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Select item 110917071.

Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation

Maoxiong Wu, Jing Tan, Zhengyu Cao, Yangwei Cai, Zhaoqi Huang, Zhiteng Chen, Wanbing He, Xiao Liu, Yuan Jiang, Qingyuan Gao, Bingqing Deng, Jingfeng Wang, Woliang Yuan, Haifeng Zhang, Yangxin Chen

Redox Biol. 2024 Jul; 73: 103184. Published online 2024 May 5. doi: 10.1016/j.redox.2024.103184

PMCID:: PMC11091707

Abstract Article PDF–14M

Select item 103633992.

In-depth analysis of the Sirtuin 5-regulated mouse brain malonylome and succinylome using library-free data-independent acquisitions

Joanna Bons, Jacob Rose, Ran Zhang, Jordan B Burton, Christopher Carrico, Eric Verdin, Birgit Schilling

Proteomics. Author manuscript; available in PMC 2023 Jul 23.

Published in final edited form as: Proteomics. 2023 Feb; 23(3-4): e2100371. Published online 2022 Dec 18. doi: 10.1002/pmic.202100371

PMCID:: PMC10363399

Abstract Article PDF–2.0M

Select item 99850523.

Histone malonylation is regulated by SIRT5 and KAT2A

Ran Zhang, Joanna Bons, Grace Scheidemantle, Xiaojing Liu, Olga Bielska, Chris Carrico, Jacob Rose, Indra Heckenbach, Morten Scheibye-Knudsen, Birgit Schilling, Eric Verdin

iScience. 2023 Mar 17; 26(3): 106193. Published online 2023 Feb 13. doi: 10.1016/j.isci.2023.106193

PMCID:: PMC9985052

Abstract Article PDF–3.8M

Select item 92939764.

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

Angela H. Guo, Rachael Baliira, Mary E. Skinner, Surinder Kumar, Anthony Andren, Li Zhang, Robert S. Goldsmith, Shaday Michan, Norma J. Davis, Merissa W. Maccani, Sharlene M. Day, David A. Sinclair, Matthew J. Brody, Costas A. Lyssiotis, Adam B. Stein, David B. Lombard

Sci Rep. 2022; 12: 12258. Published online 2022 Jul 18. doi: 10.1038/s41598-022-16506-7

PMCID:: PMC9293976

Abstract Article PDF–3.0M

Select item 88047365.

Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions

Shouan Zhu, Albert Batushansky, Anita Jopkiewicz, Dawid Makosa, Kenneth M. Humphries, Holly Van Remmen, Timothy M. Griffin

Cartilage. 2021 Dec; 13(2 Suppl): 1185S–1199S. Published online 2021 Feb 11. doi: 10.1177/1947603521993209

PMCID:: PMC8804736

Abstract Article PDF–1.4M

Select item 87107266.

Sirtuin 5 is Dispensable for CD8⁺ T Cell Effector and Memory Differentiation

Qianqian Duan, Jiying Ding, Fangfang Li, Xiaowei Liu, Yunan Zhao, Hongxiu Yu, Yong Liu, Lianjun Zhang

Front Cell Dev Biol. 2021; 9: 761193. Published online 2021 Dec 13. doi: 10.3389/fcell.2021.761193

PMCID:: PMC8710726

Abstract Article PDF–3.6M

Select item 76479677.

SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis

Cuiping Zhang, Ke Wang, Zuojian Hu, Lujie Yang, Bin Wei, Shan Li, Xue Qin, Pengyuan Yang, Hongxiu Yu

Protein Cell. 2020 Nov; 11(11): 846–851. Published online 2020 May 15. doi: 10.1007/s13238-020-00709-7

PMCID:: PMC7647967

Article PDF–420K

Select item 69007908.

Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

Takuto Chiba, Kevin D. Peasley, Kasey R. Cargill, Katherine V. Maringer, Sivakama S. Bharathi, Elina Mukherjee, Yuxun Zhang, Anja Holtz, Nathan Basisty, Shiva D. Yagobian, Birgit Schilling, Eric S. Goetzman, Sunder Sims-Lucas

J Am Soc Nephrol. 2019 Dec; 30(12): 2384–2398. Published online 2019 Oct 1. doi: 10.1681/ASN.2019020163

PMCID:: PMC6900790

Abstract Article

Select item 62558799.

Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections

Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy, Thierry Roger

Front Immunol. 2018; 9: 2675. Published online 2018 Nov 20. doi: 10.3389/fimmu.2018.02675

PMCID:: PMC6255879

Abstract Article PDF–1.9M

Select item 579763110.

Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain

Kevin B. Koronowski, Nathalie Khoury, Kahlilia C. Morris-Blanco, Holly M. Stradecki-Cohan, Timothy J. Garrett, Miguel A. Perez-Pinzon

Front Neurosci. 2018; 12: 32. Published online 2018 Jan 30. doi: 10.3389/fnins.2018.00032

PMCID:: PMC5797631

Abstract Article PDF–7.5M

Select item 571261711.

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

Kathleen A. Hershberger, Dennis M. Abraham, Angelical S. Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W. Locasale, Matthew D. Hirschey

J Biol Chem. 2017 Dec 1; 292(48): 19767–19781. Published online 2017 Oct 2. doi: 10.1074/jbc.M117.809897

PMCID:: PMC5712617

Abstract Article PDF–3.9M

Select item 492202312.

SIRT5 Deficiency Enhances Susceptibility to Kainate-Induced Seizures and Exacerbates Hippocampal Neurodegeneration not through Mitochondrial Antioxidant Enzyme SOD2

Fengling Li, Lei Liu

Front Cell Neurosci. 2016; 10: 171. Published online 2016 Jun 27. doi: 10.3389/fncel.2016.00171

PMCID:: PMC4922023

Abstract Article PDF–3.2M

Select item 484347413.

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella D. Nelson, John A. Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert S. Weiss, Jason W. Locasale, Johan Auwerx, Hening Lin

Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16): 4320–4325. Published online 2016 Apr 5. doi: 10.1073/pnas.1519858113

PMCID:: PMC4843474

Abstract Article PDF–1.0M

Select item 457148714.

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

Yuya Nishida, Matthew J. Rardin, Chris Carrico, Wenjuan He, Alexandria K. Sahu, Philipp Gut, Rami Najjar, Mark Fitch, Marc Hellerstein, Bradford W. Gibson, Eric Verdin

Mol Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Mol Cell. 2015 Jul 16; 59(2): 321–332. Published online 2015 Jun 11. doi: 10.1016/j.molcel.2015.05.022

PMCID:: PMC4571487

Abstract Article PDF–1.7M

Select item 378629715.

Metabolic Characterization of a Sirt5 deficient mouse model

Jiujiu Yu, Sushabhan Sadhukhan, Lilia G. Noriega, Norman Moullan, Bin He, Robert S. Weiss, Hening Lin, Kristina Schoonjans, Johan Auwerx

Sci Rep. 2013; 3: 2806. Published online 2013 Sep 30. doi: 10.1038/srep02806

PMCID:: PMC3786297

Abstract Article PDF–1.4M

Select item 280602916.

Urea cycle regulation by mitochondrial sirtuin, SIRT5

Takashi Nakagawa, Leonard Guarente

Aging (Albany NY) 2009 Jun; 1(6): 578–581. Published online 2009 Jun 29. doi: 10.18632/aging.100062

PMCID:: PMC2806029

Abstract Article PDF–272K

Select item 1075809317.

Can Wei, Meixin Shi, Shiyun Dong, Zhitao Li, Bingbing Zhao, Dan Liu, Guopeng Li, Jie Cen, Ligen Yu, Xiao Liang, Lili Shi

Int J Biol Sci. 2024; 20(2): 585–605. Published online 2024 Jan 1. doi: 10.7150/ijbs.83306

PMCID:: PMC10758093

Abstract Article PDF–11M

Select item 999637018.

The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease

Judy Baek, Kelli Sas, Chenchen He, Viji Nair, William Giblin, Ayaka Inoki, Hongyu Zhang, Yang Yingbao, Jeffrey Hodgin, Robert G. Nelson, Frank C. Brosius, III, Matthias Kretzler, Paul M. Stemmer, David B. Lombard, Subramaniam Pennathur

J Biol Chem. 2023 Mar; 299(3): 102960. Published online 2023 Feb 2. doi: 10.1016/j.jbc.2023.102960

PMCID:: PMC9996370

Abstract Article PDF–2.7M

Select item 975327419.

Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1

Qian Xia, Shuai Gao, Tangrui Han, Meng Mao, Gaofeng Zhan, Yonghong Wang, Xing Li

J Neuroinflammation. 2022; 19: 301. Published online 2022 Dec 14. doi: 10.1186/s12974-022-02665-x

PMCID:: PMC9753274

Abstract Article PDF–11M

Select item 898994820.

Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage

Xing Liu, Fangjing Rong, Jinhua Tang, Chunchun Zhu, Xiaoyun Chen, Shuke Jia, Zixuan Wang, Xueyi Sun, Hongyan Deng, Huangyuan Zha, Gang Ouyang, Wuhan Xiao

Cell Death Differ. 2022 Apr; 29(4): 722–736. Published online 2021 Oct 12. doi: 10.1038/s41418-021-00886-w