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Select item 106884501.

U2AF1 in various neoplastic diseases and relevant targeted therapies for malignant cancers with complex mutations (Review)

Qing Nian, Yihui Li, Jingwei Li, Liyun Zhao, Fernando Rodrigues Lima, Jinhao Zeng, Rongxing Liu, Zhijun Ye

Oncol Rep. 2024 Jan; 51(1): 5. Published online 2023 Nov 16. doi: 10.3892/or.2023.8664

PMCID:: PMC10688450

Abstract Article PDF–1.4M

Select item 105143092.

U2AF1 pathogenic variants in myeloid neoplasms and precursor states: distribution of co-mutations and prognostic heterogeneity

Talha Badar, Yenny A. Moreno Vanegas, Ahmad Nanaa, James M. Foran, Aref Al-Kali, Abhishek Mangaonkar, Hemant Murthy, Hassan B. Alkhateeb, David Viswanatha, Rong He, Mithun Shah, Cecilia Arana Yi, Mark R. Litzow, Naseema Gangat, Ayalew Tefferi, Mrinal M. Patnaik

Blood Cancer J. 2023 Dec; 13(1): 149. Published online 2023 Sep 21. doi: 10.1038/s41408-023-00922-7

PMCID:: PMC10514309

Abstract Article PDF–1.2M

Select item 92045093.

Clinical features and biological implications of different U2AF1 mutation types in myelodysplastic syndromes

Bing Li, Jinqin Liu, Yujiao Jia, Jingya Wang, Zefeng Xu, Tiejun Qin, Zhongxun Shi, Zhen Song, Shuailing Peng, Huijun Huang, Liwei Fang, Hongli Zhang, Lijuan Pan, Naibo Hu, Shiqiang Qu, Yue Zhang, Jian Wu, Na Liu, Kun Ru, Gang Huang, Zhijian Xiao

Genes Chromosomes Cancer. Author manuscript; available in PMC 2022 Jun 17.

Published in final edited form as: Genes Chromosomes Cancer. 2018 Feb; 57(2): 80–88. Published online 2017 Nov 23. doi: 10.1002/gcc.22510

PMCID:: PMC9204509

Abstract Article PDF–1.1M

Select item 89889224.

Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies

Giulia Biancon, Poorval Joshi, Joshua T Zimmer, Torben Hunck, Yimeng Gao, Mark D Lessard, Edward Courchaine, Andrew ES Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D Simon, Karla M Neugebauer, Toma Tebaldi, Stephanie Halene

Mol Cell. Author manuscript; available in PMC 2023 Mar 17.

Published in final edited form as: Mol Cell. 2022 Mar 17; 82(6): 1107–1122.e7. doi: 10.1016/j.molcel.2022.02.025

PMCID:: PMC8988922

Abstract Article PDF–2.6M

Select item 87147225.

Bilineal evolution of a U2AF1-mutated clone associated with acquisition of distinct secondary mutations

Nathan D. Montgomery, Jonathan Galeotti, Steven M. Johnson, Leah Commander, Eric T. Weimer, Pranil K. Chandra, Tariq Nazir, Thomas B. Alexander, Joshua F. Zeidner, Matthew C. Foster

Blood Adv. 2021 Dec 28; 5(24): 5612–5616. Published online 2021 Dec 28. doi: 10.1182/bloodadvances.2021005308

PMCID:: PMC8714722

Abstract Article PDF–811K

Select item 77832726.

Prognostic significance of U2AF1 mutations in myelodysplastic syndromes: a meta-analysis

Bixia Li, Duobing Zou, Shujun Yang, Guifang Ouyang, Qitian Mu

J Int Med Res. 2020 Mar; 48(3): 0300060519891013. Published online 2019 Dec 11. doi: 10.1177/0300060519891013

PMCID:: PMC7783272

Abstract Article PDF–1.1M

Select item 77449617.

Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence

Jun Yao, Dong Ding, Xueping Li, Ting Shen, Haihui Fu, Hua Zhong, Gang Wei, Ting Ni

Aging Cell. 2020 Dec; 19(12): e13276. Published online 2020 Dec 4. doi: 10.1111/acel.13276

PMCID:: PMC7744961

Abstract Article PDF–1.3M

Select item 76605408.

Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation

Abdalla Akef, Kathy McGraw, Steven D. Cappell, Daniel R. Larson

PLoS Biol. 2020 Nov; 18(11): e3000920. Published online 2020 Nov 2. doi: 10.1371/journal.pbio.3000920

PMCID:: PMC7660540

Abstract Article PDF–3.7M

Select item 75964959.

Differential U2AF1 mutation sites, burden and co-mutation genes can predict prognosis in patients with myelodysplastic syndrome

Haiqiong Wang, Yongbo Guo, Zhenkun Dong, Tao Li, Xinsheng Xie, Dingming Wan, Zhongxing Jiang, Jifeng Yu, Rong Guo

Sci Rep. 2020; 10: 18622. Published online 2020 Oct 29. doi: 10.1038/s41598-020-74744-z

PMCID:: PMC7596495

Abstract Article PDF–1.0M

Select item 754970710.

The core spliceosomal factor U2AF1 controls cell-fate determination via the modulation of transcriptional networks

Abdelhamid Mahdi Laaref, Laurent Manchon, Yacine Bareche, Laure Lapasset, Jamal Tazi

RNA Biol. 2020; 17(6): 857–871. Published online 2020 Mar 9. doi: 10.1080/15476286.2020.1733800

PMCID:: PMC7549707

Abstract Article PDF–7.2M

Select item 735791011.

