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Select item 111385001.

Human MutY: gene structure, protein functions and interactions, and role in carcinogenesis

A. R. Parker, J. R. Eshleman

Cell Mol Life Sci. 2003 Oct; 60(10): 2064–2083. doi: 10.1007/s00018-003-3053-4

PMCID:: PMC11138500

Abstract Article PDF–778K

Select item 83730692.

Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover

Sunbok Jang, Matthew A Schaich, Cindy Khuu, Brittani L Schnable, Chandrima Majumdar, Simon C Watkins, Sheila S David, Bennett Van Houten

Nucleic Acids Res. 2021 Aug 20; 49(14): 8177–8188. Published online 2021 Jul 7. doi: 10.1093/nar/gkab591

PMCID:: PMC8373069

Abstract Article PDF–3.9M

Select item 82665923.

Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer

Teruya Nakamura, Kohtaro Okabe, Shogo Hirayama, Mami Chirifu, Shinji Ikemizu, Hiroshi Morioka, Yusaku Nakabeppu, Yuriko Yamagata

Nucleic Acids Res. 2021 Jul 9; 49(12): 7154–7163. Published online 2021 Jun 18. doi: 10.1093/nar/gkab492

PMCID:: PMC8266592

Abstract Article PDF–3.5M

Select item 70762184.

The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites

Alan G. Raetz, Douglas M. Banda, Xiaoyan Ma, Gege Xu, Anisha N. Rajavel, Paige L. McKibbin, Carlito B. Lebrilla, Sheila S. David

J Biol Chem. 2020 Mar 13; 295(11): 3692–3707. Published online 2020 Jan 30. doi: 10.1074/jbc.RA119.010497

PMCID:: PMC7076218

Abstract Article PDF–3.1M

Select item 46373135.

The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis

Francesca Grasso, Serena Di Meo, Gabriele De Luca, Luca Pasquini, Stefania Rossi, Monica Boirivant, Mauro Biffoni, Margherita Bignami, Emma Di Carlo

Oncotarget. 2015 Aug 14; 6(23): 19671–19684. Published online 2015 Jun 18. doi: 10.18632/oncotarget.4284

PMCID:: PMC4637313

Abstract Article PDF–7.4M

Select item 44806946.

MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation

Francesca Grasso, Vitalba Ruggieri, Gabriele De Luca, Paola Leopardi, Maria Teresa Mancuso, Ida Casorelli, Pietro Pichierri, Peter Karran, Margherita Bignami

Oncotarget. 2015 Apr 10; 6(10): 7481–7492. Published online 2014 Dec 2. doi: 10.18632/oncotarget.3037

PMCID:: PMC4480694

Abstract Article PDF–3.8M

Select item 41472267.

Abnormality in Wnt Signaling is Causatively Associated with Oxidative Stress-Induced Intestinal Tumorigenesis in MUTYH-Null Mice

Takuro Isoda, Yoshimichi Nakatsu, Kazumi Yamauchi, Jingshu Piao, Takashi Yao, Hiroshi Honda, Yusaku Nakabeppu, Teruhisa Tsuzuki

Int J Biol Sci. 2014; 10(8): 940–947. Published online 2014 Aug 23. doi: 10.7150/ijbs.9241

PMCID:: PMC4147226

Abstract Article PDF–917K

Select item 36276028.

Understanding the role of the Q338H MUTYH variant in oxidative damage repair

Eleonora Turco, Ilenia Ventura, Anna Minoprio, Maria Teresa Russo, Paola Torreri, Paolo Degan, Sara Molatore, Guglielmina Nadia Ranzani, Margherita Bignami, Filomena Mazzei

Nucleic Acids Res. 2013 Apr; 41(7): 4093–4103. Published online 2013 Mar 4. doi: 10.1093/nar/gkt130

PMCID:: PMC3627602

Abstract Article PDF–1.8M

Select item 29194039.

The Mutyh Base Excision Repair Gene Influences the Inflammatory Response in a Mouse Model of Ulcerative Colitis

Ida Casorelli, Tania Pannellini, Gabriele De Luca, Paolo Degan, Federica Chiera, Ivano Iavarone, Alessandro Giuliani, Alessia Butera, Monica Boirivant, Piero Musiani, Margherita Bignami

PLoS One. 2010; 5(8): e12070. Published online 2010 Aug 10. doi: 10.1371/journal.pone.0012070

PMCID:: PMC2919403

Abstract Article PDF–3.7M

Select item 54835810.

