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Items: 1 to 20 of 69

1.
R‐spondin‐3 is an oncogenic driver of poorly differentiated invasive breast cancer
Eline J ter Steege, Mandy Boer, Nikki C Timmer, Carola ME Ammerlaan, Ji‐Ying Song, Patrick WB Derksen, John Hilkens, Elvira RM Bakker
J Pathol. 2022 Nov; 258(3): 289–299. Published online 2022 Sep 15. doi: 10.1002/path.5999
PMCID:
PMC9825844
AbstractArticlePDF–24M
2.
R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton
Kenichi Nagano, Kei Yamana, Hiroaki Saito, Riku Kiviranta, Ana Clara Pedroni, Dhairya Raval, Christof Niehrs, Francesca Gori, Roland Baron
eLife. 2022; 11: e84171. Published online 2022 Nov 2. doi: 10.7554/eLife.84171
PMCID:
PMC9681208
AbstractArticlePDF–3.8M
3.
R-spondin3 is a myokine that differentiates myoblasts to type I fibres
Yoshitaka Mita, Haonan Zhu, Yasuro Furuichi, Hiroki Hamaguchi, Yasuko Manabe, Nobuharu L. Fujii
Sci Rep. 2022; 12: 13020. Published online 2022 Jul 29. doi: 10.1038/s41598-022-16640-2
PMCID:
PMC9338073
AbstractArticlePDF–2.1M
4.
Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other
Karin H. Nilsson, Jianyao Wu, Karin L. Gustafsson, Maha El Shahawy, Antti Koskela, Juha Tuukkanen, Jan Tuckermann, Petra Henning, Ulf H. Lerner, Claes Ohlsson, Sofia Movérare-Skrtic
Am J Physiol Endocrinol Metab. 2022 Mar 1; 322(3): E211–E218. Published online 2022 Jan 24. doi: 10.1152/ajpendo.00383.2021
PMCID:
PMC8896994
AbstractArticle
5.
Rspo3 regulates the abnormal differentiation of small intestinal epithelial cells in diabetic state
Ti-Dong Shan, Han Yue, Xue-Guo Sun, Yue-Ping Jiang, Li Chen
Stem Cell Res Ther. 2021; 12: 330. Published online 2021 Jun 7. doi: 10.1186/s13287-021-02385-8
PMCID:
PMC8186182
AbstractArticlePDF–7.5M
6.
Intestinal Lymphatic Endothelial Cells Produce R-Spondin3
Reiki Ogasawara, Daigo Hashimoto, Shunsuke Kimura, Eiko Hayase, Takahide Ara, Shuichiro Takahashi, Hiroyuki Ohigashi, Kosuke Yoshioka, Takahiro Tateno, Emi Yokoyama, Ko Ebata, Takeshi Kondo, Junichi Sugita, Masahiro Onozawa, Toshihiko Iwanaga, Takanori Teshima
Sci Rep. 2018; 8: 10719. Published online 2018 Jul 16. doi: 10.1038/s41598-018-29100-7
PMCID:
PMC6048029
AbstractArticlePDF–2.3M
7.
R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage
Lakshmi Kannan, Katalin Kis-Toth, Kazuhisa Yoshiya, To-Ha Thai, Seema Sehrawat, Tanya N. Mayadas, Jurandir J. Dalle Lucca, George C. Tsokos
Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35): 14348–14353. Published online 2013 Aug 13. doi: 10.1073/pnas.1309393110
PMCID:
PMC3761629
AbstractArticlePDF–1.5M
8.
R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori–associated metaplasia in mice
Anne-Sophie Fischer, Stefanie Müllerke, Alexander Arnold, Julian Heuberger, Hilmar Berger, Manqiang Lin, Hans-Joachim Mollenkopf, Jonas Wizenty, David Horst, Frank Tacke, Michael Sigal
J Clin Invest. 2022 Nov 1; 132(21): e151363. Published online 2022 Nov 1. doi: 10.1172/JCI151363
PMCID:
PMC9621134
AbstractArticlePDF–37M
9.
Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs
Mingjun Zhang, Michael Haughey, Nai-Yu Wang, Kate Blease, Ann M. Kapoun, Suzana Couto, Igor Belka, Timothy Hoey, Matthew Groza, James Hartke, Brydon Bennett, Jennifer Cain, Austin Gurney, Brent Benish, Paola Castiglioni, Clifton Drew, Jean Lachowicz, Leon Carayannopoulos, Steven D. Nathan, Jorg Distler, David A. Brenner, Kandasamy Hariharan, Ho Cho, Weilin Xie
PLoS One. 2020; 15(3): e0229445. Published online 2020 Mar 11. doi: 10.1371/journal.pone.0229445
PMCID:
PMC7065809
AbstractArticlePDF–7.5M
10.
R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
Christine Harnack, Hilmar Berger, Agne Antanaviciute, Ramon Vidal, Sascha Sauer, Alison Simmons, Thomas F. Meyer, Michael Sigal
Nat Commun. 2019; 10: 4368. Published online 2019 Sep 25. doi: 10.1038/s41467-019-12349-5
PMCID:
PMC6761174
AbstractArticlePDF–12M
11.
