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Select item 111370131.

Dysregulated Wnt and NFAT signaling in a Parkinson’s disease LRRK2 G2019S knock-in model

Andrea Wetzel, Si Hang Lei, Tiansheng Liu, Michael P. Hughes, Yunan Peng, Tristan McKay, Simon N. Waddington, Simone Grannò, Ahad A. Rahim, Kirsten Harvey

Sci Rep. 2024; 14: 12393. Published online 2024 May 29. doi: 10.1038/s41598-024-63130-8

PMCID:: PMC11137013

Abstract Article PDF–13M

Select item 110840372.

Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice

Dan Li, Shu-fang Yu, Lin Lin, Jie-ru Guo, Si-mei Huang, Xi-lin Wu, Han-lin You, Xiao-juan Cheng, Qiu-yang Zhang, Yu-qi Zeng, Xiao-dong Pan

J Neuroinflammation. 2024; 21: 123. Published online 2024 May 9. doi: 10.1186/s12974-024-03125-4

PMCID:: PMC11084037

Abstract Article PDF–3.8M

Select item 109107833.

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression

Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett, Michael X. Henderson

Transl Neurodegener. 2024; 13: 13. Published online 2024 Mar 4. doi: 10.1186/s40035-024-00403-2

PMCID:: PMC10910783

Abstract Article PDF–15M

Select item 104009614.

LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition

Narayana Yadavalli, Shawn M. Ferguson

Proc Natl Acad Sci U S A. 2023 Aug 1; 120(31): e2303789120. Published online 2023 Jul 24. doi: 10.1073/pnas.2303789120

PMCID:: PMC10400961

Abstract Article PDF–9.0M

Select item 103908765.

Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease

Qinfang Liu, Dong Zhu, Naren Li, Shifan Chen, Liang Hu, Jianzhong Yu, Yulan Xiong

EMBO J. 2023 Aug; 42(15): e113410. Published online 2023 Jun 27. doi: 10.15252/embj.2022113410

PMCID:: PMC10390876

Abstract Article PDF–8.0M

Select item 103406686.

LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer’s and Parkinson’s Disease-Related Neuroinflammation

Veronica Mutti, Giulia Carini, Alice Filippini, Stefania Castrezzati, Lorena Giugno, Massimo Gennarelli, Isabella Russo

Cells. 2023 Jul; 12(13): 1799. Published online 2023 Jul 6. doi: 10.3390/cells12131799

PMCID:: PMC10340668

Abstract Article PDF–16M

Select item 103289027.

Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis

Diego Cabezudo, George Tsafaras, Eva Van Acker, Chris Van den Haute, Veerle Baekelandt

Acta Neuropathol. 2023; 146(2): 245–261. Published online 2023 Jun 8. doi: 10.1007/s00401-023-02595-9

PMCID:: PMC10328902

Abstract Article PDF–2.2M

Select item 98654648.

Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages

Asmaa Oun, Emmy Hoeksema, Ahmed Soliman, Famke Brouwer, Fabiola García-Reyes, Henderikus Pots, Marina Trombetta-Lima, Arjan Kortholt, Amalia M. Dolga

Int J Mol Sci. 2023 Jan; 24(2): 1644. Published online 2023 Jan 13. doi: 10.3390/ijms24021644

PMCID:: PMC9865464

Abstract Article PDF–3.3M

Select item 96872719.

Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice

Giacomo Sitzia, Olga Skiteva, Karima Chergui

Biomolecules. 2022 Nov; 12(11): 1635. Published online 2022 Nov 4. doi: 10.3390/biom12111635

PMCID:: PMC9687271

Abstract Article PDF–1.3M

Select item 964968810.

R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations

Harry S. Xenias, Chuyu Chen, Shuo Kang, Suraj Cherian, Xiaolei Situ, Bharanidharan Shanmugasundaram, Guoxiang Liu, Giuseppe Scesa, C. Savio Chan, Loukia Parisiadou

Commun Biol. 2022; 5: 1211. Published online 2022 Nov 10. doi: 10.1038/s42003-022-04136-8

PMCID:: PMC9649688

Abstract Article PDF–2.5M

Select item 933876411.

Cognitive deficits and altered cholinergic innervation in young adult male mice carrying a Parkinson’s disease Lrrk2^G2019S knockin mutation

Ayan Hussein, Alexander Tielemans, Mark G. Baxter, Deanna L. Benson, George W. Huntley

Exp Neurol. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Exp Neurol. 2022 Sep; 355: 114145. Published online 2022 Jun 19. doi: 10.1016/j.expneurol.2022.114145

PMCID:: PMC9338764

Abstract Article PDF–1.0M

Select item 921788912.

