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Select item 32916551.

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

Rik Schrijvers, Jan De Rijck, Jonas Demeulemeester, Noritaka Adachi, Sofie Vets, Keshet Ronen, Frauke Christ, Frederic D. Bushman, Zeger Debyser, Rik Gijsbers

PLoS Pathog. 2012 Mar; 8(3): e1002558. Published online 2012 Mar 1. doi: 10.1371/journal.ppat.1002558

Correction in:: PLoS Pathog. 2020 Sep; 16(9): e1008894.

PMCID:: PMC3291655

Abstract Article PDF–1.6M

Select item 88437442.

Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t(4;14) translocation

Jingjing Wang, Xu Zhu, Lin Dang, Hongmei Jiang, Ying Xie, Xin Li, Jing Guo, Yixuan Wang, Ziyi Peng, Mengqi Wang, Jingya Wang, Sheng Wang, Qian Li, Yafei Wang, Qiang Wang, Lingqun Ye, Lirong Zhang, Zhiqiang Liu

J Clin Invest. 2022 Feb 15; 132(4): e149526. Published online 2022 Feb 15. doi: 10.1172/JCI149526

PMCID:: PMC8843744

Abstract Article PDF–2.4M

Select item 67747273.

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

Gary LeRoy, Ozgur Oksuz, Nicolas Descostes, Yuki Aoi, Rais A. Ganai, Havva Ortabozkoyun Kara, Jia-Ray Yu, Chul-Hwan Lee, James Stafford, Ali Shilatifard, Danny Reinberg

Sci Adv. 2019 Oct; 5(10): eaay3068. Published online 2019 Oct 2. doi: 10.1126/sciadv.aay3068

PMCID:: PMC6774727

Abstract Article PDF–3.2M

Select item 34851734.

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

Rik Schrijvers, Sofie Vets, Jan De Rijck, Nirav Malani, Frederic D Bushman, Zeger Debyser, Rik Gijsbers

Retrovirology. 2012; 9: 84. Published online 2012 Oct 9. doi: 10.1186/1742-4690-9-84

PMCID:: PMC3485173

Abstract Article PDF–590K

Select item 78359585.

Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

Siska Van Belle, Sara El Ashkar, Kateřina Čermáková, Filip Matthijssens, Steven Goossens, Alessandro Canella, Courtney H. Hodges, Frauke Christ, Jan De Rijck, Pieter Van Vlierberghe, Václav Veverka, Zeger Debyser

Cells. 2021 Jan; 10(1): 192. Published online 2021 Jan 19. doi: 10.3390/cells10010192

PMCID:: PMC7835958

Abstract Article PDF–4.0M

Select item 31194736.

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

Hong Wu, Hong Zeng, Robert Lam, Wolfram Tempel, Maria F. Amaya, Chao Xu, Ludmila Dombrovski, Wei Qiu, Yanming Wang, Jinrong Min

PLoS One. 2011; 6(6): e18919. Published online 2011 Jun 20. doi: 10.1371/journal.pone.0018919

PMCID:: PMC3119473

Abstract Article PDF–3.0M

Select item 73379027.

HRP2–DPF3a–BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription

Xu Zhu, Bingxue Lan, Xianfu Yi, Chaoran He, Lin Dang, Xingquan Zhou, Yumei Lu, Yongzhan Sun, Zhiheng Liu, Xue Bai, Kai Zhang, Bing Li, Mulin Jun Li, Yupeng Chen, Lirong Zhang

Nucleic Acids Res. 2020 Jul 9; 48(12): 6563–6582. Published online 2020 May 27. doi: 10.1093/nar/gkaa441

PMCID:: PMC7337902

Abstract Article PDF–9.5M

Select item 47972818.

Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination

Annika Baude, Tania Løve Aaes, Beibei Zhai, Nader Al-Nakouzi, Htoo Zarni Oo, Mads Daugaard, Mikkel Rohde, Marja Jäättelä

Nucleic Acids Res. 2016 Mar 18; 44(5): 2214–2226. Published online 2015 Dec 31. doi: 10.1093/nar/gkv1526

PMCID:: PMC4797281

Abstract Article PDF–4.2M

Select item 51237619.

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

Judd F. Hultquist, Kathrin Schumann, Jonathan M. Woo, Lara Manganaro, Michael J. McGregor, Jennifer Doudna, Viviana Simon, Nevan J. Krogan, Alexander Marson

Cell Rep. Author manuscript; available in PMC 2016 Nov 25.

Published in final edited form as: Cell Rep. 2016 Oct 25; 17(5): 1438–1452. doi: 10.1016/j.celrep.2016.09.080

PMCID:: PMC5123761

Abstract Article PDF–1.7M

Select item 729557610.