A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

Yasuhiro Ushijima, Yohei Tominaga, Tomofumi Miura, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu

Nucleic Acids Res. 2005; 33(2): 672–682. Published online 2005 Jan 28. doi: 10.1093/nar/gki214

PMCID:: PMC548358

Abstract Article PDF–676K

Select item 871434311.

MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease

Yuri Mizuno, Nona Abolhassani, Guianfranco Mazzei, Kunihiko Sakumi, Takashi Saito, Takaomi C. Saido, Toshiharu Ninomiya, Toru Iwaki, Ryo Yamasaki, Jun-ichi Kira, Yusaku Nakabeppu

Oxid Med Cell Longev. 2021; 2021: 8635088. Published online 2021 Dec 21. doi: 10.1155/2021/8635088

Correction in:: Oxid Med Cell Longev. 2023; 2023: 9794081.

PMCID:: PMC8714343

Abstract Article PDF–4.6M

Select item 787891812.

MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model

Hiroki Sakamoto, Koji Miyanishi, Shingo Tanaka, Ryo Ito, Kota Hamaguchi, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Takahiro Osuga, Kazuyuki Murase, Kohichi Takada, Yusaku Nakabeppu, Masayoshi Kobune, Junji Kato

Sci Rep. 2021; 11: 3599. Published online 2021 Feb 11. doi: 10.1038/s41598-021-83138-8

PMCID:: PMC7878918

Abstract Article PDF–5.4M

Select item 760362713.

MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis in a Bleomycin-Induced Model

Qingmin Sun, Jingwen Chen, Lizhi Xu, Jiaqi Kang, Xin Wu, Yan Ren, Yusaku Nakabeppu, Yaping Wang

Oxid Med Cell Longev. 2020; 2020: 4828256. Published online 2020 Oct 16. doi: 10.1155/2020/4828256

PMCID:: PMC7603627

Abstract Article PDF–2.5M

Select item 645111714.

Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant

Shane R Nelson, Scott D Kathe, Thomas S Hilzinger, April M Averill, David M Warshaw, Susan S Wallace, Andrea J Lee

Nucleic Acids Res. 2019 Apr 8; 47(6): 3058–3071. Published online 2019 Jan 30. doi: 10.1093/nar/gkz045

PMCID:: PMC6451117

Abstract Article PDF–2.6M

Select item 606178715.

Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

Johanna H K Kauppila, Nina A Bonekamp, Arnaud Mourier, Marita A Isokallio, Alexandra Just, Timo E S Kauppila, James B Stewart, Nils-Göran Larsson

Nucleic Acids Res. 2018 Jul 27; 46(13): 6642–6669. Published online 2018 May 31. doi: 10.1093/nar/gky456

PMCID:: PMC6061787

Abstract Article PDF–3.0M

Select item 503375216.

MUTYH promotes oxidative microglial activation and inherited retinal degeneration

Shunji Nakatake, Yusuke Murakami, Yasuhiro Ikeda, Noriko Morioka, Takashi Tachibana, Kohta Fujiwara, Noriko Yoshida, Shoji Notomi, Toshio Hisatomi, Shigeo Yoshida, Tatsuro Ishibashi, Yusaku Nakabeppu, Koh-Hei Sonoda

JCI Insight. 2016 Sep 22; 1(15): e87781. Published online 2016 Sep 22. doi: 10.1172/jci.insight.87781

PMCID:: PMC5033752

Abstract Article PDF–2.4M

Select item 446122717.

Mammalian MutY homolog (MYH or MUTYH) protects cells from oxidative DNA damage

Bor-Jang Hwang, Gouli Shi, A-Lien Lu

DNA Repair (Amst) Author manuscript; available in PMC 2015 Jun 9.

Published in final edited form as: DNA Repair (Amst). 2014 Jan; 13: 10–21. Published online 2013 Dec 4. doi: 10.1016/j.dnarep.2013.10.011

PMCID:: PMC4461227

Abstract Article PDF–1021K

Select item 37333818.

Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts

Akimasa Ichinoe, Mehrdad Behmanesh, Yohei Tominaga, Yasuhiro Ushijima, Seiki Hirano, Yasunari Sakai, Daisuke Tsuchimoto, Kunihiko Sakumi, Norio Wake, Yusaku Nakabeppu

Nucleic Acids Res. 2004; 32(2): 477–487. Published online 2004 Jan 23. doi: 10.1093/nar/gkh214