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Select item 112039791.

The Role of TPM3 in Protecting Cardiomyocyte from Hypoxia-Induced Injury via Cytoskeleton Stabilization

Ke Huang, Weijia Yang, Mingxuan Shi, Shiqi Wang, Yi Li, Zhaoqing Xu

Int J Mol Sci. 2024 Jun; 25(12): 6797. Published online 2024 Jun 20. doi: 10.3390/ijms25126797

PMCID:: PMC11203979

Abstract Article PDF–3.4M

Select item 106718542.

A Novel Variant in TPM3 Causing Muscle Weakness and Concomitant Hypercontractile Phenotype

Katarzyna Robaszkiewicz, Małgorzata Siatkowska, Renske I. Wadman, Erik-Jan Kamsteeg, Zhiyong Chen, Ashirwad Merve, Matthew Parton, Enrico Bugiardini, Charlotte de Bie, Joanna Moraczewska

Int J Mol Sci. 2023 Nov; 24(22): 16147. Published online 2023 Nov 9. doi: 10.3390/ijms242216147

PMCID:: PMC10671854

Abstract Article PDF–5.2M

Select item 86229053.

Structural Effects of Disease-Related Mutations in Actin-Binding Period 3 of Tropomyosin

Balaganesh Kuruba, Marta Kaczmarek, Małgorzata Kęsik-Brodacka, Magdalena Fojutowska, Małgorzata Śliwinska, Alla S. Kostyukova, Joanna Moraczewska

Molecules. 2021 Nov; 26(22): 6980. Published online 2021 Nov 19. doi: 10.3390/molecules26226980

PMCID:: PMC8622905

Abstract Article PDF–1.1M

Select item 82923674.

Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents

Xing Xu, Yao Wang, Nicole S. Bryce, Katrina Tang, Nicola S. Meagher, Eun Young Kang, Linda E. Kelemen, Martin Köbel, Susan J. Ramus, Michael Friedlander, Caroline E. Ford, Edna C. Hardeman, Peter W. Gunning

Br J Cancer. 2021 Jul 20; 125(2): 265–276. Published online 2021 May 12. doi: 10.1038/s41416-021-01420-y

PMCID:: PMC8292367

Abstract Article PDF–3.6M

Select item 72021795.

Congenital myopathy-related mutations in tropomyosin disrupt regulatory function through altered actin affinity and tropomodulin binding

Joanna Moraczewska, Katarzyna Robaszkiewicz, Małgorzata Śliwinska, Marta Czajkowska, Thu Ly, Alla Kostyukova, Han Wen, Wenjun Zheng

FEBS J. Author manuscript; available in PMC 2020 May 6.

Published in final edited form as: FEBS J. 2019 May; 286(10): 1877–1893. Published online 2019 Mar 5. doi: 10.1111/febs.14787

PMCID:: PMC7202179

Abstract Article PDF–2.8M

Select item 63215046.

The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies

Yurii S. Borovikov, Olga E. Karpicheva, Armen O. Simonyan, Stanislava V. Avrova, Elena A. Rogozovets, Vladimir V. Sirenko, Charles S. Redwood

Int J Mol Sci. 2018 Dec; 19(12): 3975. Published online 2018 Dec 10. doi: 10.3390/ijms19123975

PMCID:: PMC6321504

Abstract Article PDF–4.0M

Select item 53673717.

Proteomic analysis indicates the importance of TPM3 in esophageal squamous cell carcinoma invasion and metastasis

Shao-Bin Yu, Qin Gao, Wen-Wei Lin, Ming-Qiang Kang

Mol Med Rep. 2017 Mar; 15(3): 1236–1242. Published online 2017 Jan 25. doi: 10.3892/mmr.2017.6145

PMCID:: PMC5367371

Abstract Article PDF–1.4M

Select item 51546238.

TPM3 deletions cause a hypercontractile congenital muscle stiffness phenotype

S. Donkervoort, M. Papadaki, JM. de Winter, MB. Neu, J. Kirschner, V. Bolduc, ML. Yang, MA. Gibbons, Y. Hu, J. Dastgir, ME. Leach, A. Rutkowski, AR. Foley, M. Krüger, EP. Wartchow, E. McNamara, R. Ong, KJ. Nowak, NG. Laing, NF. Clarke, CAC. Ottenheijm, SB. Marston, CG. Bönnemann

Ann Neurol. Author manuscript; available in PMC 2016 Dec 13.

Published in final edited form as: Ann Neurol. 2015 Dec; 78(6): 982–994. Published online 2015 Nov 13. doi: 10.1002/ana.24535

PMCID:: PMC5154623

Abstract Article PDF–2.2M

Select item 49556989.

Comprehensive Analysis of Tropomyosin Isoforms in Skeletal Muscles by Top-down Proteomics

Yutong Jin, Ying Peng, Ziqing Lin, Yi-Chen Chen, Liming Wei, Timothy A. Hacker, Lars Larsson, Ying Ge

J Muscle Res Cell Motil. Author manuscript; available in PMC 2017 Apr 18.

Published in final edited form as: J Muscle Res Cell Motil. 2016 Apr; 37(1-2): 41–52. Published online 2016 Apr 18. doi: 10.1007/s10974-016-9443-7

PMCID:: PMC4955698

Abstract Article PDF–2.2M

Select item 461470010.

Muscle weakness in TPM3-myopathy is due to reduced Ca²⁺-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres

Michaela Yuen, Sandra T. Cooper, Steve B. Marston, Kristen J. Nowak, Elyshia McNamara, Nancy Mokbel, Biljana Ilkovski, Gianina Ravenscroft, John Rendu, Josine M. de Winter, Lars Klinge, Alan H. Beggs, Kathryn N. North, Coen A.C. Ottenheijm, Nigel F. Clarke

Hum Mol Genet. 2015 Nov 15; 24(22): 6278–6292. Published online 2015 Aug 24. doi: 10.1093/hmg/ddv334

PMCID:: PMC4614700

Abstract Article PDF–1.2M

Select item 308731511.

Tropomyosin3 overexpression and a potential link to epithelial-mesenchymal transition in human hepatocellular carcinoma

Hye-Sun Choi, Seon-Hee Yim, Hai-Dong Xu, Seung-Hyun Jung, Seung-Hun Shin, Hae-Jin Hu, Chan-Kwon Jung, Jong Young Choi, Yeun-Jun Chung

BMC Cancer. 2010; 10: 122. Published online 2010 Apr 1. doi: 10.1186/1471-2407-10-122

PMCID:: PMC3087315

Abstract Article PDF–7.6M

Select item 281519912.

Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in congenital fiber type disproportion

Michael W. Lawlor, Elizabeth T. DeChene, Emily Roumm, Amelia S. Geggel, Behzad Moghadaszadeh, Alan H Beggs

Hum Mutat. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: Hum Mutat. 2010 Feb; 31(2): 176–183. doi: 10.1002/humu.21157

PMCID:: PMC2815199

Abstract Article PDF–212K

Select item 271189113.

The trk Tyrosine Protein Kinase Mediates the Mitogenic Properties of Nerve Growth Factor and Neurotrophin-3

Carlos Cordon-Cardo, Peter Tapley, Shuqian Jing, Venkata Nanduri, Edward O’Rourke, Fabienne Lamballe, Karla Kovary, Rüdiger Klein, Kevin R. Jones, Louis F. Reichardt, Mariano Barbacid

Cell. Author manuscript; available in PMC 2009 Jul 16.

Published in final edited form as: Cell. 1991 Jul 12; 66(1): 173–183. doi: 10.1016/0092-8674(91)90149-s