PMC Links for Gene (Select 7347) - PMC

Chunyan Liao, Ryan Beveridge, Jessica J.R. Hudson, Jacob D. Parker, Shih-Chieh Chiang, Swagat Ray, Mohamed E. Ashour, Ian Sudbery, Mark J. Dickman, Sherif F. El-Khamisy

Cell Rep. 2018 Jun 12; 23(11): 3352–3365. Published online 2018 Jun 13. doi: 10.1016/j.celrep.2018.05.033

PMCID:: PMC6019701

Abstract Article PDF–4.0M

Select item 50795964.

Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization

Meijiao Wang, Tinghe Yu, Lina Hu, Zhi Cheng, Min Li

PLoS One. 2016; 11(10): e0165198. Published online 2016 Oct 25. doi: 10.1371/journal.pone.0165198

PMCID:: PMC5079596

Abstract Article PDF–1.8M

Select item 33723815.

Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes

Olga A. Issaenko, Alexander Yu Amerik

Cell Cycle. 2012 May 1; 11(9): 1804–1817. doi: 10.4161/cc.20174

Correction in:: Cell Cycle. 2012 Sep 15; 11(18): 3518.

Expression of Concern in:: Cell Cycle. 2013 May 15; 12(10): 1643.

PMCID:: PMC3372381

Abstract Article PDF–1.2M

Select item 33679746.

A Novel RNAi Lethality Rescue Screen to Identify Regulators of Adipogenesis

Olivier van Beekum, Yuan Gao, Ruud Berger, Arjen Koppen, Eric Kalkhoven

PLoS One. 2012; 7(6): e37680. Published online 2012 Jun 5. doi: 10.1371/journal.pone.0037680

PMCID:: PMC3367974

Abstract Article PDF–425K

Select item 26350397.

Substrate Filtering by the Active Site Crossover Loop in UCHL3 Revealed by Sortagging and Gain-of-function Mutations

Maximilian W. Popp, Katerina Artavanis-Tsakonas, Hidde L. Ploegh

J Biol Chem. 2009 Feb 6; 284(6): 3593–3602. doi: 10.1074/jbc.M807172200

PMCID:: PMC2635039

Abstract Article PDF–1.1M

Select item 11700028.

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution.

S C Johnston, C N Larsen, W J Cook, K D Wilkinson, C P Hill

EMBO J. 1997 Jul 1; 16(13): 3787–3796. doi: 10.1093/emboj/16.13.3787

PMCID:: PMC1170002

Summary PDF–772K

Select item 112251949.

UCHL3 promotes hepatocellular carcinoma progression by stabilizing EEF1A1 through deubiquitination

Jie Zhao, Qiang Huo, Ji Zhang, Kexiang Sun, Jinhui Guo, Feng Cheng, Xiaoge Hu, Qiuran Xu

Biol Direct. 2024; 19: 53. Published online 2024 Jul 4. doi: 10.1186/s13062-024-00495-w

PMCID:: PMC11225194

Abstract Article PDF–11M

Select item 1093236610.

CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3

Gengchen Xie, Bo Lei, Zhijie Yin, Fei Xu, Xinghua Liu

Int J Mol Sci. 2024 Mar; 25(5): 2817. Published online 2024 Feb 29. doi: 10.3390/ijms25052817

PMCID:: PMC10932366

Abstract Article PDF–6.7M

Select item 1015438511.

The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway

Jianing Tang, Qian Yang, Chao Mao, Desheng Xiao, Shuang Liu, Liang Xiao, Ledu Zhou, Gaosong Wu, Yongguang Tao

Cell Death Differ. 2023 May; 30(5): 1247–1259. Published online 2023 Feb 22. doi: 10.1038/s41418-023-01134-z

PMCID:: PMC10154385

Abstract Article PDF–6.3M

Select item 1003604012.

UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin

Qiancheng Ma, Qiliang Lu, Xiangxiang Lei, Jie Zhao, Wen Sun, Jun Wang, Qing Zhu, Dongsheng Huang

Front Oncol. 2023; 13: 1088475. Published online 2023 Mar 9. doi: 10.3389/fonc.2023.1088475

PMCID:: PMC10036040

Abstract Article PDF–5.6M

Select item 729779413.

