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Select item 102027151.

Loss of AKAP12 aggravates rheumatoid arthritis-like symptoms and cardiac damage in collagen-induced arthritis mice

Yanhui Ni, Jingjing Cao, Jing Yuan, Xiaoran Ning

Exp Anim. 2023; 72(2): 242–252. Published online 2022 Dec 5. doi: 10.1538/expanim.22-0103

PMCID:: PMC10202715

Abstract Article PDF–4.9M

Select item 95319472.

Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models

Komal Ramani, Nirmala Mavila, Aushinie Abeynayake, Maria Lauda Tomasi, Jiaohong Wang, Michitaka Matsuda, Eki Seki

eLife. 2022; 11: e78430. Published online 2022 Oct 4. doi: 10.7554/eLife.78430

Correction in:: eLife. 2023; 12: e88586.

PMCID:: PMC9531947

Abstract Article PDF–8.1M

Select item 91189253.

AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway

Xuan Wu, Yuhong Luo, Shan Wang, Yueying Li, Meiyu Bao, Yuanjiang Shang, Lei Chen, Weiwei Liu

Redox Biol. 2022 Jul; 53: 102328. Published online 2022 May 6. doi: 10.1016/j.redox.2022.102328

PMCID:: PMC9118925

Abstract Article PDF–16M

Select item 83105274.

Roles of A-kinase anchor protein 12 in astrocyte and oligodendrocyte precursor cell in postnatal corpus callosum

Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Ji Hyun Park, Kelly K. Chung, Irwin H. Gelman, Kyu-Won Kim, Josephine Lok, Eng H. Lo, Ken Arai

Stem Cell Rev Rep. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Stem Cell Rev Rep. 2021 Aug; 17(4): 1446–1455. Published online 2021 Jan 25. doi: 10.1007/s12015-021-10118-w

PMCID:: PMC8310527

Abstract Article PDF–2.9M

Select item 77304305.

AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke

Ji Hae Seo, Takakuni Maki, Nobukazu Miyamoto, Yoon Kyong Choi, Kelly K. Chung, Gen Hamanaka, Ji Hyun Park, Emiri T. Mandeville, Hajime Takase, Kazuhide Hayakawa, Josephine Lok, Irwin H. Gelman, Kyu-Won Kim, Eng H. Lo, Ken Arai

Int J Mol Sci. 2020 Dec; 21(23): 9078. Published online 2020 Nov 28. doi: 10.3390/ijms21239078

PMCID:: PMC7730430

Abstract Article PDF–2.9M

Select item 68430106.

Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis

Qiying Fan, Xing Yin, Abeer Rababa’h, Andrea Diaz Diaz, Cori S. Wijaya, Sonal Singh, Santosh V. Suryavanshi, Henry Hiep Vo, Moawiz Saeed, Yang Zhang, Bradley K. McConnell

Am J Physiol Heart Circ Physiol. 2019 Oct 1; 317(4): H793–H810. Published online 2019 Aug 23. doi: 10.1152/ajpheart.00215.2019

PMCID:: PMC6843010

Abstract Article

Select item 59181587.

A-Kinase Anchor Protein 12 is required for oligodendrocyte differentiation in adult white matter

Takakuni Maki, Yoon Kyung Choi, Nobukazu Miyamoto, Akihiro Shindo, Anna C. Liang, Bum Ju Ahn, Emiri T. Mandeville, Seiji Kaji, Kanako Itoh, Ji Hae Seo, Irwin H. Gelman, Josephine Lok, Ryosuke Takahashi, Kyu-Won Kim, Eng H. Lo, Ken Arai

Stem Cells. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Stem Cells. 2018 May; 36(5): 751–760. Published online 2018 Jan 22. doi: 10.1002/stem.2771

PMCID:: PMC5918158

Abstract Article PDF–890K

Select item 54904898.

Force development and intracellular Ca²⁺ in intact Cardiac Muscles from Gravin Mutant Mice

Zhitao Li, Sonal Singh, Santosh V. Suryanvanshi, Wengang Ding, Xiaoxu Shen, Cori S. Wijaya, Wei Dong Gao, Bradley K. McConnell

Eur J Pharmacol. Author manuscript; available in PMC 2018 Jul 15.

Published in final edited form as: Eur J Pharmacol. 2017 Jul 15; 807: 117–126. Published online 2017 Apr 17. doi: 10.1016/j.ejphar.2017.04.020

PMCID:: PMC5490489

Abstract Article PDF–560K

Select item 39975719.

AKAP12 Mediates Barrier Functions of Fibrotic Scars during CNS Repair

Jong-Ho Cha, Hee-Jun Wee, Ji Hae Seo, Bum Ju Ahn, Ji-Hyeon Park, Jun-Mo Yang, Sae-Won Lee, Eun Hee Kim, Ok-Hee Lee, Ji Hoe Heo, Hyo-Jong Lee, Irwin H. Gelman, Ken Arai, Eng H. Lo, Kyu-Won Kim

PLoS One. 2014; 9(4): e94695. Published online 2014 Apr 23. doi: 10.1371/journal.pone.0094695

PMCID:: PMC3997571

Abstract Article PDF–17M

Select item 310793810.

Carcinogen-induced squamous papillomas and oncogenic progression in the absence of the SSeCKS/AKAP12 metastasis suppressor correlates with FAK upregulation

Shin Akakura, Rene Bouchard, Wiam Bshara, Carl Morrison, Irwin H. Gelman

Int J Cancer. Author manuscript; available in PMC 2012 Oct 15.

