional consequences of a disease mutation in the telomere protein TPP1

Kamlesh Bisht, Eric M. Smith, Valerie M. Tesmer, Jayakrishnan Nandakumar

Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46): 13021–13026. Published online 2016 Nov 2. doi: 10.1073/pnas.1605685113

PMCID:: PMC5135350

Abstract Article PDF–1.4M

Select item 45621236.

A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells

Jean-François Spinella, Pauline Cassart, Nicolas Garnier, Philippe Rousseau, Claire Drullion, Chantal Richer, Manon Ouimet, Virginie Saillour, Jasmine Healy, Chantal Autexier, Daniel Sinnett

BMC Cancer. 2015; 15: 621. Published online 2015 Sep 7. doi: 10.1186/s12885-015-1639-5

PMCID:: PMC4562123

Abstract Article PDF–813K

Select item 42153087.

Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1

Yiran Guo, Melissa Kartawinata, Jiankang Li, Hilda A. Pickett, Juliana Teo, Tatjana Kilo, Pasquale M. Barbaro, Brendan Keating, Yulan Chen, Lifeng Tian, Ahmad Al-Odaib, Roger R. Reddel, John Christodoulou, Xun Xu, Hakon Hakonarson, Tracy M. Bryan

Blood. 2014 Oct 30; 124(18): 2767–2774. Prepublished online 2014 Sep 9. doi: 10.1182/blood-2014-08-596445

PMCID:: PMC4215308

Abstract Article

Select item 41979468.

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

Alec N. Sexton, Samuel G. Regalado, Christine S. Lai, Gregory J. Cost, Colleen M. O’Neil, Fyodor D. Urnov, Philip D. Gregory, Rudolf Jaenisch, Kathleen Collins, Dirk Hockemeyer

Genes Dev. 2014 Sep 1; 28(17): 1885–1899. doi: 10.1101/gad.246819.114

PMCID:: PMC4197946

Abstract Article PDF–1.8M

Select item 41809729.

Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1

Hande Kocak, Bari J. Ballew, Kamlesh Bisht, Rebecca Eggebeen, Belynda D. Hicks, Shalabh Suman, Adri O’Neil, Neelam Giri, NCI DCEG Cancer Genomics Research Laboratory, NCI DCEG Cancer Sequencing Working Group, Ivan Maillard, Blanche P. Alter, Catherine E. Keegan, Jayakrishnan Nandakumar, Sharon A. Savage

Genes Dev. 2014 Oct 1; 28(19): 2090–2102. doi: 10.1101/gad.248567.114

PMCID:: PMC4180972

Abstract Article PDF–860K

Select item 411215610.

Multiple facets of TPP1 in telomere maintenance

Malligarjunan Rajavel, Michael R. Mullins, Derek J. Taylor

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Sep; 1844(9): 1550–1559. Published online 2014 Apr 26. doi: 10.1016/j.bbapap.2014.04.014

PMCID:: PMC4112156

Abstract Article PDF–1.5M

Select item 383429411.

Telomere-Binding Protein TPP1 Modulates Telomere Homeostasis and Confers Radioresistance to Human Colorectal Cancer Cells

Lei Yang, Wenbo Wang, Liu Hu, Xiaoxi Yang, Juan Zhong, Zheng Li, Hui Yang, Han Lei, Haijun Yu, ZhengKai Liao, Fuxiang Zhou, Conghua Xie, Yunfeng Zhou

PLoS One. 2013; 8(11): e81034. Published online 2013 Nov 19. doi: 10.1371/journal.pone.0081034

PMCID:: PMC3834294

Abstract Article PDF–2.0M

Select item 361929312.

Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment

Yi Zhang, Liuh-Yow Chen, Xin Han, Wei Xie, Hyeung Kim, Dong Yang, Dan Liu, Zhou Songyang

Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14): 5457–5462. Published online 2013 Mar 18. doi: 10.1073/pnas.1217733110

PMCID:: PMC3619293

Abstract Article PDF–1.0M

Select item 352187213.

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

Jayakrishnan Nandakumar, Caitlin F. Bell, Ina Weidenfeld, Arthur J. Zaug, Leslie A. Leinwand, Thomas R. Cech

Nature. Author manuscript; available in PMC 2013 Jun 13.

Published in final edited form as: Nature. 2012 Dec 13; 492(7428): 285–289. Published online 2012 Oct 24. doi: 10.1038/nature11648

PMCID:: PMC3521872

Abstract Article PDF–898K

Select item 1108130914.

TPP1 is associated with risk of advanced precursors and cervical cancer survival

Qiao-Li Wang, Caifeng Gong, Xiang-Yu Meng, Min Fu, Hui Yang, Fuxiang Zhou, Qiuji Wu, Yunfeng Zhou

PLoS One. 2024; 19(5): e0298118. Published online 2024 May 9. doi: 10.1371/journal.pone.0298118

PMCID:: PMC11081309

Abstract Article PDF–2.0M

Select item 1059047615.

TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma

Pattra Chun-on, Angela M. Hinchie, Holly C. Beale, Agustin A. Gil Silva, Elizabeth Rush, Cindy Sander, Carla J. Connelly, Brittani K.N. Seynnaeve, John M. Kirkwood, Olena M. Vaske, Carol W. Greider, Jonathan K. Alder

Science. Author manuscript; available in PMC 2023 Oct 22.

Published in final edited form as: Science. 2022 Nov 11; 378(6620): 664–668. Published online 2022 Nov 10. doi: 10.1126/science.abq0607