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Select item 100974241.

Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma

Wenjuan Ma, Yanling Wang, Rongxin Zhang, Fan Yang, Duo Zhang, Menggui Huang, Lin Zhang, Jay F. Dorsey, Zev A. Binder, Donald M. O’Rourke, Joseph A. Fraietta, Yanqing Gong, Yi Fan

Nat Cancer. Author manuscript; available in PMC 2023 Apr 12.

Published in final edited form as: Nat Cancer. 2021 Jan; 2(1): 83–97. Published online 2020 Nov 30. doi: 10.1038/s43018-020-00147-8

PMCID:: PMC10097424

Abstract Article PDF–3.6M

Select item 83408522.

PAK4 inhibition improves PD-1 blockade immunotherapy

Gabriel Abril-Rodriguez, Davis Y. Torrejon, Wei Liu, Jesse M. Zaretsky, Theodore S. Nowicki, Jennifer Tsoi, Cristina Puig-Saus, Ignacio Baselga-Carretero, Egmidio Medina, Michael J. Quist, Alejandro J. Garcia, William Senapedis, Erkan Baloglu, Anusha Kalbasi, Gardenia Cheung-Lau, Beata Berent-Maoz, Begoña Comin-Anduix, Siwen Hu-Lieskovan, Cun-Yu Wang, Catherine S. Grasso, Antoni Ribas

Nat Cancer. Author manuscript; available in PMC 2021 Aug 5.

Published in final edited form as: Nat Cancer. 2020; 1(1): 46–58. Published online 2019 Dec 9. doi: 10.1038/s43018-019-0003-0

PMCID:: PMC8340852

Abstract Article PDF–4.2M

Select item 80166433.

PAK4 suppresses motor neuron degeneration in hSOD1^G93A‐linked amyotrophic lateral sclerosis cell and rat models

Chaohua Cong, Weiwei Liang, Chunting Zhang, Ying Wang, Yueqing Yang, Xudong Wang, Shuyu Wang, Di Huo, Hongyong Wang, Di Wang, Honglin Feng

Cell Prolif. 2021 Apr; 54(4): e13003. Published online 2021 Feb 21. doi: 10.1111/cpr.13003

PMCID:: PMC8016643

Abstract Article PDF–2.7M

Select item 67834344.

Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion

Parisa Rabieifar, Ting Zhuang, Tânia D. F. Costa, Miao Zhao, Staffan Strömblad

Sci Rep. 2019; 9: 14436. Published online 2019 Oct 8. doi: 10.1038/s41598-019-50819-4

PMCID:: PMC6783434

Abstract Article PDF–4.0M

Select item 57423025.

PAK4 crystal structures suggest unusual kinase conformational movements

Eric Y. Zhang, Byung Hak Ha, Titus J. Boggon

Biochim Biophys Acta. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Biochim Biophys Acta. 2018 Feb; 1866(2): 356–365. Published online 2017 Oct 7. doi: 10.1016/j.bbapap.2017.10.004

PMCID:: PMC5742302

Abstract Article PDF–1018K

Select item 55392016.

Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

Miao Zhao, Parisa Rabieifar, Tânia D. F. Costa, Ting Zhuang, Audrey Minden, Matthias Löhr, Rainer Heuchel, Staffan Strömblad

Sci Rep. 2017; 7: 7031. Published online 2017 Aug 1. doi: 10.1038/s41598-017-07322-5

PMCID:: PMC5539201

Abstract Article PDF–2.1M

Select item 28226237.

The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice

Yingying Liu, Hang Xiao, Yanmei Tian, Tanya Nekrasova, Xingpei Hao, Hong Jin Lee, Nanjoo Suh, Chung S. Yang, Audrey Minden

Mol Cancer Res. Author manuscript; available in PMC 2010 Feb 16.

Published in final edited form as: Mol Cancer Res. 2008 Jul; 6(7): 1215. doi: 10.1158/1541-7786.MCR-08-0087

PMCID:: PMC2822623

Abstract Article PDF–1.3M

Select item 12657988.

Pak4 Induces Premature Senescence via a Pathway Requiring p16^INK4/p19^ARF and Mitogen-Activated Protein Kinase Signaling

Marta S. Cammarano, Tanya Nekrasova, Beatrice Noel, Audrey Minden

Mol Cell Biol. 2005 Nov; 25(21): 9532–9542. doi: 10.1128/MCB.25.21.9532-9542.2005

PMCID:: PMC1265798

Abstract Article PDF–866K

Select item 111294099.

Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity

Yi Ma, Chelsea Dumesny, Li Dong, Ching-Seng Ang, Khashayar Asadi, Yifan Zhan, Mehrdad Nikfarjam, Hong He

Cell Commun Signal. 2024; 22: 287. Published online 2024 May 27. doi: 10.1186/s12964-024-01670-2

PMCID:: PMC11129409

Abstract Article PDF–2.6M

Select item 1043551910.

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1

Min Yan Shi, Hwang Chan Yu, Chang Yeob Han, In Hyuk Bang, Ho Sung Park, Kyu Yun Jang, Sangkyu Lee, Jeong Bum Son, Nam Doo Kim, Byung-Hyun Park, Eun Ju Bae

Nat Commun. 2023; 14: 4987. Published online 2023 Aug 17. doi: 10.1038/s41467-023-40597-z

Correction in:: Nat Commun. 2023; 14: 7007.