Published in final edited form as: Int J Cancer. 2011 Oct 15; 129(8): 2025–2031. Published online 2011 Apr 1. doi: 10.1002/ijc.25828

PMCID:: PMC3107938

Abstract Article PDF–1.9M

Select item 304803511.

Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12

Shin Akakura, Peter Nochajski, Lingqiu Gao, Paul Sotomayor, Sei-ichi Matsui, Irwin H Gelman

Cell Cycle. 2010 Dec 1; 9(23): 4656–4665. Published online 2010 Dec 1. doi: 10.4161/cc.9.23.13974

PMCID:: PMC3048035

Abstract Article PDF–771K

Select item 283916412.

Loss of the ssecks/gravin/akap12 Gene Results in Prostatic Hyperplasia

Shin Akakura, Changhui Huang, Peter J. Nelson, Barbara Foster, Irwin H. Gelman

Cancer Res. Author manuscript; available in PMC 2010 Mar 16.

Published in final edited form as: Cancer Res. 2008 Jul 1; 68(13): 5096–5103. doi: 10.1158/0008-5472.CAN-07-5619

PMCID:: PMC2839164

Abstract Article PDF–990K

Select item 593802513.

Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution

Hye Shin Lee, Jinhyeok Choi, Taekwon Son, Hee-Jun Wee, Sung-Jin Bae, Ji Hae Seo, Ji Hyun Park, Soo Hyung Ryu, Danbi Lee, Myoung Kuk Jang, Eunsil Yu, Young-Hwa Chung, Kyu-Won Kim

Exp Mol Med. 2018 Apr; 50(4): 48. Published online 2018 Apr 27. doi: 10.1038/s12276-018-0074-5

PMCID:: PMC5938025

Abstract Article PDF–5.6M

Select item 434806514.

Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury

Jong-Ho Cha, Hee-Jun Wee, Ji Hae Seo, Bum Ju Ahn, Ji-Hyeon Park, Jun-Mo Yang, Sae-Won Lee, Ok-Hee Lee, Hyo-Jong Lee, Irwin H. Gelman, Ken Arai, Eng H. Lo, Kyu-Won Kim

Nat Commun. Author manuscript; available in PMC 2015 Mar 3.

Published in final edited form as: Nat Commun. 2014; 5: 4952. Published online 2014 Sep 17. doi: 10.1038/ncomms5952

PMCID:: PMC4348065

Abstract Article PDF–1.0M

Select item 391678015.

A transgenic mouse model for early prostate metastasis to lymph nodes

Hyun-Kyung Ko, Shin Akakura, Jennifer Peresie, David W. Goodrich, Barbara A. Foster, Irwin H. Gelman

Cancer Res. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Cancer Res. 2014 Feb 1; 74(3): 945–953. doi: 10.1158/0008-5472.CAN-13-1157

Correction in:: volume 74 on page 2374

PMCID:: PMC3916780

Abstract Article PDF–3.2M

Select item 377674916.

Enhanced Cardiac Function in Gravin Mutant Mice Involves Alterations in the β-Adrenergic Receptor Signaling Cascade

Ashley N. Guillory, Xing Yin, Cori S. Wijaya, Andrea C. Diaz Diaz, Abeer Rababa’h, Sonal Singh, Fatin Atrooz, Sakthivel Sadayappan, Bradley K. McConnell

PLoS One. 2013; 8(9): e74784. Published online 2013 Sep 18. doi: 10.1371/journal.pone.0074784

PMCID:: PMC3776749

Abstract Article PDF–2.4M

Select item 1076656117.

PTEN-regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression

Karina A. Miller, Seamus Degan, Yanqing Wang, Joseph Cohen, Sheng Yu Ku, David W. Goodrich, Irwin H. Gelman

Oncogene. 2024; 43(1): 22–34. Published online 2023 Oct 24. doi: 10.1038/s41388-023-02875-4

Correction in:: Oncogene. 2024; 43(1): 76.

PMCID:: PMC10766561

Abstract Article PDF–3.9M

Select item 421475318.

Suppression of Chemotaxis by SSeCKS via Scaffolding of Phosphoinositol Phosphates and the Recruitment of the Cdc42 GEF, Frabin, to the Leading Edge

Hyun-Kyung Ko, Li-wu Guo, Bing Su, Lingqiu Gao, Irwin H. Gelman

PLoS One. 2014; 9(10): e111534. Published online 2014 Oct 30. doi: 10.1371/journal.pone.0111534

PMCID:: PMC4214753

Abstract Article PDF–7.7M

Select item 353325119.

Gravin Orchestrates Protein Kinase A and β2-Adrenergic Receptor Signaling Critical for Synaptic Plasticity and Memory

Robbert Havekes, David A. Canton, Alan J. Park, Ted Huang, Ting Nie, Jonathan P. Day, Leonardo A. Guercio, Quinn Grimes, Vincent Luczak, Irwin H. Gelman, George S. Baillie, John D. Scott, Ted Abel

J Neurosci. 2012 Dec 12; 32(50): 18137–18149. doi: 10.1523/JNEUROSCI.3612-12.2012

PMCID:: PMC3533251

Abstract Article PDF–3.2M

Select item 1107575220.

AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction

Hanan Qasim, Mehrdad Rajaei, Ying Xu, Arfaxad Reyes-Alcaraz, Hala Y. Abdelnasser, M. David Stewart, Satadru K. Lahiri, Xander H.T. Wehrens, Bradley K. McConnell

Circ Res. 2024 Apr 12; 134(8): 1006–1022. Published online 2024 Mar 20. doi: 10.1161/CIRCRESAHA.123.323655