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Select item 54784751.

Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts

Kai Hu, Bjorn R. Olsen, Tatiana Y. Besschetnova

Matrix Biol. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Matrix Biol. 2017 Oct; 62: 105–114. Published online 2016 Dec 20. doi: 10.1016/j.matbio.2016.12.002

PMCID:: PMC5478475

Abstract Article PDF–1024K

Select item 47186982.

Anthrax Toxin Receptor 1 Is Essential for Arteriogenesis in a Mouse Model of Hindlimb Ischemia

N. J. Andersen, E. A. Boguslawski, A. S. Naidu, C. Szot, J. L. Bromberg-White, K. Kits, C. Y. Kuk, L. E. Holton, B. St. Croix, C. M. Chambers, N. S. Duesbery

PLoS One. 2016; 11(1): e0146586. Published online 2016 Jan 19. doi: 10.1371/journal.pone.0146586

PMCID:: PMC4718698

Abstract Article PDF–1.7M

Select item 35640633.

The Receptors that Mediate the Direct Lethality of Anthrax Toxin

Shihui Liu, Yi Zhang, Benjamin Hoover, Stephen H. Leppla

Toxins (Basel) 2013 Jan; 5(1): 1–8. Published online 2012 Dec 27. doi: 10.3390/toxins5010001

PMCID:: PMC3564063

Abstract Article PDF–329K

Select item 96747014.

Cancer cell survival depends on collagen uptake into tumor-associated stroma

Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo, Brad St. Croix

Nat Commun. 2022; 13: 7078. Published online 2022 Nov 18. doi: 10.1038/s41467-022-34643-5

PMCID:: PMC9674701

Abstract Article PDF–7.1M

Select item 82404515.

Targeted silencing of TEM8 suppresses non-small cell lung cancer tumor growth via the ERK/Bcl-2 signaling pathway

Quan Gong, Jing Deng, Lijuan Zhang, Chunyan Zhou, Chaojiang Fu, Xicai Wang, Li Zhuang

Mol Med Rep. 2021 Aug; 24(2): 595. Published online 2021 Jun 22. doi: 10.3892/mmr.2021.12234

PMCID:: PMC8240451

Abstract Article PDF–771K

Select item 50639856.

Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting

Kuang-Hua Chen, Shihui Liu, Clinton E. Leysath, Sharmina Miller-Randolph, Yi Zhang, Rasem Fattah, Thomas H. Bugge, Stephen H. Leppla

J Biol Chem. 2016 Oct 14; 291(42): 22021–22029. Published online 2016 Aug 23. doi: 10.1074/jbc.M116.753301

PMCID:: PMC5063985

Abstract Article PDF–338K

Select item 32895477.

TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types

Amit Chaudhary, Mary Beth Hilton, Steven Seaman, Diana C. Haines, Susan Stevenson, Peter K. Lemotte, William R. Tschantz, Xiaoyan M. Zhang, Saurabh Saha, Tony Fleming, Brad St. Croix

Cancer Cell. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Cancer Cell. 2012 Feb 14; 21(2): 212–226. doi: 10.1016/j.ccr.2012.01.004

PMCID:: PMC3289547

Abstract Article PDF–6.3M

Select item 32643078.

Anthrax Edema Toxin Impairs Clearance in Mice

Inka Sastalla, Shixing Tang, Devorah Crown, Shihui Liu, Michael A. Eckhaus, Indira K. Hewlett, Stephen H. Leppla, Mahtab Moayeri

Infect Immun. 2012 Feb; 80(2): 529–538. doi: 10.1128/IAI.05947-11

PMCID:: PMC3264307

Abstract Article PDF–2.1M

Select item 27218009.

Host-Derived Tumor Endothelial Marker 8 (TEM8) Promotes the Growth of Melanoma

Mike Cullen, Steven Seaman, Amit Chaudhary, Mi Young Yang, Mary Beth Hilton, Daniel Logsdon, Diana C. Haines, Lino Tessarollo, Brad St. Croix

Cancer Res. Author manuscript; available in PMC 2010 Aug 1.

Published in final edited form as: Cancer Res. 2009 Aug 1; 69(15): 6021–6026. Published online 2009 Jul 21. doi: 10.1158/0008-5472.CAN-09-1086

PMCID:: PMC2721800

Abstract Article PDF–3.6M

Select item 197315410.

Transcriptional Stimulation of Anthrax Toxin Receptors by Anthrax Edema Toxin and Bacillus anthracis Sterne Spore

Qingfu Xu, Eric D. Hesek, Mingtao Zeng

Microb Pathog. Author manuscript; available in PMC 2008 Jul 1.

Published in final edited form as: Microb Pathog. 2007 Jul; 43(1): 37–45. Published online 2007 Mar 15. doi: 10.1016/j.micpath.2007.03.002

PMCID:: PMC1973154

Abstract Article PDF–360K

Select item 871633311.

Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry

Carly Merritt, Elizabeth M. Chun, Rasem J. Fattah, Lakmali M. Silva, Quinn Q. Ma, Mahtab Moayeri, Dennis Paliga, Sebastian Neumann, Rolf Heumann, Stephen H. Leppla, Thomas H. Bugge

J Biol Chem. 2022 Jan; 298(1): 101467. Published online 2021 Dec 4. doi: 10.1016/j.jbc.2021.101467

PMCID:: PMC8716333

Abstract Article PDF–6.5M

Select item 602598812.