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
Teng Han, Emma M. Schatoff, Charles Murphy, Maria Paz Zafra, John E. Wilkinson, Olivier Elemento, Lukas E. Dow
Nat Commun. 2017; 8: 15945. Published online 2017 Jul 11. doi: 10.1038/ncomms15945
PMCID:
PMC5508203
AbstractArticlePDF–3.7M
12.
Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury
Brisa Palikuqi, Jérémie Rispal, Efren A. Reyes, Dedeepya Vaka, Dario Boffelli, Ophir Klein
Cell Stem Cell. Author manuscript; available in PMC 2023 Aug 4.
Published in final edited form as: Cell Stem Cell. 2022 Aug 4; 29(8): 1262–1272.e5. doi: 10.1016/j.stem.2022.07.007
PMCID:
PMC9387209
AbstractArticlePDF–2.2M
13.
RSPO3 is important for trabecular bone and fracture risk in mice and humans
Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, Thomas Levin Andersen, Charlotte Ejersted, Jianyao Wu, Karin L. Gustafsson, Antti Koskela, Juha Tuukkanen, Pedro P. C. Souza, Jan Tuckermann, Mattias Lorentzon, Linda Engström Ruud, Terho Lehtimäki, Jon H. Tobias, Sirui Zhou, Ulf H. Lerner, J. Brent Richards, Sofia Movérare-Skrtic, Claes Ohlsson
Nat Commun. 2021; 12: 4923. Published online 2021 Aug 13. doi: 10.1038/s41467-021-25124-2
PMCID:
PMC8363747
AbstractArticlePDF–2.5M
14.
R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin
Shiying Liu, Yue Yin, Ruili Yu, Yin Li, Weizhen Zhang
Biochem Biophys Res Commun. Author manuscript; available in PMC 2018 Oct 3.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Apr 30; 499(1): 59–65. Published online 2018 Mar 19. doi: 10.1016/j.bbrc.2018.03.126
PMCID:
PMC6170193
AbstractArticlePDF–1.3M
15.
Transcriptional Profiling of the Adult Hair Follicle Mesenchyme Reveals R-spondin as a Novel Regulator of Dermal Progenitor Function
Andrew Hagner, Wisoo Shin, Sarthak Sinha, Whitney Alpaugh, Matthew Workentine, Sepideh Abbasi, Waleed Rahmani, Natacha Agabalyan, Nilesh Sharma, Holly Sparks, Jessica Yoon, Elodie Labit, John Cobb, Ina Dobrinski, Jeff Biernaskie
iScience. 2020 Apr 24; 23(4): 101019. Published online 2020 Apr 2. doi: 10.1016/j.isci.2020.101019
PMCID:
PMC7155209
AbstractArticlePDF–35M
16.
RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis
John Hilkens, Nikki C Timmer, Mandy Boer, Gerjon J Ikink, Matthias Schewe, Andrea Sacchetti, Martijn A J Koppens, Ji-Ying Song, Elvira R M Bakker
Gut. 2017 Jun; 66(6): 1095–1105. Published online 2016 Aug 10. doi: 10.1136/gutjnl-2016-311606
PMCID:
PMC5532462
AbstractArticlePDF–4.5M
17.
Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury
Norihiro Goto, Saori Goto, Shinya Imada, Sahar Hosseini, Vikram Deshpande, Ömer H. Yilmaz
Cell Stem Cell. Author manuscript; available in PMC 2023 Aug 4.
Published in final edited form as: Cell Stem Cell. 2022 Aug 4; 29(8): 1246–1261.e6. doi: 10.1016/j.stem.2022.06.013
PMCID:
PMC9720889
AbstractArticlePDF–3.1M
18.
Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
Alison E. Jarmas, Eric W. Brunskill, Praneet Chaturvedi, Nathan Salomonis, Raphael Kopan
Nat Commun. 2021; 12: 6332. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26626-9
PMCID:
PMC8566581
AbstractArticlePDF–6.8M
19.
Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development
Nora Alhazmi, Shannon H. Carroll, Kenta Kawasaki, Katherine C. Woronowicz, Shawn A. Hallett, Claudio Macias Trevino, Edward B. Li, Roland Baron, Francesca Gori, Pamela C. Yelick, Matthew P. Harris, Eric C. Liao
Sci Rep. 2021; 11: 5871. Published online 2021 Mar 12. doi: 10.1038/s41598-021-85415-y
PMCID:
PMC7954795
AbstractArticlePDF–10M
20.
Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock
Sarina Harshuk-Shabso, Hila Dressler, Christof Niehrs, Emil Aamar, David Enshell-Seijffers
Nat Commun. 2020; 11: 5114. Published online 2020 Oct 9. doi: 10.1038/s41467-020-18643-x
PMCID:
PMC7547083
AbstractArticlePDF–9.0M

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