The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor

Lianlian Ouyang, Bin Yan, Yating Liu, Chao Mao, Min Wang, Na Liu, Zuli Wang, Shouping Liu, Ying Shi, Ling Chen, Xiang Wang, Yan Cheng, Ya Cao, Desheng Xiao, Lingqiang Zhang, Shuang Liu, Yongguang Tao

Signal Transduct Target Ther. 2020; 5: 78. Published online 2020 Jun 17. doi: 10.1038/s41392-020-0181-3

PMCID:: PMC7297794

Abstract Article PDF–6.4M

Select item 678067014.

UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization

Zhiwang Song, Junhe Li, Ling Zhang, Jun Deng, Ziling Fang, Xiaojun Xiang, Jianping Xiong

Am J Cancer Res. 2019; 9(9): 1970–1981. Published online 2019 Sep 1.

PMCID:: PMC6780670

Abstract Article PDF–2.3M

Select item 950105315.

Structural Insights into the Phosphorylation-Enhanced Deubiquitinating Activity of UCHL3 and Ubiquitin Chain Cleavage Preference Analysis

Yujing Ren, Beiming Yu, Lihui Zhou, Feng Wang, Yanfeng Wang

Int J Mol Sci. 2022 Sep; 23(18): 10789. Published online 2022 Sep 15. doi: 10.3390/ijms231810789

PMCID:: PMC9501053

Abstract Article PDF–2.1M

Select item 652944816.

A novel UCHL₃ inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Zhiwang Song, Xinyi Tu, Qin Zhou, Jinzhou Huang, Yuping Chen, Jiaqi Liu, SeungBaek Lee, Wootae Kim, Somaira Nowsheen, Kuntian Luo, Jian Yuan, Zhenkun Lou

Cell Death Dis. 2019 Jun; 10(6): 398. Published online 2019 May 21. doi: 10.1038/s41419-019-1628-8

PMCID:: PMC6529448

Abstract Article PDF–1.7M

Select item 369906617.

Genome-wide association study in a Chinese population with diabetic retinopathy

Wayne H.-H. Sheu, Jane Z. Kuo, I-Te Lee, Yi-Jen Hung, Wen-Jane Lee, Hin-Yeung Tsai, J.-S. Wang, Mark O. Goodarzi, Ronald Klein, Barbara E. K. Klein, Eli Ipp, Shin-Yi Lin, Xiuqing Guo, Chang-Hsun Hsieh, Kent D. Taylor, Chia-Po Fu, Jerome I. Rotter, Yii-Der I. Chen

Hum Mol Genet. 2013 Aug 1; 22(15): 3165–3173. Published online 2013 Apr 4. doi: 10.1093/hmg/ddt161

PMCID:: PMC3699066

Abstract Article PDF–215K

Select item 276624118.

Positional-scanning fluorogenic substrate libraries reveal unexpected specificity determinants of deubiquitinating enzymes (DUBs)

Marcin Drag, Jowita Mikolajczyk, Miklos Bekes, Francisca E. Reyes-Turcu, Jonathan A. Ellman, Keith D. Wilkinson, Guy S. Salvesen

Biochem J. Author manuscript; available in PMC 2009 Nov 1.

Published in final edited form as: Biochem J. 2008 Nov 1; 415(3): 367–375. doi: 10.1042/BJ20080779

PMCID:: PMC2766241

Abstract Article PDF–1.2M

Select item 1051756719.

Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression

Tao Liu, Meng-Qi Fan, Xiao-Xiao Xie, Qi-Peng Shu, Xue-Hua Du, Lin-Zhi Qi, Xiao-Dong Zhang, Ming-Hui Zhang, Guang Shan, Run-Lei Du, Shang-Ze Li

J Transl Med. 2023; 21: 656. Published online 2023 Sep 22. doi: 10.1186/s12967-023-04311-3

PMCID:: PMC10517567

Abstract Article PDF–7.4M

Select item 1047429220.

The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis

Soo Yeon Lee, Soo-Yeon Park, Seung-Hyun Lee, Hyunsik Kim, Jae-Hwan Kwon, Jung-Yoon Yoo, Kyunggon Kim, Moo Suk Park, Chun Geun Lee, Jack A. Elias, Myung Hyun Sohn, Hyo Sup Shim, Ho-Geun Yoon

Exp Mol Med. 2023 Aug; 55(8): 1795–1805. Published online 2023 Aug 1. doi: 10.1038/s12276-023-01066-1