PMCID:: PMC10435519

Abstract Article PDF–3.6M

Select item 958590311.

P21-Activated Kinase 4 Pak4 Maintains Embryonic Stem Cell Pluripotency via Akt Activation

Fangyuan Cheng, Mingyue Li, Rick Francis Thorne, Guangzhi Liu, Yuwei Zhang, Mian Wu, Lianxin Liu

Stem Cells. 2022 Oct; 40(10): 892–905. Published online 2022 Aug 1. doi: 10.1093/stmcls/sxac050

PMCID:: PMC9585903

Abstract Article PDF–11M

Select item 871803612.

p21‐activated kinase 4 phosphorylates peroxisome proliferator‐activated receptor Υ and suppresses skeletal muscle regeneration

Yuancheng Mao, Chang Yeob Han, Lihua Hao, In Hyuk Bang, Eun Ju Bae, Byung‐Hyun Park

J Cachexia Sarcopenia Muscle. 2021 Dec; 12(6): 1776–1788. Published online 2021 Aug 24. doi: 10.1002/jcsm.12774

PMCID:: PMC8718036

Abstract Article PDF–12M

Select item 531643113.

Increased Circulating Endothelial Microparticles Associated with PAK4 Play a Key Role in Ventilation-Induced Lung Injury Process

Shuming Pan, Aihua Fei, Lihong Jing, Xiangyu Zhang, Chengjin Gao

Biomed Res Int. 2017; 2017: 4902084. Published online 2017 Feb 5. doi: 10.1155/2017/4902084

PMCID:: PMC5316431

Abstract Article PDF–4.3M

Select item 297400314.

The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis

Yingying Liu, Ning Chen, Xiaoxing Cui, Xi Zheng, Li Deng, Sandy Price, Vassiliki Karantza, Audrey Minden

Oncogene. Author manuscript; available in PMC 2011 May 4.

Published in final edited form as: Oncogene. 2010 Nov 4; 29(44): 5883–5894. Published online 2010 Aug 9. doi: 10.1038/onc.2010.329

PMCID:: PMC2974003

Abstract Article PDF–861K

Select item 373457015.

Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

Florian Gnad, Amy Young, Wei Zhou, Karen Lyle, Christy C. Ong, Matthew P. Stokes, Jeffrey C. Silva, Marcia Belvin, Lori S. Friedman, Hartmut Koeppen, Audrey Minden, Klaus P. Hoeflich

Mol Cell Proteomics. 2013 Aug; 12(8): 2070–2080. Published online 2013 Apr 22. doi: 10.1074/mcp.M112.027052

PMCID:: PMC3734570

Abstract Article PDF–1.5M

Select item 668909116.

PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer

Tânia D. F. Costa, Ting Zhuang, Julie Lorent, Emilia Turco, Helene Olofsson, Miriam Masia-Balague, Miao Zhao, Parisa Rabieifar, Neil Robertson, Raoul Kuiper, Jonas Sjölund, Matthias Spiess, Pablo Hernández-Varas, Uta Rabenhorst, Pernilla Roswall, Ran Ma, Xiaowei Gong, Johan Hartman, Kristian Pietras, Peter D. Adams, Paola Defilippi, Staffan Strömblad

Nat Commun. 2019; 10: 3589. Published online 2019 Aug 9. doi: 10.1038/s41467-019-11510-4

PMCID:: PMC6689091

Abstract Article PDF–2.6M

Select item 23031717.

Targeted Disruption of the Gene for the PAK5 Kinase in Mice

Xiaofan Li, Audrey Minden

Mol Cell Biol. 2003 Oct; 23(20): 7134–7142. doi: 10.1128/MCB.23.20.7134-7142.2003

Correction in:: Mol Cell Biol. 2004 Jun; 24(12): 5637.

PMCID:: PMC230317

Abstract Article PDF–939K

Select item 924707718.

p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1

So-Yoon Won, Jung-Jin Park, Soon-Tae You, Jong-A Hyeun, Hyong-Kyu Kim, Byung Kwan Jin, Catriona McLean, Eun-Young Shin, Eung-Gook Kim

Cell Death Dis. 2022 Jun; 13(6): 575. Published online 2022 Jun 30. doi: 10.1038/s41419-022-05030-1

PMCID:: PMC9247077

Abstract Article PDF–4.6M

Select item 23031319.

PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development

Jian Qu, Xiaofan Li, Bennet G. Novitch, Ye Zheng, Matthew Kohn, Jian-Ming Xie, Spencer Kozinn, Roderick Bronson, Amer A. Beg, Audrey Minden

Mol Cell Biol. 2003 Oct; 23(20): 7122–7133. doi: 10.1128/MCB.23.20.7122-7133.2003

PMCID:: PMC230313

Abstract Article PDF–813K

Select item 361930220.

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

Bridget M. Dolan, Sergio G. Duron, David A. Campbell, Benedikt Vollrath, B. S. Shankaranarayana Rao, Hui-Yeon Ko, Gregory G. Lin, Arvind Govindarajan, Se-Young Choi, Susumu Tonegawa

Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14): 5671–5676. Published online 2013 Mar 18. doi: 10.1073/pnas.1219383110

PMCID:: PMC3619302

Abstract Article PDF–454K

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