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Select item 78829931.

An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity

Jian‐Nan Liu, Xiang‐Shuo Kong, Ping Sun, Rui Wang, Wang Li, Qi‐Feng Chen

J Cell Mol Med. 2021 Feb; 25(4): 2082–2097. Published online 2020 Dec 29. doi: 10.1111/jcmm.16147

PMCID:: PMC7882993

Abstract Article PDF–3.6M

Select item 70604822.

Transcription factor AP‐4 (TFAP4)‐upstream ORF coding 66 aa inhibits the malignant behaviors of glioma cells by suppressing the TFAP4/long noncoding RNA 00520/microRNA‐520f‐3p feedback loop

Yipeng Wang, Chunqing Yang, Xiaobai Liu, Jian Zheng, Fangfang Zhang, Di Wang, Yixue Xue, Xiaozhi Li, Shuyuan Shen, Lianqi Shao, Yang Yang, Libo Liu, Jun Ma, Yunhui Liu

Cancer Sci. 2020 Mar; 111(3): 891–906. Published online 2020 Feb 11. doi: 10.1111/cas.14308

PMCID:: PMC7060482

Abstract Article PDF–4.2M

Select item 65905773.

TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3K/AKT Signaling Pathway

Tao Huang, Qi-Feng Chen, Bo-Yang Chang, Lu-Jun Shen, Wang Li, Pei-Hong Wu, Wei-Jun Fan

Dis Markers. 2019; 2019: 7129214. Published online 2019 Jun 10. doi: 10.1155/2019/7129214

PMCID:: PMC6590577

Abstract Article PDF–6.8M

Select item 36985214.

AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer

Rene Jackstadt, Simone Röh, Jens Neumann, Peter Jung, Reinhard Hoffmann, David Horst, Christian Berens, Georg W. Bornkamm, Thomas Kirchner, Antje Menssen, Heiko Hermeking

J Exp Med. 2013 Jul 1; 210(7): 1331–1350. doi: 10.1084/jem.20120812

PMCID:: PMC3698521

Abstract Article PDF–3.9M

Select item 33539135.

Down-Regulation of AP-4 Inhibits Proliferation, Induces Cell Cycle Arrest and Promotes Apoptosis in Human Gastric Cancer Cells

Xinghua Liu, Bo Zhang, Yan Guo, Qi Liang, Changyao Wu, Lei Wu, Kaixiong Tao, Guobin Wang, Jianying Chen

PLoS One. 2012; 7(5): e37096. Published online 2012 May 16. doi: 10.1371/journal.pone.0037096

PMCID:: PMC3353913

Abstract Article PDF–2.8M

Select item 102444356.

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

Margaret A. Potts, Shinsuke Mizutani, Alexandra L. Garnham, Connie S. N. Li Wai Suen, Andrew J. Kueh, Lin Tai, Martin Pal, Andreas Strasser, Marco J. Herold

Cell Death Differ. 2023 Jun; 30(6): 1447–1456. Published online 2023 Mar 9. doi: 10.1038/s41418-023-01145-w

PMCID:: PMC10244435

Abstract Article PDF–3.2M

Select item 99295167.

Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer

Kimberly R. Hagel, Rand Arafeh, Sydney Gang, Taylor E. Arnoff, Rebecca C. Larson, John G. Doench, Nathan D. Mathewson, Kai W. Wucherpfennig, Marcela V. Maus, William C. Hahn

Cancer Res. 2023 Feb 15; 83(4): 613–625. Published online 2022 Dec 22. doi: 10.1158/0008-5472.CAN-22-2245

PMCID:: PMC9929516

Abstract Article PDF–2.5M

Select item 88059578.

Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma

Weiwei Wang, Jianjun Wu, Xulei Dai, Kun Cheng

Bioengineered. 2022; 13(1): 1626–1636. Published online 2022 Jan 8. doi: 10.1080/21655979.2021.2021125

PMCID:: PMC8805957

Abstract Article PDF–3.5M

Select item 88059419.

Upregulating microRNA-373-3p promotes apoptosis and inhibits metastasis of hepatocellular carcinoma cells

Hongbin Li, Nan Wang, Yuntian Xu, Xiao Chang, Jing Ke, Jun Yin

Bioengineered. 2022; 13(1): 1304–1319. Published online 2022 Jan 5. doi: 10.1080/21655979.2021.2014616

PMCID:: PMC8805941

Abstract Article PDF–4.2M

Select item 674892310.

The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression

Rachael Thomas, Davide Trapani, Lily Goodyer-Sait, Marketa Tomkova, Ceres Fernandez-Rozadilla, Nora Sahnane, Connor Woolley, Hayley Davis, Laura Chegwidden, Skirmantas Kriaucionis, Timothy Maughan, Simon Leedham, Claire Palles, Daniela Furlan, Ian Tomlinson, Annabelle Lewis

Sci Rep. 2019; 9: 13463. Published online 2019 Sep 17. doi: 10.1038/s41598-019-49952-x

PMCID:: PMC6748923

Abstract Article PDF–2.7M

Select item 617219211.

Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma

Shuobo Boboila, Gonzalo Lopez, Jiyang Yu, Debarshi Banerjee, Angela Kadenhe-Chiweshe, Eileen P. Connolly, Jessica J. Kandel, Presha Rajbhandari, Jose M. Silva, Andrea Califano, Darrell J. Yamashiro

Oncogene. 2018; 37(40): 5451–5465. Published online 2018 Jun 7. doi: 10.1038/s41388-018-0326-9

PMCID:: PMC6172192

Abstract Article PDF–4.9M

Select item 568056912.

AP4 modulated by the PI3K/AKT pathway promotes prostate cancer proliferation and metastasis of prostate cancer via upregulating L-plastin

Changhao Chen, Qingqing Cai, Wang He, Thomas B Lam, Jianxun Lin, Yue Zhao, Xu Chen, Peng Gu, Hao Huang, Miaoxin Xue, Hao Liu, Feng Su, Jian Huang, Jianping Zheng, Tianxin Lin

Cell Death Dis. 2017 Oct; 8(10): e3060. Published online 2017 Oct 5. doi: 10.1038/cddis.2017.437

PMCID:: PMC5680569

Abstract Article PDF–7.1M

Select item 546481913.

USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4

Yongmin Li, Yanmei Yang, Jingwen Li, He Liu, Fuxun Chen, Bingyang Li, Binbin Cui, Yanlong Liu

Oncotarget. 2017 May 16; 8(20): 32683–32695. Published online 2017 Mar 6. doi: 10.18632/oncotarget.15950

PMCID:: PMC5464819

Abstract Article PDF–3.5M

Select item 534239214.

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4

Chengyuan Xue, Denise M.T. Yu, Samuele Gherardi, Jessica Koach, Giorgio Milazzo, Laura Gamble, Bing Liu, Emanuele Valli, Amanda J. Russell, Wendy B. London, Tao Liu, Belamy B. Cheung, Glenn M. Marshall, Giovanni Perini, Michelle Haber, Murray D. Norris

Oncotarget. 2016 Aug 23; 7(34): 54937–54951. Published online 2016 Jul 19. doi: 10.18632/oncotarget.10709