伴U2AF1基因突变骨髓增生异常综合征患者临床特征及预后分析

侯畅, 蒋淑慧, 沈宏杰, 丁子轩, 苗瞄, 陈苏宁, 徐杨, 吴德沛

Zhonghua Xue Ye Xue Za Zhi. 2020 Jan; 41(1): 72–75. Chinese. doi: 10.3760/cma.j.issn.0253-2727.2020.01.014

PMCID:: PMC7357910

Article PDF–3.4M

Select item 691104312.

Functional significance of U2AF1 S34F mutations in lung adenocarcinomas

Mohammad S. Esfahani, Luke J. Lee, Young-Jun Jeon, Ryan A. Flynn, Henning Stehr, Angela B. Hui, Noriko Ishisoko, Eric Kildebeck, Aaron M. Newman, Scott V. Bratman, Matthew H. Porteus, Howard Y. Chang, Ash A. Alizadeh, Maximilian Diehn

Nat Commun. 2019; 10: 5712. Published online 2019 Dec 13. doi: 10.1038/s41467-019-13392-y

PMCID:: PMC6911043

Abstract Article PDF–1.6M

Select item 665281913.

Knockdown of spliceosome U2AF1 significantly inhibits the development of human erythroid cells

Jieying Zhang, Huizhi Zhao, Kunlu Wu, Yuanliang Peng, Xu Han, Huan Zhang, Long Liang, Huiyong Chen, Jingping Hu, Xiaoli Qu, Shijie Zhang, Lixiang Chen, Jing Liu

J Cell Mol Med. 2019 Aug; 23(8): 5076–5086. Published online 2019 May 29. doi: 10.1111/jcmm.14370

PMCID:: PMC6652819

Abstract Article PDF–1.4M

Select item 649932214.

The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation

Murali Palangat, Dimitrios G. Anastasakis, Dennis Liang Fei, Katherine E. Lindblad, Robert Bradley, Christopher S. Hourigan, Markus Hafner, Daniel R. Larson

Genes Dev. 2019 May 1; 33(9-10): 482–497. doi: 10.1101/gad.319590.118

PMCID:: PMC6499322

Abstract Article PDF–6.3M

Select item 617039715.

U2AF1 mutation types in primary myelofibrosis: phenotypic and prognostic distinctions

Ayalew Tefferi, Christy M. Finke, Terra L. Lasho, Curtis A. Hanson, Rhett P. Ketterling, Naseema Gangat, Animesh Pardanani

Leukemia. 2018; 32(10): 2274–2278. Published online 2018 Feb 27. doi: 10.1038/s41375-018-0078-0

PMCID:: PMC6170397

Article PDF–789K

Select item 612541716.

Integrative Profiling of Alternative Splicing Induced by U2AF1 S34F Mutation in Lung Adenocarcinoma Reveals a Mechanistic Link to Mitotic Stress

Suyeon Kim, Charny Park, Yukyung Jun, Sanghyuk Lee, Yeonjoo Jung, Jaesang Kim

Mol Cells. 2018 Aug 31; 41(8): 733–741. Published online 2018 Jul 10. doi: 10.14348/molcells.2018.0176

PMCID:: PMC6125417

Abstract Article PDF–2.0M

Select item 568900117.

The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5′ splice site that impacts splicing regulation in Q157R patients

Olga Herdt, Alexander Neumann, Bernd Timmermann, Florian Heyd

RNA. 2017 Dec; 23(12): 1796–1806. doi: 10.1261/rna.061432.117

PMCID:: PMC5689001

Abstract Article PDF–4.9M

Select item 545124618.

The U2AF1^S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes

Bon Ham Yip, Violetta Steeples, Emmanouela Repapi, Richard N. Armstrong, Miriam Llorian, Swagata Roy, Jacqueline Shaw, Hamid Dolatshad, Stephen Taylor, Amit Verma, Matthias Bartenstein, Paresh Vyas, Nicholas C.P. Cross, Luca Malcovati, Mario Cazzola, Eva Hellström-Lindberg, Seishi Ogawa, Christopher W.J. Smith, Andrea Pellagatti, Jacqueline Boultwood

J Clin Invest. 2017 Jun 1; 127(6): 2206–2221. Published online 2017 Apr 24. doi: 10.1172/JCI91363

Correction in:: J Clin Invest. 2017 Sep 1; 127(9): 3557.

PMCID:: PMC5451246

Abstract Article PDF–1.9M

Select item 522770119.

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

Cara Lunn Shirai, Brian S. White, Manorama Tripathi, Roberto Tapia, James N. Ley, Matthew Ndonwi, Sanghyun Kim, Jin Shao, Alexa Carver, Borja Saez, Robert S. Fulton, Catrina Fronick, Michelle O'Laughlin, Chandraiah Lagisetti, Thomas R. Webb, Timothy A. Graubert, Matthew J. Walter

Nat Commun. 2017; 8: 14060. Published online 2017 Jan 9. doi: 10.1038/ncomms14060

PMCID:: PMC5227701

Abstract Article PDF–1.2M

Select item 507715120.

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

Dennis Liang Fei, Hayley Motowski, Rakesh Chatrikhi, Sameer Prasad, Jovian Yu, Shaojian Gao, Clara L. Kielkopf, Robert K. Bradley, Harold Varmus

PLoS Genet. 2016 Oct; 12(10): e1006384. Published online 2016 Oct 24. doi: 10.1371/journal.pgen.1006384

PMCID:: PMC5077151

Abstract Article PDF–2.3M

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