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Select item 42192921.

Androgen receptor coactivators that inhibit prostate cancer growth

Garrett Daniels, Ruchi Jha, Ying Shen, Susan K Logan, Peng Lee

Am J Clin Exp Urol. 2014; 2(1): 62–70. Published online 2014 Apr 5.

PMCID:: PMC4219292

Abstract Article PDF–401K

Select item 38227282.

Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion

Yi Peng, Yirong Li, Lan Lin Gellert, Xuanyi Zou, Jun Wang, Baljit Singh, Ruliang Xu, Luis Chiriboga, Garrett Daniels, Ruimin Pan, David Y Zhang, Michael J Garabedian, Robert J Schneider, Zhengxin Wang, Peng Lee

J Cell Mol Med. 2010 Dec; 14(12): 2780–2789. Published online 2009 Oct 16. doi: 10.1111/j.1582-4934.2009.00936.x

PMCID:: PMC3822728

Abstract Article PDF–950K

Select item 34934953.

Subcellular Localization of p44/WDR77 Determines Proliferation and Differentiation of Prostate Epithelial Cells

Shen Gao, Zhengxin Wang

PLoS One. 2012; 7(11): e49173. Published online 2012 Nov 8. doi: 10.1371/journal.pone.0049173

PMCID:: PMC3493495

Abstract Article PDF–10M

Select item 31927954.

Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer

Martin Ligr, Ruzeen Rohintan Patwa, Garrett Daniels, Lorraine Pan, Xinyu Wu, Yirong Li, Liantian Tian, Zhenxing Wang, Ruliang Xu, Jingjing Wu, Fan Chen, Jinsong Liu, Jian-Jun Wei, Peng Lee

PLoS One. 2011; 6(10): e26250. Published online 2011 Oct 13. doi: 10.1371/journal.pone.0026250

Correction in:: PLoS One. 2011; 6(10): 10.1371/annotation/fe4fca93-8211-430e-bfe0-8a371b9cc20d.

PMCID:: PMC3192795

Abstract Article PDF–634K

Select item 83468925.

Germ-line mutations in WDR77 predispose to familial papillary thyroid cancer

Yanyang Zhao, Tian Yu, Jie Sun, Feiliang Wang, Chaoze Cheng, Shurong He, Lan Chen, Donghui Xie, Liping Fu, Xuhuizi Guan, An Yan, Yao Li, Gang Miao, Xiaoquan Zhu

Proc Natl Acad Sci U S A. 2021 Aug 3; 118(31): e2026327118. Published online 2021 Jul 29. doi: 10.1073/pnas.2026327118

PMCID:: PMC8346892

Abstract Article PDF–1.6M

Select item 83439986.

HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver

Hongfeng Yuan, Lina Zhao, Ying Yuan, Haolin Yun, Wei Zheng, Yu Geng, Guang Yang, Yufei Wang, Man Zhao, Xiaodong Zhang

Theranostics. 2021; 11(17): 8362–8378. Published online 2021 Jul 25. doi: 10.7150/thno.57531

PMCID:: PMC8343998

Abstract Article PDF–3.1M

Select item 58622597.

Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation

Kamalika Saha, Matthew L Fisher, Gautam Adhikary, Daniel Grun, Richard L Eckert

Carcinogenesis. 2017 Aug; 38(8): 827–836. Published online 2017 May 10. doi: 10.1093/carcin/bgx044

Correction in:: Carcinogenesis. 2023 Jul; 44(7): 626–627.

PMCID:: PMC5862259

Abstract Article PDF–12M

Select item 58432158.

Cryo-electron microscopy structure of a human PRMT5:MEP50 complex

David E. Timm, Valorie Bowman, Russell Madsen, Charles Rauch

PLoS One. 2018; 13(3): e0193205. Published online 2018 Mar 8. doi: 10.1371/journal.pone.0193205

PMCID:: PMC5843215

Abstract Article PDF–14M

Select item 49702769.

Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation

Xiumei Sheng, Zhengxin Wang

BMC Cancer. 2016; 16: 567. Published online 2016 Aug 2. doi: 10.1186/s12885-016-2632-3

PMCID:: PMC4970276

Abstract Article PDF–2.1M

Select item 489998210.

MEP50/PRMT5 reduces gene expression by histone arginine methylation and this is reversed by PKCd/p38d signaling

Kamalika Saha, Gautam Adhikary, Richard L. Eckert

J Invest Dermatol. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: J Invest Dermatol. 2016 Jan; 136(1): 214–224. doi: 10.1038/JID.2015.400

PMCID:: PMC4899982

Abstract Article PDF–856K

Select item 443036811.

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

Nicole Stopa, Jocelyn E. Krebs, David Shechter

Cell Mol Life Sci. 2015 Jun; 72(11): 2041–2059. Published online 2015 Feb 7. doi: 10.1007/s00018-015-1847-9

PMCID:: PMC4430368

Abstract Article PDF–1.7M

Select item 313763512.

Nuclear Transport Signals Control Cellular Localization and Function of Androgen Receptor Cofactor p44/WDR77

Zhongping Gu, Liran Zhou, Shen Gao, Zhengxin Wang

PLoS One. 2011; 6(7): e22395. Published online 2011 Jul 15. doi: 10.1371/journal.pone.0022395

PMCID:: PMC3137635

Abstract Article PDF–2.7M

Select item 1093215013.

Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2^low Adult T-Cell Leukemia/Lymphoma

Tomonaga Ichikawa, Akira Suekane, Shingo Nakahata, Hidekatsu Iha, Kazuya Shimoda, Takashi Murakami, Kazuhiro Morishita

Int J Mol Sci. 2024 Mar; 25(5): 2842. Published online 2024 Feb 29. doi: 10.3390/ijms25052842

PMCID:: PMC10932150

Abstract Article PDF–3.7M

Select item 468774714.

JAK2V617F-mediated phosphorylation of PRMT5 down-regulates its methyltransferase activity and promotes myeloproliferation

Fan Liu, Xinyang Zhao, Fabiana Perna, Lan Wang, Priya Koppikar, Omar Abdel-Wahab, Michael W. Harr, Ross L. Levine, Hao Xu, Ayalew Tefferi, Anthony Deblasio, Megan Hatlen, Silvia Menendez, Stephen D. Nimer

Cancer Cell. Author manuscript; available in PMC 2015 Dec 22.

Published in final edited form as: Cancer Cell. 2011 Feb 15; 19(2): 283–294. doi: 10.1016/j.ccr.2010.12.020

PMCID:: PMC4687747

Abstract Article PDF–1.1M

Select item 461511515.

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)

Tamara Ratovitski, Nicolas Arbez, Jacqueline C Stewart, Ekaterine Chighladze, Christopher A Ross

Cell Cycle. 2015 Jun 3; 14(11): 1716–1729. Published online 2015 Apr 30. doi: 10.1080/15384101.2015.1033595

PMCID:: PMC4615115

Abstract Article PDF–1.1M

Select item 227817816.

Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer

Yi Peng, Fei Chen, Jonathan Melamed, Luis Chiriboga, Jianjun Wei, Xiangtian Kong, Maureen Mcleod, Yirong Li, Caihong X. Li, Alice Feng, Michael J. Garabedian, Zhengxin Wang, Robert G. Roeder, Peng Lee

Proc Natl Acad Sci U S A. 2008 Apr 1; 105(13): 5236–5241. Published online 2008 Mar 20. doi: 10.1073/pnas.0712262105

PMCID:: PMC2278178

Abstract Article PDF–747K

Select item 848147817.

Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer

Xinye Wang, Ting Qiu, Yingying Wu, Chuanyu Yang, Yi Li, Guangshi Du, Yaohui He, Wen Liu, Rong Liu, Chuan-huizi Chen, Yujie Shi, Jingxuan Pan, Jia Zhou, Dewei Jiang, Ceshi Chen

Cell Death Differ. 2021 Oct; 28(10): 2931–2945. Published online 2021 May 10. doi: 10.1038/s41418-021-00793-0