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Select item 61851041.

UBE2G1 governs the destruction of cereblon neomorphic substrates

Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe

eLife. 2018; 7: e40958. Published online 2018 Sep 20. doi: 10.7554/eLife.40958

PMCID:: PMC6185104

Abstract Article PDF–5.4M

Select item 30505792.

Allosteric Activation of E2-RING Finger Mediated Ubiquitylation by a Structurally-Defined Specific E2 Binding Region of gp78

Ranabir Das, Jennifer Mariano, Yien Che Tsai, Ravi C. Kalathur, Zlatka Kostova, Jess Li, Sergey G. Tarasov, Robert L. McFeeters, Amanda S. Altieri, Xinhua Ji, R. Andrew Byrd, Allan M. Weissman

Mol Cell. Author manuscript; available in PMC 2011 Mar 8.

Published in final edited form as: Mol Cell. 2009 Jun 26; 34(6): 674–685. doi: 10.1016/j.molcel.2009.05.010

PMCID:: PMC3050579

Abstract Article PDF–1.6M

Select item 79511803.

LncRNA H19 Alleviates Muscular Dystrophy Through Stabilizing Dystrophin

Yaohua Zhang, Yajuan Li, Qingsong Hu, Yutao Xi, Zhen Xing, Zhao Zhang, Lisa Huang, Jianbo Wu, Ke Liang, Tina K. Nguyen, Sergey D. Egranov, Chengcao Sun, Zilong Zhao, David H. Hawke, Jin Li, Deqiang Sun, Jean J. Kim, Ping Zhang, Jie Cheng, Abid Farida, Mien-Chie Hung, Leng Han, Radbod Darabi, Chunru Lin, Liuqing Yang

Nat Cell Biol. Author manuscript; available in PMC 2021 Apr 26.

Published in final edited form as: Nat Cell Biol. 2020 Nov; 22(11): 1332–1345. Published online 2020 Oct 26. doi: 10.1038/s41556-020-00595-5

PMCID:: PMC7951180

Abstract Article PDF–6.7M

Select item 14136644.

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

Ewen Gallagher, Min Gao, Yun-Cai Liu, Michael Karin

Proc Natl Acad Sci U S A. 2006 Feb 7; 103(6): 1717–1722. Published online 2006 Jan 30. doi: 10.1073/pnas.0510664103

Correction in:: Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16): 7616.

PMCID:: PMC1413664

Abstract Article PDF–469K

Select item 93395815.

PARK2 Regulates eIF4B-Driven Lymphomagenesis

Bandish B. Kapadia, Anirban Roychowdhury, Forum Kayastha, Nahid Nanaji, Ronald B. Gartenhaus

Mol Cancer Res. 2022 May 4; 20(5): 735–748. Published online 2022 Feb 1. doi: 10.1158/1541-7786.MCR-21-0729

PMCID:: PMC9339581

Abstract Article PDF–1.7M

Select item 19514766.

Ubiquitination-Induced Conformational Change within the Deiodinase Dimer Is a Switch Regulating Enzyme Activity

G. D. Vivek Sagar, Balázs Gereben, Isabelle Callebaut, Jean-Paul Mornon, Anikó Zeöld, Wagner S. da Silva, Cristina Luongo, Monica Dentice, Susana M. Tente, Beatriz C. G. Freitas, John W. Harney, Ann Marie Zavacki, Antonio C. Bianco

Mol Cell Biol. 2007 Jul; 27(13): 4774–4783. Published online 2007 Apr 23. doi: 10.1128/MCB.00283-07

PMCID:: PMC1951476

Abstract Article PDF–1.0M

Select item 65175997.

GP78 Cooperates with Dual-Specificity Phosphatase 1 To Stimulate Epidermal Growth Factor Receptor-Mediated Extracellular Signal-Regulated Kinase Signaling

Dhong Hyo Kho, Mohammed Hafiz Uddin, Madhumita Chatterjee, Andreas Vogt, Avraham Raz, Gen Sheng Wu

Mol Cell Biol. 2019 Jun 1; 39(11): e00485-18. Prepublished online 2019 May 6. Published online 2019 May 14. doi: 10.1128/MCB.00485-18

PMCID:: PMC6517599

Abstract Article PDF–3.1M

Select item 61484468.

Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4^CRBN activity

Quinlan L. Sievers, Jessica A. Gasser, Glenn S. Cowley, Eric S. Fischer, Benjamin L. Ebert

Blood. 2018 Sep 20; 132(12): 1293–1303. Prepublished online 2018 Jul 24. doi: 10.1182/blood-2018-01-821769

PMCID:: PMC6148446

Abstract Article

Select item 45050579.

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCF^FBXL2 E3 Ligase

SeungHye Han, Travis B. Lear, Jacob A. Jerome, Shristi Rajbhandari, Courtney A. Snavely, Dexter L. Gulick, Kevin F. Gibson, Chunbin Zou, Bill B. Chen, Rama K. Mallampalli

J Biol Chem. 2015 Jul 17; 290(29): 18124–18133. Published online 2015 Jun 2. doi: 10.1074/jbc.M115.645549

PMCID:: PMC4505057

Abstract Article PDF–1.4M

Select item 324868210.

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2

Jing Zhang, Shu Kan, Brian Huang, Zhenyue Hao, Tak W. Mak, Qing Zhong

Genes Dev. 2011 Dec 15; 25(24): 2610–2618. doi: 10.1101/gad.170605.111

PMCID:: PMC3248682

Abstract Article PDF–782K

Select item 113897311.

TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum

Gerco Hassink, Marjolein Kikkert, Sjaak van Voorden, Shiow-Ju Lee, Robbert Spaapen, Theo van Laar, Catherine S. Coleman, Eric Bartee, Klaus Früh, Vincent Chau, Emmanuel Wiertz

Biochem J. 2005 Jun 1; 388(Pt 2): 647–655. Prepublished online 2005 Jan 27. Published online 2005 May 24. doi: 10.1042/BJ20041241

PMCID:: PMC1138973

Abstract Article PDF–711K

Select item 431900412.

Human Liver Cytochrome P450 3A4 Ubiquitination: MOLECULAR RECOGNITION BY UBC7-gp78 AUTOCRINE MOTILITY FACTOR RECEPTOR AND UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 UBIQUITIN LIGASE COMPLEXES

YongQiang Wang, Sung-Mi Kim, Michael J. Trnka, Yi Liu, A. L. Burlingame, Maria Almira Correia

J Biol Chem. 2015 Feb 6; 290(6): 3308–3332. Published online 2014 Dec 1. doi: 10.1074/jbc.M114.611525

PMCID:: PMC4319004

Abstract Article PDF–5.0M

Select item 430367613.

Differential Ubiquitin Binding by the Acidic Loops of Ube2g1 and Ube2r1 Enzymes Distinguishes Their Lys-48-ubiquitylation Activities

Yun-Seok Choi, Yun-Ju Lee, Seo-Yeon Lee, Lei Shi, Jung-Hye Ha, Hae-Kap Cheong, Chaejoon Cheong, Robert E. Cohen, Kyoung-Seok Ryu

J Biol Chem. 2015 Jan 23; 290(4): 2251–2263. Published online 2014 Dec 3. doi: 10.1074/jbc.M114.624809

PMCID:: PMC4303676

Abstract Article PDF–5.3M

Select item 418291714.

PARC/CUL9 Mediates the Degradation of Mitochondrial-released Cytochrome c and Promotes Survival in Neurons and Cancer Cells

Vivian Gama, Vijay Swahari, Johanna Schafer, Adam J. Kole, Allyson Evans, Yolanda Huang, Anna Cliffe, Brian Golitz, Noah Sciaky, Xin-Hai Pei, Yue Xiong, Mohanish Deshmukh

Sci Signal. Author manuscript; available in PMC 2015 Jan 15.

Published in final edited form as: Sci Signal. 2014 Jul 15; 7(334): ra67. Published online 2014 Jul 15. doi: 10.1126/scisignal.2005309

PMCID:: PMC4182917

Abstract Article PDF–1.8M

Select item 376343315.

Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis

B B Chen, J R Glasser, T A Coon, R K Mallampalli

Cell Death Dis. 2013 Aug; 4(8): e759. Published online 2013 Aug 8. doi: 10.1038/cddis.2013.271

PMCID:: PMC3763433

Abstract Article PDF–3.1M

Select item 345752616.

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

Wei Wei, Meng Li, Jiyong Wang, Fen Nie, Lin Li

Mol Cell Biol. 2012 Oct; 32(19): 3903–3912. doi: 10.1128/MCB.00251-12

PMCID:: PMC3457526

Abstract Article PDF–2.2M

Select item 327775117.

Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination: A PIVOTAL ROLE OF ITS SER-478 RESIDUE IN THE gp78-CATALYZED REACTION

YongQiang Wang, Shenheng Guan, Poulomi Acharya, Yi Liu, Ranjit K. Thirumaran, Relly Brandman, Erin G. Schuetz, Alma L. Burlingame, Maria Almira Correia

Mol Cell Proteomics. 2012 Feb; 11(2): M111.010132. Published online 2011 Nov 18. doi: 10.1074/mcp.M111.010132

PMCID:: PMC3277751

Abstract Article PDF–2.3M

Select item 305898018.

Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1: IDENTIFICATION OF SITES TARGETED FOR PHOSPHORYLATION AND UBIQUITINATION

YongQiang Wang, Shenheng Guan, Poulomi Acharya, Dennis R. Koop, Yi Liu, Mingxiang Liao, Alma L. Burlingame, Maria Almira Correia

J Biol Chem. 2011 Mar 18; 286(11): 9443–9456. Published online 2011 Jan 5. doi: 10.1074/jbc.M110.176685

PMCID:: PMC3058980

Abstract Article PDF–1.5M

Select item 580361719.

A muscle‐specific MuRF1‐E2 network requires stabilization of MuRF1‐E2 complexes by telethonin, a newly identified substrate

Cécile Polge, Stéphanie Cabantous, Christiane Deval, Agnès Claustre, Antoine Hauvette, Catherine Bouchenot, Julien Aniort, Daniel Béchet, Lydie Combaret, Didier Attaix, Daniel Taillandier

J Cachexia Sarcopenia Muscle. 2018 Feb; 9(1): 129–145. Published online 2017 Dec 22. doi: 10.1002/jcsm.12249

PMCID:: PMC5803617

Abstract Article PDF–822K

Select item 332187320.

F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation

Bill B. Chen, Jennifer R. Glasser, Tiffany A. Coon, Chunbin Zou, Hannah L. Miller, Moon Fenton, John F. McDyer, Michael Boyiadzis, Rama K. Mallampalli

Blood. 2012 Mar 29; 119(13): 3132–3141. Prepublished online 2012 Feb 8. doi: 10.1182/blood-2011-06-358911

PMCID:: PMC3321873

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