Tumor stroma–targeted antibody-drug conjugate triggers localized anticancer drug release

Christopher Szot, Saurabh Saha, Xiaoyan M. Zhang, Zhongyu Zhu, Mary Beth Hilton, Karen Morris, Steven Seaman, James M. Dunleavey, Kuo-Sheng Hsu, Guo-Jun Yu, Holly Morris, Deborah A. Swing, Diana C. Haines, Yanping Wang, Jennifer Hwang, Yang Feng, Dean Welsch, Gary DeCrescenzo, Amit Chaudhary, Enrique Zudaire, Dimiter S. Dimitrov, Brad St. Croix

J Clin Invest. 2018 Jul 2; 128(7): 2927–2943. Published online 2018 Jun 4. doi: 10.1172/JCI120481

PMCID:: PMC6025988

Abstract Article PDF–18M

Select item 301441813.

The Cell Surface Structure of Tumor Endothelial Marker 8 (TEM8) is Regulated by the Actin Cytoskeleton

Mi Young Yang, Amit Chaudhary, Steven Seaman, Jill Dunty, Janine Stevens, Mohammed K. Elzarrad, Arthur E. Frankel, Brad St. Croix

Biochim Biophys Acta. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Biochim Biophys Acta. 2011 Jan; 1813(1): 39–49. Published online 2010 Dec 1. doi: 10.1016/j.bbamcr.2010.11.013

PMCID:: PMC3014418

Abstract Article PDF–3.5M

Select item 494834514.

Solid tumor therapy by selectively targeting stromal endothelial cells

Shihui Liu, Jie Liu, Qian Ma, Liu Cao, Rasem J. Fattah, Zuxi Yu, Thomas H. Bugge, Toren Finkel, Stephen H. Leppla

Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28): E4079–E4087. Published online 2016 Jun 29. doi: 10.1073/pnas.1600982113

PMCID:: PMC4948345

Abstract Article PDF–1.1M

Select item 414092715.

Targeted Silencing of Anthrax Toxin Receptors Protects against Anthrax Toxins

Maria T. Arévalo, Ashley Navarro, Chenoa D. Arico, Junwei Li, Omar Alkhatib, Shan Chen, Diana Diaz-Arévalo, Mingtao Zeng

J Biol Chem. 2014 May 30; 289(22): 15730–15738. Published online 2014 Apr 17. doi: 10.1074/jbc.M113.538587

PMCID:: PMC4140927

Abstract Article PDF–1.1M

Select item 271837716.

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

Shihui Liu, Devorah Crown, Sharmina Miller-Randolph, Mahtab Moayeri, Hailun Wang, Haijing Hu, Thomas Morley, Stephen H. Leppla

Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30): 12424–12429. Published online 2009 Jul 15. doi: 10.1073/pnas.0905409106

PMCID:: PMC2718377

Abstract Article PDF–505K

Select item 717807917.

Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis

Qing Jiang, Xin Qin, Carolina Andrea Yoshida, Hisato Komori, Kei Yamana, Shinsuke Ohba, Hironori Hojo, Brad St. Croix, Viviane K. S. Kawata-Matsuura, Toshihisa Komori

Int J Mol Sci. 2020 Apr; 21(7): 2425. Published online 2020 Mar 31. doi: 10.3390/ijms21072425

PMCID:: PMC7178079

Abstract Article PDF–8.1M

Select item 132527118.

Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice

Edward J Michaud, Cymbeline T Culiat, Mitchell L Klebig, Paul E Barker, KT Cain, Debra J Carpenter, Lori L Easter, Carmen M Foster, Alysyn W Gardner, ZY Guo, Kay J Houser, Lori A Hughes, Marilyn K Kerley, Zhaowei Liu, Robert E Olszewski, Irina Pinn, Ginger D Shaw, Sarah G Shinpock, Ann M Wymore, Eugene M Rinchik, Dabney K Johnson

BMC Genomics. 2005; 6: 164. Published online 2005 Nov 21. doi: 10.1186/1471-2164-6-164

PMCID:: PMC1325271

Abstract Article PDF–989K

Select item 440953019.

Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis

Tatiana Y. Besschetnova, Takaharu Ichimura, Negin Katebi, Brad St. Croix, Joseph V. Bonventre, Bjorn R. Olsen

Matrix Biol. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: Matrix Biol. 2015 Mar; 42: 56–73. Published online 2015 Jan 5. doi: 10.1016/j.matbio.2014.12.002

PMCID:: PMC4409530

Abstract Article PDF–3.4M

Select item 307837320.

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier

Mike Cullen, Mohammed K. Elzarrad, Steven Seaman, Enrique Zudaire, Janine Stevens, Mi Young Yang, Xiujie Li, Amit Chaudhary, Lihong Xu, Mary Beth Hilton, Daniel Logsdon, Emily Hsiao, Erica V. Stein, Frank Cuttitta, Diana C. Haines, Kunio Nagashima, Lino Tessarollo, Brad St. Croix

Proc Natl Acad Sci U S A. 2011 Apr 5; 108(14): 5759–5764. Published online 2011 Mar 18. doi: 10.1073/pnas.1017192108