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Select item 86579121.

Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity

Charles R. Lefèvre, Marc Le Vée, Sophie Gaubert, Elodie Jouan, Arnaud Bruyere, Caroline Moreau, Olivier Fardel

Int J Mol Sci. 2021 Dec; 22(23): 12926. Published online 2021 Nov 29. doi: 10.3390/ijms222312926

PMCID:: PMC8657912

Abstract Article PDF–1.5M

Select item 84321722.

Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model

Tim N. Koepp, Alexander Tokaj, Pavel I. Nedvetsky, Ana Carolina Conchon Costa, Beatrice Snieder, Rita Schröter, Giuliano Ciarimboli

Int J Mol Sci. 2021 Sep; 22(17): 9658. Published online 2021 Sep 6. doi: 10.3390/ijms22179658

PMCID:: PMC8432172

Abstract Article PDF–5.7M

Select item 79737963.

Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy

Maiko Abumiya, Naoto Takahashi, Saori Takahashi, Tomoko Yoshioka, Yoshihiro Kameoka, Masatomo Miura

Sci Rep. 2021; 11: 6362. Published online 2021 Mar 18. doi: 10.1038/s41598-021-85757-7

PMCID:: PMC7973796

Abstract Article PDF–1.1M

Select item 70690784.

The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma

Lu Chen, Zeyang Wang, Qingwen Xu, Yuxi Liu, Le Chen, Suhang Guo, Hua Wang, Kui Zeng, Junqing Liu, Su Zeng, Lushan Yu

Theranostics. 2020; 10(8): 3562–3578. Published online 2020 Feb 18. doi: 10.7150/thno.39944

PMCID:: PMC7069078

Abstract Article PDF–2.7M

Select item 68435715.

Effects of Single Nucleotide Polymorphism Ala270Ser (rs316019) on the Function and Regulation of hOCT2

Dominik Frenzel, Christina Köppen, Oliver Bolle Bauer, Uwe Karst, Rita Schröter, Mladen V. Tzvetkov, Giuliano Ciarimboli

Biomolecules. 2019 Oct; 9(10): 578. Published online 2019 Oct 7. doi: 10.3390/biom9100578

PMCID:: PMC6843571

Abstract Article PDF–1.4M

Select item 66155356.

Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma

Qianying Zhu, Lushan Yu, Zhiyuan Qin, Lu Chen, Haihong Hu, Xiaoli Zheng, Su Zeng

Epigenetics. 2019; 14(8): 791–803. Published online 2019 May 15. doi: 10.1080/15592294.2019.1615354

PMCID:: PMC6615535

Abstract Article PDF–4.1M

Select item 45032267.

The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization

Sabine Brast, Alexander Grabner, Sonja Sucic, Harald H. Sitte, Edwin Hermann, Hermann Pavenstädt, Eberhard Schlatter, Giuliano Ciarimboli

FASEB J. Author manuscript; available in PMC 2015 Jul 15.

Published in final edited form as: FASEB J. 2012 Mar; 26(3): 976–986. Published online 2011 Nov 15. doi: 10.1096/fj.11-180679

PMCID:: PMC4503226

Abstract Article PDF–1.0M

Select item 42961868.

Organic Cation Transporter Variation and Response to Smoking Cessation Therapies

Andrew W. Bergen, Harold S. Javitz, Ruth Krasnow, Martha Michel, Denise Nishita, David V. Conti, Christopher K. Edlund, Pui-Yan Kwok, Jennifer B. McClure, Richard B. Kim, Sharon M. Hall, Rachel F. Tyndale, Timothy B. Baker, Neal L. Benowitz, Gary E. Swan

Nicotine Tob Res. 2014 Dec; 16(12): 1638–1646. Published online 2014 Aug 20. doi: 10.1093/ntr/ntu161

PMCID:: PMC4296186

Abstract Article PDF–540K

Select item 40967619.

Identification of Functional Amino Acid Residues Involved in Polyamine and Agmatine Transport by Human Organic Cation Transporter 2

Kyohei Higashi, Masataka Imamura, Satoshi Fudo, Takeshi Uemura, Ryotaro Saiki, Tyuji Hoshino, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi

PLoS One. 2014; 9(7): e102234. Published online 2014 Jul 14. doi: 10.1371/journal.pone.0102234

PMCID:: PMC4096761

Abstract Article PDF–1.8M

Select item 388547410.