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137

Fengwen Zhang, Paul D Bieniasz

eLife. 2020; 9: e55806. Published online 2020 Jun 15. doi: 10.7554/eLife.55806

PMCID:: PMC7295576

Abstract Article PDF–4.3M

Select item 535872311.

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair

Justin W.C. Leung, Nodar Makharashvili, Poonam Agarwal, Li-Ya Chiu, Renaud Pourpre, Michael B. Cammarata, Joe R. Cannon, Alana Sherker, Daniel Durocher, Jennifer S. Brodbelt, Tanya T. Paull, Kyle M. Miller

Genes Dev. 2017 Feb 1; 31(3): 260–274. doi: 10.1101/gad.292516.116

PMCID:: PMC5358723

Abstract Article PDF–1.8M

Select item 660120812.

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18

Manal Alsulami, Nayla Munawar, Eugene Dillon, Giorgio Oliviero, Kieran Wynne, Mona Alsolami, Catherine Moss, Peadar Ó Gaora, Fergal O'Meara, David Cotter, Gerard Cagney

Mol Cell Proteomics. 2019 Jul; 18(7): 1428–1436. Published online 2019 May 10. doi: 10.1074/mcp.RA119.001518

PMCID:: PMC6601208

Abstract Article PDF–1.8M

Select item 539338613.

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation

Marni S. Crow, Ileana M. Cristea

Mol Cell Proteomics. 2017 Apr; 16(4 Suppl 1): S200–S214. Published online 2017 Jan 11. doi: 10.1074/mcp.M116.064741

PMCID:: PMC5393386

Abstract Article PDF–2.6M

Select item 953348614.

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Yongzhen Mo, Yumin Wang, Yian Wang, Xiangying Deng, Qijia Yan, Chunmei Fan, Shuai Zhang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Qianjin Liao, Can Guo, Yong Li, Guiyuan Li, Zhaoyang Zeng, Weihong Jiang, Wei Xiong, Bo Xiang

Mol Cancer. 2022; 21: 192. Published online 2022 Oct 5. doi: 10.1186/s12943-022-01659-w

PMCID:: PMC9533486

Abstract Article PDF–12M

Select item 649858515.

Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes

Jee Hoon Lee, Ji-hye Han, Hyunmi Kim, Sang Myun Park, Eun-hye Joe, Ilo Jou

Acta Neuropathol Commun. 2019; 7: 68. Published online 2019 May 2. doi: 10.1186/s40478-019-0716-4

PMCID:: PMC6498585

Abstract Article PDF–6.9M

Select item 191354516.

Functional specialization of β-arrestin interactions revealed by proteomic analysis

Kunhong Xiao, Daniel B. McClatchy, Arun K. Shukla, Yang Zhao, Minyong Chen, Sudha K. Shenoy, John R. Yates, III, Robert J. Lefkowitz

Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29): 12011–12016. Published online 2007 Jul 9. doi: 10.1073/pnas.0704849104

PMCID:: PMC1913545

Abstract Article PDF–712K

Select item 303367217.

Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human Cells

Ok-Hee Lee, Hyeung Kim, Quanyuan He, Hwa Jin Baek, Dong Yang, Liuh-Yow Chen, Jiancong Liang, Heekyung Kate Chae, Amin Safari, Dan Liu, Zhou Songyang

Mol Cell Proteomics. 2011 Feb; 10(2): M110.001628. Published online 2010 Nov 11. doi: 10.1074/mcp.M110.001628

PMCID:: PMC3033672

Abstract Article PDF–1.5M

Select item 623320518.

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN

Bin Liu, Shangwen Jiang, Min Li, Xuelian Xiong, Mingrui Zhu, Duanzhuo Li, Lei Zhao, Lili Qian, Linhui Zhai, Jing Li, Han Lu, Shengnan Sun, Jiandie Lin, Yan Lu, Xiaoying Li, Minjia Tan

Nat Commun. 2018; 9: 4770. Published online 2018 Nov 13. doi: 10.1038/s41467-018-07185-y

PMCID:: PMC6233205

Abstract Article PDF–1.6M

Select item 939206319.

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling

Yansheng Zhai, Xiaoyan Huang, Keren Zhang, Yuchen Huang, Yanlong Jiang, Jingwei Cui, Zhe Zhang, Cookson K. C. Chiu, Weiye Zhong, Gang Li

Nat Commun. 2022; 13: 4906. Published online 2022 Aug 20. doi: 10.1038/s41467-022-32689-z

PMCID:: PMC9392063

Abstract Article PDF–2.0M

Select item 895660420.

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

Julia Joung, Paul C. Kirchgatterer, Ankita Singh, Jang H. Cho, Suchita P. Nety, Rebecca C. Larson, Rhiannon K. Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V. Maus, Feng Zhang

Nat Commun. 2022; 13: 1606. Published online 2022 Mar 25. doi: 10.1038/s41467-022-29205-8