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease

Ludovica Iovino, Veronica Giusti, Francesca Pischedda, Elena Giusto, Nicoletta Plotegher, Antonella Marte, Ilaria Battisti, Angela Di Iacovo, Algerta Marku, Giovanni Piccoli, Rina Bandopadhyay, Carla Perego, Tiziana Bonifacino, Giambattista Bonanno, Cristina Roseti, Elena Bossi, Giorgio Arrigoni, Luigi Bubacco, Elisa Greggio, Sabine Hilfiker, Laura Civiero

Acta Neuropathol. 2022; 144(1): 81–106. Published online 2022 May 21. doi: 10.1007/s00401-022-02437-0

PMCID:: PMC9217889

Abstract Article PDF–13M

Select item 896268713.

LRRK2 regulates actin assembly for spindle migration and mitochondrial function in mouse oocyte meiosis

Zhen-Nan Pan, Jing-Cai Liu, Jia-Qian Ju, Yue Wang, Shao-Chen Sun

J Mol Cell Biol. 2022 Jan; 14(1): mjab079. Published online 2021 Dec 16. doi: 10.1093/jmcb/mjab079

Correction in:: J Mol Cell Biol. 2022 Feb; 14(2): mjac030.

PMCID:: PMC8962687

Abstract Article PDF–3.8M

Select item 886522914.

LRRK2 is required for CD38-mediated NAADP-Ca²⁺ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells

Neel R. Nabar, Christopher N. Heijjer, Chong-Shan Shi, Il-Young Hwang, Sundar Ganesan, Mikael C. I. Karlsson, John H. Kehrl

Autophagy. 2022; 18(1): 204–222. Published online 2021 Jul 27. doi: 10.1080/15548627.2021.1954779

PMCID:: PMC8865229

Abstract Article PDF–5.8M

Select item 875134715.

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert, Andrew B. West

Mol Neurodegener. 2022; 17: 7. Published online 2022 Jan 10. doi: 10.1186/s13024-021-00509-5

PMCID:: PMC8751347

Abstract Article PDF–5.9M

Select item 863867616.

Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains

Jungwoo Wren Kim, Xiling Yin, Ian Martin, Yulan Xiong, Stephen M. Eacker, Nicholas T. Ingolia, Ted M. Dawson, Valina L. Dawson

eNeuro. 2021 Nov-Dec; 8(6): ENEURO.0310-21.2021. Prepublished online 2021 Nov 10. Published online 2021 Nov 30. doi: 10.1523/ENEURO.0310-21.2021

PMCID:: PMC8638676

Abstract Article PDF–2.5M

Select item 862267017.

Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice

Andrea Maset, Marco Albanesi, Antonio di Soccio, Martina Canova, Marco dal Maschio, Claudia Lodovichi

Cells. 2021 Nov; 10(11): 3212. Published online 2021 Nov 17. doi: 10.3390/cells10113212

PMCID:: PMC8622670

Abstract Article PDF–5.7M

Select item 853631618.

LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis

Yujie Tian, Jiaoyan Lv, Ziyan Su, Tao Wu, Xiaoguang Li, Xiaoyu Hu, Jianhong Zhang, Li Wu

Proc Natl Acad Sci U S A. 2021 Aug 31; 118(35): e2106685118. Published online 2021 Aug 26. doi: 10.1073/pnas.2106685118

PMCID:: PMC8536316

Abstract Article PDF–2.1M

Select item 852602719.

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2^R1441G mice

Huifang Liu, Philip Wing-Lok Ho, Chi-Ting Leung, Shirley Yin-Yu Pang, Eunice Eun Seo Chang, Zoe Yuen-Kiu Choi, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho

Autophagy. 2021; 17(10): 3196–3220. Published online 2020 Dec 10. doi: 10.1080/15548627.2020.1850008

PMCID:: PMC8526027

Abstract Article PDF–28M

Select item 825753720.

Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance

Linn Streubel-Gallasch, Veronica Giusti, Michele Sandre, Isabella Tessari, Nicoletta Plotegher, Elena Giusto, Anna Masato, Ludovica Iovino, Ilaria Battisti, Giorgio Arrigoni, Derya Shimshek, Elisa Greggio, Marie-Eve Tremblay, Luigi Bubacco, Anna Erlandsson, Laura Civiero

Mol Neurobiol. 2021; 58(7): 3119–3140. Published online 2021 Feb 24. doi: 10.1007/s12035-021-02327-8