Organic cation transporter 2 and tumor budding as independent prognostic factors in metastatic colorectal cancer patients treated with oxaliplatin-based chemotherapy

Shigenobu Tatsumi, Hiroshi Matsuoka, Yumi Hashimoto, Kohei Hatta, Kotaro Maeda, Shingo Kamoshida

Int J Clin Exp Pathol. 2014; 7(1): 204–212. Published online 2013 Dec 9.

PMCID:: PMC3885474

Abstract Article PDF–953K

Select item 340458511.

Functional significance of conserved cysteines in the human organic cation transporter 2

Ryan M. Pelis, Yodying Dangprapai, Yaofeng Cheng, Xiaohong Zhang, Jennifer Terpstra, Stephen H. Wright

Am J Physiol Renal Physiol. 2012 Jul 15; 303(2): F313–F320. Published online 2012 May 9. doi: 10.1152/ajprenal.00038.2012

PMCID:: PMC3404585

Abstract Article

Select item 334812612.

Pharmacogenetics Meets Metabolomics: Discovery of Tryptophan as a New Endogenous OCT2 Substrate Related to Metformin Disposition

Im-Sook Song, Do Yup Lee, Min-Hye Shin, Hyunmi Kim, Yun Gyong Ahn, Inmyoung Park, Kyoung Heon Kim, Tobias Kind, Jae-Gook Shin, Oliver Fiehn, Kwang-Hyeon Liu

PLoS One. 2012; 7(5): e36637. Published online 2012 May 8. doi: 10.1371/journal.pone.0036637

PMCID:: PMC3348126

Abstract Article PDF–1.6M

Select item 328832313.

Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients

Giuliano Ciarimboli, Cynthia S. Lancaster, Eberhard Schlatter, Ryan M. Franke, Jason A. Sprowl, Hermann Pavenstädt, Vivian Massmann, Denise Guckel, Ron H. J. Mathijssen, Wenjian Yang, Ching-Hon Pui, Mary V. Relling, Edwin Herrmann, Alex Sparreboom

Clin Cancer Res. Author manuscript; available in PMC 2013 Feb 15.

Published in final edited form as: Clin Cancer Res. 2012 Feb 15; 18(4): 1101–1108. Published online 2012 Jan 5. doi: 10.1158/1078-0432.CCR-11-2503

PMCID:: PMC3288323

Abstract Article PDF–726K

Select item 310449614.

Effect of Genetic Variation in the Organic Cation Transporter 2, OCT2, on the Renal Elimination of Metformin

Ying Chen, Shuanglian Li, Chaline Brown, Stephen Cheatham, Richard A. Castro, Maya K. Leabman, Thomas J. Urban, Ligong Chen, Sook Wah Yee, Ji Ha Choi, Yong Huang, Claire M. Brett, Esteban G. Burchard, Kathleen M. Giacomini

Pharmacogenet Genomics. Author manuscript; available in PMC 2011 May 31.

Published in final edited form as: Pharmacogenet Genomics. 2009 Jul; 19(7): 497–504. doi: 10.1097/FPC.0b013e32832cc7e9

PMCID:: PMC3104496

Abstract Article PDF–261K

Select item 282921515.

Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2)

H Burger, A Zoumaro-Djayoon, AWM Boersma, J Helleman, EMJJ Berns, RHJ Mathijssen, WJ Loos, EAC Wiemer

Br J Pharmacol. 2010 Feb; 159(4): 898–908. Published online 2010 Jan 8. doi: 10.1111/j.1476-5381.2009.00569.x

PMCID:: PMC2829215

Abstract Article PDF–381K

Select item 161319116.

Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2

Giuliano Ciarimboli, Thomas Ludwig, Detlef Lang, Hermann Pavenstädt, Hermann Koepsell, Hans-Jürgen Piechota, Jörg Haier, Ulrich Jaehde, Jochen Zisowsky, Eberhard Schlatter

Am J Pathol. 2005 Dec; 167(6): 1477–1484. doi: 10.1016/S0002-9440(10)61234-5